CN117562947A - 一种治疗急性咽炎及慢性咽炎急性发作的中药组合物及应用 - Google Patents
一种治疗急性咽炎及慢性咽炎急性发作的中药组合物及应用 Download PDFInfo
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Abstract
本发明公开了一种治疗急性咽炎及慢性咽炎急性发作的中药组合物及应用，是由以下重量份的原料药组成的：板蓝根5‑25份、牛蒡子3‑21份、玄参5‑25份、栀子3‑15份、防风2‑12份、桔梗3‑15份、薄荷1‑9份、蝉蜕2‑12份、甘草2‑15份、荆芥2‑15份、黄芩2‑15份。此组方有较强的疏风解表和清热解毒作用，对以咽喉肿痛为主要症状的温热病及外感风热证有较好治疗作用。具有见效快、治疗效果好、标本兼治等优点，对急性咽炎和慢性咽炎急性发作有显著疗效。
Description
技术领域
本发明属于中药技术领域，具体涉及到一种治疗急性咽炎及慢性咽炎急性发作的中药组合物及应用。
背景技术
急性咽炎是一种常见的呼吸系统疾病，临床表现为咽部疼痛、红肿、流脓等症状。而慢性咽炎为咽部粘膜、粘膜下及其淋巴组织的弥漫性炎症，常因上呼吸道急性炎症迁延或过度烟酒辛辣食物刺激而发病，成年人多发，病程长，易反复急性发作。对于这一问题，目前常用的解决方案主要是以药物治疗为主，如抗生素治疗等，但长时间的抗生素类药物治疗容易导致耐药性增强、副作用增加等问题。因此，探索新型的急性咽炎及慢性咽炎急性发作的治疗方法已经成为社会迫切需要解决的问题。
中医治疗急性咽炎及慢性咽炎急性发作具有其独特的优势，某些中药成分具有抗炎、抗病毒、消肿、止痛等多种药理作用，能有效缓解急性咽炎及慢性咽炎急性发作的症状，而且副作用较小。通过中医辨证论治的方式，针对不同的病因、病理机制、症状体现不同的辨证论治，可为急性咽炎及慢性咽炎急性发作治疗提供个性化、精细化治疗。
目前市场上已有治疗急性咽炎及慢性咽炎急性发作的中成药，例如银翘散、复方鱼腥草颗粒、蓝芩颗粒等。然而，这些中成药在治疗急性咽炎及慢性咽炎急性发作方面并非完美的解决方案，因为现有中成药方剂多针对感冒发热症状为主，治疗咽炎的效果不够明显，较难满足更多患者的需要。
为解决现有方剂治疗急性咽炎及慢性咽炎急性发作的不足，提高患者的生活质量，本发明旨在提供一种针对性强、疗效显著、安全性高的新型中药组方。该组方有望成为急性咽炎及慢性咽炎急性发作患者的新选择，丰富现有治疗手段，提高患者的生活质量，并为中医药行业的发展和创新做出贡献。
发明内容
本发明的目的在于提供一种治疗急性咽炎及慢性咽炎急性发作的中药组合物及应用，此组方有较强的疏风解表和清热解毒作用，对以咽喉肿痛为主要症状的温热病及外感风热证有较好治疗作用。本发明具有见效快、治疗效果好、标本兼治等优点，对急性咽炎及慢性咽炎急性发作有显著疗效。
本发明是通过以下技术方案实现的：
一种治疗急性咽炎及慢性咽炎急性发作的中药组合物，是由以下重量份的原料药组成的：板蓝根5-25份、牛蒡子3-21份、玄参5-25份、栀子3-15份、防风2-12份、桔梗3-15份、薄荷1-9份、蝉蜕2-12份、甘草2-15份、荆芥2-15份、黄芩2-15份。
优选的，是由以下重量份的原料药组成的：板蓝根10-20份、牛蒡子6-18份、玄参10-20份、栀子6-12份、防风3-9份、桔梗6-12份、薄荷3-7份、蝉蜕3-9份、甘草3-12份、荆芥3-12份、黄芩6-12份。
最优选的，是由以下重量份的原料药组成的：板蓝根15份、牛蒡子12份、玄参15份、栀子9份、防风6份、桔梗9份、薄荷5份、蝉蜕6份、甘草9份、荆芥9份、黄芩9份。
