CN117797198A - Traditional Chinese medicine fermented hydrogel for quick healing treatment of gynecological inflammation - Google Patents
Traditional Chinese medicine fermented hydrogel for quick healing treatment of gynecological inflammation Download PDFInfo
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- CN117797198A CN117797198A CN202311754338.1A CN202311754338A CN117797198A CN 117797198 A CN117797198 A CN 117797198A CN 202311754338 A CN202311754338 A CN 202311754338A CN 117797198 A CN117797198 A CN 117797198A
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Abstract
The invention provides a traditional Chinese medicine fermented hydrogel for treating gynecological inflammation, which is prepared from traditional Chinese medicine composition powder consisting of macleaya cordata, abelmoschus manihot, long pepper, dysosma versipellis, frankincense, clove, dahurian rhododendron leaf and star anise by leaching with solvent, performing biological fermentation on the obtained leaching solution to obtain traditional Chinese medicine fermentation liquor or concentrated traditional Chinese medicine fermentation paste, and blending the traditional Chinese medicine fermentation liquor or the traditional Chinese medicine fermentation paste with gel-forming auxiliary materials. The traditional Chinese medicine fermented hydrogel agent has the advantages of quick response to patients, high treatment effect, good compliance, easy application, no irritation, no foreign body sensation, long retention time, full drug effect, convenient use, storage, carrying and the like.
Description
Technical Field
The invention relates to an application of a traditional Chinese medicine fermented hydrogel in quick healing treatment of gynecological inflammation, in particular to a traditional Chinese medicine fermented hydrogel which is prepared by compounding a fermented paste prepared by extracting a traditional Chinese medicine composition by a solvent, fermenting an extracting solution and concentrating a hydrogel material and is used for quick healing treatment of female vulva itch, vulva ulcer, vulva scabies, vulva furuncle, vulvar furunculosis, trichomonas vaginitis, colpitis mycotica, bacterial vaginitis, senile vaginitis, cervicitis or cervical erosion.
Background
The vaginal structure of women has natural defensive function of preventing invasion of external pathogens, but is very easy to cause invasion of pathogens in life to cause gynecological inflammation. Researches show that the gynecological inflammation has complex etiology, is related to physical and chemical stimulus and injury, bacteria, trichomonas, virus infection and other factors, and clinically common gynecological inflammation mainly comprises female pruritus vulvae, vulval ulcer, vulval scabies, vulval furuncle and internal vaginal inflammation. Vaginitis includes trichomonas vaginitis, mycotic vaginitis, bacterial vaginitis, senile vaginitis, cervicitis and cervical erosion. At present, the clinical vaginitis is treated more distressing, and the general main means is to take antibacterial and anti-inflammatory chemical medicines orally, vaginal treatment suppository or use traditional Chinese medicine lotion which has the functions of clearing heat and drying dampness, killing parasites and relieving itching and is represented by kuh-seng for cleaning vagina. The vaginal administration preparation is characterized in that the medicine is placed in the vagina and absorbed by the vaginal wall membrane to enter the local or whole body blood circulation system, the vaginal administration has the following advantages of non-invasive administration route, self local administration, prolonged retention time of a release system, avoidance of first pass metabolism of liver and high medicine availability, thereby reducing the dosage, having higher permeability to some medicines, little enzyme degradation in the vagina, no inactivation of medicinal components caused by metabolism, being particularly suitable for treatment with serious gastrointestinal reaction, and avoiding the phenomenon of medicine concentration peaks and valleys generated by repeated administration.
The invention creates a traditional Chinese medicine fermented hydrogel for treating gynecological inflammation, which is a traditional Chinese medicine composition consisting of raw materials of macleaya cordata, abelmoschus manihot, long pepper, dysosma versipellis, frankincense, clove, dahurian rhododendron leaf and star anise, and is prepared by grinding, crushing and leaching with solvent to obtain leaching liquor; or concentrating the leaching solution under negative pressure to obtain leaching concentrated solution; and (3) performing biological fermentation and concentration on the leaching solution to obtain a fermented paste of the leaching solution of the traditional Chinese medicine composition, and compounding the fermented paste with a hydrogel material to obtain the traditional Chinese medicine fermented hydrogel. The traditional Chinese medicine fermented hydrogel is applied to the vulva or pushed into the vagina, can quickly heal and treat pruritus vulvae, vulval ulcer, vulval scabies, pustule of the vulva, furunculosis of the vulva, trichomonas vaginitis, colpitis mycotica, bacterial vaginitis, senile vaginitis, cervicitis or cervical erosion, has quick response, high cure rate, easy coating, no irritation, good compliance, no foreign matter sense, long retention time, full efficacy, and convenient use, storage and carrying.
