CN1188520C - 在植物中生产聚酮化合物 - Google Patents

在植物中生产聚酮化合物 Download PDF

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Publication number
CN1188520C
CN1188520C CNB988070812A CN98807081A CN1188520C CN 1188520 C CN1188520 C CN 1188520C CN B988070812 A CNB988070812 A CN B988070812A CN 98807081 A CN98807081 A CN 98807081A CN 1188520 C CN1188520 C CN 1188520C
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CN
China
Prior art keywords
pks
polyketide
expression system
plant
gene
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Expired - Fee Related
Application number
CNB988070812A
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English (en)
Chinese (zh)
Other versions
CN1263557A (zh
Inventor
M·C·贝拉雪
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Kosan Biosciences Inc
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Kosan Biosciences Inc
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Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of CN1263557A publication Critical patent/CN1263557A/zh
Application granted granted Critical
Publication of CN1188520C publication Critical patent/CN1188520C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1258—Polyribonucleotide nucleotidyltransferase (2.7.7.8), i.e. polynucleotide phosphorylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB988070812A 1997-07-10 1998-07-10 在植物中生产聚酮化合物 Expired - Fee Related CN1188520C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5221197P 1997-07-10 1997-07-10
US60/052,211 1997-07-10

Publications (2)

Publication Number Publication Date
CN1263557A CN1263557A (zh) 2000-08-16
CN1188520C true CN1188520C (zh) 2005-02-09

Family

ID=21976131

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988070812A Expired - Fee Related CN1188520C (zh) 1997-07-10 1998-07-10 在植物中生产聚酮化合物

Country Status (10)

Country Link
US (2) US6262340B1 (https=)
EP (1) EP1007689A2 (https=)
JP (1) JP2001509379A (https=)
KR (1) KR100540287B1 (https=)
CN (1) CN1188520C (https=)
AU (1) AU744751C (https=)
CA (1) CA2294616A1 (https=)
IL (1) IL133716A0 (https=)
NZ (1) NZ501998A (https=)
WO (1) WO1999002669A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6033883A (en) * 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
WO2000031247A2 (en) 1998-11-20 2000-06-02 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
CA2360011A1 (en) 1999-01-05 2000-07-13 Trustees Of Boston University Ordered gene assembly
WO2000055340A1 (en) * 1999-03-15 2000-09-21 Pioneer Hi-Bred International, Inc. Methods for enhancing the disease resistance of plants
EP1224317B1 (en) * 1999-10-25 2006-03-08 Kosan Biosciences, Inc. Production of polyketides
CA2388422A1 (en) * 1999-10-27 2001-05-03 Kosan Biosciences, Inc. Heterologous production of polyketides
US7256888B2 (en) * 2003-11-07 2007-08-14 Cardial Health 303, Inc. Fluid verification system and method for infusions
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
AU2012272644B2 (en) * 2011-06-23 2017-03-23 Rho Renewables, Inc. Recombinant production systems for aromatic molecules
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
CN106916834B (zh) * 2015-12-24 2022-08-05 武汉合生科技有限公司 化合物的生物合成基因簇及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3587548T2 (de) 1984-12-28 1993-12-23 Bayer Ag Rekombinante DNA, die in pflanzliche Zellen eingebracht werden kann.
US5098837A (en) 1988-06-07 1992-03-24 Eli Lilly And Company Macrolide biosynthetic genes for use in streptomyces and other organisms
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5639949A (en) * 1990-08-20 1997-06-17 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
CA2171629A1 (en) 1993-09-20 1995-03-30 Chaitan Khosla Recombinant production of novel polyketides
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
GB9319722D0 (en) 1993-09-24 1993-11-10 John Innes Foundation Plant genetic manipulation
US5716849A (en) 1994-06-08 1998-02-10 Novartis Finance Corporation Genes for the biosynthesis of soraphen
CA2232230C (en) * 1995-10-13 2005-06-28 Ralph H. Lambalot Phosphopantetheinyl transferases and uses thereof
CA2197524A1 (en) 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
ES2244001T3 (es) 1996-07-05 2005-12-01 Biotica Technology Limited Eritromicinas y procedimiento para su preparacion.
DE69720225D1 (de) 1996-09-02 2003-04-30 St Microelectronics Nv Verbesserungen bei, oder in bezug auf mehrträgerübertragungssysteme
US6033883A (en) 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
BR9809946A (pt) 1997-06-04 2000-08-01 Calgene Llc Produção de ácidos graxos poliinsaturados por expressão de genes de sìntese semelhantes a policetìdeo em plantas

Also Published As

Publication number Publication date
WO1999002669A2 (en) 1999-01-21
KR100540287B1 (ko) 2006-01-10
US6262340B1 (en) 2001-07-17
KR20010021509A (ko) 2001-03-15
EP1007689A2 (en) 2000-06-14
CN1263557A (zh) 2000-08-16
IL133716A0 (en) 2001-04-30
AU744751B2 (en) 2002-02-28
US20020002712A1 (en) 2002-01-03
AU744751C (en) 2005-11-24
AU8403398A (en) 1999-02-08
WO1999002669A3 (en) 1999-04-01
NZ501998A (en) 2001-04-27
JP2001509379A (ja) 2001-07-24
CA2294616A1 (en) 1999-01-21

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