CN1177598C - Medicine for eliminating side effect of radiotherapy and chemotherapy to treat malignant tumor and its prepn - Google Patents
Medicine for eliminating side effect of radiotherapy and chemotherapy to treat malignant tumor and its prepn Download PDFInfo
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- CN1177598C CN1177598C CNB011149655A CN01114965A CN1177598C CN 1177598 C CN1177598 C CN 1177598C CN B011149655 A CNB011149655 A CN B011149655A CN 01114965 A CN01114965 A CN 01114965A CN 1177598 C CN1177598 C CN 1177598C
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Abstract
The present invention discloses a Chinese herbal compound and a preparing method thereof. The Chinese herbal compound is used for treating bone marrow depression caused by radio-chemotherapy for malignant tumors. The Chinese herbal compound uses pilose asiabell root, milkvetch root, tuckahoe, largehead atractylodesrhizome, glossy privet fruit, barbary wolfberry fruit, scorch hawthorn and liquorice root as raw materials; according to the different characteristics of each traditional Chinese medicine, after freeze drying or air drying is carried out, the traditional Chinese medicines are respectively pretreated by slicing, etc., are prepared in a proportion and then are made into a decoction by maturing and sterilization. The Chinese herbal compound has the advantages of unique formula and manufacture method and obvious therapeutic effect.
Description
Technical field
The present invention relates to a kind of medicine that concurrent chemoradiotherapy of malignant tumor causes side reaction for the treatment of, is the Chinese medicine decoction of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Background technology
Malignant tumor is the serious disease that threatens human health and life now.Delivered data in 1985 according to World Health Organization (WHO), the annual morbidity of whole world malignant tumor 5,900,000 people, dead 4,300,000 people; China has reached 700,000 people because of the dead number of carcinoma every year.
Malignant tumor is difficult in early days finding that radiation and chemotherapy is one of middle and advanced stage tumor and metastatic tumo(u)r Therapeutic Method commonly used.But easily bring out bone marrow depression, complication such as infecting can appear in weight person, hemorrhage causes death.
Both at home and abroad to the primary disease Drug therapy, run into following thorny problem at present:
1. Western medicine leukocyte increasing oral medicine, weak effect, delay treatment.
2. though colony-stimulating factor is effective, cost an arm and a leg, financial burden is heavy.
3. though the Chinese patent medicine of some concurrent chemoradiotherapy of malignant tumor side reactions is also arranged,, and does not often use for the patient because effect is general.
Summary of the invention
The object of the present invention is to provide a kind of efficacy enhancing and toxicity reducing, the control concurrent chemoradiotherapy of malignant tumor causes bone marrow depression, the medicine of the treatment concurrent chemoradiotherapy of malignant tumor side reaction that cost is low, be beneficial to popularization.
Another object of the present invention provides the preparation method of this treatment concurrent chemoradiotherapy of malignant tumor side reaction medicine.
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to tumor and complication mechanism thereof, achieve with reference to modern study, from motherland's medicine treasure-house, filter out strengthening spleen, tonifying kidney, the Chinese medicine of QI invigorating and blood regulating by the theory of Chinese medical science prescription, skims the cream off milk, make its performance human body immunity improving function, the effect of efficacy enhancing and toxicity reducing.Reduce the complication that chemicotherapy causes, improve life quality.
Medicine of the present invention is the medicament of being made by the following weight proportion raw material:
Radix Codonopsis 12-18 Radix Astragali 12-30 Poria 9-12 Rhizoma Atractylodis Macrocephalae 9-12
The Fructus Crataegi 12-18 Radix Glycyrrhizae 6-9 that Fructus Ligustri Lucidi 12-18 Fructus Lycii 12-18 is burned
Medicine of the present invention, wherein the optimum weight proportioning of each raw material is:
Radix Codonopsis 15 Radixs Astragali 20 Poria 10 Rhizoma Atractylodis Macrocephalaes 10
Fructus Crataegi 15 Radix Glycyrrhizaes 6 that Fructus Ligustri Lucidi 15 Fructus Lycii 15 are burned
Above-mentioned each component is made medicine production method of the present invention is:
With above-mentioned 8 flavor Chinese medicine lyophilizing or the section of air-dry back, take by described weight proportion, decoct with water each 1 hour 2 times, merge 2 times the decocting liquid standing over night, the leaching supernatant concentrates, and stirs evenly, packing is sealed, and the ripening disinfecting action is sterilized 10-30 minute promptly for 110 ℃.
