CN117062594A - 化妆品 - Google Patents
化妆品 Download PDFInfo
- Publication number
- CN117062594A CN117062594A CN202180096090.7A CN202180096090A CN117062594A CN 117062594 A CN117062594 A CN 117062594A CN 202180096090 A CN202180096090 A CN 202180096090A CN 117062594 A CN117062594 A CN 117062594A
- Authority
- CN
- China
- Prior art keywords
- cosmetic
- mass
- amount
- retinol
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 75
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 60
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 36
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229960003471 retinol Drugs 0.000 claims abstract description 30
- 235000020944 retinol Nutrition 0.000 claims abstract description 30
- 239000011607 retinol Substances 0.000 claims abstract description 30
- 150000003839 salts Chemical class 0.000 claims abstract description 18
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 16
- 239000011718 vitamin C Substances 0.000 claims abstract description 16
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 16
- 150000007524 organic acids Chemical class 0.000 claims description 23
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 claims description 8
- LPDGWMLCUHULJF-UHFFFAOYSA-N 3-piperidin-1-ylpropanoic acid Chemical compound OC(=O)CCN1CCCCC1 LPDGWMLCUHULJF-UHFFFAOYSA-N 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 22
- 230000007794 irritation Effects 0.000 abstract description 10
- 238000002156 mixing Methods 0.000 description 15
- 239000003921 oil Substances 0.000 description 13
- 235000019198 oils Nutrition 0.000 description 13
- 230000003020 moisturizing effect Effects 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- -1 amino acid salt Chemical class 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 230000037303 wrinkles Effects 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 3
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 3
- 229920005862 polyol Polymers 0.000 description 3