所述的治疗急性咽炎及慢性咽炎急性发作的中药组合物，其剂型为汤剂、合剂、颗粒剂、片剂、丸剂、散剂、胶囊剂等。以汤剂为例：取各原料药放入容器内，加水10倍量，文火加热一小时，滤过。滤渣加10倍量水，再次文火加热一小时，滤过，两次滤液合并浓缩至300ml，口服，一日二次，每次150ml。
本发明提供的中药组合物具有清热解毒，消肿利咽的功效，主治风热喉痹，对急性咽炎及慢性咽炎急性发作具有显著疗效，具有见效快、治疗效果好、标本兼治等优点。方中板蓝根、牛蒡子、玄参清热解毒，消肿利咽为君药；栀子、黄芩清热泻火为臣药；荆芥、防风、薄荷、蝉蜕、桔梗疏风散邪，祛痰利咽为佐药；此方寒热并用，甘草调和诸药为使药。
具体实施方式
下面结合实施例对本发明作进一步的说明。
实施例1、制备治疗急性咽炎及慢性咽炎急性发作的中药组合物
配方为：板蓝根15克、牛蒡子12克、玄参15克、栀子9克、防风6克、桔梗9克、薄荷5克、蝉蜕6克、甘草9克、荆芥9克、黄芩9克。
制备方法为：取各原料药放入容器内(薄荷后下)，加水10倍量，文火加热一小时，滤过。滤渣加10倍量水，再次文火加热一小时，滤过，两次滤液合并浓缩至300ml，口服，一日二次，每次150ml。
实施例2、制备治疗急性咽炎及慢性咽炎急性发作的中药组合物
配方为：板蓝根750克、牛蒡子600克、玄参750克、栀子450克、防风300克、桔梗450克、薄荷250克、蝉蜕300克、甘草450克、荆芥450克、黄芩450克。
制备方法为：将上述药物(薄荷后下)放入容器内，加水10倍量，浸泡1小时使药物润透，煎煮二次，每次1.5小时，合并煎液放入浓缩锅浓缩至适量，加入白砂糖及尼泊金乙酯，搅匀，浓缩至5000ml，静置48小时，吸取上清液，灌装封口，115℃高压灭菌30分钟，即得。口服，一日二次，每次50ml。
实施例3、制备治疗急性咽炎及慢性咽炎急性发作的中药组合物
配方为：板蓝根750克、牛蒡子600克、玄参750克、栀子450克、防风300克、桔梗450克、薄荷250克、蝉蜕300克、甘草450克、荆芥450克、黄芩450克。
制备方法为：将上述药物(薄荷后下)放入容器内，加水10倍量浸泡1小时使药物润透，煎煮2次，第一次1.5小时，第二次1小时，合并煎液，滤过，滤液浓缩至约4000ml，放冷，加入95％乙醇，搅匀，至含醇量至70％，静置72小时，取上清液回收乙醇，乙醇回收完毕后，减压浓缩至约4000ml，加入已溶解的白砂糖及尼泊金乙酯，加水至5000ml，搅匀，分装250ml每瓶，封口，115℃高压灭菌30分钟，即得。口服，一日二次，每次50ml。
实施例4、制备治疗急性咽炎及慢性咽炎急性发作的中药组合物
配方为：板蓝根375克、牛蒡子300克、玄参375克、栀子225克、防风150克、桔梗225克、薄荷125克、蝉蜕150克、甘草225克、荆芥225克、黄芩225克。
制备方法为：将上述药物(薄荷后下)放入容器内，加水10倍量，浸泡1小时使药物润透，煎煮二次，每次1.5小时，合并煎液放入浓缩锅浓缩至适量，加入适量蔗糖与糊精，混匀，制成颗粒，干燥，制成1000克，分装成100袋，每袋10克。口服，一日二次，每次2袋。
实施例5、治疗急性咽炎及慢性咽炎急性发作的中药组合物的临床评价
临床资料
一般资料：咽炎患者共207例，其中，男106例，女103例，年龄22～69岁，平均35岁。急性咽炎107例，慢性咽炎急性发作100例。
诊断标准：参照《中华人民共和国中医药行业标准-中医耳鼻喉科病证诊断疗效标准》(ZY/T 001.6-94)。
①咽痛，病情重者有吞咽困难及恶寒、发热等症。
②咽部检查：粘膜充血、肿胀，咽侧索红肿，咽后壁淋巴滤泡增生。
③起病较急，病程较短。
④应与乳蛾、急喉风鉴别。
治疗方案：治疗组服用实施例1的药物，每日二次，服用三日后观察统计疗效。
疗效评价标准：参照《中华人民共和国中医药行业标准-中医耳鼻喉科病证诊断疗效标准》(ZY/T 001.6-94)。