The ripening disinfecting action here is to adopt step type cooling ripening sterilization, and temperature is raised to 110 ℃ rapidly, decomposes section then and drops to 100 ℃, and the ripening sterilization time is 30 minutes.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, to select natural plant for use be raw material in the present invention, and each component meets the pharmaceutical control law regulation.Utilize the comprehensive function treatment tumor chemoradiotherapy of the Chinese medicine of respectively distinguishing the flavor of to cause bone marrow depression, do not have chemical sweet taste, nontoxic to human body.
2, the present invention decocts conveniently, and taking convenience meets the pertinent regulations under 8 mixture items of Chinese Pharmacopoeia appendix of 95 years versions.
3, the present invention is cheap, and therapeutic effect is obvious, can alleviate bone marrow depression significantly, strengthens passive protective physical fitness.
4, modern medicine proves: Chinese medicine Radix Codonopsis, the Radix Astragali can improve NK cell, macrophage, t lymphocyte subset group activity, and hemopoietic system is had the better protect effect, correct the weakness of the spleen and kidney symptom, improve life quality.We propose the Therapeutic Principle of " strengthening spleen, tonifying kidney, QI invigorating and blood regulating ".Take the lead in by monarch, minister at home, help, make prescription, Radix Codonopsis, Radix Astragali replenishing QI to invigorate the spleen stomach function regulating make the biochemical active monarch drug that is of QI and blood, minister is with Poria, Rhizoma Atractylodis Macrocephalae invigorating the spleen and regulating the stomach, and assistant is with Fructus Lycii, Fructus Ligustri Lucidi life essence-filling, marrow-benefitting, nourishing the liver and kidney, make with the Fructus Crataegi (parched to brown) stomach function regulating Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.
For showing medicine of the present invention to the bone marrow depression therapeutic effect, the present invention is through the clinical observation of 80 routine systems, and selection medical history, the state of an illness, age, sex and suitable bone marrow depression patient 40 examples of former Therapeutic Method are matched group.From selecting case in hospital, press the acute or subacute toxicity calibration of WHO cancer therapy drug standard, Chinese drug-treated group bone marrow depression 80 examples, wherein male 33 examples, women 47 examples, age 23-72 year, 45.8 years old mean age, bone marrow depression: 1 degree, 35 examples, 2 degree, 28 examples, 3 degree, 15 examples, 4 degree, 2 examples, obeyed medicine of the present invention one day twice, and obeyed 100ml at every turn, 7 days was 1 course of treatment, treat a course of treatment, among the 80 routine patients, 65 examples of fully recovering account for 81.25%, 15 examples take a turn for the better, account for 18.75%, the result shows: Chinese drug-treated group cure rate 80%, improvement rate are 100%
Matched group: male 15 examples, women 25 examples, age 25-69 year, 45.6 years old mean age, bone marrow depression: 1 degree, 17 examples, 2 degree, 16 examples, 3 degree, 7 examples, 4 degree, 0 example, clothes batilol 100mg, vitamin B
4, every day 3 times, the thing of taking medicine 7 days was 1 course of treatment, treated a course of treatment, and 10 examples of fully recovering account for 25%, and 10 examples that take a turn for the better account for 25%, and invalid 20 examples account for 50%, and the result shows: Chinese drug-treated group cure rate 25%, improvement rate are 25%, and invalid is 50%.
Observed result shows, treatment group cure rate and improvement rate and matched group relatively, all there were significant differences, and treatment malignant tumor patient chemotherapy is caused that bone marrow depression has significant curative effect and medicine cost low, is worthy to be popularized.
The specific embodiment
Take by weighing raw material by following weight proportion:
Radix Codonopsis 15 Radixs Astragali 20 Poria 10 Rhizoma Atractylodis Macrocephalaes 10
Fructus Crataegi 15 Radix Glycyrrhizaes 6 that Fructus Ligustri Lucidi 15 Fructus Lycii 15 are burned
Production method is as follows:
With above-mentioned 8 flavor Chinese medicine lyophilizing or the section of air-dry back, form 424g by weight ratio, decoct with water 2 times, for the first time decoct with water each 1 hour, the leaching supernatant decocts with water each 1 hour for the second time, the leaching supernatant merges 2 times the decocting liquid standing over night, the leaching supernatant, be concentrated into 1000ml, stir evenly, packing, seal, then temperature is raised to 110 ℃ rapidly, decompose section then and drop to 100 ℃, the ripening sterilization time is 30 minutes, promptly gets decoction.
