CN118078948A - 一种治疗慢性萎缩性胃炎的方剂 - Google Patents
一种治疗慢性萎缩性胃炎的方剂 Download PDFInfo
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Abstract
本发明涉及中药技术领域，且公开了一种治疗慢性萎缩性胃炎的方剂，由下列原料组成：枳壳9～15g，厚朴9～15g，干姜6～9g，党参15～30g，茯苓15～30g，半夏9～15g，三七粉6～9g，白花蛇舌草15～30g，半枝莲9～15g，由下列原料组成：枳壳12g，干姜6g，厚朴12g，党参20g，茯苓15g，法半夏12g，三七粉9g，半枝莲12g，白花蛇舌草15g。治疗组95.00％总有效率较之对照组72.50％更高(P＜0.05)；两组治疗后TNF‑α、IL‑2、IL‑6水平较之同组治疗前更低(P＜0.05)；治疗组治疗后TNF‑α、IL‑2、I L‑6水平较之对照组更低(P＜0.05)。
Description
技术领域
本发明涉及中药技术领域，具体为一种治疗慢性萎缩性胃炎的方剂。
背景技术
慢性萎缩性胃炎(Chronic Atrophic Gastritis，CAG)是慢性胃炎的一种类型。系指胃黏膜上皮遭受反复损伤后出现腺体萎缩且数目减少，伴或不伴有肠上皮化生及假幽门腺化生的一类慢性胃部疾病。是临床常见病，难治病。研究认为幽门螺杆菌诱发的慢性萎缩性胃炎与胃癌的发生有关，幽门螺杆菌感染后可出现Correa级联反应，即慢性非萎缩性胃炎—慢性萎缩性胃炎—肠上皮化生—不典型增生—胃癌的发展趋势。其中慢性萎缩性胃炎和肠上皮化生(IM)被认为是癌前病变，在全球的年发病率为10.9％，萎缩性胃炎患者在确诊后5年内胃癌的年发病为0.1％，且在全球最新发布的癌症统计数据中，胃癌的发病率和癌症相关死亡率分别排名第五和第三。因此如何降低胃癌发生率及相关死亡率，阻断“炎－癌转化”至关重要。目前西医对于治疗慢性萎缩性胃炎缺乏理想的治疗方式，主要治疗是通过消除幽门螺杆菌及对症治疗，抑制胃酸分泌、保护胃黏膜、促进胃肠动力等方式，但效果欠佳，容易复发。
中医传统辨证论治方案，对医生的辨证论治水平要求高。一人一方，方随证变，导致治疗方案的可推广性和患者依从性差。影响了中医药疗法在治疗慢性萎缩性胃炎中的应用。
发明内容
本发明提供了一种治疗慢性萎缩性胃炎的方剂，解决了上述背景技术所提出的问题。
本发明提供如下技术方案：一种治疗慢性萎缩性胃炎的方剂，由下列原料组成：枳壳9～15g，厚朴9～15g，干姜6～9g，党参15～30g，茯苓15～30g，半夏9～15g，三七粉6～9g，白花蛇舌草15～30g，半枝莲9～15g。
优选的，由下列原料组成：枳壳12g，干姜6g，厚朴12g，党参20g，茯苓15g，法半夏12g，三七粉9g，半枝莲12g，白花蛇舌草15g。
优选的，汤剂的煎煮方法为：
步骤S1：煎煮前，首先将上述中药饮片放入陶瓷器皿中用冷水浸泡，液面淹过饮片约2cm为宜，浸泡30min后；
步骤S2：用武火迅速煮沸，改用文火维持15～20min左右；
步骤S3：趁热滤取药汁后，再重新加水煎煮2次；
步骤S4：最后将3次煎煮所得1000ml药液混合后即可服用；
服药方法：一日三次，每次150ml，饭后温服。
优选的，散剂的制备方法：将以上中药混合，使用中药粉碎机粉碎，过100目筛细粉；
服用方法：一日两次，每次10g，加开水100ml左右浸泡10min后温服。
