CN1052407C - Traditional Chinese medicine synergist for tumour chemotherapy and its preparation method - Google Patents
Traditional Chinese medicine synergist for tumour chemotherapy and its preparation method Download PDFInfo
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Abstract
The present invention relates to a synergistic agent as a traditional Chinese medicine for tumor chemotherapy and a preparation method thereof. Most of existing medicines for tumor chemotherapy, such as mitomycin, adriamycin, cisplatin, cyclophosphamide, fluorouracil, etc., have the disadvantages of poor clinical curative effect, damage to the immunological function of a human body, obvious toxic side effect, etc., so that the present invention provides the synergistic agent as the traditional Chinese medicine for tumor chemotherapy. The synergistic agent can enhance the immunological unction of a tumor patient, eliminate and lighten the toxic side effect caused by chemotherapy medicines, and have no toxic effect. Besides, If being used singly, the synergistic agent can strengthen the body and prolong lifetime.
Description
Chemotherapy of tumors Chinese medicine synergist belongs to a kind of new product of Chinese medicine category that strengthens the tumor chemotherapeutic drug curative effect and alleviate toxic and side effects.
The tumor chemotherapeutic drug of clinical existing application such as mitomycin, amycin, cisplatin, cyclophosphamide and fluorouracil etc., majority exists clinical efficacy not high, infringement body's immunity, and shortcoming such as toxicity is stronger.For solving the curative effect and the toxicity problem of chemotherapeutics, when the treatment with chemotherapy medicine, many 5 use some biological regulators abroad, as molten chain bacterium goods, bacillus calmette-guerin vaccine, Acne, prodigiosin, levamisole, local anaesthetics, (Chen Xinqian: new pharmacology 646～652 such as nitrendipine and Angiotensin II, the People's Health Publisher, nineteen ninety), though these chemical substances of 5 usefulness have certain potentiation to chemotherapeutics, but these materials also have pharmacological action and toxicity, cause multiple drug-induced disease easily, the tumour patient state of an illness is increased the weight of, thereby the applied chemistry material is restricted as synergist.
The objective of the invention is to design and develop a kind of pure Chinese medicine synergist of chemotherapy of tumors, can improve multiple chemotherapeutics cancer suppressing ratio of existing usefulness and clinical efficacy, can improve the immunologic function of tumour patient again, eliminate or alleviate the toxicity that chemotherapeutics causes, for tumor patient provides a kind of new product of Chinese medicine that remarkable potentiation, Detoxication are arranged in the chemotherapy of tumors process.
The present invention is achieved in that the Chinese medicine that the tumor chemotherapeutic drug tumour inhibiting rate is had the raising effect with pharmacological experimental method primary election, and then compatibility becomes compound recipe to carry out the screening of antitumor activity potentiation, select the prescription of the most significant herbal mixture of tumor chemotherapeutic drug potentiation being established this Chinese medicine synergist, extract its active ingredient with the modern pharmacy method synthesis then, make new product of Chinese medicine such as electuary, powder, tablet, capsule and oral liquid respectively.
The umber proportioning of effective components of Chinese medicinal of the present invention is as follows, Radix Ginseng (5～7), the Radix Astragali (6～8), Fructus Schisandrae Chinensis (6～8), Fructus Lycii (5～7), Radix Polygoni Multiflori (6～8), Lentinus Edodes (8～10), Rhizoma Chuanxiong (3～5), Poria (5～7), Radix Glycyrrhizae (3～5), Cortex Cinnamomi (1～3), the Rhizoma Atractylodis Macrocephalae (6～8), Radix Rehmanniae Preparata (9～11), Radix Angelicae Sinensis (10～12), the Radix Paeoniae Alba (6～8), Radix Et Caulis Acanthopanacis Senticosi extractum (2～4), broker wall bee pollen (4～6).