Claims (5)
1, a kind of medicine for the treatment of the concurrent chemoradiotherapy of malignant tumor side reaction, it is characterized in that: it is made by the following weight proportion raw material:
Radix Codonopsis 12-18 Radix Astragali 12-30 Poria 9-12 Rhizoma Atractylodis Macrocephalae 9-12
The Fructus Crataegi 12-18 Radix Glycyrrhizae 6-9 that Fructus Ligustri Lucidi 12-18 Fructus Lycii 12-18 is burned.
2, according to the medicine of right 1 described treatment concurrent chemoradiotherapy of malignant tumor side reaction, wherein the weight proportion of each raw material is
Radix Codonopsis 15 Radixs Astragali 20 Poria 10 Rhizoma Atractylodis Macrocephalaes 10
Fructus Crataegi 15 Radix Glycyrrhizaes 6 that Fructus Ligustri Lucidi 15 Fructus Lycii 15 are burned.
3, the preparation method of the medicine of the described treatment concurrent chemoradiotherapy of malignant tumor of claim 1 side reaction is characterized in that: with above-mentioned 8 flavor Chinese medicine lyophilizing or the section of air-dry back, mix by described weight proportion, decoct with water 2 times, each 1 hour, merge 2 times the decocting liquid standing over night, the leaching supernatant, concentrate, stir evenly, packing is sealed, the ripening disinfecting action is sterilized 10-30 minute promptly for 110 ℃.
4, the preparation method of the medicine of treatment concurrent chemoradiotherapy of malignant tumor according to claim 3 side reaction, ripening disinfecting action wherein is to adopt step type cooling ripening sterilization, temperature is raised to 110 ℃ rapidly, decomposes section then and drop to 100 ℃, the ripening sterilization time is 30 minutes.
5, the preparation method of the medicine of treatment concurrent chemoradiotherapy of malignant tumor according to claim 4 side reaction, ripening disinfecting action wherein is that decoct is incubated 10 minutes down at 110 ℃, and then cool to 105 ℃ and kept 5 minutes, cool to 100 ℃ again and kept 15 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011149655A CN1177598C (en) | 2001-05-24 | 2001-05-24 | Medicine for eliminating side effect of radiotherapy and chemotherapy to treat malignant tumor and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011149655A CN1177598C (en) | 2001-05-24 | 2001-05-24 | Medicine for eliminating side effect of radiotherapy and chemotherapy to treat malignant tumor and its prepn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1357354A CN1357354A (en) | 2002-07-10 |
| CN1177598C true CN1177598C (en) | 2004-12-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011149655A Expired - Fee Related CN1177598C (en) | 2001-05-24 | 2001-05-24 | Medicine for eliminating side effect of radiotherapy and chemotherapy to treat malignant tumor and its prepn |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885998B (en) * | 2012-11-05 | 2014-01-22 | 陈兴旺 | Medicine composition for preventing or treating bone marrow suppression caused by tumor radiotherapy |
| CN104491182A (en) * | 2015-01-08 | 2015-04-08 | 李宏 | Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method |
| CN104825863A (en) * | 2015-04-27 | 2015-08-12 | 陶俊荣 | Health-care medicated diet for relieving side effects of radiotherapy and preparation method thereof |
| CN104800692A (en) * | 2015-04-27 | 2015-07-29 | 陶俊荣 | Chinese material medicine preparation for alleviating side effects from radiation therapy and preparation method |
| CN105726776A (en) * | 2016-03-03 | 2016-07-06 | 郑州大学 | Traditional Chinese medicine for alleviating bone marrow inhibition reaction caused by paclitaxel chemotherapy |
| CN106361904A (en) * | 2016-11-12 | 2017-02-01 | 曹芳 | Traditional Chinese medicine composition for relieving chemotherapy side reactions of tumor patients |
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2001
- 2001-05-24 CN CNB011149655A patent/CN1177598C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1357354A (en) | 2002-07-10 |
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