CN109172729A

CN109172729A - A kind of lung-heat clearing plaster and preparation method thereof

Info

Publication number: CN109172729A
Application number: CN201811311937.5A
Authority: CN
Inventors: 杨靖; 罗光雄; 李光
Original assignee: Yunnan Quzhong Biomedical Technology Co Ltd
Current assignee: Yunnan Quzhong Biomedical Technology Co Ltd
Priority date: 2018-11-06
Filing date: 2018-11-06
Publication date: 2019-01-11
Anticipated expiration: 2038-11-06
Also published as: CN109172729B

Abstract

The invention discloses a kind of lung-heat clearing plasters and preparation method thereof, the various raw material components and its mass parts ratio that the medicine includes are as follows: 35~45g of the root bark of white mulberry, 35~45g of radix scutellariae, 18~23g of the coptis, 48~55g of semen armeniacae amarae, capital 48~55g of the tuber of pinellia, 45~55g of Poria cocos, 48~56g of fritillaria thunbergii, 35~45g of dried orange peel, 48~55g of lepidium seed, 45~55g of semen brassicae, 48~58g of hawthorn, build 48~58g of song, 35~45g of schizonepeta, 35~45g of radix saposhnikoviae, 25~30g of Radix Glycyrrhizae, 35~45g of cape jasmine, 255~263g of Radix Astragali, 72~80g of Radix Salviae Miltiorrhizae, 48~55g of perilla seed, 35~45g of 48~56g of radish seed and Schisandra chinensis.Preparation method includes: in addition to building song, and after remaining 20 kinds of component is mixed plus boiling mentions three times；The supernatant after the filtrate after mentioning merges, stands will be boiled and be condensed into clear cream；It bent fine powder will be built will be added in clear cream and thick paste is made；It can be prepared by finished product after sugar refinery, menthol is added in thick paste.The present invention is a kind of good drug efficacy, quick, Small side effects, oral medication convenient to take.

Description

A kind of lung-heat clearing plaster and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of lung-heat clearing plaster and preparation method thereof.

Background technique

Chinese medicine thinks that lung being a delicate viscus does not allow foreign matter intolerant to fever and chills.Lung position highest, communicates with the outside world, affection of exogenous wind-cold summer-heat and damp It is scorching fire six evils enter from fur or mouth and nose, most easily violate lung and it is sick；Other viscera lesions are also often involved in lung.Lung is and the external world Environment contacts most frequent organ, and is easiest to accumulation toxin, and the daily respiratory capacity of people is about 1000 liters of air, empty Various harmful substances in gas also lead to various respiratory diseases and pulmonary disease into lung by throat therewith.Clearing lung-heat, Refer to a kind of method for treating lung-heat yin-deficiency.It is chiefly used in deficiency of Yin sore-throat and diphtheria, epersalgia cough, dry cough lacks phlegm, the accidental trace of blood, noon Low-heat afterwards, sensation of oppression and faint pain in the chest, the red equal diseases of dry tongue.Phlegm is divided into cold phlegm, wind phlegm, hot phlegm, damp phlegm and sticky sputum etc., chronic cough by Chinese medicine Most commonly seen with cough variant asthma, the disease is to cough as only symptom, therefore clinical characters lack specificity, and misdiagnosis rate is very It is high.Wherein 50~80% cough variant asthma children can develop as typical asthma, 10~33% adult cough variant Asthma can also develop as typical asthma, therefore the early diagnosis of cough variant asthma and early treatment are very to prevention of asthma disease Important.Currently on the market, although there are many clearing lung-heat, the Chinese patent drug of cough-relieving, Western medicine, generally existing there are clearing lung-heat, prevention lung Portion's illness therapeutic effect is unobvious, and taking effect, slower, being discontinued is easy recurrent exerbation, is not easy the problems such as taking for a long time.Therefore, it grinds System develop a kind of preparation process is simple, therapeutic effect is significant, it is quick, uneasy to recur, have no toxic side effect, be convenient to take, treatment Lung-heat clearing plaster at low cost and preparation method thereof is desirability.

Summary of the invention

In order to solve the problems, such as background technique, the purpose of the present invention is to provide a kind of preparation processes simply, controls Therapeutic effect is significant, it is quick, uneasy to recur, have no toxic side effect, be convenient to take, the lung-heat clearing plaster and its preparation side that treatment cost is low Method.

The various raw material components and its mass parts ratio of lung-heat clearing plaster of the present invention are as follows: 35~45g of the root bark of white mulberry, radix scutellariae 35~ 45g, 18~23g of the coptis, 48~55g of semen armeniacae amarae, capital 48~55g of the tuber of pinellia, 45~55g of Poria cocos, 48~56g of fritillaria thunbergii, dried orange peel 35 ~45g, 48~55g of lepidium seed, 45~55g of semen brassicae, 48~58g of hawthorn, 48~58g of song, 35~45g of schizonepeta, radix saposhnikoviae are built 35~45g, 25~30g of Radix Glycyrrhizae, 35~45g of cape jasmine, 255~263g of Radix Astragali, 72~80g of Radix Salviae Miltiorrhizae, 48~55g of perilla seed, radish 35~45g of son 48~56g and Schisandra chinensis.

The preparation method of the lung-heat clearing plaster, which is characterized in that include the following steps

1. weighing following raw material by weight: 35~45g of the root bark of white mulberry, 35~45g of radix scutellariae, 18~23g of the coptis, semen armeniacae amarae 48~ 55g, capital 48~55g of the tuber of pinellia, 45~55g of Poria cocos, 48~56g of fritillaria thunbergii, 35~45g of dried orange peel, 48~55g of lepidium seed, semen brassicae 45~55g, 48~58g of hawthorn, build 48~58g of song, 35~45g of schizonepeta, 35~45g of radix saposhnikoviae, 25~30g of Radix Glycyrrhizae, cape jasmine 35~ 45g, 255~263g of Radix Astragali, 72~80g of Radix Salviae Miltiorrhizae, 35~45g of 48~55g of perilla seed, 48~56g of radish seed and Schisandra chinensis；

2. raw material disposal: Qu Jinhang will be built and individually crushed, 60~80 meshes are crossed and obtain building bent fine powder, the capital tuber of pinellia is individually smashed to pieces Fragment is spare；

3. first time heating extraction: capital tuber of pinellia fragment, lepidium seed, semen brassicae and the perilla seed and the root bark of white mulberry, Huang bound up with gauze A kind of reed mentioned in ancient books, the coptis, semen armeniacae amarae, Poria cocos, fritillaria thunbergii, dried orange peel, hawthorn, schizonepeta, radix saposhnikoviae, Radix Glycyrrhizae, cape jasmine, Radix Astragali, Radix Salviae Miltiorrhizae, radish seed and five After the mixing of taste, the water that 7~10 times of amounts are added impregnates 0.5~1h, then carries out first time heating extraction, then carries out first time mistake Filtrate is collected in filter, and the time of first time heating extraction is 1~1.5h；

4. second of heating extraction: the water of 5~6 times of amounts being added into filtered filter residue for the first time, carries out second of heating and mentions It takes, the time of the second heating extraction is 1~1.5h, then carries out second and filters, collects filtrate；

5. third time heating extraction: the water of 5~6 times of amounts being added into second of filtered filter residue, carries out third time heating and mentions It takes, the time of third heating extraction is 1~1.5h, then carries out third time filtering, collects filtrate；

6. concentration: first merge first time filtering, second of filtering and the filtered filtrate of third time to obtain mixed liquor, then Mixed liquor is stood and filters sediment after placing 15~20h, takes supernatant, it is 75~80 that supernatant heating, which is concentrated into temperature, DEG C, relative density be 1.25~1.3 clear cream；

7. plus building song: building step is 2. obtained bent fine powder and be added to step 6. in clear cream obtained, keep after mixing evenly micro- 0.5~1h is boiled into thick paste；

8. preparing sugar refinery: first weighing 15~20kg of sucrose, then 8~12kg water and 15~20g tartaric acid are added in sucrose, add After heat of solution, keep 110~115 DEG C of the slightly boiled 1.5~2h of temperature that sugar refinery is made；

9. mixing cream processed: after first dissolving the menthol of 18~22g with ethyl alcohol, then being added and pass through in step 7. thick paste obtained Step 8. sugar refinery obtained, the compound of 1000g is made in concentration after mixing, and compound is cooled to 60 DEG C hereinafter, existing again later Be added in compound and dissolve complete menthol, dispensed after mixing evenly, sterilize after can be prepared by lung-heat clearing plaster finished product.

Each raw material component in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine It carries.It is raw material that the present invention, which selects one of the most common Chinese medicine, gives full play to the pharmacological effect of each component:

The root bark of white mulberry: it is sweet in flavor, pungent, cold in nature, there is the effect of removing heat from lung and relieving asthma, inducing diuresis for removing edema, for treating dyspnea and cough due to lung-heat phlegm, water drink Stop lung, turgor asthma urgency, oedema, tinea pedis, difficult urination；

Radix scutellariae: it is bitter, cold in nature, there are heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention and other effects.Cure mainly warm heat disease, upper respiratory tract sense The diseases such as dye, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, threatened abortion, hypertension, carbuncle swells furuncle sore；

The coptis: taste is extremely bitter, has heat-clearing and damp-drying drug, the effect of purging fire for removing toxin, cures mainly damp and hot feeling of fullness, vomits acid regurgitation, dysentery, jaundice, Unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache are quenched one's thirst, the diseases such as carbuncle swells furunculosis；

Semen armeniacae amarae: warm-natured, bitter, it is slightly poisonous, there is the effect of relieving cough and asthma sending down abnormally ascending, relax bowel and defecation, for treating cough gas The diseases such as asthma, fullness sensation in chest abundant expectoration, the withered, dry constipation of intestines of deficiency of blood saliva；

The capital tuber of pinellia: for the processed product of the tuber of pinellia, acrid flavour is flat, and raw slightly cold, ripe temperature is toxic, the effect of having invigorating the spleen preventing or arresting vomiting, remove sputum；

Poria cocos: property is sweet, light, puts down, return heart, spleen, kidney channel have the effect of clearing damp and promoting diuresis, bowl spares invigorating the spleen, antitoxic heart-soothing and sedative, cure mainly water Swelling full, the anorexia and loose stool of difficult urination, the insufficiency of the spleen with overabundance of dampness, palpitation and severe palpitation, insomnia forgetfulness etc.；

Fritillaria thunbergii: it is bitter in taste, it is sweet, it is slightly cold, there is the effect of clearing heat and eliminating phlegm, powder detoxifcation, cure mainly and control cough due to wind-heat evil, pulmonary abscess larynx Numbness, scrofula, sore swollen toxin etc.；

Dried orange peel: the effects of gas is fragrant and bitter, has and drives away internal moisture, regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm cures mainly incoordination between the spleen and the stomach, chest Distention and fullness in the abdomen, do not feel like eating, cough ant phlegm etc.；

Lepidium seed: acrid flavour, hardship, it is cold in nature, enter lung, bladder, large intestine channel, there is purging the lung of pathogenic fire sending down abnormally ascending, eliminating phlegm and relieving asthma, inducing diuresis for removing edema expels the heat-evil The effect of by heresy, cures mainly the dyspnea and cough with excessive sputum of sputum stop up lung, pulmonary abscess, oedema, chest and abdomen ponding, difficult urination, chronic pulmonary heart Disease, the asthma of heart failure is swollen, ulcer malignant sore, scrofula tuberculosis etc.；

The effect of semen brassicae: odorless, acrid flavour is peppery, has warm lung slit phlegm benefit gas, and mammary gland dissipating bind is removed obstruction in channels to relieve pain, cures mainly cold phlegm asthma cough, Distending pain in the chest and hypochondrium, the stagnant channels and collaterals of phlegm, joint numbness, pain, phlegm-damp oozing in the body, negative subcutaneous ulcer pyogenic infections etc.；

Hawthorn: sour sweet, tepor enters spleen, stomach, Liver Channel, has reducing blood lipid, blood pressure, heart tonifying, arrhythmia, spleen benefiting and stimulating the appetite, helps digestion The effect of changing stagnant, phlegm reduction of blood circulation promoting；

Build song: gas faint scent, taste are micro-, have inducing diaphoresis and it is middle the effect of, cure mainly fever and chills headache, in food resistance, vomiting turgor etc.；

Schizonepeta: acrid flavour, slight bitter, slightly warm in nature enter lung, Liver Channel, have the effect of town phlegm, wind-dispelling, cool blood, cure mainly influenza, head Ache fever and chills sweating, vomiting etc.；

The effect of radix saposhnikoviae: acrid flavour, sweet, slightly warm in nature return bladder, lung, spleen, Liver Channel, have and expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, relieving convulsion, it is main Control exogenous disease exterior syndrome, rubella itch, rheumatic arthralgia, tetanus just, the insufficiency of the spleen with overabundance of dampness；

Radix Glycyrrhizae: clearing heat and detoxicating, expelling phlegm and arresting coughing, stomach duct and abdomen etc. are cured mainly；

Cape jasmine: have the effects that protect liver, cholagogue, decompression, calmness, hemostasis, detumescence.It is usually used in treating icteric liver in tcm clinical practice Inflammation, bruise, hypertension, diabetes etc.；

Radix Astragali: it is warm-natured, it is sweet in flavor, there is the effect of invigorating qi for strengthening superficies, pus draining and toxin expelling, diuresis, myogenic, it is de- to cure mainly deficiency of vital energy and acking in strength, chronic diarrhea Long disunion of anus, spontaneous perspiration, oedema, sub-official prolapses, chronic rephrilis protinuria, diabetes, the open sore part etc.；

The effect of Radix Salviae Miltiorrhizae: bitter, slightly cold, converge to heart and liver channels have promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness and restlessness, cool blood to disappear carbuncle, it is main Control chest impediment and cardialgia, stomach duct and abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhea menostasis, sore swell and ache curative；

Perilla seed: its effective component is perilla oil, has the effect of reducing blood lipid, blood pressure lowering, anti-cancer and cancer-preventing, cures mainly cough against phlegm Asthma；

Radish seed: pungent, sweet and neutral, return lung, spleen, stomach meridian have the effect of help digestion and eliminate flatulence, lowering the adverse-rising QI to resolve phlegm, cure mainly retention of food and drink, gastral cavity Abdominal distention and pain, constipation, stagnation and diarrhea, phlegm choking, dyspnea and cough etc.；

Schisandra chinensis: distinctive bitter, peppery, sour, sweet tea, fiber crops cure mainly astringing lung-QI, and nourshing kidney is promoted the production of body fluid, and receive sweat, arresting seminal emission.It controls the deficiency syndrome of the lung to breath with cough, dry Make yearningly, spontaneous perspiration, night sweat, internal lesion caused by overexertion is thin thin, emission, protracted dysentery and diarrhea etc..

The present invention is inventor by long-term and arduous research and practice, and one kind of acquisition has clearing lung-heat, resolving sputum, stops Cough, the composite formula relievingd asthma, it is larger with the difference of existing formula, it can be safe and efficiently for treating cough against breather gas Slightly, the sticky color of abundant expectoration is yellow, difficult expectoration, and irritable feverish sensation in chest, dry throat urinates the patient's condition such as red or constipation.

Discrimination method to this product ingredient is:

(1) 15 g of this product is taken, 15 mL of water is added to dilute, 45 mL of n-butanol is saturated with water and mixes, ultrasonic extraction 30 minutes.Divide and takes just Butanol layer is washed 3 times with ammonia solution, uses ammonia solution 20mL every time, is divided and is taken n-butanol liquid, is evaporated, and residue makes to dissolve with 5 mL methanol, As test solution.Gardenoside reference substance separately is taken, adds methanol that the solution that every 1 mL contains 1 mg is made, as reference substance solution. It is tested according to thin-layered chromatography (Chinese Pharmacopoeia), draws above two 3 uL of test sample, put respectively on same silica gel g thin-layer plate, It is to be unfolded on solvent with chloroform-acetone-water-formic acid (4:6:0.5:0.5), takes out, dry, sprays with 10% sulfuric acid ethyl alcohol It is clear to be heated to spot development at 105 DEG C for test solution.In sample chromatogram, on reference substance chromatography corresponding position, identical face is shown The spot of color.

(2) test liquid under identification (1) item is taken separately to take Berberine hydrochloride reference substance as test solution, methanol is added to dissolve The solution that every 1mL contains 0.5 mg is made, as reference substance solution.It tests, draws above-mentioned according to thin-layered chromatography (Chinese Pharmacopoeia) Two kinds of 2 uL of test solution are put respectively on same silica gel g thin-layer plate, are tried with the dense ammonia of chloroform-acetate-methanol- Liquid (4:1:2:0.25) is solvent expansion, takes out, dries, inspect in ultraviolet lamp (365 nm).In sample chromatogram, with On reference substance chromatography corresponding position, the phosphor dot of same color is shown.

(3) 15 g of this product is taken, after adding 60 mL of water to dilute, 0.5 mL of hydrochloric acid is added to shake, ultrasonic extraction 30 minutes, is filtered, filter Liquid is set separatory funnel and is extracted with ethyl acetate 2 times, and 50 mL, combined ethyl acetate liquid are evaporated every time, and it is molten that residue adds methanol 5mL to make Solution, as test solution.Tanshin polyphenolic acid B reference substance separately is taken, adds methanol that the solution that every 1 mL contains 1 mg is made, it is molten as reference substance Liquid.It is tested according to thin-layered chromatography (Chinese Pharmacopoeia), draws above two 3~5 uL of test sample, put respectively in same silica G thin layer It is solvent expansion with chloroform-acetic ether-methanoic acid (5:5:1) on plate, taking-up is dried, and spray is tried with 9% ferric trichloride Liquid, it is clear to spot development to dry.In sample chromatogram, on reference substance chromatography corresponding position, the spot of same color is shown.

(4) 15 g of this product is taken, ammonification 20 mL of test solution dilution is stood overnight, surpassed with adding 40 mL of water-saturated n-butanol to mix Sound extracts 30 minutes, divides and takes n-butanol liquid, is evaporated, residue methanol 5mL makes to dissolve, as test solution.Separately take Radix Astragali first Glycosides reference substance adds methanol that the solution that every 1 mL contains 1 mg is made, as reference substance solution.It is tried according to thin-layered chromatography (Chinese Pharmacopoeia) It tests, draws above two 3~5uL of test sample, put respectively on same silica gel g thin-layer plate, with [chloroform-methanol-water (65: 36:10) lower layer's solution]-formic acid (10:0.5) is solvent, expansion, taking-up dries, and sprays with 10% sulfuric acid ethyl alcohol test solution, in 105 It is clear DEG C to be heated to spot development.In sample chromatogram, on reference substance chromatography corresponding position, the spot of same color is shown.

In this product chromatography, it is on corresponding reference substance chromatography corresponding position, shows the spot of phase same color.

Beneficial effects of the present invention: first is that composition of the invention is combined by a variety of Chinese medicine composition, in composition Supplementing qi and nourishing yin mentions the turbid active constituent of phlegm, clearing heat and detoxicatingization, mutually acts synergistically, the direct needle cause of disease, and what it is in main ingredient and adjuvant is It acts on lower priming and is entered network thoroughly, the cause of disease of going directly, therapeutic effect is fast, and effect rapidly, controls difficulty in relapse after healing；Second is that of the invention Composition is made of natural Chinese medicinal herb, has no obvious adverse reaction in use, can be taken for a long time, without side-effects；Three It is composition of the invention for clearing lung-heat, treatment and prevention Pulmonary Diseases significant effect, cure rate can reach 96%；Fourth is that this hair Bright preparation process is simple, convenient to take, at low cost, can significantly alleviate the medicine burden of sufferer.To sum up, the present invention is exactly For a kind of Chinese medicine preparation of clearing lung-heat, cough-relieving, resolving sputum treatment and proposition, the medicine effect prepared using the formula is good, quick, It is a good Chinese prescription, is particularly suitable for clinical use.

Specific embodiment

Below with reference to embodiment, the present invention is further illustrated, but the present invention is limited in any way, Based on present invention teach that it is made it is any transform or replace, all belong to the scope of protection of the present invention.

Embodiment 1:

The various raw material components and its mass parts ratio of lung-heat clearing plaster described in the present embodiment 1 are as follows: root bark of white mulberry 35g, radix scutellariae 35g, Huang Even 18g, semen armeniacae amarae 48g, capital tuber of pinellia 48g, Poria cocos 45g, fritillaria thunbergii 48g, dried orange peel 35g, lepidium seed 48g, semen brassicae 45g, hawthorn 48g, bent 48g, schizonepeta 35g, radix saposhnikoviae 35g, Radix Glycyrrhizae 25g, cape jasmine 35g, Radix Astragali 255g, Radix Salviae Miltiorrhizae 72g, perilla seed 48g, radish are built Sub- 48g and Schisandra chinensis 35g.

The preparation method of the lung-heat clearing plaster, comprising the following steps:

1. weighing following raw material by weight: root bark of white mulberry 35g, radix scutellariae 35g, coptis 18g, semen armeniacae amarae 48g, capital tuber of pinellia 48g, Poria cocos 45g, fritillaria thunbergii 48g, dried orange peel 35g, lepidium seed 48g, semen brassicae 45g, hawthorn 48g, build bent 48g, schizonepeta 35g, radix saposhnikoviae 35g, Radix Glycyrrhizae 25g, cape jasmine 35g, Radix Astragali 255g, Radix Salviae Miltiorrhizae 72g, perilla seed 48g, radish seed 48g and Schisandra chinensis 35g；

2. raw material disposal: Qu Jinhang will be built and individually crushed, 60 meshes are crossed and obtain building bent fine powder, individually smash the capital tuber of pinellia to pieces fragment It is spare；

3. first time heating extraction: capital tuber of pinellia fragment, lepidium seed, semen brassicae and the perilla seed and the root bark of white mulberry, Huang bound up with gauze A kind of reed mentioned in ancient books, the coptis, semen armeniacae amarae, Poria cocos, fritillaria thunbergii, dried orange peel, hawthorn, schizonepeta, radix saposhnikoviae, Radix Glycyrrhizae, cape jasmine, Radix Astragali, Radix Salviae Miltiorrhizae, radish seed and five After the mixing of taste, the water that 7 times of amounts are added impregnates 0.5h, then carries out first time heating extraction, then carries out first time filtering, collects Filtrate, the time of first time heating extraction are 1h, and the temperature of first time heating extraction is 100 DEG C；

4. second of heating extraction: the water of 5 times of amounts is added into filtered filter residue for the first time, carries out second of heating extraction, The time of second heating extraction is 1h, and the temperature of second of heating extraction is 100 DEG C, then carries out second and filters, collects filter Liquid；

5. third time heating extraction: the water of 5 times of amounts is added into second of filtered filter residue, carries out third time heating extraction, The time of third heating extraction is 1h, and the temperature of third time heating extraction is 100 DEG C, then carries out third time filtering, collects filter Liquid；

6. concentration: first merge first time filtering, second of filtering and the filtered filtrate of third time to obtain mixed liquor, then Will mixed liquor stand place 15h after filter sediment, take supernatant, by supernatant heating be concentrated into temperature be 75 DEG C, it is relatively close The clear cream that degree is 1.25；

7. plus building song: building step is 2. obtained bent fine powder and be added to step 6. in clear cream obtained, keep after mixing evenly micro- 0.5h is boiled into thick paste；

8. preparing sugar refinery: first weighing sucrose 15kg, then 8kg water and 15g tartaric acid are added in sucrose, after heating for dissolving, keep Sugar refinery is made in the slightly boiled 1.5h of 110 DEG C of temperature；

9. mixing cream processed: after first dissolving the menthol of 18g with ethyl alcohol, then being added through step in step 7. thick paste obtained 8. sugar refinery obtained, the compound of 1000g is made in concentration after mixing, compound is cooled to 60 DEG C later, then in compound Be added and dissolve complete menthol, dispensed after mixing evenly, sterilize after can be prepared by lung-heat clearing plaster finished product.

Embodiment 2:

The various raw material components and its mass parts ratio of lung-heat clearing plaster described in the present embodiment 2 are as follows: root bark of white mulberry 39g, radix scutellariae 39g, Huang Even 20.8g, semen armeniacae amarae 52g, capital tuber of pinellia 52g, Poria cocos 52g, fritillaria thunbergii 52g, dried orange peel 39g, lepidium seed 52g, semen brassicae 52g, mountain Short, bristly hair or beard 52g, bent 52g, schizonepeta 39g, radix saposhnikoviae 39g, Radix Glycyrrhizae 26g, cape jasmine 39g, Radix Astragali 260g, Radix Salviae Miltiorrhizae 78g, perilla seed 52g, Lay are built Fu 52g and Schisandra chinensis 39g.

1. weighing following raw material by weight: root bark of white mulberry 39g, radix scutellariae 39g, coptis 20.8g, semen armeniacae amarae 52g, the capital tuber of pinellia 52g, Fu Siberian cocklebur 52g, fritillaria thunbergii 52g, dried orange peel 39g, lepidium seed 52g, semen brassicae 52g, hawthorn 52g, build bent 52g, schizonepeta 39g, radix saposhnikoviae 39g, Radix Glycyrrhizae 26g, cape jasmine 39g, Radix Astragali 260g, Radix Salviae Miltiorrhizae 78g, perilla seed 52g, radish seed 52g and Schisandra chinensis 39g；

2. raw material disposal: Qu Jinhang will be built and individually crushed, 70 meshes are crossed and obtain building bent fine powder, individually smash the capital tuber of pinellia to pieces fragment It is spare；

3. first time heating extraction: capital tuber of pinellia fragment, lepidium seed, semen brassicae and the perilla seed and the root bark of white mulberry, Huang bound up with gauze A kind of reed mentioned in ancient books, the coptis, semen armeniacae amarae, Poria cocos, fritillaria thunbergii, dried orange peel, hawthorn, schizonepeta, radix saposhnikoviae, Radix Glycyrrhizae, cape jasmine, Radix Astragali, Radix Salviae Miltiorrhizae, radish seed and five After the mixing of taste, the water that 8.5 times of amounts are added impregnates 0.8h, then carries out first time heating extraction, then carries out first time filtering, receives Collect filtrate, the time of first time heating extraction is 1.2h, and the temperature of first time heating extraction is 108 DEG C；

4. second of heating extraction: the water of 5.5 times of amounts being added into filtered filter residue for the first time, carries out second of heating and mentions It takes, the time of the second heating extraction is 1.2h, and the temperature of second of heating extraction is 108 DEG C, then carries out second and filters, receives Collect filtrate；

5. third time heating extraction: the water of 5 times of amounts is added into second of filtered filter residue, carries out third time heating extraction, The time of third heating extraction is 1.2h, and the temperature of third time heating extraction is 108 DEG C, then carries out third time filtering, collects Filtrate；

6. concentration: first merge first time filtering, second of filtering and the filtered filtrate of third time to obtain mixed liquor, then Mixed liquor is stood and filters sediment after placing 18h, takes supernatant, it is 75~80 DEG C, phase that supernatant heating, which is concentrated into temperature, The clear cream for being 1.8 to density；

7. plus building song: building step is 2. obtained bent fine powder and be added to step 6. in clear cream obtained, keep after mixing evenly micro- 0.8h is boiled into thick paste；

8. preparing sugar refinery: first weighing sucrose 18kg, then 10kg water and 18g tartaric acid are added in sucrose, after heating for dissolving, keep Sugar refinery is made in the slightly boiled 1.8h of 112 DEG C of temperature；

9. mixing cream processed: after first dissolving the menthol of 20g with ethyl alcohol, then being added through step in step 7. thick paste obtained 8. sugar refinery obtained, the compound of 1000g is made in concentration after mixing, compound is cooled to 50 DEG C later, then in compound Be added and dissolve complete menthol, dispensed after mixing evenly, sterilize after can be prepared by lung-heat clearing plaster finished product.

Embodiment 3

The various raw material components and its mass parts ratio of lung-heat clearing plaster described in the present embodiment 3 are as follows: root bark of white mulberry 45g, radix scutellariae 45g, Huang Even 23g, semen armeniacae amarae 55g, capital tuber of pinellia 55g, Poria cocos 55g, fritillaria thunbergii 56g, dried orange peel 45g, lepidium seed 55g, semen brassicae 55g, hawthorn 58g, bent 58g, schizonepeta 45g, radix saposhnikoviae 45g, Radix Glycyrrhizae 30g, cape jasmine 45g, 255~263g of Radix Astragali, Radix Salviae Miltiorrhizae 80g, perilla seed are built 55g, radish seed 56g and Schisandra chinensis 45g.

1. weighing following raw material by weight: root bark of white mulberry 45g, radix scutellariae 45g, coptis 23g, semen armeniacae amarae 55g, capital tuber of pinellia 55g, Poria cocos 55g, fritillaria thunbergii 56g, dried orange peel 45g, lepidium seed 55g, semen brassicae 55g, hawthorn 58g, build bent 58g, schizonepeta 45g, radix saposhnikoviae 45g, Radix Glycyrrhizae 30g, cape jasmine 45g, 255~263g of Radix Astragali, Radix Salviae Miltiorrhizae 80g, perilla seed 55g, radish seed 56g and Schisandra chinensis 45g；

2. raw material disposal: Qu Jinhang will be built and individually crushed, 80 meshes are crossed and obtain building bent fine powder, individually smash the capital tuber of pinellia to pieces fragment It is spare；

3. first time heating extraction: capital tuber of pinellia fragment, lepidium seed, semen brassicae and the perilla seed and the root bark of white mulberry, Huang bound up with gauze A kind of reed mentioned in ancient books, the coptis, semen armeniacae amarae, Poria cocos, fritillaria thunbergii, dried orange peel, hawthorn, schizonepeta, radix saposhnikoviae, Radix Glycyrrhizae, cape jasmine, Radix Astragali, Radix Salviae Miltiorrhizae, radish seed and five After the mixing of taste, the water that 10 times of amounts are added impregnates 1h, then carries out first time heating extraction, then carries out first time filtering, collects Filtrate, the time of first time heating extraction are 1.5h, and the temperature of first time heating extraction is 110 DEG C；

4. second of heating extraction: the water of 6 times of amounts is added into filtered filter residue for the first time, carries out second of heating extraction, The time of second heating extraction is 1.5h, and the temperature of second of heating extraction is 110 DEG C, then carries out second and filters, collects Filtrate；

5. third time heating extraction: the water of 6 times of amounts is added into second of filtered filter residue, carries out third time heating extraction, The time of third heating extraction is 1.5h, and the temperature of third time heating extraction is 110 DEG C, then carries out third time filtering, collects Filtrate；

6. concentration: first merge first time filtering, second of filtering and the filtered filtrate of third time to obtain mixed liquor, then Mixed liquor is stood and filters sediment after placing 20h, takes supernatant, it is 75~80 DEG C, phase that supernatant heating, which is concentrated into temperature, The clear cream for being 1.3 to density；

7. plus building song: building step is 2. obtained bent fine powder and be added to step 6. in clear cream obtained, keep after mixing evenly micro- 1h is boiled into thick paste；

8. preparing sugar refinery: first weighing sucrose 20kg, then 12kg water and 20g tartaric acid are added in sucrose, after heating for dissolving, keep Sugar refinery is made in the slightly boiled 2h of 115 DEG C of temperature；

9. mixing cream processed: after first dissolving the menthol of 22g with ethyl alcohol, then being added through step in step 7. thick paste obtained 8. sugar refinery obtained, the compound of 1000g is made in concentration after mixing, compound is cooled to 40 DEG C later, then in compound Be added and dissolve complete menthol, dispensed after mixing evenly, sterilize after can be prepared by lung-heat clearing plaster finished product.

Use semifluid of the product made from the present embodiment 1~3 for yellowish-brown to sepia stiff；Gas is pungent, bitter, sweet tea, Cool, for treating cough with dyspnea and rough breath, the sticky color of abundant expectoration is yellow, difficult expectoration, irritable feverish sensation in chest, dry throat, and urinating red or constipation has significantly Curative effect, be a kind of good drug efficacy, quick, Small side effects, oral medication convenient to take, especially for treatment the elderly's Chronic asthma disease effect is preferable.

It is as follows that spy lifts two typical cases:

Case 1, Deng, male, 87 years old.On 07 07th, 2017 medical, and readme cough, cough occurs after suffering from cold over more than 10 years because of flu Phlegm, it is uncomfortable in chest, it take a favorable turn to other hospital admissions, before 3 days, no obvious inducement shortness of breath occurs and wheezes, and cough aggravates, and companion is not intended to drink Food, when being admitted to hospital symptoms include cough with dyspnea and rough breath, abundant expectoration, sticky color Huang, difficult expectoration, irritable feverish sensation in chest, dry throat urinate red or constipation, tongue nature It is red, moss thin yellow, slippery and rapid pulse.WBC, RBC are normal in blood routine examination, and HGB is higher, and liver function test is normal.The lung-distension is diagnosed as, Chinese medical discrimination is Phlegm-heat obstructing lung.It is oral to give lung-heat clearing plaster, 3 times a day, after 9 days, the diseases such as rough, irritable feverish sensation in chest, dry throat of wheezing Shape recovery from illness.

Case 2, section, female, 75 years old.On October 31st, 2016 is medical.There is cough, cough without obvious inducement before readme 20 years Phlegm, asthma, uncomfortable in chest, whenever winter-spring season or after suffering from cold, above-mentioned symptom is recurred and is gradually aggravated, and symptom is sent out again before 7 years, with double lower limb Edema, before 2 days, above-mentioned symptom is sent out again after suffering from cold accidentally, and symptom of being admitted to hospital is shown in, cough with dyspnea and rough breath, excessive thick and yellow sputum, difficult cough Out, irritable feverish sensation in chest, dry throat receives difference, dormancy can, stool is adjusted, and red urine, urgent urination, frequent micturition, blood routine examination HGB is higher, liver function inspection It looks into normal.It is diagnosed as chronic cor pulmonale, Chinese medical discrimination is Phlegm-heat obstructing lung.It is oral to give lung-heat clearing plaster, 3 times a day, often Secondary 40g, after 24 days, expectoration, red urine, irritable feverish sensation in chest, dry throat symptom recovery from illness.

Claims

1. a kind of lung-heat clearing plaster, it is characterised in that, the various raw material components and its mass parts ratio of the lung-heat clearing plaster are as follows: the root bark of white mulberry 35~45g, 35~45g of radix scutellariae, 18~23g of the coptis, 48~55g of semen armeniacae amarae, capital 48~55g of the tuber of pinellia, 45~55g of Poria cocos, bulb of thunberg fritillary 48~56g of mother, 35~45g of dried orange peel, 48~55g of lepidium seed, 45~55g of semen brassicae, 48~58g of hawthorn, build 48~58g of song, 35~45g of schizonepeta, 35~45g of radix saposhnikoviae, 25~30g of Radix Glycyrrhizae, 35~45g of cape jasmine, 255~263g of Radix Astragali, 72~80g of Radix Salviae Miltiorrhizae, purple 35~45g of 48~55g of perillaseed, 48~56g of radish seed and Schisandra chinensis.

2. a kind of lung-heat clearing plaster according to claim 1, it is characterised in that, the various raw material components of the lung-heat clearing plaster and its Mass parts ratio is as follows: root bark of white mulberry 39g, radix scutellariae 39g, coptis 20.8g, semen armeniacae amarae 52g, capital tuber of pinellia 52g, Poria cocos 52g, fritillaria thunbergii 52g, dried orange peel 39g, lepidium seed 52g, semen brassicae 52g, hawthorn 52g, bent 52g, schizonepeta 39g, radix saposhnikoviae 39g, Radix Glycyrrhizae 26g, cape jasmine are built 39g, Radix Astragali 260g, Radix Salviae Miltiorrhizae 78g, perilla seed 52g, radish seed 52g and Schisandra chinensis 39g.

3. a kind of preparation method of lung-heat clearing plaster, which comprises the following steps:

4. a kind of preparation method of lung-heat clearing plaster according to claim 3, it is characterised in that: step 4., 5., 6. in, institute The temperature for stating first time heating extraction, second of heating extraction and third time heating extraction is 100~110 DEG C.

5. a kind of preparation method of lung-heat clearing plaster according to claim 3, it is characterised in that: step 9. in compound it is cold But temperature is 40~60 DEG C.