Disclosure of Invention
The invention relates to a traditional Chinese medicine fermented hydrogel for quick-healing treatment of gynecological inflammation, wherein the traditional Chinese medicine fermented hydrogel is prepared by extracting a traditional Chinese medicine composition consisting of the following raw materials in parts by weight through ethanol and water, obtaining traditional Chinese medicine leaching liquor, fermenting the traditional Chinese medicine leaching liquor through microorganisms to obtain traditional Chinese medicine fermentation liquor, concentrating the traditional Chinese medicine fermentation liquor, and compounding the traditional Chinese medicine fermentation liquor with a hydrogel material to obtain the traditional Chinese medicine fermented hydrogel for quick-healing treatment of gynecological inflammation.
The traditional Chinese medicine composition comprises, by weight, 6-12 parts of macleaya cordata, 6-12 parts of abelmoschus manihot, 6-12 parts of long pepper, 6-12 parts of dysosma versipellis, 2-12 parts of frankincense, 2-8 parts of dahurian rhododendron leaf, 2-8 parts of clove and 2-8 parts of star anise.
The gynecological inflammation refers to female pruritus vulvae, vulval ulcer, vulval scabies, vulval furuncle, vulval furunculosis, trichomonas vaginitis, colpitis mycotica, bacterial vaginitis, senile vaginitis, cervicitis or cervical erosion.
The preparation method of the traditional Chinese medicine hydrogel comprises the following steps:
the first step: preparation of Chinese medicine leaching liquor
6-12 parts of macleaya cordata, 6-12 parts of abelmoschus manihot, 6-12 parts of long pepper, 6-12 parts of dysosma versipellis, 2-12 parts of frankincense, 2-8 parts of dahurian rhododendron leaf, 2-8 parts of clove and 2-8 parts of star anise are sequentially weighed, mixed together and ground to obtain traditional Chinese medicine composition powder. Immersing the traditional Chinese medicine composition powder into ethanol which is 5-10 times of the traditional Chinese medicine composition powder in weight, controlling the temperature to be 15-80 ℃ and stirring and leaching for 2-200 hours, and filtering to obtain traditional Chinese medicine ethanol leaching liquid for later use; and then pouring the filtered Chinese medicine residues into water with the weight being 1-5 times of that of the Chinese medicine residues, refluxing and boiling for 0.5-5 hours under stirring, cooling and filtering to obtain Chinese medicine water leaching solution. Mixing the Chinese medicinal water extract and the Chinese medicinal ethanol extract together to obtain Chinese medicinal composition extract, which is called Chinese medicinal extract for short.
Wherein the preferable raw material medicines comprise 12 parts of macleaya cordata, 12 parts of abelmoschus manihot, 12 parts of long pepper, 12 parts of dysosma versipellis, 6 parts of dahurian rhododendron leaf, 6 parts of frankincense, 2 parts of clove and 2 parts of star anise.
The preferred raw material medicaments comprise 8 parts of dahurian rhododendron leaf, 8 parts of dysosma versipellis, 6 parts of macleaya cordata, 6 parts of abelmoschus manihot, 6 parts of long pepper, 2 parts of frankincense, 2 parts of clove and 2 parts of star anise.
The present inventors have selected a process and method for the segmental leaching of a Chinese medicine with water and ethanol, respectively, in order to further utilize the active ingredients in the Chinese medicine. Experiments show that the traditional Chinese medicine residues obtained by leaching the traditional Chinese medicine powder with ethanol can be further leached out by leaching with water, and the obtained traditional Chinese medicine leaching solution has higher efficacy.
Wherein macleaya cordata is warm in nature, pungent in flavor, bitter in flavor and toxic. The main bioactive substances of macleaya cordata comprise isoquinoline alkaloids such as sanguinarine, chelerythrine, protopine, allocryptopine and the like, and have various biological activities such as antimicrobial, insecticidal, antiviral, anti-inflammatory, antitumor, liver function improving, immunity enhancing and the like. The macleaya cordata has the effects of clearing heat and detoxicating, detumescence and relieving pain, eliminating dampness and stopping leukorrhagia, killing parasites and relieving itching. Pharmacological researches show that the macleaya cordata is effective in treating various inflammations, has a killing effect on fly maggots, has a stimulating effect on functions of T lymphocytes and B lymphocytes, and can better enhance the immune function. In addition, sanguinarine can obviously inhibit the growth, proliferation and development of pancreatic cancer cells or human liver cancer cells, has strong inhibition capability on colony formation and has obvious killing effect on liver cancer cells.