优选的，丸剂的制备方法：
步骤S1：将以上中药混合，使用中药粉碎机粉碎，过100目筛细粉；
步骤S2：将蜂蜜加热至沸，色变深，有黏滞性，转文火加热至出现浅红色有光泽的泡沫，用手拈之粘性较强，但无白丝时关火，冷却后则为炼蜜；
步骤S3：每细粉100g用炼蜜30g制成小蜜丸；
服用方法：一日2次，每次约8g，饭后温水服用
本发明具备以下有益效果：
1、该治疗慢性萎缩性胃炎的方剂，党参为君药，其归脾、肺经，可健脾益肺，养血生津，具有气血双补的功效；
白术、茯苓、半夏、枳壳、厚朴为臣药。
白术健脾燥湿，与党参相须，更添益气健脾之功。
茯苓健脾渗湿，半夏燥湿和胃消痞，三者合用，可健脾和胃祛湿，助脾胃纳运；
枳壳可理气宽中、行气消胀，厚朴燥湿，下气除满，二者相合健脾行气，共同调畅中焦气机；
三七粉散瘀消胀止痛，半枝莲解毒消瘀，白花蛇舌草清热解毒、活血止痛，三药相伍，即可活血化瘀，又兼有清热解毒散瘀止痛的功效；
干姜性热既可温护脾阳，又可中和其他寒凉药物之性，为佐药。
诸药相合，共奏运脾益气，活血解毒之功
2、该治疗慢性萎缩性胃炎的方剂，益气康萎汤在临床治疗慢性萎缩性胃炎的实践中具有良好的治疗效果，兼具副作用少、价格相对较低、可长期服用优点，具有广阔的应用前景；
同时有助于推动有独特临床疗效的中药成方进行制剂研究和成果转化，具有非常重要的社会经济价值。
3、该治疗慢性萎缩性胃炎的方剂，治疗组95.00％总有效率较之对照组72.50％更高(P＜0.05)；
两组治疗后TNF-α、IL-2、IL-6水平较之同组治疗前更低(P＜0.05)；治疗组治疗后TNF-α、IL-2、IL-6水平较之对照组更低(P＜0.05)。
附图说明
图1为本发明两组治疗效果比较[n(％)]图；
图2为本发明两组炎性因子水平比较图。
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
请参阅图1-2，一种治疗慢性萎缩性胃炎的方剂，由下列原料组成：枳壳9～15g，厚朴9～15g，干姜6～9g，党参15～30g，茯苓15～30g，半夏9～15g，三七粉6～9g(冲服)，白花蛇舌草15～30g，半枝莲9～15g。
其中，由下列原料组成：枳壳12g，干姜6g，厚朴12g，党参20g，茯苓15g，法半夏12g，三七粉9g，半枝莲12g，白花蛇舌草15g。
其中，汤剂的煎煮方法为：
步骤S1：煎煮前，首先将上述中药饮片放入陶瓷器皿(如砂锅、瓦罐)中用冷水浸泡，液面淹过饮片约2cm为宜，浸泡30min后；
步骤S2：用武火迅速煮沸，改用文火维持15～20min左右；
步骤S3：趁热滤取药汁后，再重新加水煎煮2次；
步骤S4：最后将3次煎煮所得1000ml药液混合后即可服用；
服药方法：一日三次，每次150ml，饭后温服。
其中，散剂的制备方法：将以上中药混合，使用中药粉碎机粉碎，过100目筛细粉；
服用方法：一日两次，每次10g，加开水100ml左右浸泡10min后温服。
其中，丸剂的制备方法：
步骤S1：将以上中药混合，使用中药粉碎机粉碎，过100目筛细粉；
步骤S2：将蜂蜜加热至沸，色变深，有黏滞性，转文火加热至出现浅红色有光泽的泡沫，用手拈之粘性较强，但无白丝时关火，冷却后则为炼蜜；
步骤S3：每细粉100g用炼蜜30g制成小蜜丸；
服用方法：一日2次，每次约8g，饭后温水服用。
益气康萎汤化裁于《兰室秘藏》“枳实消痞丸”，具有益气运脾，清热解毒、理气活血利湿的功效。
