CN1182892C - 在静脉导管上制作端头的方法 - Google Patents

在静脉导管上制作端头的方法 Download PDF

Info

Publication number
CN1182892C
CN1182892C CNB971297649A CN97129764A CN1182892C CN 1182892 C CN1182892 C CN 1182892C CN B971297649 A CNB971297649 A CN B971297649A CN 97129764 A CN97129764 A CN 97129764A CN 1182892 C CN1182892 C CN 1182892C
Authority
CN
China
Prior art keywords
conduit
flash
plug
catheter
cutting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB971297649A
Other languages
English (en)
Other versions
CN1196959A (zh
Inventor
J��M�����ض�
J·M·帕特尔
�޾ջ�
D·比尔勒基
J·J·常
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
This new Co.
Ethicon Endo Surgery Inc
Ethicon Inc
Smiths Medical ASD Inc
Original Assignee
Surgikos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surgikos Inc filed Critical Surgikos Inc
Publication of CN1196959A publication Critical patent/CN1196959A/zh
Application granted granted Critical
Publication of CN1182892C publication Critical patent/CN1182892C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0009—Making of catheters or other medical or surgical tubes
    • A61M25/001—Forming the tip of a catheter, e.g. bevelling process, join or taper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C57/00—Shaping of tube ends, e.g. flanging, belling or closing; Apparatus therefor, e.g. collapsible mandrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/008—Strength or flexibility characteristics of the catheter tip
    • A61M2025/0081—Soft tip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2793/00—Shaping techniques involving a cutting or machining operation
    • B29C2793/009—Shaping techniques involving a cutting or machining operation after shaping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7542—Catheters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)

Abstract

本发明包括一种用于制作导管端头的两步骤方法。在第一步中，将一个管状导管置于一个芯棒上，并将该芯棒及导管的组件插入具有模具内表面的模具中，模制一锥形导管端头。然后将带有溢料的模制导管由模具中撤出，并将芯棒由导管中撤出。将该导管和溢料插入限定一个开口的夹具中，溢料伸出该开口。由一个切割表面限定该开口，溢料伸出该切割表面。然后沿切割表面移动一个切刀，以便在沿导管长度方向的一个适当点处精确地切除该溢料，从而保留一个制得的修整导管。然后将该导管由夹具中移出，以便进一步加工。

