CN117883357A - Multi-effect traditional Chinese medicine composition and application thereof in preparation of oral care products - Google Patents
Multi-effect traditional Chinese medicine composition and application thereof in preparation of oral care products Download PDFInfo
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- CN117883357A CN117883357A CN202410052086.6A CN202410052086A CN117883357A CN 117883357 A CN117883357 A CN 117883357A CN 202410052086 A CN202410052086 A CN 202410052086A CN 117883357 A CN117883357 A CN 117883357A
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Abstract
The invention provides a multi-effect traditional Chinese medicine composition and application thereof in preparing oral care products. The traditional Chinese medicine composition for oral care is prepared from the following raw materials in parts by weight: 1-20 parts of dyers woad salt; 1-40 parts of cuttlefish bone sheath; 1-20 parts of pearl powder; 1-15 parts of kuh-seng, 2-25 parts of radix isatidis and 2-15 parts of wrinkled gianthyssop; 2-15 parts of eupatorium; 2-25 parts of peppermint; 1-25 parts of radix sileris; oral care products that can be prepared from the traditional Chinese medicine composition of the invention include, but are not limited to, toothpastes, tooth cleaning powders. The traditional Chinese medicine composition for oral care of the invention uses the traditional Chinese medicine composition to achieve the effects of diminishing inflammation, relieving pain, cleaning teeth and fixing teeth; is combined with the form of oral care products, belongs to the functional components and has the addition amount of 5 to 95 percent. The oral cavity health care product has the advantages of reducing the stimulation of other chemical raw materials to the oral cavity, mildly caring the oral cavity health, achieving various daily health care effects of cleaning teeth, fixing teeth, preventing loosening of teeth, tartar and calculus, decayed teeth and the like, and also relieving gum discomfort, refreshing breath and the like.
Description
Technical Field
The invention relates to an oral care composition, belongs to the technical field of personal care products, and in particular relates to a traditional Chinese medicine composition for oral care and application thereof in preparation of oral care products.
Background
The oral cavity is in a sub-health state, so that great life inconvenience and trouble are brought to people, and even the problem of oral teeth is caused from the tooth replacement period.
People have great working and living pressure, do not pay attention to oral health, remain food and drink, and the like, and the problems of slight oral sub-health, such as halitosis, decayed tooth, dental ulcer, gum red swelling, and the like, are often ignored in many cases. The small problems require long care, but most are difficult to adhere to, or misuse can result in more serious oral diseases, even cancer.
The oral cavity product is an indispensable cleaning product in life of people. Traditional Chinese medicine health care combined with ancient people wisdom inherits is introduced into oral care products, so that multiple effects are provided for oral care, the oral environment is balanced, the oral problem is simply and efficiently solved, convenience is increased for life of people, and happiness is improved.
With the science popularization of various large platforms, great importance is attached to oral health. Toothpaste with more traditional Chinese medicine combinations also appears on the market. However, the traditional Chinese medicine culture is profound, the traditional Chinese medicine composition for oral care still has the effects of increasing the sweetener for relieving the taste, achieving the tooth cleaning effect by means of other abrasives and the like, and cannot exert the maximum performance of the traditional Chinese medicine.
The existing oral care products such as traditional Chinese medicine toothpaste and the like can not effectively solve the problems, and the product which can comprehensively and effectively solve the oral problems by comprehensively utilizing traditional Chinese medicine materials and combining the traditional Chinese medicine materials to exert the maximum efficacy and preparing the multi-effect oral product still has the technical problem which is needed to be solved by the technicians in the field.
Disclosure of Invention
The invention aims to provide an oral care traditional Chinese medicine composition with multiple effects, which combines various functional components of traditional Chinese medicines to achieve multiple effects of diminishing inflammation, relieving pain, cleaning teeth, fixing teeth and the like.
Another object of the present invention is to provide an application of the above-mentioned Chinese medicinal composition for oral care, wherein the Chinese medicinal composition is added into an oral care product, so that the oral care product achieves various health care effects of fixing teeth, whitening teeth, preventing loosening of teeth, removing tartar, preventing calculus, freshening breath, preventing caries, etc.
