CN117919152B - Whitening and spot-fading water-soluble composition and preparation method thereof - Google Patents
Whitening and spot-fading water-soluble composition and preparation method thereof Download PDFInfo
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- CN117919152B CN117919152B CN202410121118.3A CN202410121118A CN117919152B CN 117919152 B CN117919152 B CN 117919152B CN 202410121118 A CN202410121118 A CN 202410121118A CN 117919152 B CN117919152 B CN 117919152B
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- water
- whitening
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- skin
- soluble composition
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 35
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 238000005562 fading Methods 0.000 title abstract description 7
- 239000000284 extract Substances 0.000 claims abstract description 53
- 244000124209 Crocus sativus Species 0.000 claims abstract description 38
- 235000015655 Crocus sativus Nutrition 0.000 claims abstract description 38
- 240000002853 Nelumbo nucifera Species 0.000 claims abstract description 23
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims abstract description 23
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims abstract description 23
- 239000003795 chemical substances by application Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 238000000855 fermentation Methods 0.000 claims description 11
- 230000004151 fermentation Effects 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 10
- 241000235646 Cyberlindnera jadinii Species 0.000 claims description 9
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 9
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 9
- 239000000287 crude extract Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- 239000003906 humectant Substances 0.000 claims description 6
- 238000011081 inoculation Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- -1 polydimethylsiloxane Polymers 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000004695 Polyether sulfone Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 229920006393 polyether sulfone Polymers 0.000 claims description 3
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 2
- XYTHHAXRVHHXKO-JIUYZRCGSA-N 18-[(2r,3s,4r,5r)-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxyoctadecanoic acid;ethanol Chemical compound CCO.COC1O[C@H](CO)[C@@H](OCCCCCCCCCCCCCCCCCC(O)=O)[C@H](O)[C@H]1O XYTHHAXRVHHXKO-JIUYZRCGSA-N 0.000 claims description 2
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 2
- 239000004475 Arginine Substances 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 2
- 241001558929 Sclerotium <basidiomycota> Species 0.000 claims description 2
- 206010070834 Sensitisation Diseases 0.000 claims description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 2
- 229960000458 allantoin Drugs 0.000 claims description 2
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- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 229960003237 betaine Drugs 0.000 claims description 2
- BRXCDHOLJPJLLT-UHFFFAOYSA-N butane-2-sulfonic acid Chemical compound CCC(C)S(O)(=O)=O BRXCDHOLJPJLLT-UHFFFAOYSA-N 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 2
- 230000003020 moisturizing effect Effects 0.000 claims description 2
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- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 2
- 229940104261 taurate Drugs 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 18
- 239000002537 cosmetic Substances 0.000 abstract description 8
- 230000009044 synergistic interaction Effects 0.000 abstract 1
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- 235000004237 Crocus Nutrition 0.000 description 5
- 241000596148 Crocus Species 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000001804 emulsifying effect Effects 0.000 description 4
- 241001145025 Saussurea involucrata Species 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 239000007933 dermal patch Substances 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
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- 239000003153 chemical reaction reagent Substances 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
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- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 1
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- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 description 1
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- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a whitening and spot-fading water-soluble composition and a preparation method thereof, and particularly belongs to the field of cosmetic preparations; the water-soluble composition comprises the following components: snow lotus herb extract and white crocus sativus bulb extract; the snow lotus extract and the white crocus sativus bulb extract in the whitening and spot-fading composition provided by the invention have synergistic interaction; the crocus sativus bulb extract has effects of whitening and spot-fading under specific addition.
Description
Technical Field
The invention belongs to the field of cosmetic preparations, and particularly relates to a whitening and spot-fading water-soluble composition and a preparation method thereof.
Background
In the field of skin beauty, whitening and lightening have been the focus of consumer attention. Along with the acceleration of the life rhythm and the influence of environmental factors, the skin is easy to generate the problems of color spots, darkness and the like, so that the development of efficient and safe whitening and spot-lightening products is always a research hot spot of the industry.