Description

在静脉导管上制作端头的方法
技术领域
本发明涉及一种用于制造医器械的方法，特别是一种在静脉导管上制作端头的方法。
背景技术
为了便于插入过程，早已公知将导管、尤其是外部插入的静脉导管端头制成锥形。进一步发现今天的许多产品在导管端头处形成双斜面，第一斜面具有大约3°的锥度，第二斜面具有大约27°的锥度。
这些端头的制作可以通过例如利用激光切割，如美国专利US.5,425,903所述，或者利用模制，如授予Daugherty的美国专利US.4,661,300所述。
Daugherty的专利描述了一种模制方法，其中采用了单一步骤操作来形成并夹紧导管。那就是，采用将管材料伸出芯棒外，而使导管置于一个芯棒上，然后将此装置插入一个已加热的模具中，以形成导管的外表面。使芯棒前进至一点处，在该处它使模具表面在一个单一步骤中夹紧导管的溢料。
然而，这种单一步骤方法的显著不利之处在于，由于其模具和芯棒都用作切削装置，因而必须接合并互相磨损，从而工具寿命较短。这意味着，在使用过程中，导管上形成的外表面随着芯棒和模具之间的接触对模具内表面的磨损而变化。另外，为了在模具上保持锋利边缘以提供精确的切割操作，必须更换刀具。
发明内容
本发明致力于一种在静脉导管上制作端头的方法，包括在一个伸到导管端部以外或突出的端头区域的芯棒上设置一个管状导管的步骤。将一个具有符合制成导管所需外表面的锥形模具内表面的模具加热，并将该带导管的芯棒插入所述模具中，使导管材料与模具内表面接合。导管材料与模具内表面的接合使导管材料软化并与模具内表面一致，从而形成伸到所需导管端头外的溢料。当材料冷却后，从中撤去所述导管和芯棒，然后再从导管中撤去芯棒。另外，也可一步完成，从导管中撤去芯棒，再从模具中取出导管。
在另一操作中，将带有溢料的导管插入一个具有限定一个开口的切削表面的夹具中。导管向夹具的插入允许其溢料通过所述开口伸出至其切削表面外。一个切刀沿所述切割表面移动，切下伸出该表面的溢料，并将此溢料与导管的其余部分分离开。这就制得了一个修整的导管，它随后由夹具中移出，以便进一步处理。
可将所述夹具制成为限定一个通道，该通道终止于所需开口。所述通道可与导管外表面一致，以便于设置导管使其溢料伸出适当距离。所述切刀可以是单面或者复合的刀片，例如手持操作的剃须刀片。刀片的厚度可优选为从约0.0762毫米(0.003英寸)至约0.254毫米(0.010英寸)，导管可由例如聚四氟乙烯(PTFE)或聚氨酯材料制成。
附图说明
下面参照附图对本发明进行描述，其中：
图1为本发明的模制过程的图示；以及
图2为本发明的切割夹具和切割过程的图示。
具体实施方式
本发明涉及一种用于制作导管端头的简化而精确的方法。特别地，在制作锥形导管端头时，必须既形成锥形还要去除可能形成的任何溢料。
在本方法中，将由例如聚四氟乙烯或聚氨酯制成的管状导管1设置于一个同轴芯棒2上。芯棒2容纳于导管套管的内腔3之内，并从导管的端部5伸出。模具6具有与所需最终导管外表面一致的锥形内表面7。例如，它可优选为沿导管的一定长度形成约3°的小角度锥形，并在导管的最为端头处提供一个例如27°的较尖锐的斜面，以使导管表面向上拉延，使与通过导管内腔的针头套管相符。将模具加热至适于软化导管材料的温度。例如，对于20号(即直径1.143毫米或0.045英寸)的聚四氟乙烯导管，该温度为从约343摄氏度(650华氏度)至约399摄氏度(750华氏度)。或者，对于聚氨酯导管，将模具加热至从约232摄氏度(450华氏度)至约288摄氏度(550华氏度)。以公知方法将导管1和芯棒2插入模具6中，以使导管材料与加热的模具表面相接合。模具材料受热软化，并流入围绕芯棒的模具内的空隙。一部分导管材料流出所需模制区域，形成一个溢料8。
应当指出，本方法的芯棒2通往溢料端之外，用以支撑它，使得在冷却时柱状的溢料8伸出至所需导管端头之外。此溢料8后面将加以去除，并以如下方式延伸，以提供模具的连续填料，也提供一个由接下去的切割过程去除的连续部分。
使模具6和导管1得以冷却，从而使导管1和芯棒2由内模具通道中撤出。然后从导管内撤出芯棒，并将芯棒插入一个阴夹具9(图2)。阴夹具9有一个通过它的通道10，该通道与最终导管所需外表面一致。该通道10止于上切割表面11，该上切割表面11相对于通道10精确地位于导管需要被切割之处。
通过导管1在该通道之内的插入，溢料8伸出切割表面11，并露出夹具之外。然后将一切割刀片沿切割表面11运动，以切下溢料8并将其由导管端部去除。该切割刀片12应当薄至能够满足切割导管材料的足够强度，以便在切割过程中防止导管自身破裂。显而易见的是，一个钝的或厚的切割刀锋在沿切割表面移动时，易于将与刀片接触的起始侧向相对侧而被压碎，从而损坏导管和最终切割。
于是，从导管1的端头去除溢料，从阴夹具9中撤出导管，以便进一步加工。
已经接合附图及其优选实施例对本发明进行了描述。对本发明可作出些微改动，而不超出所述发明的范围。

Claims (7)