Abelmoschus manihot is cool and sweet in taste, and contains mainly flavone and flavonoid glycoside bark extract-3-locust glucoside, quercetin-3-glucoside, hyperoside, myricetin and quercetin by chemical analysis. Abelmoschus manihot has effects of clearing heat, eliminating dampness, detumescence, promoting urination, and clearing heat and detoxicating. Pharmacological experiments prove that a large amount of flavone and flavonoid glycoside have the effects of resisting inflammation, easing pain and resisting cancer, can resist oxidation, remove free radicals in vivo, remove garbage and toxins at kidney parts, have the effects of protecting liver and promoting toxin discharge.
Fructus Piperis Longi flavor is pungent and warm, and contains piperine, palmitic acid, tetrahydropiperic acid, undec-1-ene-3, 4-methylenedioxybenzene, piperonyl amine, and diisoeucalyptol. The volatile oil contains beta-bisabolene, tridecane, caryophyllene, beta-apirene, beta-cubelene, alpha-gingerol, pentadecane, alpha-humulone and the like, and has obvious anti-ulcer effect, and pharmacology shows that the volatile oil has inhibition effect on staphylococcus aureus, bacillus subtilis, bacillus cereus, tubercle bacillus, bacillus dysenteriae, salmonella typhi T and B, sarcina vitellina and the like and influenza viruses.
Dysosma versipellis is cool in nature, bitter and pungent in flavor and toxic. The bioactive components of Dysosma versipellis include lignans, flavonoids, alkaloids and sterols. Wherein the medicinal active ingredients are mainly podophyllotoxin and its derivatives, podophyllotoxin ketone, its glycoside, dysosmallpox alcohol, kaempferol, quercetin, kaempferol glycoside. Modern pharmacological tests show that podophyllotoxin of dysosma versipellis has remarkable inhibiting effect on herpesvirus, wherein kaempferol has inhibiting effect on staphylococcus aureus, typhoid fever, pseudomonas aeruginosa and the like. The dysosma versipellis has the functions of clearing heat and detoxicating, drawing out toxin and promoting tissue regeneration, removing blood stasis and relieving pain, and resolving phlegm and resolving masses.
The mastic is pungent, bitter and warm, wherein the resin content in the chemical components is high, the gum accounts for only 27-35%, and the volatile oil accounts for 3-8%. The resin contains free alpha, beta-boswellic acid and boswellic hydrocarbon as main components. The gum is calcium salt and magnesium salt of araffinic acid, and also has sirolimus; in addition, terpene volatile oil is contained. The frankincense has the effects of regulating qi and activating blood, detumescence and promoting granulation, promoting the healing of sores and ulcers and has obvious analgesic and analgesic effects. Meanwhile, the frankincense can promote the increase of white blood cells, can phagocytize dead blood cells and cells so as to improve metabolism of a body, has the purposes of resisting bacteria and diminishing inflammation, and is often used for treating sores and ulcers, which are not healed for a long time.
The oleum Rhododendri Dahurian is prepared from fructus Schisandrae of Schisandraceae, and its chemical components comprise triterpene acid, diphenyl cyclooctadiene lignan, deoxyschizandrin, volatile oil, etc., wherein the main material of volatile oil is methyl salicylate. The pharmacological action shows that the water decoction with the dahurian rhododendron leaf concentration of 75 percent has obvious inhibition effect on influenza A virus in chicken embryo. The compound injection of the extract of the root and leaf of the dahurian rhododendron leaf can relieve fever and pain, diminish inflammation and sterilize, promote blood circulation and remove meridian obstruction, dispel wind and remove dampness, is commonly used for treating toothache, traumatic injury and swelling and pain, insect and snake bite, and can treat lung cancer.
The bioactive components of the eugenol, the octyl and the large fever are mainly volatile oil, and the volatile oil contains eugenol, beta-eugenol, acetyl eugenol and the like, and also contains eugenol, acetyl eugenol, isoquercetin, kaempferol, quercetin, caryophyllene oxide, oleanolic acid, alpha-tuna oil and the like. Flos Caryophylli has inhibiting effect on various pathogenic fungi, coccus, streptococcus, pneumonia, dysentery, bacillus such as large intestine and typhoid, and influenza virus. Flos Caryophylli has antiulcer, analgesic, antihypoxic, anticoagulant, antimutagenic, antibacterial, and insecticidal effects.
Fructus Anisi Stellati, warm and pungent, also known as fructus Anisi Stellati, belongs to the family of Magnoliaceae, and ripe fruits are commonly used as flavoring. The chemical components of fructus Anisi Stellati fruit include flavonoids, sesquiterpene lactone and its derivatives, phenylpropanes and lignans. The star anise perfume decoction has the inhibiting effect on tubercle bacillus and bacillus subtilis, and the ethanol extract has relatively high inhibiting effect on staphylococcus aureus, pneumococcus, diphtheria bacillus, vibrio cholerae, typhoid bacillus, dysentery bacillus and some common bacteria. Which is capable ofWarming yang, strengthening body resistance, dissipating heat, removing dampness, regulating qi, relieving pain,Expelling parasites and detoxicatingEtc.