The invention is realized by adopting the following technical scheme:
a multi-effect traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 1-20 parts of dyers woad salt; 1-40 parts of cuttlefish bone sheath; 1-20 parts of pearl powder; 1-15 parts of kuh-seng, 2-25 parts of radix isatidis and 2-15 parts of wrinkled gianthyssop; 2-15 parts of eupatorium; 2-25 parts of peppermint; 1-25 parts of radix sileris;
further, the multi-effect traditional Chinese medicine composition is prepared from the following components in parts by weight:
1-10 parts of dyers woad salt; 1-15 parts of cuttlefish bone sheath; 1-10 parts of pearl powder; 1-4 parts of kuh-seng; 2-8 parts of radix isatidis; 2-5 parts of patchouli powder; 2-7 parts of eupatorium; 2-15 parts of peppermint; 1-15 parts of radix sileris;
further, the multi-effect traditional Chinese medicine composition is prepared from the following components in parts by weight:
11-20 parts of dyers woad salt; 16-40 parts of cuttlebone; 11-20 parts of pearl powder; 5-15 parts of kuh-seng; 8-25 parts of radix isatidis; 6-15 parts of patchouli powder; 8-15 parts of eupatorium; 15-25 parts of peppermint; 1-15 parts of radix sileris;
further, the multi-effect traditional Chinese medicine composition is prepared by the following process:
1) Grinding: grinding Margarita into fine powder with particle size less than 40 μm; weighing other raw materials in parts by weight, and respectively putting into a pulverizer to pulverize for 30s and 2-3 times.
2) Mixing: mixing other Chinese medicinal materials powder and Margarita fine powder, grinding, and mixing;
3) Processing: mixing and grinding, and slowly adding water and uniformly mixing until the mixture becomes pasty;
4) And (3) drying: putting the pasty mixture into a baking oven at 45 ℃ for baking;
5) Fine grinding: and (3) putting the dried mixture into a powdering machine, starting powdering for 30s to 2 minutes each time, repeating for 2 to 3 times, and grinding to 2000-mesh traditional Chinese medicine composition.
In addition, the invention also provides application of the multi-effect traditional Chinese medicine composition in preparing oral care products, wherein the oral care products comprise, but are not limited to toothpastes and tooth powders, but can also be applied to other oral care products such as mouthwashes, oral sprays and the like.
Furthermore, the traditional Chinese medicine composition is added in the preparation of oral care products, belongs to functional components, and can be added in a total amount of 5% -95%.
Further, the traditional Chinese medicine composition is added into toothpaste, and the toothpaste comprises the following raw material components in percentage by weight:
further, the thickener is one or more of cellulose gum, carrageenan, xanthan gum, guar gum and carbomer;
the surfactant is one or more of sodium or potassium laurylsulfate, cocamidopropyl betaine, sodium or potassium lauroyl sarcosinate, or one or more of nonionic surfactant such as tween, polyoxyethylene hydrogenated castor oil, polyoxyethylene and polyoxypropylene block copolymer, etc.;
the grinding agent is one or a mixture of more of hydrated silica, calcium carbonate, calcium hydrophosphate, calcium pyrophosphate, aluminum hydroxide and microcrystalline cellulose;
the humectant is one or more of sorbitol, glycerol, propylene glycol and xylitol;
the preservative is one or more of decanediol, octanediol, phenoxyethanol and 1, 2-hexanediol.
In addition, the traditional Chinese medicine composition is added into a dentifrice, and the dentifrice comprises the following raw material components in percentage by weight:
80% -95% of traditional Chinese medicine composition;
5% -20% of a surfactant;
the surfactant is one or more of sodium or potassium laurylsulfate, cocamidopropyl betaine, sodium or potassium lauroyl sarcosinate, sodium cocoyl glycinate, or one or more of nonionic surfactant powder such as sodium fatty alcohol ether sulfate and anionic surfactant.
