CN117586401A - 抗pd-1抗体及其用途 - Google Patents

抗pd-1抗体及其用途 Download PDF

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Publication number
CN117586401A
CN117586401A CN202311368997.1A CN202311368997A CN117586401A CN 117586401 A CN117586401 A CN 117586401A CN 202311368997 A CN202311368997 A CN 202311368997A CN 117586401 A CN117586401 A CN 117586401A
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seq
antibody
fragment
cancer
antibodies
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陈列平
罗利群
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Tayu Huaxia Biotech Medical Co Ltd
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Tayu Huaxia Biotech Medical Co Ltd
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C—CHEMISTRY; METALLURGY
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CN202311368997.1A 2017-01-20 2018-01-19 抗pd-1抗体及其用途 Pending CN117586401A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201710046148 2017-01-20
CN2017100461482 2017-01-20
PCT/CN2018/073383 WO2018133837A1 (en) 2017-01-20 2018-01-19 Anti-pd-1 antibodies and uses thereof
CN201880007550.2A CN110382536B (zh) 2017-01-20 2018-01-19 抗pd-1抗体及其用途

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CN117586401A true CN117586401A (zh) 2024-02-23

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CN202311368997.1A Pending CN117586401A (zh) 2017-01-20 2018-01-19 抗pd-1抗体及其用途
CN201880002948.7A Active CN110291109B (zh) 2017-01-20 2018-01-19 人程序性死亡受体pd-1的单克隆抗体及其片段
CN201880007550.2A Active CN110382536B (zh) 2017-01-20 2018-01-19 抗pd-1抗体及其用途

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CN201880002948.7A Active CN110291109B (zh) 2017-01-20 2018-01-19 人程序性死亡受体pd-1的单克隆抗体及其片段
CN201880007550.2A Active CN110382536B (zh) 2017-01-20 2018-01-19 抗pd-1抗体及其用途

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US (3) US10465007B2 (enExample)
EP (1) EP3571231A4 (enExample)
JP (2) JP7275030B2 (enExample)
KR (2) KR102536145B1 (enExample)
CN (3) CN117586401A (enExample)
AU (1) AU2018209556C1 (enExample)
BR (1) BR112019013238A2 (enExample)
MX (1) MX2019007848A (enExample)
TW (1) TWI771361B (enExample)
WO (2) WO2018133842A1 (enExample)

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JP7275030B2 (ja) 2017-01-20 2023-05-17 タユー ファシャ バイオテック メディカル グループ カンパニー， リミテッド 抗ｐｄ－１抗体およびその使用
TWI806870B (zh) * 2018-05-23 2023-07-01 中國大陸商大有華夏生物醫藥集團有限公司 抗pd-1抗體及其用途
WO2019227490A1 (en) 2018-06-01 2019-12-05 Tayu Huaxia Biotech Medical Group Co., Ltd. Compositions and methods for imaging
JP2021525806A (ja) 2018-06-01 2021-09-27 タユー ファシャ バイオテック メディカル グループ カンパニー， リミテッド 疾患または状態を処置するための組成物およびそれらの使用
EP3823991A4 (en) * 2018-07-19 2022-08-03 Tayu Huaxia Biotech Medical Group Co., Ltd. ANTI-PD-1 ANTIBODIES, DOSAGE FORMS AND USES THEREOF
CN110845614A (zh) * 2018-08-21 2020-02-28 大有华夏生物医药集团有限公司 人细胞表面免疫调节分子
CN109053895B (zh) * 2018-08-30 2020-06-09 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
WO2020063823A1 (en) * 2018-09-27 2020-04-02 Zai Lab (Shanghai) Co., Ltd. Anti-pd-1 antibodies and uses thereof
CA3124660A1 (en) * 2018-12-21 2020-06-25 Gloriana Therapeutics Sarl Mammalian cell culture-produced neublastin antibodies
CN113795511B (zh) 2019-01-23 2024-07-23 大有华夏生物医药集团有限公司 抗pd-l1双抗体及其用途
MX2021009041A (es) * 2019-02-03 2021-08-19 Jiangsu Hengrui Medicine Co Anticuerpo anti-pd-1, fragmento de union a antigeno del mismo y uso farmaceutico del mismo.
CN114072426B (zh) * 2019-07-08 2024-01-26 南京金斯瑞生物科技有限公司 抗cd47/抗pd-1双特异抗体及其制备方法和应用
WO2021043261A1 (zh) * 2019-09-06 2021-03-11 北京拓界生物医药科技有限公司 抗pd-1单域抗体、其衍生蛋白及其医药用途
CA3176606A1 (en) * 2020-03-26 2021-09-30 Cureimmune Therapeutics Inc. Anti-pd-1 antibodies and methods of use
CA3181776A1 (en) * 2020-05-26 2021-12-02 Boehringer Ingelheim International Gmbh Anti-pd-1 antibodies
WO2021247769A1 (en) 2020-06-02 2021-12-09 Dynamicure Biotechnology Llc Anti-cd93 constructs and uses thereof
CN116529260A (zh) 2020-06-02 2023-08-01 当康生物技术有限责任公司 抗cd93构建体及其用途
IL300121A (en) 2020-07-29 2023-03-01 Dynamicure Biotechnology Llc Anti-cd93 constructs and uses thereof
US20250270320A1 (en) * 2020-12-10 2025-08-28 Eutilex Co., Ltd. Anti-pd-1 antibody and uses thereof
WO2022204724A1 (en) 2021-03-25 2022-09-29 Dynamicure Biotechnology Llc Anti-igfbp7 constructs and uses thereof
CN115521379B (zh) * 2021-07-16 2023-12-22 南京吉盛澳玛生物医药有限公司 Pd-1抗体及其用途
CN116589572B (zh) * 2023-06-28 2023-11-10 湖南诺合新生物科技有限公司 一种抗ha标签的单克隆抗体及其应用

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