- 150000003077 polyols Chemical class 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-M 9-cis,12-cis-Octadecadienoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC([O-])=O OYHQOLUKZRVURQ-HZJYTTRNSA-M 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 239000010495 camellia oil Substances 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229960000735 docosanol Drugs 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000010696 ester oil Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229940049918 linoleate Drugs 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000007764 o/w emulsion Substances 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 229930002330 retinoic acid Natural products 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- 229960001727 tretinoin Drugs 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- IQHNEQZYMGDQDV-ACFLWUFDSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3-(2,3-dihydroxypropoxy)-4-hydroxy-2h-furan-5-one Chemical compound OCC(O)COC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO IQHNEQZYMGDQDV-ACFLWUFDSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
- JNAYPSWVMNJOPQ-UHFFFAOYSA-N 2,3-bis(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C JNAYPSWVMNJOPQ-UHFFFAOYSA-N 0.000 description 1
- QAQJMLQRFWZOBN-UHFFFAOYSA-N 2-(3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)C1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-UHFFFAOYSA-N 0.000 description 1
- SRVQNCAIKJCEFV-UHFFFAOYSA-N 2-[2-(2-octadecanoyloxypropoxy)propoxy]propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)OCC(C)OCC(C)OC(=O)CCCCCCCCCCCCCCCCC SRVQNCAIKJCEFV-UHFFFAOYSA-N 0.000 description 1
- GTJOHISYCKPIMT-UHFFFAOYSA-N 2-methylundecane Chemical compound CCCCCCCCCC(C)C GTJOHISYCKPIMT-UHFFFAOYSA-N 0.000 description 1
- 229940078578 2-o-ethyl ascorbic acid Drugs 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical compound CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 description 1
- GXRFOOHMMLYYNW-UJURSFKZSA-N 3-o-Ethyl-L-ascorbic acid Chemical compound CCOC1=C(O)[C@@H]([C@@H](O)CO)OC1=O GXRFOOHMMLYYNW-UJURSFKZSA-N 0.000 description 1
- 229940120145 3-o-ethylascorbic acid Drugs 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- BGAVZPPPWLEAKZ-UHFFFAOYSA-N 4-piperidin-1-ylbutanoic acid Chemical compound OC(=O)CCCN1CCCCC1 BGAVZPPPWLEAKZ-UHFFFAOYSA-N 0.000 description 1
