CN117503819A - Composition for assisting in reducing blood pressure and preparation method thereof - Google Patents
Composition for assisting in reducing blood pressure and preparation method thereof Download PDFInfo
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- CN117503819A CN117503819A CN202311660176.5A CN202311660176A CN117503819A CN 117503819 A CN117503819 A CN 117503819A CN 202311660176 A CN202311660176 A CN 202311660176A CN 117503819 A CN117503819 A CN 117503819A
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- gynostemma pentaphylla
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- 230000036772 blood pressure Effects 0.000 title claims abstract description 30
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- 230000001603 reducing effect Effects 0.000 title abstract description 15
- 238000002360 preparation method Methods 0.000 title description 4
- 235000002956 Gynostemma pentaphyllum Nutrition 0.000 claims abstract description 29
- 244000040691 Plumeria rubra f. acutifolia Species 0.000 claims abstract description 15
- 235000003417 Plumeria rubra f acutifolia Nutrition 0.000 claims abstract description 14
- 241001065361 Gynostemma Species 0.000 claims description 28
- 241000219784 Sophora Species 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 5
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 5
- 229930182490 saponin Natural products 0.000 claims description 5
- 150000007949 saponins Chemical class 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 244000046101 Sophora japonica Species 0.000 claims description 2
- 235000010586 Sophora japonica Nutrition 0.000 claims description 2
- 238000003809 water extraction Methods 0.000 claims description 2
- 244000126002 Ziziphus vulgaris Species 0.000 claims 1
- 235000008529 Ziziphus vulgaris Nutrition 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 2
- 235000013376 functional food Nutrition 0.000 abstract description 2
- 241000628997 Flos Species 0.000 abstract 1
- 240000006509 Gynostemma pentaphyllum Species 0.000 abstract 1
- 230000004531 blood pressure lowering effect Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 22
- 206010020772 Hypertension Diseases 0.000 description 9
- 230000000694 effects Effects 0.000 description 6
- 230000000638 stimulation Effects 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 5
- 230000035487 diastolic blood pressure Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 3
- 230000035488 systolic blood pressure Effects 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 241000700159 Rattus Species 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000003255 drug test Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000219104 Cucurbitaceae Species 0.000 description 1
- 208000007530 Essential hypertension Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 201000004239 Secondary hypertension Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- General Health & Medical Sciences (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of health-care food, functional food or medicines, and relates to a composition with an auxiliary blood pressure reducing effect, which comprises, by weight, 5-20 parts of gynostemma pentaphylla, 200-500 parts of black dates and 1-10 parts of pagodatree flower. The composition has good blood pressure lowering effect by using fructus Jujubae and herba Gynostemmatis and flos Sophorae Immaturus as auxiliary materials.
Description
Technical Field
The invention belongs to the technical field of functional foods, health-care foods or medicines, and particularly relates to a composition for assisting in reducing blood pressure and a preparation method thereof.
Background
Hypertension (hypertension) refers to a clinical syndrome which is characterized by an increase in the blood pressure of the human circulatory arteries (systolic and/or diastolic blood pressure) (systolic pressure. Gtoreq.140 mmHg, diastolic pressure. Gtoreq.90 mmHg), and can be accompanied by functional or organic impairment of organs such as heart, brain, kidneys, etc. Hypertension is the most common chronic disease, and is also the most important risk factor for cardiovascular and cerebrovascular diseases, and it is classified into primary hypertension and secondary hypertension.
The blood pressure criteria recommended by the world health organization (wha) are: systolic pressure is between 141 and 159mmHg (18.9 and 21.2 kPa), diastolic pressure is between 91 and 94mmHg (12.1 and 12.5 kPa), and is critical hypertension. In diagnosing hypertension, it is necessary to measure blood pressure several times, and at least two times of diastolic blood pressure is measured with an average value of 90mmHg (12.0 kPa) or more to confirm hypertension. The main method for treating hypertension is to treat hypertension in a single pure blood pressure reducing mode, and the phenomenon of repeated rising of blood pressure can occur once the medicine is stopped although a certain effect can be achieved.
Disclosure of Invention
The invention aims to provide a composition for assisting in reducing blood pressure and a preparation method thereof.
The technical scheme of the invention is as follows:
a composition with auxiliary blood pressure lowering function is characterized by comprising, by mass, 5-20 parts of gynostemma pentaphylla, 200-500 parts of black dates and 1-10 parts of sophora flowers.