In conclusion, the basic researches such as chemical component analysis and pharmacological test of the raw materials are the scientific theory basis for the quick healing treatment of gynecological inflammation by the traditional Chinese medicine fermented hydrogel. The inventor confirms the raw material medicines and the weight parts thereof in the traditional Chinese medicine composition for treating the disease according to repeated drug property comparison, gynecological inflammation dialectical and clinical application verification.
And a second step of: preparation of saccharomycete expanding culture liquid
Dispersing the yeast strains in the culture solution according to the weight ratio of the yeast strains to the culture solution of 1:10-100, stirring uniformly, and then carrying out shaking fermentation at 20-42 ℃ for 12-18 hours to obtain a yeast expansion culture solution for later use;
wherein the substances in the culture solution comprise 10 parts of potato powder, 2 parts of agar, 2 parts of sucrose, 0.005 part of dipotassium hydrogen phosphate, 0.008 part of sodium chloride and 100 parts of tap water; uniformly mixing the materials, steaming at 120 ℃ for 10-15 minutes under 1 atmosphere pressure in an autoclave, sterilizing, and cooling to room temperature for later use;
and a third step of: preparation of traditional Chinese medicine fermented paste
Mixing the traditional Chinese medicine leaching solution in the first step and the saccharomycete expanding culture solution in the second step according to the weight ratio of 1:0.1-0.5, controlling the temperature to be 20-42 ℃, oscillating for 0.2-48 hours for fermentation, and filtering to remove residues to obtain the traditional Chinese medicine fermentation liquor; and (3) carrying out negative pressure distillation and concentration on the traditional Chinese medicine fermentation liquid at the temperature of 20-42 ℃, stopping concentrating until the solid content is 35-55 g/100 mL, and cooling to obtain a fermented paste of the traditional Chinese medicine composition leaching liquid, namely the traditional Chinese medicine fermented paste for later use.
Fourth step: preparation of traditional Chinese medicine fermented hydrogel
And uniformly mixing the fermented paste of the traditional Chinese medicine composition leaching solution and the hydrogel material according to the weight ratio of 1:1-20 at room temperature, and standing for 2-24 hours to prepare the traditional Chinese medicine fermented hydrogel.
The hydrogel material is prepared by compounding gel matrix, purified water, cosolvent and pH value regulator in a weight ratio of 1:1-100:0-10:0-10. The preparation method of the gel material comprises the following steps: according to the weight ratio, purified water is firstly added into an opened and stirred reaction kettle, the temperature is controlled to be 20-100 ℃, then the gel matrix is added into the purified water, after stirring for 0.2-2.5 hours, the gel matrix is uniformly dissolved and dispersed, then a cosolvent and a pH value regulator are sequentially added, and stirring is continued for 0.2-2.5 hours, so that the hydrogel material is prepared.
The gel matrix is a basic material of hydrogel and is mainly selected from hydrophilic polymer materials including natural high molecular polysaccharide or protein, and synthetic hydrophilic polyhydroxy polymer or polyelectrolyte. The gel matrix of the invention refers to hyaluronic acid, bletilla striata polysaccharide, glucomannan, chitosan, sodium alginate,
One or more of carbomer, carboxymethyl cellulose, polyvinyl alcohol and polyvinylpyrrolidone;
the purified water refers to water for medicine supply prepared by a distillation method, an ion exchange method, a reverse osmosis method or other suitable methods;
the cosolvent is one or more than two of glycerol, monoacetin, diacetin, monoacetin or polyethylene glycol; the purpose of the cosolvent is to assist in dissolving the solid matters of the traditional Chinese medicine fermentation paste, so that the uniform and transparent traditional Chinese medicine fermentation hydrogel can be prepared, or the viscosity of the hydrogel material can be adjusted;
the pH value regulator is one or more of acetic acid, lactic acid, citric acid, benzoic acid, sorbic acid, ammonium ascorbate, triethanolamine or caustic soda, and is mainly used for regulating the pH value of the acid-base of the traditional Chinese medicine fermented hydrogel to be 4.0-7.5, preferably 5.5-6.5.
Detailed Description
The following is a further explanation of the traditional Chinese medicine fermented hydrogel for treating gynecological inflammation according to the present invention by combining specific examples, so that the medical value of the traditional Chinese medicine fermented hydrogel according to the present invention can be further recognized and understood by the person skilled in the art. While various changes and modifications to the present invention will occur to those skilled in the art, and are intended to be included within the scope of the present invention as defined in the appended claims.
