CN117618423A - 色氨酸双加氧酶(ido1和tdo)的抑制剂和其在治疗中的用途 - Google Patents

色氨酸双加氧酶(ido1和tdo)的抑制剂和其在治疗中的用途 Download PDF

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CN117618423A
CN117618423A CN202311408585.6A CN202311408585A CN117618423A CN 117618423 A CN117618423 A CN 117618423A CN 202311408585 A CN202311408585 A CN 202311408585A CN 117618423 A CN117618423 A CN 117618423A
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azolo
pyridin
iso
amine
nhr
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Chinese (zh)
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B·D·帕尔默
L·M·秦
S·A·加米奇
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Auckland Uniservices Ltd
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33Heterocyclic compounds
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/423Oxazoles condensed with carbocyclic rings
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202311408585.6A 2014-08-13 2015-08-12 色氨酸双加氧酶(ido1和tdo)的抑制剂和其在治疗中的用途 Pending CN117618423A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NZ62868814 2014-08-13
NZ628688 2014-08-13
CN201580055358.7A CN106794176A (zh) 2014-08-13 2015-08-12 色氨酸双加氧酶(ido1和tdo)的抑制剂和其在治疗中的用途
PCT/IB2015/056129 WO2016024233A1 (en) 2014-08-13 2015-08-12 Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy

Related Parent Applications (1)

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CN201580055358.7A Division CN106794176A (zh) 2014-08-13 2015-08-12 色氨酸双加氧酶(ido1和tdo)的抑制剂和其在治疗中的用途

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Publication Number Publication Date
CN117618423A true CN117618423A (zh) 2024-03-01

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Application Number Title Priority Date Filing Date
CN202311408585.6A Pending CN117618423A (zh) 2014-08-13 2015-08-12 色氨酸双加氧酶(ido1和tdo)的抑制剂和其在治疗中的用途
CN201580055358.7A Pending CN106794176A (zh) 2014-08-13 2015-08-12 色氨酸双加氧酶(ido1和tdo)的抑制剂和其在治疗中的用途
CN202311412286.XA Pending CN117599049A (zh) 2014-08-13 2015-08-12 色氨酸双加氧酶(ido1和tdo)的抑制剂和其在治疗中的用途

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CN201580055358.7A Pending CN106794176A (zh) 2014-08-13 2015-08-12 色氨酸双加氧酶(ido1和tdo)的抑制剂和其在治疗中的用途
CN202311412286.XA Pending CN117599049A (zh) 2014-08-13 2015-08-12 色氨酸双加氧酶(ido1和tdo)的抑制剂和其在治疗中的用途

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US (3) US10888567B2 (enExample)
EP (1) EP3180002B1 (enExample)
JP (2) JP7323985B2 (enExample)
KR (3) KR102746352B1 (enExample)
CN (3) CN117618423A (enExample)
AU (2) AU2015302908B2 (enExample)
CA (1) CA2957884A1 (enExample)
ES (1) ES2925471T3 (enExample)
WO (1) WO2016024233A1 (enExample)
ZA (1) ZA201700924B (enExample)

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MA46649A (fr) 2016-10-13 2019-08-21 Juno Therapeutics Inc Méthodes et compositions d'immunothérapie impliquant des modulateurs de la voie métabolique du tryptophane
CN110191709A (zh) 2017-01-17 2019-08-30 德州大学系统董事会 可用作吲哚胺2,3-双加氧酶和/或色氨酸双加氧酶抑制剂的化合物
CN106905256A (zh) * 2017-03-06 2017-06-30 中国药科大学 苯并五元杂环类ido1抑制剂、其制备方法及应用
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WO2020018670A1 (en) 2018-07-17 2020-01-23 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
JP6912016B1 (ja) * 2020-04-10 2021-07-28 小野薬品工業株式会社 Sting作動化合物
KR102653960B1 (ko) * 2020-07-23 2024-04-03 의료법인 성광의료재단 암 치료를 위한 면역체크포인트 억제제의 병용 요법
WO2022184930A2 (en) 2021-03-05 2022-09-09 Universität Basel Compositions for the treatment of ebv associated diseases or conditions
EP4052705A1 (en) 2021-03-05 2022-09-07 Universität Basel Vizerektorat Forschung Compositions for the treatment of ebv associated diseases or conditions
WO2023166492A2 (en) 2022-03-04 2023-09-07 Antido Therapeutics International Sàrl Dual inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy
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WO2016024233A1 (en) 2016-02-18
AU2020203116B2 (en) 2021-10-21
KR102746352B1 (ko) 2024-12-24
CA2957884A1 (en) 2016-02-18
ZA201700924B (en) 2022-11-30
JP2021006579A (ja) 2021-01-21
CN106794176A (zh) 2017-05-31
KR20170034439A (ko) 2017-03-28
US10888567B2 (en) 2021-01-12
US20210145839A1 (en) 2021-05-20
KR20240017411A (ko) 2024-02-07
CN117599049A (zh) 2024-02-27
EP3180002B1 (en) 2022-04-20
AU2020203116A1 (en) 2020-05-28
US11826316B2 (en) 2023-11-28
JP7323985B2 (ja) 2023-08-09
ES2925471T3 (es) 2022-10-18
EP3180002A1 (en) 2017-06-21
AU2015302908B2 (en) 2020-02-13
US20170224701A1 (en) 2017-08-10
EP3180002A4 (en) 2018-07-04
AU2015302908A1 (en) 2017-02-23
KR20250007032A (ko) 2025-01-13
JP2017527548A (ja) 2017-09-21
US20240285641A1 (en) 2024-08-29

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