The snow lotus herb extract is considered to have remarkable whitening and antioxidation effects because of being rich in various active ingredients, and is widely applied in the field of cosmetics. However, although cosmetics containing snow lotus herb extracts have a certain share in the market, they have some remarkable drawbacks in practical use. Firstly, when the snow lotus herb extract is singly used, the whitening effect is often not obvious enough, and the snow lotus herb extract can achieve the ideal effect only by being compounded with other components; secondly, the effect of the composition compounded with lotus extract on the market is always unsatisfactory, the synergistic effect of the combination of the raw materials is poor, the synergistic effect cannot be achieved, and even the composition can be eliminated, so that the effect of each component is weakened when the components are independently acted.
Therefore, in order to overcome the defects of the prior cosmetic containing the snow lotus herb extract, the invention provides a novel water-soluble composition, which is compounded by introducing the white crocus sativus bulb extract and the snow lotus herb extract, and aims to improve the whitening and freckle-removing effects of the compounded composition and promote the performance and efficacy of the snow lotus herb extract.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a water-soluble composition for whitening and lightening spots, which can quickly penetrate into the deep layer of skin, inhibit the formation and transportation of melanin, improve the oxidation resistance, promote the metabolism of the skin and accelerate the lightening and discharge of spots.
In order to achieve the above purpose, the present invention discloses the following technical solutions:
in a first aspect, the present invention provides a water soluble composition comprising the components saussurea involucrata extract and crocus sativus bulb extract.
Further, the composition comprises the following components in parts by weight:
15-20 parts of snow lotus herb extract;
1-3 parts of crocus sativus bulb extract;
77-84 parts of water;
the preparation method of the crocus sativus bulb extract comprises the following steps:
(1) Pulverizing a certain amount of crocus sativus corms, soaking in water for at least 12h at 55-65deg.C at a mass ratio of 1 (2.7-3.3) to obtain a mixture of materials and water;
(2) Adding the material water mixture into saccharomyces cerevisiae and candida utilis for mixed strain fermentation for 12-24 hours, and filtering and sterilizing after fermentation to obtain a crude extract;
(3) Adding 95v/v% ethanol water solution into the crude extract, standing for 6-8 hr, removing 95v/v% ethanol water solution, concentrating, and drying to obtain crocus sativus corm extract.
Still further, the fermentation temperature in the step (2) is maintained at 20-30 ℃;
the inoculation concentration of the saccharomyces cerevisiae viable bacteria is (2.0-2.6) multiplied by 10 6 CFU/g;
The inoculation concentration of the candida utilis viable bacteria is (0.7-1.1) multiplied by 10 6 CFU/g.
And (3) filtering and sterilizing in the step (2) by passing through a polyether sulfone filter core with the diameter of less than or equal to 0.45 mu m.
Still further, the volume ratio of the crude extract to the 95v/v% aqueous ethanol solution is 1: (1.5-2.5).
In a second aspect, the present invention provides the use of a water-soluble composition according to the first aspect for the preparation of a skin care product having tightening, soothing, anti-sensitization, whitening, spot-lightening, moisturizing, anti-wrinkle, repairing and/or anti-acne efficacy.
In a third aspect, the present invention provides a skin-resident agent for whitening and lightening spots, comprising the water-soluble composition of the first aspect;
the water-soluble composition is added to the skin residence agent in an amount of 1-10wt%.
Further, the skin resident agent for whitening and lightening the spots further comprises a humectant, a film forming agent, a preservative, a pH regulator, an emulsifier and a solvent.
Further, the humectant is at least one of butanediol, allantoin, betaine, sclerotium gum, sodium hyaluronate and 1, 2-hexanediol;
The film forming agent is at least one of polydimethylsiloxane, PEG-60 hydrogenated castor oil and octyl dodecanol;
The preservative is at least one of p-hydroxyacetophenone and phenoxyethanol;
the pH regulator is at least one of arginine, sodium hydroxide and disodium hydrogen phosphate;
the emulsifier is at least one of sodium polyacryl dimethyl taurate, polyacrylamide methyl propane sulfonic acid, PEG-20 methyl glucose sesquistearate and EDTA disodium.
In a fourth aspect, the present invention provides a method for preparing the skin residence agent for whitening and lightening spots, comprising the following steps:
(1) Uniformly stirring and mixing the humectant, the film forming agent, the preservative, the pH regulator, the emulsifier and the solvent at the temperature of 55-80 ℃;
(2) Cooling the step (1) to 30-45 ℃, adding the water-soluble composition according to any one of claims 1-5, mixing, and stirring uniformly to obtain the skin residence agent for whitening and lightening spots.
The snow lotus herb extract contains ingredients such as flavonoid reed, snow lotus lactone, snow lotus polysaccharide and the like, can effectively protect skin from being damaged by ultraviolet rays, has sun-screening and anti-aging effects, and simultaneously contains rich active substances such as amino acids, vitamins, sugar, mineral substances and the like, wherein the substances can accelerate metabolism of the skin, balance endocrine, reduce wrinkles and moisten and whiten the skin;
The crocus sativus corm extract contains rich chemical components such as amino acids, saccharides, saponins, flavonoids, organic acids, phenols, steroids, coumarin and the like, is beneficial to improving the microcirculation of the skin, promoting the blood flow, and eliminating skin darkness and color spots, has a good antioxidation effect, and can remove free radicals in the body, thereby achieving the effects of whitening and lightening the spots.
The synergistic mechanism of the snow lotus herb extract and the white crocus sativus bulb extract in cosmetics is mainly based on two aspects, namely antioxidant synergy: both the snow lotus flower and white saffron bulbs are rich in antioxidant substances such as flavonoids, polysaccharides and other phenolic compounds. When these ingredients are co-present in the formulation, they can complement each other, providing more comprehensive antioxidant protection, thereby more effectively scavenging free radicals, reducing oxidative stress and aging of the skin; the second is to promote blood circulation: the crocus sativus bulb extract has the effects of promoting blood circulation to remove blood stasis, improving skin microcirculation, increasing blood and nutrient flow, promoting skin utilization and absorption of active substances in the crocus sativus extract, promoting skin cell regeneration and repair, and improving whitening and speckle-reducing effects.
According to the invention, substances with certain low toxicity in the crocus sativus corms are decomposed, absorbed and combined in a mode of fermenting the compound saccharomyces cerevisiae and candida utilis, and simultaneously protein macromolecular substances in the crocus sativus corms are further decomposed into small molecular polypeptides, so that the utilization and absorption of skin are facilitated, and the whitening effect is improved.
The invention has the beneficial effects that:
1. The snow lotus extract and the white crocus sativus bulb extract in the whitening and spot-fading composition provided by the invention have the mutual promotion and mutual synergy effects;
2. The crocus sativus bulb extract provided by the invention has the effect of promoting whitening and spot-lightening of the saussurea involucrata extract under a certain proportion.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples. It will be appreciated by persons skilled in the art that the specific embodiments described herein are for purposes of illustration only and are not intended to be limiting.
The test methods used in the specific embodiments are all conventional methods unless otherwise specified; materials, reagents, and the like used, unless otherwise specified, are commercially available; the percentages mentioned in the detailed description are mass percentages unless otherwise indicated.
In the invention, the following components are added:
the herba Saussureae Involueratae extract is herba Saussureae Involueratae (SAUSSUREA INVOLUCRATA) extract, INCI name SAUSSUREA INVOLUCRATAEXTRACT, available from Oriental vast Sen Biotechnology Co., ltd. In Beijing;
the Latin theory of white crocus is Crocus alatavicus REGEL ET SEM, the crocus corm is the underground corm of white crocus, also called as nux vomica, purchased from Yining urban forest planting source seedling planting farmer professional cooperation, and the crocus corm before two years of flowering is selected;
The crocus sativus latin school name is Crocus salivusl, crocus sativus corms are underground corms of crocus sativus, purchased from Yining elsen plant source nursery stock planting farmer specialty co-workers;
The Latin chemical name of Saccharomyces cerevisiae is Saccharomyces cerevisiae, purchased from Henan Longfeng edible fungus industry Co., ltd;
the Latin chemical name of Candida utilis is Candida utilis, and is purchased from Henan Longfeng edible fungi industry Co.
Other starting materials reagents are commercially available.
Preparation of crocus sativus corm extract
(1) Taking a certain amount of crocus sativus corms, cutting, grinding, adding water with a material-water mass ratio of 1 (2.7-3.3), soaking for 12-20h at 55-65 ℃, intermittently stirring during the soaking, and obtaining a material-water mixture after fermentation is completed;
(2) Transferring the material water mixture into a fermentation tank, adding saccharomyces cerevisiae and candida utilis to ferment for 12-24h, maintaining the fermentation temperature at 20-30 ℃, filtering and sterilizing the obtained fermentation liquor through a 0.22 mu m polyether sulfone filter element, wherein the inoculation concentration of the saccharomyces cerevisiae is (2.0-2.6) multiplied by 10 6 CFU/g, the inoculation concentration of the candida utilis is (0.7-1.1) multiplied by 10 6 CFU/g, and the ventilation amount in the fermentation process is maintained at 0.65 VM, and the stirring rotating speed is 300 r/min;
(3) Adding 95v/v% ethanol water solution into the crude extract, wherein the volume ratio of the crude extract to the ethanol water solution is 1 (1.5-2.5), standing for 8h, removing ethanol, concentrating and drying at normal temperature and low pressure to obtain the dry crocus sativus bulb extract. The specific preparation parameters were as shown in table 1.
TABLE 1 parameters for preparation of crocus sativus bulb extract
Preparation of crocus sativus corm extract
The crocus sativus corm extract is identical to the preparation method of the crocus sativus corm extract, and the preparation parameters are the same as those of the crocus sativus corm extract ②, so as to obtain a crocus sativus corm extract ④.
Preparation of Water-soluble compositions
The raw materials are weighed according to the mass parts in the table 2, and then stirred and mixed uniformly to obtain the water-soluble composition.
TABLE 2 preparation of raw materials for Water-soluble compositions
Note that: the raw materials in the table are in parts by mass, "-" means not added.
Preparation of skin resident agent for whitening and lightening spots
Taking the required raw materials according to a table 3;
Pretreatment:
① Taking a clean and sterilized container, and uniformly mixing the components of the phase B for later use;
processing the E phase for standby by the same method;
② Taking a clean and sterilized stainless steel container, mixing and heating the D phase to 60 ℃, and dissolving the D phase to be complete for later use;
step (1), cleaning and disinfecting production equipment;
sequentially adding the components of the phase A into an emulsifying pot, adding the mixed phase B raw materials into the pot, stirring and heating to 82 ℃, homogenizing and dispersing for 5-8min at a rotating speed of 3000r/min, and preserving heat for 10 min;
Sequentially adding the raw materials of the phase C into an oil phase pot, uniformly stirring, heating to 70 ℃ and preserving heat;
step (4), when the temperature of the emulsifying pot is reduced to 70 ℃, pumping the oil phase pot material into the emulsifying pot, uniformly stirring, vacuumizing, and homogenizing for 2-4min;
continuously cooling to 40 ℃, and sequentially adding all the pretreated raw materials of the D phase, the E phase and the F phase into an emulsifying pot, and uniformly stirring;
and (6) filtering with 300-mesh filter cloth, and discharging to obtain the skin resident agent for whitening and lightening spots.
TABLE 3 raw materials for skin resident agent
Note that: the units in the table are mass percent, "-" indicates no addition.
Performance testing
Multiple skin irritation test:
Materials and methods
1. Test article: skin residence agent examples 1-5, tan lotion, product was used directly.
2. Experimental animals and feeding environment
2.1 Experimental animals: 4 Japanese white rabbits, female, weighing 2.0kg-2.5kg, were supplied by Changyang western mountain farm in Beijing city, and were common animals.
2.2 Feeding environment: the temperature of the animal house is controlled at 19-26 ℃, the relative humidity is 40-70%, the animal house is illuminated for 12 hours, and the animal house is dark for 12 hours. The raising cage is made of stainless steel, the raising mode is single cage raising, animals can eat and drink water freely.
2.3 Feed: purchased from ston Bei Fu (beijing) biotechnology limited.
3. Test method
3.1 Dehairing the two sides of the spine of the back of the household 24 hours before the test, and about 3cm x 3cm each, so that the skin cannot be damaged.
3.2 The test article was applied directly to the skin on the left side (2.5 cm. Times.2.5 cm) of the animal in an amount of 0.5ml, 1 time per day for 4 consecutive days. The right skin (2.5 cm. Times.2.5 cm) was not smeared as a blank. From the next day, the hair was removed before application and the residual test substance was removed with water. After one hour the results were observed and the control and test areas were treated identically.
3.3 Evaluation of results: skin irritation response scores were performed as specified in cosmetic safety specifications (2015 edition) (chapter six), the mean of the integral per animal per day was calculated, the mean integral per animal per day = sigma erythema and edema integral per number of animals tested/14, and skin irritation intensity grading was performed, and the results are shown in table 4.
Experimental results
TABLE 4 test results of multiple skin irritation test of test substances on rabbits
TABLE 4 test results of multiple skin irritation test of test subjects on rabbits (follow-up)
Note that: the integrated mean retains 2-bit decimal.
Analysis of results
Multiple skin irritation tests were performed on the animals using the test subjects, with an average score of 0.00 (0 to < 0.5) per day, and the test subjects were non-irritating to the multiple skin irritation.
Human skin patch test:
The 5 examples of the preparation are referred to the human skin patch experiments in 2022 cosmetic safety technical Specification.
Skin reactions were observed as standard at 30min (after the disappearance of the indentations), 24h and 48h, respectively, and the observations were recorded, see table 5.
TABLE 5 human safety test results
| Numbering device | 30min | 24h | 48h |
| Example 1 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 2 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 3 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 4 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 5 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
The test results of the human skin patch show that skin adverse reactions occur in 0 cases of 30 people.
Whitening effect test:
Test environmental conditions: under stable indoor environment, the indoor temperature is 24-27 ℃ and the relative humidity is 40-50%.
Test article: examples 1-5 skin residence agents were used directly.
The subject: volunteers aged 30+ -2 years were selected with skin tone L values close to those belonging to sensitive muscles.
Test protocol: each of the test subjects was subjected to a use test corresponding to 5 volunteers, the test parts of the volunteers were faces, the initial ITA value of each group of volunteers was measured by using a multifunctional skin tester (model: MPA 580) manufactured by the company Courage Khazaka, germany, the test subjects of examples 1 to 5 were used 10ml at a time, the application mode was carried out 2 times a day for 4 weeks, the ITA value (average value) of each group of volunteers was measured, the whitening effect of the test subjects was evaluated, the higher the ITA value was, the better the whitening effect was, and the test results were shown in Table 6 below.
TABLE 6 ITA value test results for examples 1-5
Analysis of results:
From the results in Table 6, the results of examples 1-3 showed that the whitening and spot-lightening effects of the test substances were higher than those of examples 4 and 5, and the results showed that the ITA values were more varied and the final data were better before and after the use of examples 1-3, indicating that the snow lotus extract and the white crocus sativus bulb extract in the skin resident agents of examples 1-3 had a synergistic effect;
compared with example 4 and example 5, the data difference is not large, which shows that the snow lotus extract and the crocus sativus bulb extract have no interaction effect, the effect of the snow lotus extract alone is not large, the white crocus sativus bulb extract has the effect of promoting the whitening and spot-lightening effects of the snow lotus extract, and the snow lotus extract and the crocus sativus bulb extract are compounded according to a certain proportion to realize synergistic effect, so that better whitening and spot-lightening effects are realized.
Finally, it should be noted that the above embodiments and comparative examples are only for illustrating the technical solution of the present invention and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions may be made to the technical solution of the present invention without departing from the spirit and scope of the technical solution of the present invention.
Claims (6)
1. The water-soluble composition is characterized by comprising the following components in parts by mass:
15-20 parts of snow lotus herb extract;
1-3 parts of crocus sativus bulb extract;
77-84 parts of water;
the preparation method of the crocus sativus bulb extract comprises the following steps:
(1) Pulverizing a certain amount of crocus sativus corms, soaking in water for at least 12h at 55-65deg.C at a mass ratio of 1 (2.7-3.3) to obtain a mixture of materials and water;
(2) Adding the material water mixture into saccharomyces cerevisiae and candida utilis for mixed strain fermentation for 12-24 hours, and filtering and sterilizing after fermentation to obtain a crude extract;
(3) Adding 95v/v% ethanol water solution into the crude extract, standing for 6-8h, removing 95v/v% ethanol water solution, concentrating and drying to obtain crocus sativus corm extract;
The fermentation temperature in the step (2) is maintained at 20-30 ℃;
the inoculation concentration of the saccharomyces cerevisiae viable bacteria is (2.0-2.6) multiplied by 10 6 CFU/g;
the inoculation concentration of the candida utilis viable bacteria is (0.7-1.1) multiplied by 10 6 CFU/g;
The volume ratio of the crude extract to the 95v/v% ethanol water solution is1 (1.5-2.5).
2. The water-soluble composition according to claim 1, wherein the filter sterilization in the step (2) is filter sterilization by passing through a polyether sulfone filter cartridge of 0.45 μm or less.
3. Use of the water-soluble composition according to claim 1 or 2 for the preparation of a skin care product having tightening, soothing, anti-sensitization, whitening, spot-lightening, moisturizing, anti-wrinkle, repairing and/or anti-acne efficacy.
4. A skin residence agent for whitening and lightening spots, which is characterized by comprising the water-soluble composition as claimed in claim 1 or 2, and further comprising a humectant, a film forming agent, a preservative, a pH regulator, an emulsifier and a solvent;
the water-soluble composition is added to the skin residence agent in an amount of 1-10wt%.
5. The skin-resident agent for whitening and spot-lightening according to claim 4, wherein the humectant is at least one of butylene glycol, allantoin, betaine, sclerotium gum, sodium hyaluronate, 1, 2-hexanediol;
the film forming agent is at least one of polydimethylsiloxane, PEG-60 hydrogenated castor oil and octyl dodecanol;
The preservative is at least one of p-hydroxyacetophenone and phenoxyethanol;
the pH regulator is at least one of arginine, sodium hydroxide and disodium hydrogen phosphate;
the emulsifier is at least one of sodium polyacryl dimethyl taurate, polyacrylamide methyl propane sulfonic acid and PEG-20 methyl glucose sesquistearate.
6. The method for preparing the skin residence agent for whitening and lightening spots according to claim 4 or 5, comprising the following steps:
(1) Uniformly stirring and mixing the humectant, the film forming agent, the preservative, the pH regulator, the emulsifier and the solvent at the temperature of 55-80 ℃;
(2) And (3) cooling the step (1) to 30-45 ℃, adding the water-soluble composition, mixing, and uniformly stirring to obtain the skin resident agent for whitening and lightening the spots.
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| CN102641235A (en) * | 2012-05-18 | 2012-08-22 | 通德集团有限公司 | Rhodiola crenulata essence with skin softening and anti-wrinkle effects |
| CN105640841A (en) * | 2016-02-22 | 2016-06-08 | 广州科玛生物科技有限公司 | Anti-senile and anti-freckle mask liquid and preparation method thereof |
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| CN106589152A (en) * | 2016-12-02 | 2017-04-26 | 伊犁师范学院 | Extraction process of Xinjiang Alatao crocus sativus corm polysaccharides |
| CN113143829A (en) * | 2021-04-16 | 2021-07-23 | 梧州市华夏医药科技有限公司 | Eucommia male flower skin-tendering liquid and application thereof |
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| CN102641235A (en) * | 2012-05-18 | 2012-08-22 | 通德集团有限公司 | Rhodiola crenulata essence with skin softening and anti-wrinkle effects |
| CN105640841A (en) * | 2016-02-22 | 2016-06-08 | 广州科玛生物科技有限公司 | Anti-senile and anti-freckle mask liquid and preparation method thereof |
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