Preferably, the gynostemma pentaphylla is gynostemma pentaphylla extract with the total saponin content of 20-30%.
Further preferably, the gynostemma pentaphylla is a gynostemma pentaphylla extract with the total saponin content of 30%.
Preferably, the black date is a black date extract with a water concentration ratio of 20:1.
Further preferably, the pagodatree flower is a pagodatree flower extract with a water extraction concentration ratio of 10:1.
Further preferably, the weight ratio of the gynostemma pentaphylla, the black date and the pagodatree flower is (1-5): (50-60): 1.
still more preferably, the weight ratio of gynostemma pentaphylla, black date and pagodatree flower is 2:60:1.
The method of the composition is characterized by comprising the step of uniformly mixing gynostemma pentaphylla, black date and pagodatree flower.
The technical scheme of the invention has the following advantages:
1. the composition with auxiliary blood pressure reducing function provided by the invention adopts gynostemma pentaphylla, black date and pagodatree flower as main raw materials, wherein gynostemma pentaphylla is sweet and bitter in taste, cold in nature and enters lung, spleen and kidney channels, is the whole herb of gynostemma pentaphylla belonging to cucurbitaceae, and has the effects of clearing heat and detoxicating, relieving cough and eliminating phlegm, strengthening spleen and tonifying qi, nourishing heart and soothing nerves; the black dates are sweet in taste and flat in nature, enter spleen and stomach channels, have the effects of tonifying spleen and stomach and nourishing yin and blood, and are used for treating various symptoms caused by deficiency of middle-jiao and weakness of spleen and stomach; the pagodatree flower is the dried flower and bud of the leguminous plant pagodatree, has bitter and slightly cold property, enters liver and large intestine channel, and has the effects of cooling blood, stopping bleeding, clearing liver and purging fire. The invention uses the black date and the gynostemma pentaphylla and the pagodatree flower as auxiliary materials, and has good blood pressure reducing effect.
Detailed Description
For the purpose of making the technical solution and advantages of the present invention more apparent, embodiments of the present invention will be described in further detail below. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the disclosure herein, are intended to be within the scope of the present disclosure.
The examples do not identify specific experimental procedures or conditions, which may be followed by procedures or conditions that are routine in the art described in the literature. All reagents were not manufacturer-identified and were conventional reagent products commercially available. Sophora flower is purchased from Jiahe biotechnology Co., ltd, shaanxi, model 10:1. Gynostemma pentaphylla is purchased from the Ankang Yuan medicine technology Co., ltd, and the total saponin content is 30%. Black date extract was purchased from Shaanxi North Biotechnology Co.Ltd. In specification at 20:1.
Example 1
The embodiment provides a composition for assisting in reducing blood pressure, which comprises 5 parts of gynostemma pentaphylla, 500 parts of black date and 1 part of pagodatree flower, and is prepared by weighing and uniformly mixing according to weight.
Example 2
The embodiment provides a composition for assisting in reducing blood pressure, which comprises 20 parts of gynostemma pentaphylla extract, 200 parts of black date extract and 10 parts of sophora flower extract.
Example 3
The embodiment provides a composition for assisting in reducing blood pressure, which comprises 10 parts of gynostemma pentaphylla extract, 300 parts of black date extract and 5 parts of sophora flower extract.
Example 4
The embodiment provides a composition for assisting in reducing blood pressure, which comprises 15 parts of gynostemma pentaphylla extract, 450 parts of black date extract and 7.5 parts of sophora flower extract.
Example 5
The embodiment provides a composition for assisting in reducing blood pressure, which comprises 12 parts of gynostemma pentaphylla extract, 360 parts of black date extract and 6 parts of sophora flower extract, and is prepared by weighing and uniformly mixing the materials according to weight.
Comparative example 1
This comparative example provides a composition for aiding in lowering blood pressure, which differs from example 3 in that only 315 parts of gynostemma pentaphylla extract is included.
Comparative example 2
This comparative example provides a composition for aiding in lowering blood pressure, which differs from example 3 in that it includes only 315 parts of the black date extract.
Comparative example 3
This comparative example provides a composition for aiding in lowering blood pressure, which differs from example 3 in that only 315 parts of the extract of Sophora japonica flower are included.
Comparative example 4
This comparative example provides a composition for assisting in lowering blood pressure, which is different from example 3 in that it comprises 200 parts of gynostemma pentaphylla extract, 300 parts of black date extract and 5 parts of sophora flower extract.
Experimental example 1 blood pressure reduction experiment
The compositions obtained in examples 1-5 and comparative examples 1-4.
The experimental method comprises the following steps:
healthy SD rats weighing 180 g.+ -.5 g, SD rats were randomly divided into a blank, an experimental control, a example 1, a example 2, a example 3, a example 4, a example 5, a comparative example 1, a comparative example 2, a comparative example 3 and a comparative example 4, each group being 10.
The blank control group was not treated; the experimental control group, the example 1 group, the example 2 group, the example 3 group, the example 4 group, the example 5 group, the comparative example 1 group, the comparative example 2 group, the comparative example 3 group and the comparative example 4 group are subjected to compound stimulation by bell sound and horn sound, defensive condition reflection is respectively established, after the condition reflection is basically formed and slightly consolidated, the bell sound and the horn sound are subjected to compound stimulation, the action time is prolonged to 30-60s, and stronger electric stimulation (about 50 v) is given in the time, so that animals are in a tension state with unstable fleeing, the interval is 1-2min, the stimulation is repeated for 1-2 times every day, 12-30 stimulations are given for two weeks, and a hypertension model group is constructed.
The experimental process comprises the following steps:
(1) Distilled water is drunk by a blank control group and an experimental control group every day; example 1, example 2, example 3, example 4, example 5, comparative example 1, comparative example 2, comparative example 3 and comparative example 4 were each administered with the corresponding composition at a dose of 3.6mg/kg for 30 consecutive days, then blood pressure was measured 1 time every 4 days, and the total measured 4 times were averaged, and the test results are shown in table 1 below:
TABLE 1
As shown by the experimental results of the table, the average value after the experiment of the medicines in the examples 1-5 is compared with the average value after the stimulation, and P is less than 0.05, so that the composition obtained in the examples 1-5 has the efficacy of reducing blood pressure; and the average blood pressure after 10d of stopping the administration of the medicine in the examples 3-5 is compared with the average blood pressure after the medicine test, and the P is more than 0.05, so that the medicine has good effect of maintaining the blood pressure to be stable. And the average value of the drug test of comparative examples 1-4 is less than 0.5 compared with the average value of the drug test of example 3, which shows that the components of the invention cooperate to achieve the effect of reducing blood pressure.
It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. While still being apparent from variations or modifications that may be made by those skilled in the art are within the scope of the invention.
Claims (8)
1. A composition with auxiliary blood pressure lowering function is characterized by comprising, by mass, 5-20 parts of gynostemma pentaphylla, 200-500 parts of black dates and 1-10 parts of sophora flowers.
2. The composition of claim 1, wherein the gynostemma pentaphylla is a gynostemma pentaphylla extract with a total saponin content of 20-30%.
3. The composition of claim 2, wherein the gynostemma pentaphylla is a gynostemma pentaphylla extract having a total saponin content of 30%.
4. The composition of claim 1, wherein the black date is a black date extract having a water concentrate ratio of 20:1.
5. The composition of claim 1, wherein the pagodatree flower is a pagodatree flower extract with a water extraction concentration ratio of 10:1.
6. The composition of claim 1, wherein the weight ratio of gynostemma pentaphylla, black date and pagodatree flower is (1-5): (50-60): 1.
7. the composition of claim 6, wherein the weight ratio of gynostemma pentaphylla, black date and pagodatree flower is 2:60:1.
8. A method of preparing the composition of any one of claims 1-7, comprising the step of mixing gynostemma pentaphylla, zizyphus jujuba and sophora japonica uniformly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311660176.5A CN117503819A (en) | 2023-12-06 | 2023-12-06 | Composition for assisting in reducing blood pressure and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311660176.5A CN117503819A (en) | 2023-12-06 | 2023-12-06 | Composition for assisting in reducing blood pressure and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117503819A true CN117503819A (en) | 2024-02-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311660176.5A Withdrawn CN117503819A (en) | 2023-12-06 | 2023-12-06 | Composition for assisting in reducing blood pressure and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117503819A (en) |
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2023
- 2023-12-06 CN CN202311660176.5A patent/CN117503819A/en not_active Withdrawn
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20240206 |