In addition, the traditional Chinese medicine composition is added into the dentifrice, and the preparation process of the dentifrice is as follows:
1) Putting the prepared raw materials into a powdering machine, powdering for 1-2 minutes each time, and repeating for 2-4 times to reach 2000 meshes;
2) Delivering the ground dentifrice into the mixer again for stirring and mixing to ensure uniform mixing;
3) Placing into a drying agent, removing water, sieving, sterilizing by irradiation, and bottling until the detection is qualified.
In summary, the invention has the following advantages and beneficial technical effects:
1) The traditional Chinese medicine composition is directly added into the oral care product in the form of medicinal powder for the first time, and the antibacterial effect is exerted through the pharmacological synergistic effect of the combination of the eupatorium and the wrinkled giant hyssop, so that the effects of inhibiting harmful bacteria in the oral cavity, preventing dental caries, periodontitis and the like are achieved, halitosis factors are eliminated, and the effect of refreshing the breath is achieved.
2) According to the invention, the combination of the dyer salt and the pearl powder is adopted, the traditional Chinese medicine powder composition is ground into 2000 mesh fine powder through a preparation process, and various stains on the surface of teeth, such as tea stains, coffee stains, smoke stains and the like, are effectively removed through physical friction; the pearl powder with extremely small molecules permeates into the small gaps of the teeth to lighten the staining of the teeth, thereby achieving the effects of whitening the teeth and preventing dental calculus.
3) The oral care product is prepared by adopting a very simple formula, so that the addition of other chemical components is reduced as much as possible, the irritation of chemical additives, essence and the like to the oral cavity is reduced, the traditional Chinese medicine composition is added into the formula as effective components, the addition amount can reach 5% -95%, the oral care product is combined with the oral care product form, the irritation to the oral cavity environment is reduced, and the health care effects of low sensitivity and no irritation are achieved, and the oral resistance is improved.
4) The oral care product has the effects of diminishing inflammation, strengthening teeth, cleaning teeth, removing dental calculus and the like, and can also prevent loosening of teeth, dental calculus, decayed teeth, toothache, fresh breath and the like. Can be used when oral cavity problem exists, and can also be used for daily health care and prevention. The multifunctional oral cavity nursing device has the advantages of providing more effects for oral cavity nursing, balancing oral cavity environments, simply and efficiently solving oral cavity problems, increasing convenience for life of people and improving happiness.
Detailed Description
The present invention will be described in further detail with reference to the following examples, which are not intended to limit the scope of the invention.
The invention provides a multi-effect traditional Chinese medicine composition which is prepared from the following raw materials in parts by weight:
9-20 parts of dyers woad salt; 9-40 parts of cuttlefish bone sheath; 2-5 parts of pearl powder; 2-25 parts of kuh-seng powder, 2-25 parts of radix isatidis and 2-10 parts of wrinkled gianthyssop herb; 2-10 parts of eupatorium; 15-24 parts of peppermint; 3-11 parts of radix sileris.
The following are the mechanisms of action of the nine traditional Chinese medicine components of the invention:
(1) dyers woad salt
The product is crystal of chloride stone group mineral stone; salty and cold in taste, it can not only grind teeth, but also rinse eyes by soaking in water. Is mainly used for treating lingual tooth hemorrhage and toothache, and has the effects of clearing heat and purging pathogenic fire, purging heat and moistening dryness.
(2) Cuttlefish sheath
The product is dried inner shell of Sepiella maindroni Sepiella maindroni de Rochebrune or Sepia esculenta Hoyle, has effects of astringing, stopping bleeding, relieving hyperacidity and relieving pain, and has bone defect repairing, radioprotective, antitumor and antiulcer effects.
(3) Pearl powder
The natural pearl powder is produced by physical method, and features no addition of other matters, no damage to any matters and retaining all the nutrients of pearl. The medicinal use has been recorded in China for over 2000 years. The main components are protein, calcium carbonate, more than 20 trace components and vitamin B. In recent years, the skin care product has the external whitening effect. It has effects in treating various skin injuries and pain, removing dental calculus, cleaning dental calculus, enhancing oral resistance, preventing loosening of teeth, strengthening teeth, cleaning teeth, and whitening skin by adding calcium carbonate into oral product.