Preparation method of the present invention is as follows: get above-mentioned preceding 14 its active ingredients of flavor Chinese medicine extraction by proportioning, method is to be solvent with water, extracts at least twice with the backflow lifting manipulation, each one hour.To extract lixiviation and remove after the insoluble matter, again its reduced vacuum will be condensed into the thick paste shape, add Radix Et Caulis Acanthopanacis Senticosi extractum (2～4) and broker wall bee pollen (4～6) then, puddle evenly, and form and concentrate thick paste shape spice.
The chemotherapy of tumors Chinese medicine synergist that is made by the present invention has following characteristics:
1, this Chinese medicine synergist and fit applications such as mitomycin, amycin, cisplatin, cyclophosphamide and fluorouracil, can make mitomycin improve tumour inhibiting rate 15.95% (S180), 14.35% (Lewis lung cancer), make cisplatin improve tumour inhibiting rate 11.1% (S180), 11.78% (Lewis lung cancer), make fluorouracil improve tumour inhibiting rate 20.5% (S180), 15.91% (Lewis lung cancer), make the ring mebenil improve tumour inhibiting rate 16.66% (Lewis lung cancer), learn by statistics and handle P＜0.01～0.001.The tumour inhibiting rate of using this agent separately is 22.91～38.2% (S180, Lewis lung cancer).
2, this Chinese medicine synergist and fit applications such as mitomycin, cisplatin, cyclophosphamide and fluorouracil; can eliminate infringements such as medulla hematopoietic system that these chemotherapeutics cause and nervous system; make leukocyte continue to maintain in normal range, alopecia, insomnia and dermatitis etc. that chemotherapeutic is caused also have obvious protective effect.
3, this Chinese medicine synergist can obviously improve the immunologic function of tumour patient, atrophy of immune organ such as the thymus that elimination use chemotherapeutics causes, spleen, prevent the body chromosomal aberration that chemotherapeutics causes, and can improve the phagocytic activity and the NK cytoactive of body macrophage, transfer the anti-cancer ability of body self.
4, this Chinese medicine synergist, is measured through acute toxicity test without any toxic and side effects by multiple Chinese prescription preparation with temperature compensation QI and blood and Yin-nourishing and Yang-supporting performance, and dosage increases to 2500mg/kg, LD
50Still fail to measure, illustrate that this agent use is fool proof.This agent is used separately and can be treated various deficient property diseases, makes body constitution strong gradually, and body weight increases to some extent, and energy is more abundant.The middle-aged and elderly people prolonged application that has a delicate constitution can play building body and life lengthening effect.
Embodiment 1:
Get Radix Ginseng (5～7), the Radix Astragali (6～8), Fructus Schisandrae Chinensis (6～8), Fructus Lycii (5～7), Radix Polygoni Multiflori (6～8), Herba Glossogynes tenuifoliae (8～10), Rhizoma Chuanxiong (3～5), Poria (5～7), Radix Glycyrrhizae (3～5), Cortex Cinnamomi (1～3), the Rhizoma Atractylodis Macrocephalae (6～8), Radix Rehmanniae Preparata (9～11), Radix Angelicae Sinensis (10～12), the Radix Paeoniae Alba (6～8) according to proportioning.After above-mentioned Chinese medicine thinly sliced mixing, put in the Chinese medicine extraction device, add water reflux, extract, at least 2 times, each 1 hour.Behind extracting solution filtering insoluble matter, reduced vacuum is condensed into the thick paste shape, adds Radix Acanthopanacis Senticosi extractum (2～4), broker wall bee pollen (4～6) (expression proportioning umber in the bracket) again, puddles evenly, forms thick paste shape spice.
In addition, getting high quality white Saccharum Sinensis Roxb. places in the drying baker, be 80～90 ℃ of dryings, make water content drop to 0.5%, put cold back and pulverize by behind 100 mesh sieves, the above-mentioned thick paste shape spice that makes is added, mixing in mixer adopts wet granulation again, by 14 mesh sieves, granulate after 85 ℃ of dryings packs in aluminium foil bag.Promptly get the electuary (every bag contains crude drug 9g) of every bag of 15g.
