CN118338885A - 化妆品 - Google Patents
化妆品 Download PDFInfo
- Publication number
- CN118338885A CN118338885A CN202280072890.XA CN202280072890A CN118338885A CN 118338885 A CN118338885 A CN 118338885A CN 202280072890 A CN202280072890 A CN 202280072890A CN 118338885 A CN118338885 A CN 118338885A
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- China
- Prior art keywords
- cosmetic
- amount
- mass
- salt
- organic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 70
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 34
- VNXWANZMRATDQM-UHFFFAOYSA-N 2-(2-phenylethyl)benzene-1,3-diol Chemical compound OC1=CC=CC(O)=C1CCC1=CC=CC=C1 VNXWANZMRATDQM-UHFFFAOYSA-N 0.000 claims abstract description 27
- 150000007524 organic acids Chemical class 0.000 claims abstract description 25
- 150000003839 salts Chemical class 0.000 claims abstract description 18
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 15
- 239000011718 vitamin C Substances 0.000 claims abstract description 15
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 15
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 claims description 9
- LPDGWMLCUHULJF-UHFFFAOYSA-N 3-piperidin-1-ylpropanoic acid Chemical compound OC(=O)CCN1CCCCC1 LPDGWMLCUHULJF-UHFFFAOYSA-N 0.000 claims description 4
- 230000007794 irritation Effects 0.000 abstract description 15
- 230000002087 whitening effect Effects 0.000 abstract description 13
- 239000003921 oil Substances 0.000 description 13
- 235000019198 oils Nutrition 0.000 description 13
- -1 phenethyl resorcinol Chemical class 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 238000002156 mixing Methods 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 230000003020 moisturizing effect Effects 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 6
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 229960000541 cetyl alcohol Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 3
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 3
- 229920005862 polyol Polymers 0.000 description 3
- 150000003077 polyols Chemical class 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 150000005207 1,3-dihydroxybenzenes Chemical class 0.000 description 2
