KR102896762B1 - 고순도 마그네슘 l-락테이트의 결정화 - Google Patents

고순도 마그네슘 l-락테이트의 결정화

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Publication number
KR102896762B1
KR102896762B1 KR1020237027752A KR20237027752A KR102896762B1 KR 102896762 B1 KR102896762 B1 KR 102896762B1 KR 1020237027752 A KR1020237027752 A KR 1020237027752A KR 20237027752 A KR20237027752 A KR 20237027752A KR 102896762 B1 KR102896762 B1 KR 102896762B1
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South Korea
Prior art keywords
lactate
magnesium
delete delete
crystals
organic waste
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KR1020237027752A
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English (en)
Korean (ko)
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KR20230135613A (ko
Inventor
츠비카 그리너
닛산 파포
아사프 하르노이
Original Assignee
트리플더블유 리미티드
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Publication of KR20230135613A publication Critical patent/KR20230135613A/ko
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0018—Evaporation of components of the mixture to be separated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/08—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020237027752A 2021-01-21 2022-01-19 고순도 마그네슘 l-락테이트의 결정화 Active KR102896762B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257040429A KR20260003312A (ko) 2021-01-21 2022-01-19 고순도 마그네슘 l-락테이트의 결정화

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163139894P 2021-01-21 2021-01-21
US63/139,894 2021-01-21
US202163280150P 2021-11-17 2021-11-17
US63/280,150 2021-11-17
PCT/IL2022/050081 WO2022157768A1 (en) 2021-01-21 2022-01-19 Crystallization of high-purity magnesium l-lactate

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257040429A Division KR20260003312A (ko) 2021-01-21 2022-01-19 고순도 마그네슘 l-락테이트의 결정화

Publications (2)

Publication Number Publication Date
KR20230135613A KR20230135613A (ko) 2023-09-25
KR102896762B1 true KR102896762B1 (ko) 2025-12-05

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020237027752A Active KR102896762B1 (ko) 2021-01-21 2022-01-19 고순도 마그네슘 l-락테이트의 결정화
KR1020257040429A Pending KR20260003312A (ko) 2021-01-21 2022-01-19 고순도 마그네슘 l-락테이트의 결정화

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020257040429A Pending KR20260003312A (ko) 2021-01-21 2022-01-19 고순도 마그네슘 l-락테이트의 결정화

Country Status (12)

Country Link
US (1) US20240300880A1 (https=)
EP (2) EP4736977A2 (https=)
JP (1) JP7720646B2 (https=)
KR (2) KR102896762B1 (https=)
CN (1) CN119330822A (https=)
AU (1) AU2022211203A1 (https=)
CA (1) CA3207836A1 (https=)
DK (1) DK4281432T3 (https=)
FI (1) FI4281432T3 (https=)
IL (1) IL303988B2 (https=)
MX (1) MX2023008459A (https=)
WO (1) WO2022157768A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116829529B (zh) * 2021-01-21 2024-10-18 三W有限公司 高纯度l-乳酸镁的结晶
CN119562940A (zh) * 2022-07-27 2025-03-04 三W有限公司 L-乳酸或其盐的对映体富集

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020110108A1 (en) 2018-11-26 2020-06-04 3Plw Ltd. Purification of magnesium lactate from fermentation broths having high amounts of impurities

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101018756B (zh) 2004-06-17 2011-06-08 普拉克生化公司 由含乳酸镁的介质制备乳酸或乳酸盐的方法
KR20110105845A (ko) * 2008-12-26 2011-09-27 도레이 카부시키가이샤 락트산 및 폴리락트산의 제조 방법
EP2399658A1 (en) * 2010-06-24 2011-12-28 Biosyn Arzneimittel GmbH Method for producing pharmacologically pure crystals
BR112013014646A2 (pt) 2010-12-13 2016-08-02 Toray Industries método para produção de um sal de ácido lático
EP2604696A1 (en) 2011-12-16 2013-06-19 PURAC Biochem BV Process for the fermentative production of lactic acid from a plant extract in the presence of a caustic magnesium salt
FR2994569B1 (fr) * 2012-08-17 2016-11-04 Roquette Freres Procede de fabrication de compositions riches en cristaux de mannitol sous forme delta, compositions et cristaux obtenus ainsi que leurs utilisations
WO2016016233A1 (en) 2014-07-28 2016-02-04 Purac Biochem Bv Method for the preparation of lactic acid
CN104789607B (zh) 2015-04-21 2018-01-12 北京化工大学 一种发酵‑分离耦合制备乳酸和/或乳酸盐的方法
CN105018538B (zh) 2015-07-07 2018-10-23 北京化工大学 一种基于结晶法发酵分离耦合生产乳酸镁的方法
US10920250B2 (en) 2016-04-12 2021-02-16 Purac Biochem Bv Magnesium lactate fermentation process
KR102218931B1 (ko) 2016-05-30 2021-02-24 푸락 바이오켐 비.브이. 고체 발효 생성물로부터 바이오매스를 분리하는 방법
CN106083565A (zh) * 2016-06-06 2016-11-09 宁乡新阳化工有限公司 乳酸镁的生产方法
WO2019068642A1 (en) 2017-10-02 2019-04-11 Metabolic Explorer PROCESS FOR PRODUCING ORGANIC ACID SALTS FROM A FERMENTATION BROTH
EP4090443A1 (en) 2020-01-15 2022-11-23 Purac Biochem B.V. Method for purifying magnesium chloride solutions
MX2022010137A (es) 2020-02-19 2022-11-10 Triplew Ltd Metodos y sistemas para la produccion de acido lactico y el reciclaje del acido polilactico.
AU2022322001A1 (en) 2021-08-03 2024-02-29 TripleW Ltd. Process for producing recycled lactate salt

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020110108A1 (en) 2018-11-26 2020-06-04 3Plw Ltd. Purification of magnesium lactate from fermentation broths having high amounts of impurities

Also Published As

Publication number Publication date
AU2022211203A1 (en) 2023-08-10
JP2024504112A (ja) 2024-01-30
IL303988B1 (en) 2023-11-01
CN119330822A (zh) 2025-01-21
IL303988B2 (en) 2024-03-01
EP4736977A2 (en) 2026-05-06
MX2023008459A (es) 2023-07-27
EP4281432A1 (en) 2023-11-29
KR20230135613A (ko) 2023-09-25
IL303988A (en) 2023-08-01
EP4281432A4 (en) 2024-12-25
US20240300880A1 (en) 2024-09-12
KR20260003312A (ko) 2026-01-06
FI4281432T3 (fi) 2026-04-16
WO2022157768A1 (en) 2022-07-28
CA3207836A1 (en) 2022-07-28
EP4281432B1 (en) 2026-03-11
AU2022211203A9 (en) 2024-07-18
DK4281432T3 (da) 2026-04-20
JP7720646B2 (ja) 2025-08-08

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