Embodiment 2:
To the write out a prescription extracting solution reduced vacuum of Chinese medicine of the preparation method of pressing embodiment 1 concentrates the thick paste shape, add mixing behind Radix Et Caulis Acanthopanacis Senticosi extractum and the broker wall bee pollen again, its reduced vacuum is dried to water content below 2%, adopt mechanical activation comminution, cross 100 mesh sieves, the thick paste powder that obtains is packed in exsiccant environment in the Capsules, be pressed into aluminum-plastic packaged in sealing, promptly get every capsule that contains 0.5g thick paste powder.
Embodiment 3:
The Radix Et Caulis Acanthopanacis Senticosi extractum and the broker wall bee pollen of the extracting solution dissolving share of the prescription Chinese medicine after the preparation method of pressing embodiment 1 will be filtered, stir mix well after, directly make dry medicated powder with spray drying method, promptly make powder.
Embodiment 4:
Press the preparation method of embodiment 1, will add the spice of Radix Et Caulis Acanthopanacis Senticosi extractum and broker wall bee pollen thick paste shape, add proper amount of dry starch and Pulvis Talci wet granulation, tabletting, sugar coating are pressed into aluminum-plastic packaged interior sealing, promptly get every tablet of tablet that contains crude drug 0.3g.The heavy 0.5g of sheet.
Embodiment 5:
Preparation method according to embodiment 1, behind the extracting solution adding Radix Et Caulis Acanthopanacis Senticosi extractum and broker wall bee pollen stirring and dissolving with prescription Chinese medicine, reduced vacuum is concentrated into 1: 0.5 (the 1ml medicine contains crude drug 0.5g), adding flavoring agent is the sweet close element of 0.4% (g/ml), 2% (g/ml) Mel, and antiseptic is 2% (g/ml) sodium benzoate, after the stirring and dissolving, stored precipitation 48 hours down in 5 ℃ of low temperature, use the supercentrifugal process precipitated impurities, get supernatant, in gnotobasis, irritate in peroral ampule and seal, promptly get the oral liquid of every 10ml.
Claims (7)
1, a kind of chemotherapy of tumors Chinese medicine synergist, it is characterized in that: the weight proportion of this Chinese medicine synergist prescription composition and make as followsly, Radix Ginseng 5～7, the Radix Astragali～8, Fructus Schisandrae Chinensis 6～8, Fructus Lycii 5～7, Radix Polygoni Multiflori 6～8, Lentinus Edodes 8～10, Rhizoma Chuanxiong 3～5, Poria 5～7, Radix Glycyrrhizae 3～5, Cortex Cinnamomi 1～3, the Rhizoma Atractylodis Macrocephalae 6～8, Radix Rehmanniae Preparata 9～11, Radix Angelicae Sinensis 10～12, the Radix Paeoniae Alba 6～8, after extracting, processing makes that the thick paste shape adds Radix Et Caulis Acanthopanacis Senticosi extractum 2～4 again, broker wall bee pollen 4～6 is puddled and made.
2, a kind of preparation method of chemotherapy of tumors Chinese medicine synergist, it is characterized in that: the composition of will writing out a prescription is with weight proportion, get Radix Ginseng 5～7, the Radix Astragali 6～8, Fructus Schisandrae Chinensis 6～8, Fructus Lycii 5～7, Radix Polygoni Multiflori 6～8, Lentinus Edodes 8～10, Rhizoma Chuanxiong 3～5, Poria 5～7, Radix Glycyrrhizae 3～5, Cortex Cinnamomi 1～3, the Rhizoma Atractylodis Macrocephalae 6～8, Radix Rehmanniae Preparata 9～11, Radix Angelicae Sinensis 10～12, the Radix Paeoniae Alba 6～8, thinly slice, after the mixing, put in the Chinese medicine extraction device, add water reflux, extract, at least two hours, each one hour, behind extracting solution filtering insoluble matter, its reduced vacuum is condensed into the thick paste shape, adds Radix Et Caulis Acanthopanacis Senticosi extractum 2～4 and broker wall bee pollen 4～6 again, puddle even formation and concentrate thick paste shape spice.