①治愈：咽痛、发热等症状消失，咽部检查恢复正常。
②好转：咽痛及咽部肿胀明显减轻。
③未愈：咽部症状和体征无明显变化。
症状评价指标与治疗结果：如表1、2所示。
表1症状评价指标
| 症状 | 无 | 轻微 | 严重 |
| 咽痛或吞咽痛 | 1 | 2 | 3 |
| 咽部肿胀充血 | 1 | 2 | 3 |
| 灼热感 | 1 | 2 | 3 |
| 恶寒发热 | 1 | 2 | 3 |
| 咽部干燥、痒 | 1 | 2 | 3 |
| 异物感 | 1 | 2 | 3 |
表2急性咽炎治疗前后症状评分对比
| 症状 | 治疗前 | 治疗后 | P值 |
| 咽痛或吞咽痛 | 2.38±0.93 | 1.19±0.40 | <0.01 |
| 咽部肿胀充血 | 2.59±0.72 | 1.03±0.18 | <0.01 |
| 灼热感 | 1.43±0.65 | 1.17±0.38 | <0.05 |
| 恶寒发热 | 1.26±0.48 | 1.09±0.28 | <0.05 |
| 咽部干燥、痒 | 1.53±0.65 | 1.28±0.45 | <0.05 |
| 异物感 | 1.52±0.88 | 1.22±0.56 | <0.05 |
| 总评价 | 10.71±0.65 | 6.98±0.74 | <0.01 |
表3慢性咽炎急性发作治疗前后症状评分对比
| 症状 | 治疗前 | 治疗后 | P值 |
| 咽痛或吞咽痛 | 2.07±0.89 | 1.22±0.42 | <0.01 |
| 咽部肿胀充血 | 2.24±0.64 | 1.20±0.41 | <0.01 |
| 灼热感 | 1.44±0.50 | 1.24±0.43 | <0.05 |
| 恶寒发热 | 1.56±0.50 | 1.15±0.36 | <0.01 |
| 咽部干燥、痒 | 1.89±1.00 | 1.30±0.46 | <0.01 |
| 异物感 | 1.76±0.67 | 1.46±0.50 | <0.05 |
| 总评价 | 10.93±1.29 | 7.57±1.24 | <0.01 |
从表2、3可以看出，治疗前后各症状对比均有显著性差异，各项指标P值均小于0.05；总评价对比P值小于0.01，说明本发明的药物对急性咽炎及慢性咽炎急性发作有良好的治疗效果。治疗过程中未发现有不良反应。
Claims (5)
1.一种治疗急性咽炎及慢性咽炎急性发作的中药组合物，其特征在于，由以下重量份的原料药组成：板蓝根5-25份、牛蒡子3-21份、玄参5-25份、栀子3-15份、防风2-12份、桔梗3-15份、薄荷1-9份、蝉蜕2-12份、甘草2-15份、荆芥2-15份、黄芩2-15份。
2.根据权利要求1所述的治疗急性咽炎及慢性咽炎急性发作的中药组合物，其特征在于，由以下重量份的原料药组成：板蓝根10-20份、牛蒡子6-18份、玄参10-20份、栀子6-12份、防风3-9份、桔梗6-12份、薄荷3-7份、蝉蜕3-9份、甘草3-12份、荆芥3-12份、黄芩6-12份。
3.根据权利要求1所述的治疗急性咽炎及慢性咽炎急性发作的中药组合物，其特征在于，由以下重量份的原料药组成：板蓝根15份、牛蒡子12份、玄参15份、栀子9份、防风6份、桔梗9份、薄荷5份、蝉蜕6份、甘草9份、荆芥9份、黄芩9份。
4.根据权利要求1～3任一项所述的治疗急性咽炎及慢性咽炎急性发作的中药组合物在制备治疗咽炎药物中的应用。
5.根据权利要求4所述的应用，其特征在于，所述治疗咽炎药物的剂型为汤剂、合剂、颗粒剂、片剂、丸剂、散剂或胶囊剂。
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