(4) Radix Sophorae Flavescentis
The product is a heat-clearing and dampness-drying drug in heat-clearing drugs, has bitter cold property, and modern researches indicate that the radix sophorae flavescentis has various pharmacological effects of resisting pathogenic microorganisms, resisting inflammation, resisting allergy, resisting tumor, regulating immunity and the like.
(5) Radix Isatidis
The product is dry root of Isatis tinctoria Isatis indigotica fort of Isatis tinctoria of Brassicaceae, and has effects of clearing away heat and toxic materials, cooling blood, and relieving sore throat.
(6) Agastache rugosa
According to modern pharmacological research, agastache rugosa contains various substances beneficial to human bodies, such as protein, fat, carbohydrate, carotene, vitamin B1, vitamin C and the like, and the agastache rugosa is a good food and medicine product both from the modern medical theory and the traditional Chinese medical theory. According to the related data, the agastache rugosa has the bactericidal effect and can be used for halitosis, alcohol dispelling, infectious disease prevention and treatment and the like.
(7) Eupatorium fortunei
The product is dry aerial part of Eupatorium fortunei Eupatorium fortunei Turcz of Eupatorium of Compositae, and has effects of eliminating dampness and relieving summer heat. It is often combined with Huo Xiang with aromatic smell. The product has pharmacological effects in inhibiting diphtheria, staphylococcus aureus, sarcina, proteus, and typhoid bacillus. The volatile oil and the neryl acetate contained in the volatile oil have direct inhibition effect on influenza virus.
(8) Peppermint (peppermint)
The product is dry whole herb of Mentha piperita belonging to Labiatae, and is cultivated. Contains volatile oil mainly containing menthol, menthone, camphene, limonene, etc. Has effects of dispelling pathogenic wind and heat, and relieving inflammation, pain and itching.
(9) Wind-proof
The product is named copper brassica and returns clouds, and has long history. Has effects of dispelling pathogenic wind, relieving exterior syndrome, relieving pain, resisting bacteria, and relieving inflammation. Can be used for treating tetanus, arcuate and reverse, closed teeth, bitter taste, and tongue dryness.
The action mechanism of the traditional Chinese medicine composition for oral care is as follows:
the volatile oil and the phenolic compound of the herba eupatorii and the herba agastachis can inhibit the release of inflammatory mediators, reduce inflammation, have antibacterial effect, are excellent aromatic flavoring agents, and can clear breath and be matched with mint for use, thereby reducing the generation of oral cavity peculiar smell and preventing decayed teeth. The effects of diminishing inflammation and relieving pain are achieved through the pharmacological synergistic effect of the dyers woad leaf salt, the cuttlebone, the kuh-seng, the peppermint and the divaricate saposhnikovia root. The physical cleaning of dental calculus is achieved through the calcium carbonate component in the pearl powder. The microcrystalline particles of the compatible dyer woad salt can remove dental calculus and whiten teeth, and the effect of whitening teeth is achieved by using the isatis root for blending.
The traditional Chinese medicine components are used for daily external application, can achieve the effects of preventing loosening of teeth, calculus, toothache and the like in the oral cavity, and achieves the expected effects of cleaning teeth, strengthening teeth and daily health care.
The traditional Chinese medicine composition with multiple effects of the invention uses traditional Chinese medicine combination to achieve the effect; the addition stimulation of chemical components is reduced, the oral cavity problem is gently and multiple-effect cared, and the teeth are not only protected; the oral care product can be added into different oral care products, so that the oral problem can be relieved even if the frequency of brushing is incorrect.
The main effects of the invention are as follows: anti-inflammatory, analgesic, teeth strengthening, teeth whitening, breath refreshing, teeth loosening and teeth strengthening, calculus and toothache preventing effects.
The present invention will be described in further detail with reference to the following preferred examples, but the present invention is not limited to the following examples.
In the following examples, the units of parts by weight involved may be g or kg; percentages referred to are by weight unless otherwise indicated.
Examples 1 to 4
The composition raw materials and the weight parts of the multi-effect traditional Chinese medicine composition of the embodiments 1-4 are shown in the following table 1.