1、一种在静脉导管上制作端头的方法，包括如下步骤：
a)在一个芯棒上设置一个管状导管，使所述芯棒伸出所述导管的端部；
b)将一个具有锥形模具内表面的模具加热；
c)将该所述导管和芯棒插入所述模具中，使所述导管材料与所述模具内表面接合；
d)使所述导管材料软化并与所述模具内表面一致，从而形成伸出所需导管管头的溢料；
e)从所述模具中撤出所述导管和芯棒，并从所述导管中撤去芯棒；
f)将该导管插入一个具有限定一个开口的切削表面的夹具中，使得所述溢料通过所述开口伸出所述切削表面；
g)使一个切刀沿所述切割表面移动，以将伸出所述表面外的溢料从所述导管的其余部分切下，从而制得一个修整的导管；以及
h)将所述修整的导管由所述夹具中移出。
2、如权利要求1所述的方法，其特征在于，所述夹具限定了一个止于所述开口的通道，该通道与所述导管的外表面一致，以精确地将所述导管固定进行修整。
3、如权利要求1所述的方法，其特征在于，所述切刀为一个单一的或复合的刀片。
4、如权利要求3所述的方法，其特征在于，所述刀片厚度为0.0762毫米至0.254毫米厚。
5、如权利要求1所述的方法，其特征在于，所述切刀为沿所述表面手动地切除所述溢料的剃刀片。
6、如权利要求1所述的方法，其特征在于，所述导管由聚四氟乙烯材料制成，并将所述模具加热至从343摄氏度至399摄氏度。
7、如权利要求1所述的方法，其特征在于，所述导管由聚氨酯材料制成，并将所述模具加热至从232摄氏度至288摄氏度。
CNB971297649A 1996-12-30 1997-12-30 在静脉导管上制作端头的方法 Expired - Fee Related CN1182892C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US773942 1996-12-30
US08/773,942 US5843356A (en) 1996-12-30 1996-12-30 Catheter tip mold and cut process
US773,942 1996-12-30

Publications (2)

Publication Number Publication Date
CN1196959A CN1196959A (zh) 1998-10-28
CN1182892C true CN1182892C (zh) 2005-01-05

Family

ID=25099785

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB971297649A Expired - Fee Related CN1182892C (zh) 1996-12-30 1997-12-30 在静脉导管上制作端头的方法

Country Status (21)

