CN117752542A - Composition for reducing pores and preparation method thereof - Google Patents
Composition for reducing pores and preparation method thereof Download PDFInfo
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- CN117752542A CN117752542A CN202311489142.4A CN202311489142A CN117752542A CN 117752542 A CN117752542 A CN 117752542A CN 202311489142 A CN202311489142 A CN 202311489142A CN 117752542 A CN117752542 A CN 117752542A
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Landscapes
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of cosmetic preparations, and particularly relates to a composition for reducing pores and a preparation method thereof. The composition comprises components Acnacidol, adenosilane, silanediol salicylate, hamamelis virginiana water, sea mud extract, cyclopentadimethicone, polydimethylsiloxane, silicone elastomer DC9040, emulsifier Simulgel, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, glycerol and propylene glycol. The pore-reducing composition of the present invention cooperates in three different directions; to reduce skin oil secretion, anti-inflammatory and inhibit microbial action to improve skin surface condition and physiological balance; the moisturizing effect is enhanced in an auxiliary way, the secretion of skin grease is further reduced, and the effect of improving pores is further achieved.
Description
Technical Field
The invention belongs to the technical field of cosmetic preparations, and particularly relates to a composition for reducing pores and a preparation method thereof.
Background
The follicular orifice refers to the follicular orifice, which is a common opening of the hair follicle and sebaceous glands, with specific physiological functions. Sebaceous glands secrete grease to protect the skin; when the grease is secreted too much, the grease may not be normally discharged, and a grease plug (blackhead, whitehead) may be formed to block pores, further causing the pores to become larger in an objective sense.
Pore size can be divided into four types: horny type, oily type, water-deficient type, and aged type. Wherein, the horny type, oily type and water-deficient type mainly are caused by excessive secretion of grease, excessive thickness of horny layer and insufficient skin moisture, so that temporary visual pores become large, and the physical size of the pores is not changed greatly in practice; the aging type causes the reduction of collagen supporting the skin due to the early aging phenomenon of the skin, and the physical size of pores is enlarged; therefore, the keratose type, the shiny type and the water deficient type are generally called as large pseudo pores and the aged type as large true pores. The false pores are large for too long and are converted into true pores which are large, and when the false pores are large, the false pores can be correspondingly improved by skin care products (washing cleaning products or resident products); when the skin care product is in large pores, the problem can only be solved by medical cosmetology means, and the skin care product can not solve the corresponding problem.
At present, about 80% of skin care products with large pores are leached cleaning products; these products often use stronger surface active ingredients; this results in an excessive grease cleaning capacity and a reduced skin moisturizing capacity, which presents a number of additional problems.
Therefore, there is a need for a composition for pore reduction that does not cause problems such as reduced skin moisturizing ability.
Disclosure of Invention
The invention aims to provide a composition for reducing pores and a preparation method thereof, and the composition has good skin improvement effect.
The pore-fading composition comprises the following components in parts by mass:
in particular, the pore-reducing composition comprises the following components in parts by mass:
the preparation method of the pore-fading composition comprises the steps of weighing all raw materials; then uniformly dispersing and homogenizing to form a stable mixture state.
The application of the composition for reducing pores in preparing cosmetics mainly comprises resident cosmetics.
In the invention, the following components are added:
adenosilane (adenosine silanol) has effects of strengthening connective tissue sheath around pores, on one hand, can tighten pores, solve the problem of large pores, and reduce visible pores; on the one hand, the skin elasticity can be increased, and the skin is more elastic, tender and smooth.
Acnacidol royal jelly oil control factor is a unique patent active molecule, simulates a bionic structure similar to hydroxy acid in the royal jelly, can reconstruct physiological balance of skin, can control oil immediately, quickly and permanently, can regulate grease secretion after long-term use, and has excellent antibacterial effect on microorganisms such as acnes.
The silanediol salicylate is a derivative of salicylic acid; has antioxidant, antiallergic, astringent, skin texture improving, and pore size reducing effects.
Hamamelis virginiana water is plant water extracted from Hamamelis virginiana flower, contains rich tannin and flavonoid substances, and can clean skin, astringe pores and reduce inflammation.
The sea mud extract is a natural component extracted from deep sea mud, contains various minerals and bioactive substances, and can adsorb dirt and grease on deep skin and purify pores.
The five components are core components of the invention, and through synergistic action, the effects of cleaning pore contents and improving false pores are achieved through the combined action of three aspects of reducing skin grease secretion (cleaning skin), resisting inflammation and inhibiting microorganisms (acne bacillus, mites and metabolites thereof).
In order to enhance the improvement effect, the invention also comprises the following components:
cyclopentadimethicone is a colorless and odorless volatile liquid silicone which is used as a solvent to increase the fluidity and ductility of the formulation and improve the skin feel of the product.
The polydimethylsiloxane is an inert, nontoxic and nonflammable organosilicon polymer, can be used as a lubricant or a humectant to form a transparent protective film, prevents water loss, and can improve the skin feel of the product.
The organosilicon elastomer DC9040 is a high molecular weight organosilicon elastomer, is dispersed in cyclopentamethicone, can be used as a thickening agent, a stabilizing agent and a texture improving agent, and improves the texture of products.
The emulsifier Simulgel is a pre-neutralized liquid polymer, can be used in cold or hot process, has functions of thickening, stabilizing and regulating texture, and can stabilize and emulsify various oil phase components to prepare spray-type to thick texture.
The hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer is a pre-neutralized polymer which is present in the inverse emulsion in a liquid state and forms a non-tacky gel without prior dispersion or hydration.
Glycerin is a commonly used humectant and moisturizer that absorbs moisture from the air and locks the moisture inside the skin against dry desquamation.
Propylene glycol is a commonly used solvent and humectant that increases the solubility of water soluble ingredients in the formulation and increases the hydration of the skin.
The Eucalyptus globulus oil is an essential oil extracted from Eucalyptus globulus leaves, has fresh fragrance, antibacterial, antiinflammatory, and astringent effects, and can relieve skin irritation and red swelling.
The lignum Dalbergiae Odoriferae oil is an essential oil extracted from lignum Dalbergiae Odoriferae, has aromatic smell, antibacterial, antiinflammatory, and tranquilizing effects, and can relieve skin discomfort and pruritus.
The invention has the beneficial effects that:
(1) The pore-reducing composition of the present invention cooperates in three different directions; to reduce skin oil secretion, anti-inflammatory and inhibit microbial action to improve skin surface condition and physiological balance; the moisturizing effect is enhanced in an auxiliary way, the secretion of skin grease is further reduced, and the effect of improving pores is further achieved.
(2) The composition for reducing pores accords with various indexes in the 'cosmetic safety technical Specification' issued by China, does not contain toxic and harmful components, and has no potential hazard.
Drawings
FIG. 1 is a comparison of the effect of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the following examples, which are not intended to limit the present invention, but are merely illustrative of the present invention. The experimental methods used in the following examples are not specifically described, but the experimental methods in which specific conditions are not specified in the examples are generally carried out under conventional conditions, and the materials, reagents, etc. used in the following examples are commercially available unless otherwise specified.
The sources of the materials used in the present invention are shown in Table 1 below:
table 1 of raw material sources
Preparation of a composition for pore reduction comprising the steps of:
(1) Weighing the raw materials according to the following tables 2-1 and 2-2;
(2) Heating, stirring and dispersing the phase A uniformly, and heating the phase B until the phase B is dissolved and transparent;
(3) Adding phase B into phase A, homogenizing for 3 min;
(3) Cooling to 40deg.C, adding phase C, and stirring.
Composition table 2-1 for pore-fading
Composition table 2-2 for pore-fading
In tables 2-1 and 2-2, "-" indicates no corresponding addition.
Human body skin patch test
The obtained 10 composition is referred to the human skin patch test in the cosmetic safety technical Specification.
Skin reactions were observed as standard at 30min (after the disappearance of the indentations), 24h and 48h, respectively, and the observations were recorded, see table 3.
TABLE 3 human safety test results
Sample stability test
The appearance of the 10 component is semitransparent gel substance.
(1) Acceleration stability
Taking 10 groups of finished products prepared in the previous step, taking three pieces of finished products in each group, placing a proper amount of finished products in a centrifuge tube, sealing a tube orifice, and centrifuging at 3000rpm for 30min; visually observing the morphology; no precipitation, precipitation and other phenomena were observed, and the original appearance was maintained.
(2) Temperature stability
1. Heat resistance test: and (3) regulating the temperature of the constant temperature incubator to 40 ℃, putting three prepared 10 groups of finished products into transparent glass bottles, sealing the transparent glass bottles with 10 ml/bottle sample loading amount, putting the transparent glass bottles into the constant temperature incubator for three months, taking out the transparent glass bottles, recovering the transparent glass bottles to room temperature, and observing the appearance change.
2. Cold resistance test: and (3) regulating the temperature of the constant temperature incubator to-10 ℃, putting three finished products prepared in the constant temperature incubator into transparent glass bottles, sealing the transparent glass bottles with 10 ml/bottle sample loading amount, putting the transparent glass bottles into the constant temperature incubator for three months, taking out the transparent glass bottles, recovering the transparent glass bottles to room temperature, and observing the appearance change.
3. And (3) normal temperature test: and (3) taking three groups of 10 finished products, filling the three groups of finished products into transparent glass bottles, placing the bottles in 10 ml/bottle at normal temperature after sealing, and observing the appearance change of the essence after the bottles are placed for 6 months.
No phenomena such as precipitation and precipitation are observed in the heat resistance test, the cold resistance test and the normal temperature test, and the original appearance is maintained.
Skin moisture loss test
Percutaneous moisture loss (Trans Epidermal Water Loss, TEWL) test was used; the test was performed using a TM300 tester from Courage & Khazaka, germany, and specifically:
each group randomly picked 5 women with 20 to 40 years of age who were free of skin disease; the test subjects uniformly smeared the inner side of the forearm with a sample (0.5 ml) twice a day in the morning and evening, and then the same tester respectively tests the percutaneous water loss of the inner side of the forearm after the week 0 and the continuous use to the week 2 and the week 4; specific detection results; the results are shown in Table 5.
The rate of decrease formula for TEWL value is:
TEWL value decrease rate (%) = (A0-An)/a0×100%
Wherein A0 is the 0 th week TEWL value, an is the n th week TEWL value.
TEWL value average decrease rate (%) =sum of decrease rate of TEWL value per group/number of persons per group
TABLE 4 skin moisture loss test results
Antioxidant test
Performing an antioxidation test on the prepared sample for DPPH free radical clearance; the specific method comprises the following steps:
experimental materials: diphenyl picrylphenylhydrazine radical (abbreviated as DPPH, sigma, usa);
du800 uv-vis spectrophotometer (Beckman, usa);
the total of the test substances is 10 groups, and the sample solutions are the above samples.
The experimental method comprises the following steps: taking 0.1mL of sample solution, adding 2mL of 60 mu mol/L DPPH solution, uniformly mixing, standing for 30min, adjusting the zero point by using the original solvent, and measuring the absorbance at 517nm to be Ai; uniformly mixing 0.1mL of absolute ethyl alcohol solvent and 2mL of DPPH solution by the same method to determine that the absorbance is Ac; the absorbance was measured for Aj by mixing 0.1mL of the sample solution with 2mL of absolute ethanol solvent. The free radical clearance is calculated according to the following formula; the results are shown in Table 6.
Clearance (%) = [1- (Ai-Aj)/Ac ] ×100%
Wherein Aj reflects the contribution of the sample itself to absorbance; absorbance values after action of Ai sample on DPPH; ac is the absorption of DPPH itself at the measurement wavelength.
TABLE 5 antioxidant assay results
From the in vitro experimental results, it is shown that: the invention has better free radical scavenging capability.
Oil control effect test
Purpose and basis of experiments
The purpose is as follows: the oil control efficacy of cosmetic composition products was explored by testing the ability of the products to inhibit cellular oil secretion.
According to the following: the experiment is designed according to the experimental design of the cosmetic efficacy claiming evaluation criterion and the effect of cigarette smoke extract on SZ95 human sebaceous gland cell proliferation, apoptosis and lipid synthesis, and the oil control efficacy of the sample is verified by comparison with a normal group.
Experimental method
Experimental cells: immortalized human sebaceous gland cell line SZ95 is selected, and the cell line is detected by a cell line quality control experiment, and the result is qualified. The test algebra is as follows: p10.
Instrument: a carbon dioxide incubator, a multifunctional enzyme-linked detector, a biosafety cabinet, an inverted microscope, an inverted fluorescence microscope and an 8-channel pipette.
Reagent: fetal bovine serum, high-sugar DMEM medium, penicillin-streptomycin solution, trypsin-EDTA solution, modified oil red detection kit, paraformaldehyde, isopropanol, epigallocatechin gallate (EGCG).
Grouping and comparison:
(1) Sample group: deionized water solution of each sample at 0.5% mass concentration.
(2) Test control information: (1) blank control: complete medium; (2) positive control: 12.5. Mu. Mol/L EGCG.
Operating procedure
1) Cell preparation: cells with good growth state were inoculated into 24-well plates, 500. Mu.l PBS solution was added to the edge wells of the plates, and a blank control group, a positive control group and a sample group to be tested were set, respectively. The 24-well plate was placed in a CO2 incubator for overnight incubation.
2) Administration: the medium in the 24-well plate was discarded, and the administration was performed. The normal group was given 1ml of complete medium and the sample group was given 1m of the corresponding concentration of the test substance. After the end of the dosing, the 24-well plate was placed in a CO2 incubator for cultivation.
3) And (3) oil drop detection: after incubation, detection is carried out according to the instruction of the oil red detection kit, and the oil drop condition of each sample hole is detected by an inverted microscope and an enzyme-labeled instrument.
Evaluation criteria
The test indexes are as follows: oil drop content
Determination criteria: the drop content of the sample group was reduced compared to the blank group, and there was a significant difference (P < 0.05), indicating that the sample had the ability to inhibit oil secretion at this tested concentration.
Experimental results
Under normal culture conditions, the content of oil drops secreted by the test object to sebaceous gland cells is shown in Table 6.
TABLE 6 relative oil drop content in sebaceous gland cells
". Times." indicates p < 0.05 compared to the blank.
As can be seen from the comparison of the 3 rd, 6 th, 7 th, 8 th and 10 th groups in Table 6, when another kind of essential oil is used, hamamelis virginiana water is absent, sea sludge extract is absent, only one kind of oil is used, the oil control effect is reduced to different degrees; in contrast, group 3 and group 9 show that the effect is not further improved when the predetermined amounts of Adenosilane and silanediol salicylate are used.
Pore reduction test
Test sample: sample number 3.
The testing method comprises the following steps: 5 women aged 20 to 40 without skin disease; twice daily, samples were cut twice a day, morning and evening, and tried for 12 weeks. The volunteers applied an appropriate amount (about 0.5 ml) of the test sample to the whole face, daily in the morning with the sunscreen product. The results were tested during the following time periods, respectively: before using the sample (D0), after using the sample for 14 days (D14), after using the sample for 28 days (D28); the test was completed with interrogation and instrument photography.
Test results: as shown in fig. 1; each of the 5 volunteers showed a significant effect on pore shrinkage.
Antibacterial effect test
Finally, it should be noted that: the foregoing description of the preferred embodiments of the invention is not intended to limit the invention, but rather to enable any modification, equivalent replacement, improvement or the like to be included within the spirit and principles of the invention.
Claims (10)
1. The pore-fading composition is characterized by comprising the following components in parts by mass:
2. a pore-reducing composition according to claim 1, further comprising the following components:
3. a pore-reducing composition according to claim 1, further comprising eucalyptus blue oil.
4. A pore-reducing composition according to claim 3, wherein the eucalyptus globulus oil is added in an amount of 0.3 to 0.8 parts.
5. A pore-reducing composition according to claim 1, further comprising rosewood oil.
6. The pore-reducing composition according to claim 5, wherein the rosewood oil is added in an amount of 0.6 to 1.2 parts.
7. A pore-reducing composition according to claim 1, characterized by comprising the following components in parts by mass:
8. a pore-reducing composition according to claim 7, further comprising the following components:
eucalyptus globulus oil 0.40
0.80 of rosewood oil.
9. A method of preparing the pore-reducing composition of any one of claims 1 to 8, characterized by weighing the raw materials; then uniformly dispersing and homogenizing to form a stable mixture state.
10. Use of a pore-reducing composition according to any one of claims 1 to 8 for the preparation of a cosmetic.
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