Example 1
Step one, preparation of Chinese medicine leaching liquor
Sequentially weighing 12 parts of macleaya cordata, 12 parts of abelmoschus manihot, 12 parts of long pepper, 12 parts of dysosma versipellis, 6 parts of dahurian rhododendron leaf, 6 parts of frankincense, 2 parts of clove and 2 parts of star anise, mixing and grinding to obtain Chinese medicinal powder. Then, the Chinese medicine powder is immersed in 660 g of ethanol, leached for 72 hours at room temperature, and filtered to obtain ethanol leaching solution of the Chinese medicine. And then pouring the filtered Chinese medicinal residues into water which is 3 times of the Chinese medicinal residues, refluxing and boiling for 2 hours under stirring, cooling to room temperature, and filtering to obtain Chinese medicinal liquid extract. Mixing the Chinese medicinal water leaching solution and the Chinese medicinal ethanol leaching solution together to obtain Chinese medicinal leaching solution for standby.
Step two, preparation of saccharomycetes expanding culture liquid
Dispersing the yeast strain in the sterilized culture solution according to the weight ratio of the yeast strain to the culture solution of 1:10-1000, stirring uniformly, and then carrying out shaking fermentation at 20-42 ℃ for 12-18 hours to obtain the yeast strain culture expanding solution for later use.
Wherein the substances in the culture solution comprise 10 g of potato powder, 2 g of agar, 2 g of sucrose, 0.005 g of dipotassium hydrogen phosphate, 0.008 g of sodium chloride and 100 g of tap water; mixing the materials uniformly, steaming at 120 ℃ for 10-15 minutes under 1 atmosphere pressure in an autoclave, sterilizing, and cooling to room temperature for standby.
Step three: preparation of traditional Chinese medicine fermented paste (I)
Weighing 75 g of the traditional Chinese medicine leaching solution prepared in the first step and 25 g of the saccharomycete expanding culture solution prepared in the second step, mixing the materials in a fermentation tank, controlling the temperature to be 37+/-2 ℃, carrying out oscillation fermentation for 48 hours, and filtering to remove residues to prepare the traditional Chinese medicine fermentation liquid (I); and transferring the traditional Chinese medicine fermentation liquor into a concentration kettle, controlling the temperature to be 37+/-2 ℃, carrying out negative pressure distillation concentration, stopping when the weight of residues in the concentration kettle is 56 g, and cooling to obtain the traditional Chinese medicine fermentation paste (I).
Fourth step: preparation of traditional Chinese medicine fermented hydrogel
1.58 g carbomer 940 is weighed out # Dissolving 0.35 g of carboxymethyl cellulose and 0.35 g of sodium alginate in 45 g of purified water, stirring at the temperature of 80 ℃ for 1 hour for dissolution, adjusting the pH to be 5.8 by using triethanolamine, adding a mixture of 5 g of glycerol, 5 g of diacetin, 8 g of polyethylene glycol 2000 and 34 g of traditional Chinese medicine fermentation paste (1), uniformly stirring, and standing at room temperature for 24 hours to obtain the traditional Chinese medicine fermentation hydrogel (I).
The traditional Chinese medicine fermented hydrogel (I) is semitransparent colloidal liquid, light brown and tasteless through sensory detection, and has slow fluidity; placing the traditional Chinese medicine fermented hydrogel (I) into a baking oven at 40 ℃ for continuous observation for 24 hours to be stable without layering; the traditional Chinese medicine fermented hydrogel (I) is placed in a refrigerator at the temperature of 4 ℃ for continuous observation for 24 hours to be stable without layering. Sample feeding detection is carried out on the traditional Chinese medicine fermented hydrogel (I) according to the technical Specification for cosmetic safety of 57 th of the food and drug administration (2015), wherein the content of arsenic, mercury and lead accords with the specified index; sample feeding detection is carried out on the fermented hydrogel (I) according to the ' disinfection technical Specification ' No. 282 issued by Ministry of health of the people's republic of China Wei Jian [ 2002 ], wherein no colibacillus and pathogenic bacteria (staphylococcus aureus, pseudomonas aeruginosa and hemolytic streptococcus) are detected.
Example 2
According to the method and procedure of example 1, the carbomer 940 in step four # Carboxymethyl cellulose and sodium alginate are changed to 1.55 g carbomer 940 # And 1.5 g of polyvinylpyrrolidone K30 was dispersed in 45 g of purified water, the pH=5.8 was adjusted using triethanolamine, and then a mixture of 20 g of polyethylene glycol 2000 and 34 g of the above-mentioned Chinese medicinal fermented paste (I) of example 1 was added thereto, and after stirring uniformly, it was left at room temperature for 24 hours, to obtain a Chinese medicinal fermented hydrogel (II). The traditional Chinese medicine fermented hydrogel (II) is transparent light brown hydrogel through sensory detection, has slight fluidity and is odorless; the heavy metal content detection and the microorganism detection result were the same as in example 1.