Country Link
US (1) US5843356A (zh)
EP (1) EP0850655B1 (zh)
JP (1) JPH10201848A (zh)
KR (1) KR100515106B1 (zh)
CN (1) CN1182892C (zh)
AR (1) AR011337A1 (zh)
AT (1) ATE213654T1 (zh)
AU (1) AU717056B2 (zh)
BR (1) BR9706495A (zh)
CA (1) CA2226053C (zh)
CO (1) CO4761075A1 (zh)
DE (1) DE69710694T2 (zh)
DK (1) DK0850655T3 (zh)
ES (1) ES2171846T3 (zh)
IL (1) IL122786A (zh)
MY (1) MY126380A (zh)
NO (1) NO976135L (zh)
NZ (1) NZ329542A (zh)
RU (1) RU2177807C2 (zh)
SG (1) SG55443A1 (zh)
TW (1) TW354766B (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10195649A (ja) * 1996-12-27 1998-07-28 Sony Corp マグネトロンスパッタ装置および半導体装置の製造方法
US6080141A (en) * 1997-12-22 2000-06-27 Becton, Dickinson And Company Splittable tubular medical device and method for manufacture
US5985195A (en) * 1997-12-22 1999-11-16 Ethicon, Inc. One-step flashing bevel process for a catheter
US6402720B1 (en) 1997-12-22 2002-06-11 Cordis Corporation Balloon catheter with elongated flexible tip
US7758624B2 (en) 2000-11-13 2010-07-20 C. R. Bard, Inc. Implant delivery device
DE10012852A1 (de) * 2000-03-16 2001-09-20 Angiomed Ag Kathetersystem zum Zuführen flexibler Stents
US6740277B2 (en) 2002-04-24 2004-05-25 Becton Dickinson And Company Process of making a catheter
EP1768724A4 (en) * 2004-06-07 2010-08-25 Bard Inc C R SUBCUTANEOUS INFUSION DEVICES
EP1807140B1 (en) * 2004-11-05 2010-07-07 Gambro Lundia AB Method for manufacturing a catheter for vascular access
US7704067B2 (en) * 2006-02-07 2010-04-27 Tiodize Company, Inc. Method and mold for making non-metallic fiber reinforced parts
US20070244440A1 (en) * 2006-03-28 2007-10-18 Cook Incorporated Medical device with expandable tip
KR100837524B1 (ko) * 2006-09-07 2008-06-12 권오필 정맥 투입기의 튜브 자동 포밍 장치
US20090187143A1 (en) 2008-01-18 2009-07-23 Ev3 Inc. Angled tip catheter
CN102824683B (zh) * 2012-08-30 2014-06-04 台州华曙机械有限公司 输液器的针座与导管的自动化装配装置
CA2889820C (en) 2012-09-28 2017-12-05 Hollister Incorporated A method and apparatus for injection moulding of an elongated hollow article
CN103041465B (zh) * 2012-12-26 2014-10-29 三峡大学 自制小鼠灌胃针的制作方法
JP6506734B2 (ja) * 2013-03-15 2019-04-24 アボット、カーディオバスキュラー、システムズ、インコーポレーテッドＡｂｂｏｔｔ Ｃａｒｄｉｏｖａｓｃｕｌａｒ Ｓｙｓｔｅｍｓ Ｉｎｃ． カテーテルの材料削減先端部及びその形成方法
US20150122264A1 (en) * 2013-11-01 2015-05-07 Covidien Lp Curved distal tip for use with medical tubing and method for making the same
US10780246B2 (en) 2014-09-12 2020-09-22 Callisyn Biomedical, Inc. Vascular microcatheter
WO2017039992A1 (en) 2015-08-28 2017-03-09 Hollister Incorporated A method and apparatus for molding an elongated hollow article
CN110891640A (zh) 2017-05-26 2020-03-17 派珀接入公司 导管递送装置、系统和方法
WO2019124052A1 (ja) * 2017-12-22 2019-06-27 株式会社カネカ カテーテルの製造方法、およびカテーテル
CN109432574B (zh) * 2018-12-29 2023-10-20 佛山市顺德区思创自动化机械有限公司 静脉导管尖端成型机
WO2024033675A1 (en) 2022-08-08 2024-02-15 Embrace Medical Ltd Vascular access wire tip comprising a crank

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2804654A (en) * 1954-03-03 1957-09-03 Owens Illinois Glass Co Method of forming hollow plastic articles
US4404159A (en) * 1981-03-16 1983-09-13 Mcfarlane Richard H Apparatus and process for forming a tapered tip end on a plastic tube
US4551292A (en) * 1984-04-05 1985-11-05 Angiomedics, Inc. Method for making a catheter with a soft, deformable tip
US4661300A (en) * 1984-09-12 1987-04-28 Becton, Dickinson And Company Method and apparatus for flashless tipping of an I.V. catheter
JP2520126B2 (ja) * 1987-04-28 1996-07-31 株式会社 ニツシヨ− 留置針外針の先端部形成方法
US5178803A (en) * 1987-06-25 1993-01-12 Terumo Kabushiki Kaisha Method of manufacturing a multi-luminal catheter, and multi-luminal catheter assembly
US5135599A (en) * 1987-12-22 1992-08-04 Vas-Cath Incorporated Method of making a triple lumen catheter
US4961809A (en) * 1988-04-21 1990-10-09 Vas-Cath Incorporated Method of producing a dual lumen catheter including forming a flare
US5102324A (en) * 1990-01-22 1992-04-07 Worldwide Medical Plastics Inc. Precision tipping device for surgical catheters
GB9211064D0 (en) * 1992-05-23 1992-07-08 Boc Group Plc A tool
CA2107539A1 (en) * 1992-10-02 1994-04-03 Vas-Cath Incorporated Catheters and method of manufacture
US5470220A (en) * 1993-06-17 1995-11-28 Hoover Universal, Inc. Flexible part deflasher
US5425903A (en) 1993-09-10 1995-06-20 Critikon, Inc. Laser beveling process for catheters
US5547364A (en) * 1994-10-19 1996-08-20 Industrial Technology Research Institute Tipping device and method of producing medical catheters
JPH0929812A (ja) * 1995-07-18 1997-02-04 Toshiba Mach Co Ltd 成形機用スクリュー
US5736085A (en) * 1996-12-30 1998-04-07 Johnson & Johnson Medical, Inc. Catheter beveling and die cut process