TABLE 1 raw material composition of the Chinese medicinal compositions of examples 1-4
Wherein, the preparation process of the traditional Chinese medicine composition of the embodiment 1-4 comprises the following steps:
1) Grinding: grinding Margarita into fine powder with particle size less than 40 μm; weighing other raw materials in parts by weight, and respectively putting into a pulverizer to pulverize for 30s and 2-3 times.
2) Mixing: mixing other Chinese medicinal materials powder and Margarita fine powder, grinding, and mixing;
3) Processing: mixing and grinding, and slowly adding water and uniformly mixing until the mixture becomes pasty;
4) And (3) drying: putting the pasty mixture into a baking oven at 45 ℃ for baking;
5) Fine grinding: and (3) putting the dried mixture into a powdering machine, starting powdering for 30s to 2 minutes each time, repeating for 2 to 3 times, and grinding to 2000-mesh traditional Chinese medicine composition.
The following are examples of the application of the above-mentioned Chinese medicinal composition to different oral care products, respectively.
Examples 5 to 8
The toothpaste composition materials and weight percentages of examples 5-8 are shown in Table 2 below.
TABLE 2 toothpaste raw material compositions of examples 5-8
Wherein the toothpaste manufacturing process of examples 5-8 comprises the following steps:
1) Uniformly premixing the weighed traditional Chinese medicine composition of the example 1 or the traditional Chinese medicine composition of the example 2, hydrated silica and silicon dioxide;
2) Adding sorbitol, xylitol, cellulose gum, xanthan gum and appropriate amount of water into water phase pot, heating to 85deg.C, keeping constant temperature for 30min, homogenizing for 3-5 min, stirring, and cooling;
3) When the temperature is reduced to 65 ℃, adding the raw materials which are premixed uniformly in the step 1) into a water phase pot, stirring uniformly at a low speed, and preserving heat for 10min;
4) Sequentially adding the rest sodium lauroyl sarcosinate, cocamidopropyl betaine, phenoxyethanol, octaethylene glycol and decanediol into a water phase pot, stirring at a low speed, and cooling to 45 ℃;
5) After defoaming, starting vacuum stirring for 10-15 minutes; and (5) obtaining a paste semi-finished product sample, and filling and discharging after the paste semi-finished product sample is inspected to be qualified.
Examples 9 to 12
The dentifrice compositions of examples 9-12 were prepared as follows in Table 3.
TABLE 3 raw material composition of dentifrice of examples 9-12
The preparation method of the dentifrice of examples 9-12 above is as follows:
sequentially weighing the traditional Chinese medicine composition, sodium cocoyl glycinate, microcrystalline cellulose, vitamin C, nicotinamide, sodium phytate and yeast extract, adding the traditional Chinese medicine composition, the sodium cocoyl glycinate, the microcrystalline cellulose, the vitamin C, the nicotinamide, the sodium phytate and the yeast extract into a powdering bucket, and stirring for 15-30 minutes to ensure that the system is uniform; the powder beating barrel is placed on a base plate of a powder beating machine, a start switch is pressed, the process is repeated for 3 times every 1 minute, and powder is beaten to 2000 meshes and then bottled.
The following are test examples of technical efficacy of the products according to the examples of the present invention.
1. Antibacterial effect
Bacteria in the oral cavity are the main culprit of bad breath and caries. And common harmful bacteria in the oral cavity are streptococcus mutans, staphylococcus aureus and the like.
In order to verify the antibacterial effect of the traditional Chinese medicine composition and the application of the traditional Chinese medicine composition in toothpaste and dentifrice, the antibacterial effect of the traditional Chinese medicine composition on streptococcus mutans and candida flavus is tested by taking example 1, example 6 and example 9 as examples.
1.1 test of bacteriostatic Effect on Streptococcus mutans
Bacterial culture medium: is tryptic soy broth culture medium.
The experimental method comprises the following steps: the bacteriostatic potential of example 1, example 6, example 9 was evaluated using the diffusion method. Negative control: sterilizing and removing original hot water.
Positive control: example 1, example 6 and example 9.
Example 1 is a traditional Chinese medicine composition; example 6 is a toothpaste; example 9 is a dentifrice.
About 50mg of each product was used and sterilized to remove raw hot water 1:1 dilution.
The in vitro bacteriostasis experiment operation steps are as follows:
the bacterial culture solution cultivated with streptococcus mutans is evenly and crossly smeared on a culture medium of a culture dish and placed in a constant temperature incubator at 37 ℃ for 24 hours. The various 1:1 dilutions were equally spread on small round filter paper sheets with a 10 microliter capillary dropper, and the filter paper sheets stained with uniform concentrations were symmetrically attached to the middle area of the medium.
And finally, placing the culture medium in a constant temperature incubator at 37 ℃ for 24 hours, and respectively measuring the diameters of the quasi-circular bacteriostasis areas and taking an average value.
The antibacterial potential is evaluated and analyzed according to the size of the diameter of the area, and the larger the diameter is, the stronger the antibacterial capability is.
Experimental data: TABLE 4 antibacterial effects of Streptococcus mutans of various examples
Experimental results: experimental data indicated a negative control group of 0.
Examples 1, 6 and 9 all have inhibitory effects on Streptococcus mutans. And the antibacterial strength is in turn that example 6 > example 9 > example 1.
1.2 test of antibacterial Effect against Staphylococcus aureus
Bacterial culture medium: is mannitol sodium chloride agar medium.
The experimental method comprises the following steps: the bacteriostatic potential of example 1, example 6, example 9 was evaluated using the diffusion method. Negative control: sterilizing and removing original hot water.
Positive control: example 1, example 6 and example 9. Example 1 is a traditional Chinese medicine composition; example 6 is a toothpaste; example 9 is a dentifrice.
About 50mg of each product was used and sterilized to remove raw hot water 1:1 dilution.
The in vitro bacteriostasis experiment operation steps are as follows:
the bacterial culture solution with staphylococcus aureus is evenly and crossly coated on the culture medium of a culture dish and placed in a constant temperature incubator at 37 ℃ for 24 hours. The various 1:1 dilutions were equally spread on small round filter paper sheets with a 10 microliter capillary dropper, and the filter paper sheets stained with uniform concentrations were symmetrically attached to the middle area of the medium.
And finally, placing the culture medium in a constant temperature incubator at 37 ℃ for 24 hours, and respectively measuring the diameters of the quasi-circular bacteriostasis areas and taking an average value. The antibacterial potential is evaluated and analyzed according to the size of the diameter of the area, and the larger the diameter is, the stronger the antibacterial capability is.
Experimental data: TABLE 4 antibacterial effects of Staphylococcus aureus in various examples
Experimental results: experimental data indicated a negative control group of 0.
Examples 1, 6 and 9 all have inhibitory effects on Streptococcus mutans. And the antibacterial strength is in turn that example 1 > example 6 > example 9.
2. Multiple skin irritation test
In order to verify the irritation of the traditional Chinese medicine composition, taking example 1 and example 2 as examples, toxicity experiments are carried out, and the irritation of the traditional Chinese medicine composition is tested through multiple skin irritation experiments.
Experimental animals: common grade New Zealand rabbits, female.
The experimental method comprises the following steps: example 1, example 2 were dissolved with water to a suspension of 5% and 95% content. And shearing off the two sides of the spine of the back of the experimental animal, wherein the dehairing range is 3cm by 3cm, and the smearing area is 2.5cm by 2.5cm. Taking 0.5g of suspension with each content, uniformly applying on one side of skin, taking the other side as a control group, applying once a day, and continuously applying for 14 days. From the next day, the test material was removed with water by shearing prior to daily application.
Experimental data: table 5 results of multiple skin irritation experiments with Chinese medicinal composition
Experimental results: the 5% and 95% of the Chinese medicinal compositions of example 1 and example 2 had no erythema or edema compared to the control group. Are all non-irritating.
3. Experiment of soothing efficacy
In order to verify the soothing efficacy of the traditional Chinese medicine composition and the application thereof in toothpaste, example 5 and example 7 prepared into toothpaste are taken as samples, and whether the samples have the soothing anti-inflammatory efficacy or not is detected according to the zebra fish soothing efficacy test method.