Example 3
According to the method and the steps of the embodiment 1, the crude drugs in the first step are changed into 8 g of dahurian rhododendron leaf, 8 g of dysosma versipellis, 6 g of macleaya cordata, 6 g of abelmoschus manihot, 6 g of long pepper, 6 g of frankincense, 2 g of clove and 2 g of star anise, so as to respectively prepare a traditional Chinese medicine composition leaching solution, a traditional Chinese medicine fermentation liquor and a traditional Chinese medicine fermentation paste (II); the carbomer 940 in the fourth step # And changing carboxymethyl cellulose and sodium alginate into 2.5 g of chitosan and 0.5 g of polyvinyl alcohol-1799, dispersing the mixture into 42 g of acidic purified water, stirring and dissolving the mixture completely at the temperature of 65 ℃, adjusting the pH value to be 6.0 by using a lactic acid aqueous solution with the mass concentration of 20%, adding a mixture of 8 g of polyethylene glycol-2000 and 45 g of the traditional Chinese medicine fermentation paste (II), stirring the mixture uniformly, and standing the mixture at room temperature for 24 hours to obtain the traditional Chinese medicine fermentation hydrogel (III). The traditional Chinese medicine fermented hydrogel (III) is semitransparent brown hydrogel through sensory detection, has slight fluidity and is odorless. The heavy metal content detection and the microorganism detection result were the same as in example 1.
Example 4 biological assay
1. Bacteriostasis test: taking 2mL of the traditional Chinese medicine leaching solution, the traditional Chinese medicine fermentation liquid and the traditional Chinese medicine fermentation hydrogel of the examples 1-3 according to the proportion of 1:2, 1:5, 1:10, 1:20, 1:50 and 1:100, diluting the traditional Chinese medicine leaching solution, the traditional Chinese medicine fermentation liquid and the traditional Chinese medicine fermentation hydrogel into a sample to be tested with the same concentration by using the culture solution of the step three of the example 1, adding 2 drops of pathogenic bacterial strain liquid at the same time, fully and uniformly mixing, and culturing in a 37 ℃ incubator for 24 hours; the growth of pathogenic bacteria was observed, the Minimum Inhibitory Concentration (MIC) was calculated, and the test results are shown in table 1.
TABLE 1 bacteriostasis test
The results in Table 1 show that the traditional Chinese medicine leaching solutions, the traditional Chinese medicine fermentation solutions and the traditional Chinese medicine fermentation hydrogel of examples 1-3 have remarkable antibacterial functions on staphylococcus aureus, escherichia coli and candida albicans, and the antibacterial effect of the traditional Chinese medicine fermentation solution in the fermentation process is higher than that of the traditional Chinese medicine leaching solution subjected to fermentation treatment, so that the traditional Chinese medicine leaching solution has positive significance in improving the effect of treating skin diseases by adopting yeast strains to carry out fermentation treatment on the leaching solution of the traditional Chinese medicine composition. And secondly, the antibacterial test results show that the proportions of the raw materials in the preparation of the traditional Chinese medicine leaching solution, the traditional Chinese medicine fermentation solution and the traditional Chinese medicine fermentation hydrogel are different, and the antibacterial effect is changed, so that an experimental basis is provided for the treatment of the skin diseases by differentiating the symptoms and distinguishing the diseases.
2. Efficacy test: a traditional Chinese medicine fermentation liquid (I) is used for testing a mouse acetic acid torsion experiment, and the result shows that the traditional Chinese medicine fermentation liquid (I) can obviously reduce the number of times of acetic acid-induced mouse torsion, can shorten the amount and high dosage of the foot and yin organs of a mouse after licking and biting due to formaldehyde injury, can improve the itching threshold of guinea pigs caused by histamine, and can also improve the effect of xylene-induced auricle swelling of the mouse. The results of the drug effect tests indicate that the traditional Chinese medicine fermentation liquor has obvious analgesic, antipruritic and anti-inflammatory effects.
3. Toxicity and irritation assays: when the traditional Chinese medicine fermentation liquid (I) and the traditional Chinese medicine fermentation hydrogel (I) are used for continuously wiping the complete skin and damaged skin of the rabbit for two weeks, red swelling and inflammation phenomena occur in the whole skin and the damaged skin, and no stimulation effect is shown; meanwhile, skin allergy tests show that the traditional Chinese medicine fermentation liquid (I) and the traditional Chinese medicine fermentation hydrogel (I) are used for repeatedly smearing guinea pigs respectively, and skin allergy of the guinea pigs is not seen. The above results show that the traditional Chinese medicine fermentation liquor disclosed by the invention is free from stimulation and allergy phenomenon in external application of skin, and is safe to use.
EXAMPLE 5 traditional Chinese medicine fermented hydrogel treatment of typical cases
1. Peng Xiaojie, 23 years old, oralPruritus vulvaeThe leucorrhea has fishy smell, and the trichomonas++, the mould++, leucorrhea epithelial cells++, red blood cells-, white blood cells+ are detected by a hospital, and the diagnosis of the trichomonas vaginal infection combined with the mould is confirmed. Orally taking metronidazole according to medical advice; and the vagina is cleaned by warm water, and then the traditional Chinese medicine fermented hydrogel (I) is used for continuous treatment for 8 days, so that clinical symptoms of patients disappear.
2. Women, 34 years old, married and professional drivers, oral leucorrhea is excessive and has bad smell, the cleanliness of the leucorrhea is 3, white blood cells are 15-19hp through detection of a hospital, the colpitis is accompanied with cervical erosion is diagnosed, and gynecological Qianjin tablets, metronidazole and gynecological antipruritic capsules, vaginal drug metronidazole suppositories, chyme eliminating suppositories and the like are orally taken once, and the medicine is used for treating the two-month period of uncorrupted fruits before and after. The vagina is cleaned by warm water, the vagina is continuously treated by the traditional Chinese medicine fermented hydrogel (III) for 12 days, clinical cervical erosion of a patient is changed into squamous epithelial coverage after inspection, the surface of the cervix is smooth, the cervix is basically healed, the clinical symptoms of colpitis disappear, and the vagina is healed after a month.
3. Liu lady, 55 years old, 8 years menopause, oral dictationPruritus vulvaeThe pudendum is glowing and painful, and the sexual life is more painful. The detection in hospital shows that trichomonas vaginitis is confirmed, metronidazole is orally taken, after the vulva and vagina are cleaned by warm water, the traditional Chinese medicine fermented hydrogel (II) is pushed into the vagina, and the vulva is smeared by the traditional Chinese medicine fermented hydrogel (II), so that clinical symptoms of patients disappear after 7 days of continuous treatment.
4. Yang Xiaojie and 23 years old, the patients have colpitis mycotica for more than one year at the time of treatment, and western medicine effervescent tablets, tinidazole and other vaginal medicines are used in the period, so that symptoms are slightly relieved, but the patients can not be thoroughly cured, and the vaginal and vulvar itching is severe, so that the sleeping is influenced. After the hydrogel (I) is fermented by the traditional Chinese medicine for one week, the pruritus symptom disappears, the use is consolidated for one week, and the body is completely recovered. And the patient is re-diagnosed after half a year, and no recurrence exists.
5. Wu women, 36 years old, have a diagnosis with a normal examination of leucorrhea, and have positive infusions, mold and bacteria, and a diagnosis of mixed colpitis. Oral symptoms: vaginal secretion is more, smell and stink, pruritus vulvae, redness, swelling and burning, lower abdominal distention and pain, urgent urination and incapacity of sexual life. External medicines such as dacron suppository, baofukang suppository, nano silver and the like are used for several months by oneself, so that occasionally symptoms are relieved, and pain is aggravated. After 12 days of fermentation of hydrogel (I) with the traditional Chinese medicine, all the symptoms are completely disappeared, and several indexes of the conventional test of leucorrhea are negative.
6. Women, age 46. When in medical treatment, the hotel clothes are used for a half year before oral taking, trichomonas and mould mixed vagina inflammation is infected, the Jieeryin lotion is used for cleaning after medical treatment, and the symptoms of the Jieering dripping effervescent tablet are slightly relieved. However, the recurrence is caused later, and then the medicine is treated by the itching relieving machine in the hospital, so that the curative effect is not ideal. The hydrogel (I) is fermented by the traditional Chinese medicine, and is used for simultaneous internal and external treatment, symptoms completely disappear after one week, the treatment is consolidated after one treatment course, and the relapse is avoided after half a year.
The foregoing is a preferred embodiment of the present invention, and modifications, obvious to those skilled in the art, of the various equivalent forms of the present invention can be made without departing from the principles of the present invention, are intended to be within the scope of the appended claims.
Claims (9)
1. The traditional Chinese medicine fermented hydrogel for rapidly healing and treating gynecological inflammation is prepared by uniformly mixing fermented paste of a traditional Chinese medicine composition leaching solution and hydrogel materials according to a weight ratio of 1:1-20 at room temperature, and is characterized by comprising, by weight, 6-12 parts of macleaya cordata, 6-12 parts of abelmoschus manihot, 6-12 parts of long pepper, 6-12 parts of dysosma versipellis, 2-12 parts of frankincense, 2-8 parts of dahurian rhododendron, 2-8 parts of clove and 2-8 parts of fructus anisi.