3, preparation method according to claim 2, it is characterized in that: white sugar is put 80～90 ℃ of baking oven inner dryings, put cold back and pulverize, behind 100 mesh sieves, will puddle uniform thick paste shape spice and add, be mixed, take wet granulation again, by 14 mesh sieves, granulate after 85 ℃ of dryings, pack in aluminium foil bag, make electuary.
4, preparation method according to claim 2 is characterized in that: with the further vacuum drying of spissated thick paste shape spice, to water content below 2%, by mechanical activation comminution, cross 100 mesh sieves, in exsiccant environment, pack in the Capsules, make capsule.
5, preparation method according to claim 2 is characterized in that: Radix Et Caulis Acanthopanacis Senticosi extractum and broker wall bee pollen are dissolved in the prescription Chinese medicine extraction liquid after the filtration, stir, directly make dry medicated powder with spray drying method then, make powder.
6, preparation method according to claim 2 is characterized in that: will concentrate thick paste shape spice with dried starch, Pulvis Talci mixing, and adopt wet granulation, tabletting, sugar coating are pressed into aluminum-plastic packaged interior sealing, make tablet.
7, preparation method according to claim 2, it is characterized in that: Radix Acanthopanacis Senticosi extractum and broker wall bee pollen are dissolved in the prescription Chinese medicine extraction liquid after the filtration, it is that the 1ml medicinal liquid contains the 0.5g crude drug that reduced vacuum is concentrated into 1: 0.5, every milliliter adds the cyclamate of 0.4% gram, the Mel and the 0.2% gram sodium benzoate of 2% gram, stirring and dissolving, low-temperature precipitation 48 hours, use the supercentrifugal process precipitated impurities, divide and get supernatant, in gnotobasis, irritate in peroral ampule and seal, make oral liquid.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92113676.5 | 1992-11-25 | ||
| CH92113676.5 | 1992-11-25 | ||
| CN92113676 | 1992-11-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1087276A CN1087276A (en) | 1994-06-01 |
| CN1052407C true CN1052407C (en) | 2000-05-17 |
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| CN93118576A Expired - Fee Related CN1052407C (en) | 1992-11-25 | 1993-10-26 | Traditional Chinese medicine synergist for tumour chemotherapy and its preparation method |
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| CN (1) | CN1052407C (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1058882C (en) * | 1996-09-24 | 2000-11-29 | 来春荣 | Oral liquor for treating tumour and disease of liver, and preparation method thereof |
| AU2005336866B2 (en) * | 2005-09-30 | 2012-06-14 | Suzhou Herui Biomed Co., Ltd | The use of phthalide derivatives |
| CN101342271B (en) * | 2008-09-08 | 2010-09-29 | 张立莲 | Traditional Chinese medicine for treating qi-blood deficiency caused by tumour chemotherapy and preparation method thereof |
| CN104127427B (en) * | 2014-07-28 | 2016-02-24 | 于法周 | A kind of anticancer synergia compositions |
-
1993
- 1993-10-26 CN CN93118576A patent/CN1052407C/en not_active Expired - Fee Related
Non-Patent Citations (4)
| Title |
|---|
| 《中原杂志》(1) 1986.1.1 苏学中，浅谈中西药的联用与禁忌 * |
| 《中药药剂学》第一版 1986.11.1 曹春林主编，上海科学技术出版社 * |
| 《中药药剂学》第一版 1986.11.1 曹春林主编，上海科学技术出版社;《陕西中医》10(5) 1989.5.1 陈凯等，扶正培本方药治疗恶性肿瘤的研究概况;《中原杂志》(1) 1986.1.1 苏学中，浅谈中西药的联用与禁忌 * |
| 《陕西中医》10(5) 1989.5.1 陈凯等，扶正培本方药治疗恶性肿瘤的研究概况 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1087276A (en) | 1994-06-01 |
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