Also Published As

Publication number Publication date
AR011337A1 (es) 2000-08-16
EP0850655B1 (en) 2002-02-27
EP0850655A2 (en) 1998-07-01
AU717056B2 (en) 2000-03-16
NO976135D0 (no) 1997-12-30
NZ329542A (en) 1999-09-29
US5843356A (en) 1998-12-01
NO976135L (no) 1998-07-01
CN1196959A (zh) 1998-10-28
SG55443A1 (en) 1998-12-21
KR19980064779A (ko) 1998-10-07
RU2177807C2 (ru) 2002-01-10
CA2226053C (en) 2007-04-03
CO4761075A1 (es) 1999-04-27
KR100515106B1 (ko) 2005-12-02
DE69710694D1 (de) 2002-04-04
IL122786A (en) 2004-02-19
ES2171846T3 (es) 2002-09-16
DE69710694T2 (de) 2002-08-08
TW354766B (en) 1999-03-21
MY126380A (en) 2006-09-29
DK0850655T3 (da) 2002-03-25
ATE213654T1 (de) 2002-03-15
CA2226053A1 (en) 1998-06-30
AU4924497A (en) 1998-07-02
BR9706495A (pt) 1999-07-27
IL122786A0 (en) 1998-08-16
EP0850655A3 (en) 1998-11-18
JPH10201848A (ja) 1998-08-04

Similar Documents

Publication Publication Date Title
CN1182892C (zh) 在静脉导管上制作端头的方法
US5736085A (en) Catheter beveling and die cut process
CA2889820C (en) A method and apparatus for injection moulding of an elongated hollow article
KR101813509B1 (ko) 의료용 매선실 제조방법 및 이에 의해 제조된 매선실
US6048485A (en) Thermal gradient beveling of catheters
CN1160133C (zh) 无毛边导管斜角加工方法
CN1149107C (zh) 单步骤利用飞边形成斜边的方法
US5795521A (en) Moldless beveling of catheters
JPS63270063A (ja) 留置針外針の先端部形成方法
JPH042275B2 (zh)
JPH10137343A (ja) 留置針外針の先端成形方法
JPH09187507A (ja) 留置針外針の先端加工方法
CN205651619U (zh) 一种汽车内饰流道残料去除装置
MXPA98000180A (en) Procedure of molding and cut of tip of cate
MXPA97007510A (en) Beveling and cutting procedure for the gift of cate
KR910020378A (ko) 라이터용 가스유출 밸브의 t형 부재관 제조방법
MXPA97010061A (en) Beeting of catheters by gradiente term

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: XIN ANDU CO.

Free format text: FORMER OWNER: ETHICON, INC

Effective date: 20060414

Owner name: MAIDOX CO.,LTD.

Free format text: FORMER OWNER: ETHICON ENDO SURGERY INC.

Effective date: 20060414

C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee

Owner name: ETHICON ENDO SURGERY INC.

Free format text: FORMER NAME OR ADDRESS: XIN ANDU CO.

Owner name: ETHICON, INC

Free format text: FORMER NAME OR ADDRESS: JOHNSON + JOHNSON MEDICAL, INC.

CP01 Change in the name or title of a patent holder

Address after: Ohio, USA

Patentee after: ETHICON ENDO-SURGERY, Inc.

Address before: Ohio, USA

Patentee before: This new Co.

Address after: New jersey, USA

Patentee after: ETHICON, Inc.

Address before: Texas, USA

Patentee before: JOHNSON & JOHNSON MEDICAL LTD.

TR01 Transfer of patent right

Effective date of registration: 20060414

Address after: California, USA

Patentee after: MEDEX, Inc.

Address before: Ohio, USA

Patentee before: ETHICON ENDO-SURGERY, Inc.

Effective date of registration: 20060414

Address after: Ohio, USA

Patentee after: This new Co.

Address before: New jersey, USA

Patentee before: ETHICON, Inc.

C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee