CN1177485A - Oral liquor for treating tumour and disease of liver, and preparation method thereof - Google Patents

Abstract

The present invention provides a Chinese medicine oral liquor for curing tumor and hepatic disease. Said invented oral liquor is made up by taking 1000ml of said oral liquor as basis, and using 300g of acanthopanax root, 250g of ophiopogon tuber, 250g of capillaris, 150g of rhubarb and 75g of mume fruit as raw material therough the process of decoction by water. Said invented medicine liquor can raise the stress function of human body, support right and dispel veil to obtain the functions of inhibiting cancer and protecting liver, and can obtain good therpeutic effect.

Description

A kind of oral liquid for the treatment of tumor and hepatopathy and preparation method thereof

The present invention relates to a kind of medicine for the treatment of tumor and hepatopathy, more specifically, relate to a kind of oral liquid medicine for the treatment of tumor and hepatopathy.

Tumor is to doubt one of serious symptom now, and its sickness rate is on the rise, its state of an illness cruelty, and harm is serious, though caused the concern of the whole world numerous doctor family, ideal medicine and therapy are not arranged yet, all the more so aspect treatment by Chinese herbs.

The purpose of this invention is to provide a kind of is the new Chinese medicine oral liquid that raw material is made by Chinese herbal medicine, to set upright and the eliminating evil principle that combines, not only mends but also attack, invigorating middle warmer is attacked, reach and attack heresy and just do not hindering, support and just do not helping evil purpose, tumor and hepatopath are played good auxiliary treatment effect.

The solution of the present invention is as follows: every 1000ml makes the crude drug and the consumption that use in the medicinal liquid and is: Radix Et Caulis Acanthopanacis Senticosi 300g; Radix Ophiopogonis 250g; Radix Et Rhizoma Rhei 150g; Herba Artemisiae Scopariae 250g; Fructus Mume 75g.Can adopt traditional decocting in water to put forward technology makes.

In order to make features good taste, also can in crude drug, add flavoring agent, flavoring agent can be Mel or white sugar (sucrose), Mel and white sugar are relatively, though Mel has certain pharmacological action, it is unfavorable for that also medicinal liquid is clear and bright except the cost height, therefore preferably uses white sugar as flavoring agent in practicality.The flavoring agent use amount can be determined by taste with the need, for example adopted 100g in above prescription.

For the effective ingredient of good utilisation crude drug more, the preparation method of following oral liquid is preferred technology, describes as example as flavoring agent to use white sugar:

1. getting recipe quantity Radix Et Caulis Acanthopanacis Senticosi, Radix Ophiopogonis, Radix Et Rhizoma Rhei adds 10 times of amounts of water and boils and carry 1 hour;

2. soak the Herba Artemisiae Scopariae 3.5 hours of recipe quantities with 10 times of water gagings;

3. 1., 2. the gained medicinal liquid boils altogether and carries 0.5 hour, filter with step;

4. with step 3. the gained filtering residue add 8 times of water gagings and boil and carry 1 hour, filter;

5. combining step 3., 4. gained filtrate, concentrating under reduced pressure is standby to 1.08-1.10 concentration;

6. get the recipe quantity Fructus Mume and successively add 8 times in water amount and 6 times of amounts and boil respectively and carry 1 hour and 0.5 hour, merge leach cooking liquid twice, filter, concentrated filtrate is to 200m;

7. add recipe quantity white sugar and go into little boiling in the step Fructus Mume concentrated solution 6., stir 15 minutes one-tenth syrup, filter standby;

8. with step filtration syrup and 5. concentrated medicament merging of step 7., stir, filter cold preservation 24 hours;

9. get supernatant 1000ml patent medicine.

In above step 8. in the design of the clarification process in 9., filter operation and can adopt alcohol deposition method and high speed centrifugation Filtration, though the alcohol deposition method clarity is better, loss of effective components is big, contains the polysaccharide composition as Radix Et Caulis Acanthopanacis Senticosi, precipitate with ethanol easily loses, in the methanol extract, extract content, no precipitate with ethanol is (8.20) to precipitate with ethanol person's ratio: (5.29), yield, alcohol deposition method only reach 65% of no precipitate with ethanol.Consider in the article of the present invention that macromolecular substances such as each herbal medicine starch contained therein is less relatively, less to the clarity influence, preferably adopt twice high speed centrifugation to add cold preserving method and filter.

Fructus Mume adopts the step that decocts separately in the method, because Fructus Mume acidity is higher, boiling altogether with other drug influences the effective ingredient stripping, and pH value is about 4, and clarity is also better.Also having an advantage is that water-soluble liquefaction sugar can make sucrose partly be converted into monosaccharide, and solution reduces acidity because of consuming the part organic acid, and the Nulomoline mouthfeel is also preferable.Herba Artemisiae Scopariae is an all grass herb, more easily fries in shallow oil, and contains volatile oil component, and employing can reduce loss of active ingredients under steeping afterwards earlier.

Medicinal liquid of the present invention passes through pharmacodynamics, animal acute toxicity test, reaches long-term toxicity test for animals.Pharmacodynamics is investigated from several respects such as mice nonspecific resistance, immune organ, cellular immunization, humoral immunization, shows that medicinal liquid of the present invention can increase mouse anti-reflecting fatigue, cold-resistant, normal pressure hypoxia-bearing capability; Mouse immune organ thymus and spleen weight are increased; The phagocytic percentage of macrophage and phagocytic index increase; The formation of short mice serum hemolysin; Prove that medicinal liquid of the present invention has the effect of strengthening vital QI to eliminate pathogenic factors, increase body immunity.From animal acute toxicity test as can be known, it is safe taking under recommended dose.Long-term toxicity test for animals has been done the observation to the influence of rat body weight and sign, takes medicine 30 days, and take medicine group and matched group are no abnormal aspect activity, diet, stool, fur gloss, and body weight does not have significant change; Except that administration group thymus obviously increases, zero differences such as the heart, liver, spleen, lung, kidney, adrenal gland; The blood picture aspect, leukocyte, lymphocyte have obvious decline to high dose, but the back recovery of two week of drug withdrawal is normal; In glutamate pyruvate transaminase, total bilirubin aspect liver function, the kidney merit high dose there is obvious decline, blood urea nitrogen, flesh liver then all are obvious decline to the administration group, blood urea nitrogen, bilirubin recover normal after two weeks of drug withdrawal, and glutamate pyruvate transaminase and flesh liver still are obvious downward trend to high dose group.By tests such as drug effect, toxicitys, this medicinal liquid to human body safety, and has drug effect in recommended amounts, lifts the case of two routine clinic trial:

1. thunder * *, woman, 60 years old, Zhejiang sistcr, suffer from the gastric mucosal cell cancer, critical, dysphagia, chest pain, become thin, and can not use chemotherapy, use oral liquid of the present invention because of the hemogram difference, day is obeyed secondary, each 30ml, and clinical symptoms takes a turn for the better after one month, after three months, osteodynia disappears, and the bone metastasis disappears, check finds no cancerous cell after successively taking medicine five months, and overall health of patients is good, the conclusion clinical cure.

2. pay * *, man 55 years old.Suffer from central type carcinoma of lung, hydrothorax is obviously felt suffocated, hemoptysis, uses oral liquid of the present invention after the right lung lump obviously dwindle, the apnea difficulty is felt suffocated, body weight has begun increase.

To multiple cancer patient experimenter medication statistics, take that total effective rate reaches 95% after 15 days, wherein produce effects is 50%, medicinal liquid of the present invention obtains to press down the cancer hepatoprotective effect by strengthening the human body copingability, reaches good efficacy.

Claims (5)

1. oral liquid medicine for the treatment of tumor is characterized in that every 1000ml patent medicine uses following weight crude drug: Radix Et Caulis Acanthopanacis Senticosi 300g, Radix Ophiopogonis 250g, Herba Artemisiae Scopariae 250g, Radix Et Rhizoma Rhei 150g, Fructus Mume 75g; Adopting traditional decocting in water to put forward technology makes.

2. according to the oral liquid medicine of claim 1, it is characterized in that regulating in addition in the crude drug flavoring agent 100g of taste.

3. according to the oral liquid medicine of claim 2, it is characterized in that described flavoring agent is a kind of in white sugar or the Mel.

4. method for preparing the described oral liquid medicine of claim 3 is characterized in that: 1. get recipe quantity Radix Et Caulis Acanthopanacis Senticosi, Radix Ophiopogonis, Radix Et Rhizoma Rhei, add 10 times of amounts of water and boil and carry 1 hour;

2. soak the Herba Artemisiae Scopariae 0.5 hour of recipe quantities with 10 times of water gagings;

3. 1., 2. the gained medicinal liquid boils altogether and carries 0.5 hour, filter with step;

4. with step 3. the gained filtering residue add 8 times of water gagings and boil and carry 1 hour, filter;

5. combining step 3., 4. gained filtrate, concentrating under reduced pressure is standby to 1.08-1.10 concentration;

6. get the recipe quantity Fructus Mume and successively add 8 times in water amount and 6 times of amounts and boil respectively and carry 1 hour and 0.5 hour, merge leach cooking liquid twice, filter, concentrated filtrate is to 200ml;

7. add recipe quantity white sugar and go into little boiling in the step Fructus Mume concentrated solution 6., stir 15 minutes one-tenth syrup, filter standby;

8. with step filtration syrup and 5. concentrated medicament merging of step 7., stir, filter cold preservation 24 hours;

9. get supernatant 1000ml patent medicine.

5. method according to claim 4, it is characterized in that described step 8., filter method in 9. is that high speed centrifugation filters.