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- PQSXNIMHIHYFEE-UHFFFAOYSA-N 4-(1-phenylethyl)benzene-1,3-diol Chemical class C=1C=C(O)C=C(O)C=1C(C)C1=CC=CC=C1 PQSXNIMHIHYFEE-UHFFFAOYSA-N 0.000 description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-M 9-cis,12-cis-Octadecadienoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC([O-])=O OYHQOLUKZRVURQ-HZJYTTRNSA-M 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- 229960000735 docosanol Drugs 0.000 description 2
- 239000010696 ester oil Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 229940049918 linoleate Drugs 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000007764 o/w emulsion Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- IQHNEQZYMGDQDV-ACFLWUFDSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3-(2,3-dihydroxypropoxy)-4-hydroxy-2h-furan-5-one Chemical compound OCC(O)COC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO IQHNEQZYMGDQDV-ACFLWUFDSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
- FUTGDWNFCMWSJT-UHFFFAOYSA-N 2,3-bis(14-methylpentadecanoyloxy)propyl 14-methylpentadecanoate Chemical compound CC(C)CCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCC(C)C FUTGDWNFCMWSJT-UHFFFAOYSA-N 0.000 description 1
- QAQJMLQRFWZOBN-UHFFFAOYSA-N 2-(3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)C1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-UHFFFAOYSA-N 0.000 description 1
- LCZVSXRMYJUNFX-UHFFFAOYSA-N 2-[2-(2-hydroxypropoxy)propoxy]propan-1-ol Chemical compound CC(O)COC(C)COC(C)CO LCZVSXRMYJUNFX-UHFFFAOYSA-N 0.000 description 1
- GTJOHISYCKPIMT-UHFFFAOYSA-N 2-methylundecane Chemical compound CCCCCCCCCC(C)C GTJOHISYCKPIMT-UHFFFAOYSA-N 0.000 description 1
- 229940078578 2-o-ethyl ascorbic acid Drugs 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical compound CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 description 1
- GXRFOOHMMLYYNW-UJURSFKZSA-N 3-o-Ethyl-L-ascorbic acid Chemical compound CCOC1=C(O)[C@@H]([C@@H](O)CO)OC1=O GXRFOOHMMLYYNW-UJURSFKZSA-N 0.000 description 1
- 229940120145 3-o-ethylascorbic acid Drugs 0.000 description 1
- ANTLBIMVNRRJNP-UHFFFAOYSA-N 4-(2-phenylethyl)benzene-1,3-diol Chemical class OC1=CC(O)=CC=C1CCC1=CC=CC=C1 ANTLBIMVNRRJNP-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- BGAVZPPPWLEAKZ-UHFFFAOYSA-N 4-piperidin-1-ylbutanoic acid Chemical compound OC(=O)CCCN1CCCCC1 BGAVZPPPWLEAKZ-UHFFFAOYSA-N 0.000 description 1
- XSDBBZZUMULACW-UHFFFAOYSA-N 5-piperidin-1-ium-1-ylpentanoate Chemical compound OC(=O)CCCCN1CCCCC1 XSDBBZZUMULACW-UHFFFAOYSA-N 0.000 description 1
- LDZAHSDPMWUVET-UHFFFAOYSA-N 6-piperidin-1-ylhexanoic acid Chemical compound OC(=O)CCCCCN1CCCCC1 LDZAHSDPMWUVET-UHFFFAOYSA-N 0.000 description 1
- KGKQNDQDVZQTAG-UHFFFAOYSA-N 8-methylnonyl 2,2-dimethylpropanoate Chemical compound CC(C)CCCCCCCOC(=O)C(C)(C)C KGKQNDQDVZQTAG-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
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- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 description 1
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- 150000000996 L-ascorbic acids Chemical class 0.000 description 1
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Abstract
本发明提供兼顾美白效果高和刺激感低的化妆品。本发明的化妆品包含苯乙基间苯二酚和下述通式(I)所示的有机酸或其盐(式(I)中，n表示2～5的整数。)该化妆品可以根据需要还包含维生素C。
Description
技术领域
本发明涉及能够在抑制刺激感的同时得到充分的美白效果的化妆品。
背景技术
皮肤的斑点、雀斑等色素沉积因激素的异常、紫外线的刺激等而生成表皮色素细胞内黑色素、其在皮肤上沉积而产生。为了防止这样的色素沉积，已知使用抑制黑色素生成的物质，例如间苯二酚衍生物、抗坏血酸衍生物、(动物)胎盘蛋白等。这样的物质中，间苯二酚衍生物、特别是苯乙基间苯二酚赋予优异的效果，因此作为美白剂是有用的。然而，苯乙基间苯二酚在应用于肌肤时对肌肤有刺激感，在将苯乙基间苯二酚配合于化妆品的情况下，为了不使刺激变强，需要将配合量抑制为相对低的浓度。其结果，美白效果的改善也受到限制。
现有技术文献
专利文献
专利文献1：日本专利第4865251号说明书
发明内容
为了解决上述问题，期望开发出即使在化妆品中配合苯乙基间苯二酚，也能够抑制对皮肤的刺激感的技术。
根据本发明，提供以下的发明。
[1]一种化妆品，其包含：
(A)苯乙基间苯二酚、和
(B)下述通式(I)表示的有机酸或其盐，
(式(I)中，n表示2～5的整数。)
[2]根据[1]所述的化妆品，其中，以所述化妆品的总质量为基准，所述苯乙基间苯二酚的配合量为0.01～1质量％。
[3]根据[1]或[2]所述的化妆品，其中，以所述化妆品的总质量为基准，所述有机酸或其盐的配合量为0.005～5质量％。
[4]根据[1]～[3]中任一项所述的化妆品，其中，所述苯乙基间苯二酚的配合量相对于所述有机酸或其盐的配合量的质量比为0.025～10。
[5]根据[1]～[4]中任一项所述的化妆品，其中，所述有机酸为1-哌啶丙酸。
[6]根据[1]～[5]中任一项所述的化妆品，其还包含维生素C或其衍生物。
[7]根据[6]所述的化妆品，其中，以所述化妆品的总质量为基准，所述维生素C或其衍生物的配合量为0.005～1质量％。
[8]根据[6]或[7]所述的化妆品，其中，所述维生素C或其衍生物的配合量相对于所述有机酸的配合量的质量比为1/300～1。
根据本发明，提供：对肌肤的刺激感得到抑制、美白效果高的苯乙基间苯二酚的配合量多的化妆品。
具体实施方式
以下，对本发明的实施方式进行详细说明。
本发明的化妆品包含(A)苯乙基间苯二酚和(B)特定的有机酸作为必要成分。
[苯乙基间苯二酚]
本发明的化妆品包含苯乙基间苯二酚，苯乙基间苯二酚在化妆品、药品、准药品等领域中利用，在本发明中也可以从它们中任意选择。
苯乙基间苯二酚中，存在4-(1-苯基乙基)间苯二酚、4-(2-苯基乙基)间苯二酚、3-(1-苯基乙基)间苯二酚等这几种异构体。本发明的化妆品可以使用其中的任意种，其中4-(1-苯基乙基)间苯二酚也容易获得，可得到高的效果，因此优选。
苯乙基间苯二酚的配合量只要是对于能够发挥该成分的效果而言有效的量就没有特别限定，通常以化妆品的总质量为基准，优选为0.01～1质量％，更优选为0.05～0.7质量％。本发明中，通过并用后述的特定的有机酸，从而能使苯乙基间苯二酚的含量采用这样的范围，能够在抑制刺激感的同时得到充分的美白效果。
[有机酸或其盐]
本发明的化妆品包含特定的有机酸或其盐。该有机酸由下述通式(I)表示。
(式(I)中，n表示2～5的整数。)
该有机酸根据n的数量有1-哌啶丙酸(n＝2)、4-(1-哌啶基)丁酸(n＝3)、5-(1-哌啶基)戊酸(n＝4)、6-(1-哌啶基)己酸(n＝5)，其中，1-哌啶丙酸不仅抑制由苯乙基间苯二酚引起的刺激感，而且改善不易皮肤粗糙的肤质，并且具有抑制色素沉积的效果，因此特别优选。
另外，作为这样的有机酸的盐，没有特别限定，例如作为无机盐，可以举出盐酸盐、硫酸盐、磷酸盐、氢溴酸盐、钠盐、钾盐、镁盐、钙盐、铵盐等。作为有机盐，可举出乙酸盐、乳酸盐、马来酸盐、富马酸盐、酒石酸盐、柠檬酸盐、甲磺酸盐、对甲苯磺酸盐、三乙醇胺盐、二乙醇胺盐、氨基酸盐等。
有机酸或其盐的配合量没有特别限定，以化妆品的总质量为基准，优选为0.005～5质量％，更优选为0.01～4质量％。通过有机酸或其盐的配合量在该范围内，能够制成能够抑制刺激感并且保湿感优异、粘腻感等少、使用感优异的化妆品。
另外，本发明中，为了将基于苯乙基间苯二酚的美白效果与基于有机酸或其盐的刺激感抑制效果的平衡保持为最佳，上述苯乙基间苯二酚的配合量(a)相对于有机酸或其盐的配合量(b)的质量比(a/b)优选为0.025～10，更优选为0.1～5。
[其他成分]
本发明的化妆品包含上述的苯乙基间苯二酚和有机酸或其盐作为必要成分，但可以根据需要包含其他成分。
在这样的成分中，作为优选配合在本发明的化妆品中的成分，可以举出维生素C或其衍生物。维生素C作为营养素是已知的，作为化合物，相当于L-抗坏血酸。在化妆品中，通常使用维生素C或其衍生物。已知维生素C或其衍生物显示美白效果等，但在本发明中，显示出补充上述有机酸或其盐带来的刺激感抑制效果的效果。
维生素C为水溶性，作为其衍生物，已知有水溶性、油溶性、两亲性的物质，优选使用水溶性的物质。具体而言，可列举出2-邻-乙基抗坏血酸、3-邻-乙基抗坏血酸、抗坏血酸磷酸酯钠、抗坏血酸磷酸酯镁、抗坏血酸葡糖苷、抗坏血酸甘油酯、3-甘油基抗坏血酸酯、抗坏血酸二甘油酯及L-抗坏血酸棕榈酸酯等。
维生素C或其衍生物的配合量没有特别限定，以化妆品的总质量为基准，优选为0.005～1质量％，更优选为0.008～0.2质量％。通过使维生素C或其衍生物的配合量在该范围内，能够制成美白效果优异、刺激感也少、使用感优异的化妆品。
另外，在本发明中，为了将美白效果与刺激感抑制效果的平衡保持为最佳，上述维生素C或其衍生物的配合量(c)相对于有机酸或其盐的配合量(b)的质量比(c/b)优选为1/300～1，更优选为1/200～1/3。
本发明的化妆品除此以外，根据需要适宜配合通常在化妆品、药品等中使用的成分，例如水、油分、表面活性剂、粉末、色料、醇类、增稠剂、螯合剂、有机硅类、抗氧化剂、紫外线吸收剂、保湿剂、香料、各种药效成分、防腐剂、pH调节剂、中和剂等。
对于本发明的化妆品，特别是为了形成具有美白效果的美容液、乳液的形状，优选配合较多的水。作为水，可以使用化妆品、准药品等中使用的水，例如可以使用纯化水、离子交换水、自来水等。水的配合量根据其他成分的配合量而变化，通常以化妆品的总质量为基准，优选为20～80质量％，更优选为30～70质量％。
本发明的化妆品可以包含多元醇。这样的多元醇可以在不损害本发明的效果的范围内任意选择。具体而言，多元醇优选选自由甘油、二甘油、聚甘油、1,3-丁二醇、乙二醇、丙二醇、一缩二丙二醇、聚乙二醇、聚丙二醇、聚乙二醇·聚丙二醇、三羟甲基乙烷、三羟甲基丙烷、赤藓醇、季戊四醇、失水山梨醇、葡萄糖、山梨糖醇、麦芽糖醇、蔗糖、棉子糖、己二醇、1,2-戊二醇及海藻糖组成的组中的1种或2种以上。
多元醇发挥保湿功能、温感赋予功能，根据其目的来调整配合量。一般而言，多元醇的配合量以化妆品的总质量为基准，优选为1～30质量％，更优选为5～20质量％。
在本发明的化妆品可以包含高级醇的本发明中，高级醇只要能够在化妆品、药品、准药品等领域中使用就没有特别限定。具体而言，可列举出月桂醇、肉豆蔻醇、鲸蜡醇、硬脂醇、山嵛醇等。另外，通常已知它们的混合物、例如硬脂醇与鲸蜡醇的混合物即鲸蜡醇(鲸蜡硬脂醇)等，也可以使用其。
配合高级醇的情况下，可以使用上述的1种或2种以上。本发明中，优选使用两种以上的脂肪族醇的混合物，进一步优选为其混合物的熔点为60℃以上的组合。该熔点低于60℃时，根据配方有时体系的温度稳定性降低。本发明中，例如优选硬脂醇与山嵛醇的组合。
高级醇的配合量相对于化妆品的总质量优选为0.1～10质量％，更优选为0.5～5质量％。
本发明的化妆品可以包含表面活性剂。表面活性剂已知有非离子性、阳离子性、阴离子性、两性、有机硅系等各种表面活性剂，但可以从中任意地选择来使用。表面活性剂的配合量相对于水包油型乳化化妆品总量优选为0.1～20质量％，更优选为0.3～5质量％。
本发明的化妆品可以根据目的包含任意的油分。本发明中可以使用的油分没有特别限定，可以在不损害稳定性的范围内从化妆品中使用的油分中选择。作为优选的油分，可列举出烃油分、酯油分等极性油、硅油、液体油脂等。
具体而言，可列举出：
作为烃油，有液体石蜡、角鲨烷、角鲨烯、石蜡、异链烷烃、纯地蜡、异十六烷及异十二烷等；
作为酯油分等极性油，有季戊四醇四(乙基己酸)酯、乙基己酸鲸蜡酯、霍霍巴油、植物甾醇/辛基十二醇月桂酰谷氨酸酯、三异硬脂精、甘油二异硬脂酸酯、甘油三(乙基己酸)酯、植物甾醇/山嵛醇二聚亚油酸酯、植物甾醇/异硬脂醇/鲸蜡醇/硬脂醇/异硬脂醇/鲸蜡醇/硬脂醇/山嵛醇二聚亚油酸酯、棕榈酸异丙酯、植物甾醇澳洲坚果油酸酯、季戊四醇四(山嵛酸/苯甲酸/乙基己酸)酯、棕榈酸乙基己酯、肉豆蔻醇肉豆蔻酸酯、肉豆蔻酸异丙酯、二特戊酸三丙二醇酯、癸二酸二异丙酯及新戊酸异癸酯等；
作为硅油，有二甲基聚硅氧烷、甲基苯基聚硅氧烷、甲基氢聚硅氧烷等链状有机硅、八甲基环四硅氧烷、十甲基环五硅氧烷、十二甲基环六硅氧烷等环状有机硅、形成三维网眼结构的有机硅树脂及硅橡胶等；以及
作为液体油脂，有亚麻籽油、山茶籽油、全缘叶澳洲坚果籽油、玉米油、水貂油、油橄榄果油、鳄梨油、山茶花油、蓖麻油、红花油、菜籽油、大豆油、花生油、三聚甘油、三辛酸甘油酯、三异棕榈酸甘油酯等。另外，在包含这些油分的情况下，优选为水包油型化妆品。
油分的配合量没有特别限定，相对于水包油型乳化化妆品总量，优选为5～40质量％。
本发明的化妆品可以根据目的而配合进一步的成分。作为这样的成分，可列举出氨基酸、杀菌剂、消炎剂、收敛剂、动植物提取物、维生素C以外的维生素及其衍生物、螯合剂、色素、抗氧化剂、防腐剂以及香料等。
[化妆品]
本发明的化妆品包含上述必要成分，可以以一般的化妆品可采用的全部剂型使用。例如，具体而言，可以制成美容液、乳液、洗剂、乳霜、气雾等剂型。无论是哪种剂型，都能够制成在实现美白效果的同时兼具刺激感少和优异的使用感的化妆品。
实施例
[实施例1～11、比较例1及2]
以表1所示的配方制备各实施例和比较例的化妆品。
进而，对于这些化妆品，以以下的基准对使用时的刺激感和保湿感进行评价。
[评价方法]
使用各例的化妆品进行20名专业评委的实际使用试验。试验项目是刺激感的有无、保湿感。关于各试验项目，基于以下的评价分数基准来评价各专业评委根据其评价分数的合计进行分级。
评价分数基准(刺激感、保湿感)：
5分：非常优异。
4分：优异。
3分：普通。
2分：差。
1分：非常差。
刺激感的评价等级
A+：总分为90分以上
A：总分为80分以上
B：总分为60分以上且不足80分
C：总分为40分以上且不足60分
D：总分小于40分
保湿感的评价等级
A：总分为80分以上
B：总分为60分以上且不足80分
C：总分为40分以上且不足60分
D：总分小于40分
[表1]
根据比较例1的结果可知，通过配合苯乙基间苯二酚，有刺激感、保湿感相当劣化的倾向。然而，在实施例中，相对于比较例1，即使将苯乙基间苯二酚的配合量增加至5倍左右，也改善到与未配合苯乙基间苯二酚的比较例2相媲美的水平。另一方面，比较例2由于不含苯乙基间苯二酚，因此刺激少，但显然得不到作为本发明的目的之一的美白效果。由以上的结果可知，本发明的化妆品能够以高配合率配合苯乙基间苯二酚，因此能够实现优异的美白效果的同时刺激感少，且也能够得到优异的保湿感。
Claims (8)
1.一种化妆品，其包含：
(A)苯乙基间苯二酚、和
(B)下述通式(I)表示的有机酸或其盐，
式(I)中，n表示2～5的整数。
2.根据权利要求1所述的化妆品，其中，以所述化妆品的总质量为基准，所述苯乙基间苯二酚的配合量为0.01～1质量％。
3.根据权利要求1或2所述的化妆品，其中，以所述化妆品的总质量为基准，所述有机酸或其盐的配合量为0.005～5质量％。
4.根据权利要求1或2所述的化妆品，其中，所述苯乙基间苯二酚的配合量相对于所述有机酸或其盐的配合量的质量比为0.025～10。
5.根据权利要求1或2所述的化妆品，其中，所述有机酸为1-哌啶丙酸。
6.根据权利要求1或2所述的化妆品，其还包含维生素C或其衍生物。
7.根据权利要求6所述的化妆品，其中，以所述化妆品的总质量为基准，所述维生素C或其衍生物的配合量为0.005～1质量％。
8.根据权利要求6或7所述的化妆品，其中，所述维生素C或其衍生物的配合量相对于所述有机酸的配合量的质量比为1/300～1。
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