The difference between example 5 and example 7 is that only example 7 has no traditional Chinese medicine composition added. For the control experiments of example 5 and example 7, whether the Chinese medicinal composition prepared into toothpaste has soothing effect was tested.
Test system: transgenic neutrophil green fluorescent zebra fish;
the test method comprises the following steps: the sodium dodecyl sulfonate acts on the organism to generate a stimulus response, the stimulus enters the zebra fish body to induce an inflammatory response, and neutrophils generate an immune response and migrate and aggregate to the skin epidermis. And detecting whether the sample has a soothing effect by utilizing the quantity change of the skin neutrophils before and after the treatment of the transgenic neutrophil green fluorescent strain zebra fish.
Experimental data table 6 toothpaste example 5 and example 7 soothing test data
| Sample of | Concentration of detection (%) | Efficacy (%) | Detection result |
| Example 5 | 0.5 | 88 | Is remarkable in |
| Example 7 | 0.5 | 0.05 | Is not remarkable |
Experimental results: the data indicate that example 5 had significant soothing effects, whereas example 7 without the addition of the Chinese medicinal composition had insignificant soothing effects. Thus, the traditional Chinese medicine composition has obvious relieving effect when being applied to toothpaste.
4. Experiment for whitening teeth
In order to verify the tooth whitening efficacy of the traditional Chinese medicine composition, a control group is taken as an example 9 and an example 10, wherein the example 9 is extremely simple formula dentifrice containing 95% of the traditional Chinese medicine composition, and the example 10 is trace dentifrice containing 5% of the traditional Chinese medicine composition and other abrasives. Test subjects were selected for examples 9 and 10, and the test person: 50 men and women, test time: 14 days.
The using method comprises the following steps: a proper amount of sample is dipped by a toothbrush, and the teeth are brushed once in the morning and evening.
The testing effect is mainly based on tooth brightening card comparison and subjective evaluation by testers, and is mainly used for recording whether the effects of whitening and yellowing removal, effective removal of tooth stain pigment and improvement of bad breath and peculiar smell exist or not, and finally recording the improved object, so that the effective rate is obtained.
Effective rate = complaint with a significant number of effective samples/total number of effective test samples 100%.
The experimental results of the above examples are shown in the following table, which is a summary table 7 of experimental efficiency:
experimental results: as can be seen from the above effective rates, both examples 9 and 10 have remarkable effects of whitening and removing yellow, cleaning and removing tooth stain pigment, and improving bad breath and odor. Wherein, the effect of each effect of the embodiment 9 containing 95% of the traditional Chinese medicine composition is obviously larger than that of the embodiment 10.
Therefore, the oral care product containing the traditional Chinese medicine composition has obvious effects of whitening and removing yellow, cleaning and removing tooth stain pigment and improving bad breath and peculiar smell. And the extremely simple formula contains the oral care product effect of the traditional Chinese medicine composition with a high proportion.
In conclusion, the multi-effect traditional Chinese medicine composition has no irritation, and can inhibit bacteria, diminish inflammation, whiten and remove yellow, clean and remove tooth stain pigment, improve bad breath and peculiar smell and the like. The application of the toothpaste in the oral care product can achieve various health care effects of refreshing breath, strengthening teeth, whitening teeth, preventing loosening of teeth, removing dental calculus, preventing dental caries and the like.
The present invention is not limited to the preferred embodiments, but can be modified, equivalent, and modified in any way without departing from the technical scope of the present invention.
Claims (10)
1. A Chinese medicinal composition with multiple effects is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-20 parts of dyers woad salt; 1-40 parts of cuttlefish bone sheath; 1-20 parts of pearl powder; 1-15 parts of kuh-seng, 2-25 parts of radix isatidis and 2-15 parts of wrinkled gianthyssop; 2-15 parts of eupatorium; 2-25 parts of peppermint; 1-25 parts of radix sileris.
2. The multi-effect traditional Chinese medicine composition according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-10 parts of dyers woad salt; 1-15 parts of cuttlefish bone sheath; 1-10 parts of pearl powder; 1-4 parts of kuh-seng; 2-8 parts of radix isatidis; 2-5 parts of patchouli powder; 2-7 parts of eupatorium; 2-15 parts of peppermint; 1-15 parts of radix sileris.