2. A fermented hydrogel of traditional Chinese medicine for the rapid healing treatment of gynecological inflammation according to claim 1, characterized in that the gynecological inflammation refers to vulvar itching, vulvar ulcers, vulvar scabies, vulvar furuncle, vulvar furunculosis, trichomonas vaginitis, mycotic vaginitis, bacterial vaginitis, senile vaginitis, cervicitis or cervical erosion.
3. The fermented hydrogel for treating gynecological inflammation according to claim 1, wherein the preparation method of the Chinese medicinal composition extract is as follows:
sequentially weighing 6-12 parts of macleaya cordata, 6-12 parts of abelmoschus manihot, 6-12 parts of long pepper, 6-12 parts of dysosma versipellis, 2-12 parts of frankincense, 2-8 parts of dahurian rhododendron leaf, 2-8 parts of clove and 2-8 parts of star anise, mixing and grinding the materials together to prepare traditional Chinese medicine composition powder; immersing the traditional Chinese medicine composition powder into ethanol which is 5-10 times of the traditional Chinese medicine composition powder in weight, controlling the temperature to be 15-80 ℃ and stirring and leaching for 2-200 hours, and filtering to obtain traditional Chinese medicine ethanol leaching liquid for later use; then pouring the filtered Chinese medicine residues into water with the weight being 1-5 times of that of the Chinese medicine residues, stirring, refluxing and boiling for 0.5-5 hours, cooling, and filtering to obtain Chinese medicine water leaching solution for later use; mixing the ethanol extract of the traditional Chinese medicine with the water extract of the traditional Chinese medicine to obtain the extract of the traditional Chinese medicine composition for standby.
4. The fermented hydrogel for treating gynecological inflammation according to claim 1, wherein the fermented paste of the extract of the Chinese medicinal composition is prepared by the following steps:
firstly, dispersing a yeast strain into a culture solution according to the weight ratio of the yeast strain to the culture solution of 1:10-100 at room temperature, stirring uniformly, and then carrying out shaking fermentation at 20-42 ℃ for 12-18 hours to obtain a yeast strain expanding culture solution for later use;
wherein the substances in the culture solution comprise 10 parts of potato powder, 2 parts of agar, 2 parts of sucrose, 0.005 part of dipotassium hydrogen phosphate, 0.008 part of sodium chloride and 100 parts of tap water; uniformly mixing the materials, steaming at 120 ℃ for 10-15 minutes under 1 atmosphere pressure in an autoclave, sterilizing, and cooling to room temperature for later use;
uniformly mixing the saccharomycete expanding culture solution and the traditional Chinese medicine composition leaching solution prepared in the method of claim 3 according to the weight ratio of 1:0.1-0.5, controlling the temperature to be 20-42 ℃, oscillating for 0.2-48 hours for fermentation, and filtering and deslagging to prepare the traditional Chinese medicine fermentation liquor; and (3) carrying out negative pressure distillation and concentration on the traditional Chinese medicine fermentation liquid at the temperature of 20-42 ℃, stopping concentrating until the solid content is 35-55 g/100 mL, and cooling to obtain the fermented paste of the traditional Chinese medicine composition leaching liquid for later use.
5. The traditional Chinese medicine fermented hydrogel for rapidly healing gynecological inflammation according to claim 1, wherein the hydrogel material is prepared by compounding gel matrix, purified water, cosolvent and pH value regulator in a weight ratio of 1:1-100:0-10:0-10;
according to the weight ratio, the preparation method of the hydrogel material comprises the steps of adding purified water into an opened and stirred reaction kettle, controlling the temperature to be 20-100 ℃, adding the gel matrix into the purified water, stirring for 0.2-2.5 hours, enabling the gel matrix to be dissolved and dispersed uniformly, adding a cosolvent and a pH value regulator in sequence, adjusting the pH value to be 4.0-7.5, and continuing stirring for 0.2-2.5 hours to obtain the hydrogel material.
6. The fermented hydrogel for treating gynecological inflammation according to claim 5, wherein the gel matrix is one or more of hyaluronic acid, bletilla striata polysaccharide, glucomannan, chitosan, sodium alginate, carbomer, carboxymethyl cellulose, polyvinyl alcohol, and polyvinylpyrrolidone.
7. The fermented hydrogel for use in the rapid healing of gynecological inflammation according to claim 5, wherein the purified water is water for administration by distillation, ion exchange, reverse osmosis or other suitable method.
8. The fermented hydrogel for treating gynecological inflammation according to claim 5, wherein the cosolvent is one or more of glycerol, glycerol monoacetate, glycerol diacetate, ethylene glycol monoacetate, and polyethylene glycol.
9. The fermented hydrogel for use in rapid healing of gynecological inflammation according to claim 5, wherein the pH adjustor is one or more of acetic acid, lactic acid, citric acid, benzoic acid, sorbic acid, ammonium bradykinin, triethanolamine or caustic soda.
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