党参为君药，其归脾、肺经，可健脾益肺，养血生津，具有气血双补的功效；
白术、茯苓、半夏、枳壳、厚朴为臣药。
白术健脾燥湿，与党参相须，更添益气健脾之功。
茯苓健脾渗湿，半夏燥湿和胃消痞，三者合用，可健脾和胃祛湿，助脾胃纳运；
枳壳可理气宽中、行气消胀，厚朴燥湿，下气除满，二者相合健脾行气，共同调畅中焦气机；
三七粉散瘀消胀止痛，半枝莲解毒消瘀，白花蛇舌草清热解毒、活血止痛，三药相伍，即可活血化瘀，又兼有清热解毒散瘀止痛的功效；
干姜性热既可温护脾阳，又可中和其他寒凉药物之性，为佐药。
诸药相合，共奏运脾益气，活血解毒之功。
运用益气康萎汤加减治疗脾胃虚寒型慢性萎缩性胃炎获得了良好的治疗效果，在明显缓解患者临床症状的同时，可以使部分病人的萎缩和肠化得到逆转。
益气康萎汤在临床治疗慢性萎缩性胃炎的实践中具有良好的治疗效果，兼具副作用少、价格相对较低、可长期服用的优点，具有广阔的应用前景。
同时有助于推动有独特临床疗效的中药成方进行制剂研究和成果转化，具有非常重要的社会经济价值。
现列举案例对益气康萎汤治疗慢性萎缩性胃炎的效果进行说明：
1.一般资料
选取2020年1月～2022年1月收治的80例CAG患者，按随机数字表法分组，对照组(40例)男、女分别为26例、14例，年龄30岁～69岁，平均(49.29±1.54)岁；病程6个月～6年，平均(3.98±1.21)年。治疗组(40例)男、女分别为24例、16例，年龄31岁～72岁，平均(49.85±1.65)岁；病程4个月～6年，平均(3.59±1.33)年。两组资料比较，P＞0.05。患者对本研究内容知情，并且签署同意书。
Claims (5)
1.一种治疗慢性萎缩性胃炎的方剂，其特征在于：由下列原料组成：枳壳9～15g，厚朴9～15g，干姜6～9g，党参15～30g，茯苓15～30g，半夏9～15g，三七粉6～9g，白花蛇舌草15～30g，半枝莲9～15g。
2.根据权利要求1所述的一种治疗慢性萎缩性胃炎的方剂，其特征在于：由下列原料组成：枳壳12g，干姜6g，厚朴12g，党参20g，茯苓15g，法半夏12g，三七粉9g，半枝莲12g，白花蛇舌草15g。
3.根据权利要求1所述的一种治疗慢性萎缩性胃炎的方剂，其特征在于：汤剂的煎煮方法为：
步骤S1：煎煮前，首先将上述中药饮片放入陶瓷器皿中用冷水浸泡，液面淹过饮片约2cm为宜，浸泡30min后；
步骤S2：用武火迅速煮沸，改用文火维持15～20min左右；
步骤S3：趁热滤取药汁后，再重新加水煎煮2次；
步骤S4：最后将3次煎煮所得1000ml药液混合后即可服用；
服药方法：一日三次，每次150ml，饭后温服。
4.根据权利要求1所述的一种治疗慢性萎缩性胃炎的方剂，其特征在于：散剂的制备方法：将以上中药混合，使用中药粉碎机粉碎，过100目筛细粉；
服用方法：一日两次，每次10g，加开水100ml左右浸泡10min后温服。
5.根据权利要求1所述的一种治疗慢性萎缩性胃炎的方剂，其特征在于：丸剂的制备方法：
步骤S1：将以上中药混合，使用中药粉碎机粉碎，过100目筛细粉；
步骤S2：将蜂蜜加热至沸，色变深，有黏滞性，转文火加热至出现浅红色有光泽的泡沫，用手拈之粘性较强，但无白丝时关火，冷却后则为炼蜜；
步骤S3：每细粉100g用炼蜜30g制成小蜜丸；
服用方法：一日2次，每次约8g，饭后温水服用。
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