- XSDBBZZUMULACW-UHFFFAOYSA-N 5-piperidin-1-ium-1-ylpentanoate Chemical compound OC(=O)CCCCN1CCCCC1 XSDBBZZUMULACW-UHFFFAOYSA-N 0.000 description 1
- LDZAHSDPMWUVET-UHFFFAOYSA-N 6-piperidin-1-ylhexanoic acid Chemical compound OC(=O)CCCCCN1CCCCC1 LDZAHSDPMWUVET-UHFFFAOYSA-N 0.000 description 1
- KGKQNDQDVZQTAG-UHFFFAOYSA-N 8-methylnonyl 2,2-dimethylpropanoate Chemical compound CC(C)CCCCCCCOC(=O)C(C)(C)C KGKQNDQDVZQTAG-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
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- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- 235000000072 L-ascorbyl-6-palmitate Nutrition 0.000 description 1
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- 229910019142 PO4 Inorganic materials 0.000 description 1
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- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
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Abstract
[课题]提供一种兼具高的皱纹改善效果和低的刺激感的化妆品。[解决手段]本发明的化妆品包含视黄醇和下述通式(I)：(式(I)中，n表示2～5的整数。)所示的有机酸或其盐。所述化妆品根据需要还可以包含维生素C。
Description
技术领域
本发明涉及能够抑制刺激感的同时得到充分的皱纹改善效果的化妆品。
背景技术
防老化是护肤化妆品的一大目标，其中从美容上的出发点来看皱纹是关注度最高的皮肤老化现象。近年，作为具有改善皮肤皱纹的效果的化妆品用药物，视黄醇等受到关注，研究了作为类视黄醇的一种的视黄醇(维生素A)、视黄酸等在皮肤化妆品中的应用。众所周知，它们在角质化细胞中发挥作用而体现透明质酸合成促进效果，通过增加角质层水分的效果而发挥皱纹改善效果。特别是，视黄醇与视黄酸相比，效果温和或不显示强的副作用，因此，作为化妆品用药剂优异。但是，已知视黄醇及其衍生物在应用于肌肤时存在对肌肤的刺激感。于是，在化妆品中配合视黄醇或其衍生物的情况下也无法增多其配合量，难以赋予成分的皱纹改善效果。
现有技术文献
特許文献
专利文献1：日本专利第4865251号说明书
发明内容
发明要解决的问题
为了解决上述那样的问题，期望开发即使增多化妆品中视黄醇的配合量也能够抑制对肌肤的刺激感的技术。
用于解决问题的方案
根据本发明，提供如下发明。
[1]一种化妆品，其包含：
(A)视黄醇、和
(B)下述通式(I)所示的有机酸或其盐，
式(I)中，n表示2～5的整数。
[2]根据[1]所述的化妆品，其中，前述视黄醇的配合量以前述化妆品的总质量作为基准计为0.01～0.5质量％。
[3]根据[1]或[2]所述的化妆品，其中，前述有机酸或其盐的配合量以前述化妆品的总质量作为基准计为0.005～5质量％。
[4]根据[1]～[3]中任一项所述的化妆品，其中，前述视黄醇的配合量相对于前述有机酸或其盐的配合量的质量比为0.005～1。
[5]根据[1]～[4]中任一项所述的化妆品，其中，前述有机酸为1-哌啶丙酸。
[6]根据[1]～[5]中任一项所述的化妆品，其还包含维生素C或其衍生物。
[7]根据[6]所述的化妆品，其中，前述维生素C或其衍生物的配合量以前述化妆品的总质量作为基准计为0.005～1质量％。
[8]根据[6]或[7]所述的化妆品，其中，前述前述维生素C或其衍生物的配合量相对于前述有机酸的配合量的质量比为1/300～1。
发明的效果
根据本发明，提供一种抑制对肌肤的刺激感、皱纹改善效果高的、视黄醇的配合量多的化妆品。
具体实施方式
以下，关于本发明的实施方式，进行详细说明。
本发明的化妆品包含(A)视黄醇和(B)特定的有机酸作为必须成分。
[视黄醇]
本发明的化妆品包含视黄醇。视黄醇在化妆品、医药品、准药品等领域中被利用，本发明中也可以从这些之中任意选择。
视黄醇(又称维生素A)存在若干立体异构体：all-反型、13-顺型、9-顺型等，也可以使用它们中的任意种。
视黄醇的配合量只要为能够发挥该成分的效果而有效的量，就没有特别限定，通常以化妆品的总质量作为基准，优选为0.01～0.5质量％，更优选为0.02～0.1质量％。使视黄醇的含量设为这样的范围，能够抑制刺激感的同时得到充分的皱纹改善效果。
[有机酸或其盐]
本发明的化妆品包含特定的有机酸或其盐。该有机酸由下述通式(I)表示。
(式(I)中，n表示2～5的整数。)
该有机酸根据n的数值而存在有1-哌啶丙酸(n＝2)、4-(1-哌啶基)丁酸(n＝3)、5-(1-哌啶基)戊酸(n＝4)、6-(1-哌啶基)己酸(n＝5)，这些之中，1-哌啶丙酸不仅能够抑制起因于视黄醇的刺激感，而且改善肌肤的肤质以使肌肤不易粗糙，并且具有皱纹形成抑制的效果，因此，特别优选。
另外，作为这种有机酸的盐，没有特别限定，例如，作为无机盐，可列举出盐酸盐、硫酸盐、磷酸盐、氢溴酸盐、钠盐、钾盐、镁盐、钙盐、铵盐等。作为有机盐，可列举出乙酸盐、乳酸盐、马来酸盐、富马酸盐、酒石酸盐、柠檬酸盐、甲磺酸盐、对甲苯磺酸盐、三乙醇胺盐、二乙醇胺盐、氨基酸盐等。
有机酸或其盐的配合量没有特别限定，以化妆品的总质量作为基准，优选为0.005～5质量％，更优选为0.01～4质量％。使有机酸或其盐的配合量处于该范围，可以制成能够抑制刺激感且保湿感优异、粘腻感等少、使用感优异的化妆品。
另外，本发明中，为了将由视黄醇带来的皱纹改善效果与由有机酸或其盐带来的刺激感抑制效果的平衡保持成最佳，前述视黄醇的配合量(a)相对于有机酸或其盐的配合量(b)的质量比(a/b)优选为0.005～1，更优选为0.01～0.5。
[其他成分]
本发明的化妆品包含上述的视黄醇和有机酸或其盐作为必须成分，但根据需要可以包含其他成分。
在这些成分中，作为本发明的化妆品中优选配合的成分，可以提高维生素C或其衍生物。维生素C已知为营养素，作为化合物相当于L-抗坏血酸。在化妆品中，通常使用维生素C或其衍生物。已知维生素C或其衍生物显示美白效果等，但在本发明中，显示上述的由有机酸或其盐带来的、补充刺激感抑制效果的效果。
维生素C为水溶性，作为其衍生物，已知有水溶性、油溶性、两亲性，优选使用水溶性的物质。具体而言，可列举出2-邻-乙基抗坏血酸、3-邻-乙基抗坏血酸、抗坏血酸磷酸酯钠、抗坏血酸磷酸酯镁、抗坏血酸葡糖苷、抗坏血酸甘油酯、3-甘油基抗坏血酸酯、抗坏血酸二甘油酯及L-抗坏血酸棕榈酸酯等。
维生素C或其衍生物的配合量没有特别限定，以化妆品的总质量作为基准，优选为0.005～1质量％，更优选为0.008～0.2质量％。使维生素C或其衍生物的配合量处于该范围，可以制成皱纹改善效果优异、刺激感也少的使用感优异的化妆品。
另外，本发明中，为了将皱纹改善效果和刺激感抑制效果的平衡保持成最佳，前述维生素C或其衍生物的配合量(c)相对于有机酸或其盐的配合量(b)的质量比(c/b)优选为1/300～1，更优选为1/200～1/3。
本发明的化妆品除此以外，根据需要适宜配合通常在化妆品、医药品等中使用的成分，例如水、油分、表面活性剂、粉末、色料、醇类、增稠剂、螯合剂、有机硅类、抗氧化剂、紫外线吸收剂、保湿剂、香料、各种药效成分、防腐剂、pH调节剂、中和剂等。
为了将本发明的化妆品制成特别是具有皱纹改善效果的美容液、乳液的性状而优选配合大量的水。作为水，可以使用化妆品、准药品等中所使用的水，例如，可以使用纯化水、离子交换水、自来水等。水的配合量根据其他成分的配合量而变化，一般而言，以化妆品的总质量作为基准，优选为20～80质量％，更优选为30～70质量％。
本发明的化妆品可以包含多元醇。这种多元醇可以在不有损本发明的效果的范围内任意地选择。具体而言，多元醇优选选自由甘油、二甘油、聚甘油、1,3-丁二醇、乙二醇、丙二醇、一缩二丙二醇、聚乙二醇、聚丙二醇、聚乙二醇·聚丙二醇、三羟甲基乙烷、三羟甲基丙烷、赤藓醇、季戊四醇、失水山梨醇、葡萄糖、山梨糖醇、麦芽糖醇、蔗糖、棉子糖、己二醇、1,2-戊二醇及海藻糖组成的组中的1种或2种以上。
多元醇发挥保湿功能、温感赋予功能，但根据其目的来调整配合量。一般而言，以化妆品的总质量作为基准，多元醇的配合量优选为1～30质量％，更优选为5～20质量％。
本发明的化妆品可以包含高级醇。本发明中，高级醇只要为化妆品、医药品、准药品等领域中能够使用者就没有特别限定。具体而言，可列举出月桂醇、肉豆蔻醇、鲸蜡醇、硬脂醇、山嵛醇等。另外，通常已知有它们的混合物、例如硬脂醇与鲸蜡醇的混合物即鲸蜡硬脂醇(Cetearyl Alcohol)等，也可以使用其。
在配合高级醇的情况下，可以使用上述的1种或2种以上。本发明中优选使用2种以上的脂肪族醇的混合物，进而优选为该混合物的熔点成为60℃以上这样的组合。若其熔点低于60℃，则根据配方而体系的温度稳定性有时降低。本发明中例如优选为硬脂醇与山嵛醇的组合。
高级醇的配合量相对于化妆品的总质量优选为0.1～10质量％，更优选为0.5～5质量％。
本发明的化妆品可以包含表面活性剂。表面活性剂已知有非离子性、阳离子性、阴离子性、两性、有机硅系等各种表面活性剂，但可以从中任意地选择来使用。表面活性剂的配合量相对于水包油型乳化化妆品总量优选为0.1～20质量％，更优选为0.3～5质量％。
本发明的化妆品可以根据目的而包含任意的油分。本发明中可使用的油分没有特别限定，在不有损稳定性的范围内，可以从用于化妆品的油分中选择。作为优选的油分，可列举出烃油分、酯油分等极性油、硅油、液体油脂等。
具体而言，作为烃油，可列举出：液体石蜡、角鲨烷、角鲨烯、石蜡、异链烷烃、纯地蜡、异十六烷以及异十二烷等；
作为酯油分等极性油，可列举出：季戊四醇四(乙基己酸)酯、乙基己酸鲸蜡酯、霍霍巴油、植物甾醇/辛基十二醇月桂酰谷氨酸酯、三异硬脂精、甘油二异硬脂酸酯、甘油三(乙基己酸)酯、植物甾醇/山嵛醇二聚亚油酸酯、植物甾醇/异硬脂醇/鲸蜡醇/硬脂醇/异硬脂醇/鲸蜡醇/硬脂醇二聚亚油酸酯、棕榈酸异丙酯、植物甾醇澳洲坚果油酸酯、季戊四醇四(山嵛酸/苯甲酸/乙基己酸)酯、棕榈酸乙基己酯、肉豆蔻酸肉豆蔻酯、肉豆蔻酸异丙酯、二特戊酸三丙二醇酯、癸二酸二异丙酯及新戊酸异癸酯等；
作为硅油，可列举出二甲基聚硅氧烷、甲基苯基聚硅氧烷、甲基氢聚硅氧烷等链状有机硅、八甲基环四硅氧烷、十甲基环五硅氧烷、十二甲基环六硅氧烷等环状有机硅、形成有三维网眼结构的有机硅树脂及硅酮橡胶等；以及
作为液体油脂，可列举出亚麻籽油、山茶油、全缘叶澳洲坚果籽油、玉米油、貂油、橄榄油、鳄梨油、山茶花油、蓖麻油、红花油、菜籽油、大豆油、花生油、三聚甘油、三辛酸甘油酯及三异棕榈酸甘油酯等。
需要说明的是，包含这些油分的情况下，优选制成水包油型化妆品。
油分的配合量没有特别限定，相对于水包油型乳化化妆品总量，优选为5～40质量％。
本发明的化妆品根据目的可以配合进一步的成分。作为这样的成分，可列举出氨基酸、杀菌剂、消炎剂、收敛剂、动植物提取物、维生素C以外的维生素及其衍生物、螯合剂、色素、抗氧化剂、防腐剂以及香料等。
[化妆品]
本发明的化妆品包含上述的必须成分，能够在通常的化妆品所可采用的全部剂型中使用。例如，具体而言，可以制成美容液、乳液、洗剂、乳霜、气雾等剂型。无论何种剂型，均能够制成实现皱纹改善效果、且兼具极少的刺激感和优异的使用感的化妆品。
实施例
[实施例1～11、比较例1～4]
以表1所示配方，制备各实施例和比较例的化妆品。
此外，关于这些化妆品，基于以下基准对使用时的刺激感和保湿感进行评价。
[评价方法]
使用各例的化妆品，进行由20名专门小组成员的实际使用试验。试验项目为刺激感的有无、保湿感。关于各试验项目，基于以下的评价分基准，各专门小组成员进行评价，通过其评价分的总计来排名。
评价分基准(刺激感、保湿感)：
5分：非常优异。
4分：优异。
3分：普通。
2分：差。
1分：非常差。
刺激感的评价排名
A+：总分为90分以上
A：总分为80分以上
B：总分为60分以上且低于80分
C：总分为40分以上且低于60分
D：总分低于40分
保湿感的评价排名
A：总分为80分以上
B：总分为60分以上且低于80分
C：总分为40分以上且低于60分
D：总分低于40分
[表1-1]
表11
[表1-2]
表12
若将比较例1和3与比较例2、4相比，则如以往报道的那样，已知由于配合视黄醇而存在刺激感、保湿感相当劣化的倾向。然而，实施例中，即使对于比较例1或3而言将视黄醇的配合量增加至2.5倍左右的量，也改善到与不配合视黄醇的情况匹敌的水平。另一方面，比较例2和4由于不包含视黄醇因而刺激少，但明确可知无法获得本发明目的之一的皱纹改善效果。由以上结果可知，本发明的化妆品可以以高配合率来配合视黄醇，因此，能够实现优异的皱纹改善效果的同时刺激感少且也可以得到优异的保湿感。
Claims (8)
1.一种化妆品，其包含：
(A)视黄醇、和
(B)下述通式(I)所示的有机酸或其盐，
式(I)中，n表示2～5的整数。
2.根据权利要求1所述的化妆品，其中，所述视黄醇的配合量以所述化妆品的总质量作为基准计为0.01～0.5质量％。
3.根据权利要求1或2所述的化妆品，其中，所述有机酸或其盐的配合量以所述化妆品的总质量作为基准计为0.005～5质量％。
4.根据权利要求1～3中任一项所述的化妆品，其中，所述视黄醇的配合量相对于所述有机酸或其盐的配合量的质量比为0.005～1。
5.根据权利要求1～4中任一项所述的化妆品，其中，所述有机酸为1-哌啶丙酸。
6.根据权利要求1～5中任一项所述的化妆品，其还包含维生素C或其衍生物。
7.根据权利要求6所述的化妆品，其中，所述维生素C或其衍生物的配合量以所述化妆品的总质量作为基准计为0.005～1质量％。
8.根据权利要求6或7所述的化妆品，其中，所述所述维生素C或其衍生物的配合量相对于所述有机酸的配合量的质量比为1/300～1。
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