3. The multi-effect traditional Chinese medicine composition according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 11-20 parts of dyers woad salt; 16-40 parts of cuttlebone; 11-20 parts of pearl powder; 5-15 parts of kuh-seng; 8-25 parts of radix isatidis; 6-15 parts of patchouli powder; 8-15 parts of eupatorium; 15-25 parts of peppermint; 1-15 parts of radix sileris.
4. A multi-effect Chinese medicinal composition according to any one of claims 1 to 3, which is prepared by the following process:
1) Grinding: grinding Margarita into fine powder with particle size less than 40 μm; weighing other raw materials in parts by weight, and respectively putting the raw materials into a pulverizer to pulverize for 30s and 2-3 times;
2) Mixing: mixing other Chinese medicinal materials powder and Margarita fine powder, grinding, and mixing;
3) Processing: mixing and grinding, and slowly adding water and uniformly mixing until the mixture becomes pasty;
4) And (3) drying: putting the pasty mixture into a baking oven at 45 ℃ for baking;
5) Fine grinding: and (3) putting the dried mixture into a powdering machine, starting powdering for 30s to 2 minutes each time, repeating for 2 to 3 times, and grinding to 2000-mesh traditional Chinese medicine composition.
5. The application of a multi-effect traditional Chinese medicine composition in preparing an oral care product is characterized in that: the oral care products include, but are not limited to, toothpastes and tooth powders, but may also find application in other oral care products such as mouthwashes, oral sprays, and the like.
6. A multi-effect traditional Chinese medicine composition and application thereof in preparing oral care products are characterized in that: the traditional Chinese medicine composition is added into oral care products, belongs to effective components and has the total addition amount of 5% -95%.
7. The use of the traditional Chinese medicine composition according to claim 5 for preparing an oral care product, wherein: the traditional Chinese medicine composition is added into toothpaste, and the toothpaste comprises the following raw material components in percentage by weight:
8. the use of the traditional Chinese medicine composition according to claim 7 for preparing an oral care product, characterized in that:
the thickener is one or more of cellulose gum, carrageenan, xanthan gum, guar gum and carbomer;
the surfactant is one or more of sodium or potassium laurylsulfate, cocamidopropyl betaine, sodium or potassium lauroyl sarcosinate, or one or more of nonionic surfactant such as tween, polyoxyethylene hydrogenated castor oil, polyoxyethylene and polyoxypropylene block copolymer, etc.;
the grinding agent is one or a mixture of more of hydrated silica, calcium carbonate, calcium hydrophosphate, calcium pyrophosphate, aluminum hydroxide and microcrystalline cellulose;
the humectant is one or more of sorbitol, glycerol, propylene glycol and xylitol;
the preservative is one or more of decanediol, octanediol, phenoxyethanol and 1, 2-hexanediol.
9. The use of the traditional Chinese medicine composition according to claim 6 for preparing an oral care product, wherein: the traditional Chinese medicine composition is added into a dentifrice, and the dentifrice comprises the following raw material components in percentage by weight:
80% -95% of traditional Chinese medicine composition;
5% -20% of a surfactant; the surfactant is one or more of sodium or potassium laurylsulfate, cocamidopropyl betaine, sodium or potassium lauroyl sarcosinate, sodium cocoyl glycinate, or one or more of nonionic surfactant powder such as sodium fatty alcohol ether sulfate and anionic surfactant.
10. The use of a traditional Chinese medicine composition according to claim 8 for preparing an oral care product, characterized in that: the traditional Chinese medicine composition is added into the dentifrice, and the preparation process of the dentifrice is as follows:
1) Putting the prepared raw materials into a powdering machine, powdering for 1-2 minutes each time, and repeating for 2-4 times to reach 2000 meshes;
2) Delivering the ground dentifrice into the mixer again for stirring and mixing to ensure uniform mixing;
3) Placing into a drying agent, removing water, sieving, sterilizing by irradiation, and bottling until the detection is qualified.
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