CN117442653A - Traditional Chinese medicine composition for detoxifying and relieving itching - Google Patents
Traditional Chinese medicine composition for detoxifying and relieving itching Download PDFInfo
- Publication number
- CN117442653A CN117442653A CN202311514327.6A CN202311514327A CN117442653A CN 117442653 A CN117442653 A CN 117442653A CN 202311514327 A CN202311514327 A CN 202311514327A CN 117442653 A CN117442653 A CN 117442653A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- chinese medicine
- traditional chinese
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 90
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 20
- 230000007803 itching Effects 0.000 title claims abstract description 17
- 201000004624 Dermatitis Diseases 0.000 claims abstract description 32
- 208000010668 atopic eczema Diseases 0.000 claims abstract description 20
- 235000001405 Artemisia annua Nutrition 0.000 claims abstract description 14
- 240000000011 Artemisia annua Species 0.000 claims abstract description 14
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 14
- 244000246386 Mentha pulegium Species 0.000 claims abstract description 10
- 235000016257 Mentha pulegium Nutrition 0.000 claims abstract description 10
- 235000004357 Mentha x piperita Nutrition 0.000 claims abstract description 10
- 235000001050 hortel pimenta Nutrition 0.000 claims abstract description 10
- 240000002924 Platycladus orientalis Species 0.000 claims abstract description 7
- 240000003705 Senecio vulgaris Species 0.000 claims abstract description 4
- 230000009194 climbing Effects 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
- 239000000499 gel Substances 0.000 claims description 25
- 238000002360 preparation method Methods 0.000 claims description 21
- 238000005303 weighing Methods 0.000 claims description 14
- 108090000978 Interleukin-4 Proteins 0.000 claims description 13
- 241000219304 Portulacaceae Species 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 13
- 239000008367 deionised water Substances 0.000 claims description 11
- 229910021641 deionized water Inorganic materials 0.000 claims description 11
- 239000000706 filtrate Substances 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 11
- 238000010992 reflux Methods 0.000 claims description 11
- 210000002966 serum Anatomy 0.000 claims description 10
- 241001146210 Senecio scandens Species 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- 230000001154 acute effect Effects 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000002674 ointment Substances 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 3
- 230000001684 chronic effect Effects 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
- 241000780602 Senecio Species 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 abstract description 4
- 230000002757 inflammatory effect Effects 0.000 abstract description 3
- 206010040882 skin lesion Diseases 0.000 abstract description 2
- 231100000444 skin lesion Toxicity 0.000 abstract description 2
- 244000234609 Portulaca oleracea Species 0.000 abstract 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 30
- 239000012153 distilled water Substances 0.000 description 19
- 238000003756 stirring Methods 0.000 description 18
- 241000700159 Rattus Species 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 11
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical group C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 10
- 230000008961 swelling Effects 0.000 description 10
- 102100037850 Interferon gamma Human genes 0.000 description 9
- 108010074328 Interferon-gamma Proteins 0.000 description 9
- 239000003906 humectant Substances 0.000 description 7
- 239000011159 matrix material Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 206010015150 Erythema Diseases 0.000 description 5
- 208000028990 Skin injury Diseases 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 4
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 4
- 235000006679 Mentha X verticillata Nutrition 0.000 description 4
- 235000002899 Mentha suaveolens Nutrition 0.000 description 4
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010012442 Dermatitis contact Diseases 0.000 description 3
- 201000007100 Pharyngitis Diseases 0.000 description 3
- 208000034158 bleeding Diseases 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 208000010247 contact dermatitis Diseases 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 210000003141 lower extremity Anatomy 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 241000205585 Aquilegia canadensis Species 0.000 description 2
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 description 2
- VYZAHLCBVHPDDF-UHFFFAOYSA-N Dinitrochlorobenzene Chemical compound [O-][N+](=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 VYZAHLCBVHPDDF-UHFFFAOYSA-N 0.000 description 2
- 201000000297 Erysipelas Diseases 0.000 description 2
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 208000006877 Insect Bites and Stings Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 241000270295 Serpentes Species 0.000 description 2
- 208000004078 Snake Bites Diseases 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 230000001387 anti-histamine Effects 0.000 description 2
- 239000000739 antihistaminic agent Substances 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- 229960001803 cetirizine Drugs 0.000 description 2
- 230000035617 depilation Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000003862 glucocorticoid Substances 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 208000014617 hemorrhoid Diseases 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229960002744 mometasone furoate Drugs 0.000 description 2
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 206010040872 skin infection Diseases 0.000 description 2
- 238000010025 steaming Methods 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 210000001364 upper extremity Anatomy 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- IYLLULUTZPKQBW-UHFFFAOYSA-N Acrinol Chemical compound CC(O)C(O)=O.C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3N=C21 IYLLULUTZPKQBW-UHFFFAOYSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 201000002045 Ancylostomiasis Diseases 0.000 description 1
- 208000033211 Ankylostomiasis Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 206010020376 Hookworm infection Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000032923 Lobar pneumonia Diseases 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- JAUOIFJMECXRGI-UHFFFAOYSA-N Neoclaritin Chemical compound C=1C(Cl)=CC=C2C=1CCC1=CC=CN=C1C2=C1CCNCC1 JAUOIFJMECXRGI-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 240000004064 Poterium sanguisorba Species 0.000 description 1
- 235000008291 Poterium sanguisorba Nutrition 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 235000008282 Sanguisorba officinalis Nutrition 0.000 description 1
- 206010040799 Skin atrophy Diseases 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 206010040925 Skin striae Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 241000212749 Zesius chrysomallus Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 206010001093 acute tonsillitis Diseases 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229940045110 chitosan Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229960001271 desloratadine Drugs 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 229960004189 ethacridine lactate Drugs 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine composition for detoxifying and relieving itching, which is prepared from 1-8 parts by weight of sweet wormwood herb, 1-8 parts by weight of purslane, 1-8 parts by weight of biota orientalis, 1-8 parts by weight of climbing groundsel herb and 1-6 parts by weight of peppermint. The traditional Chinese medicine composition can directly act on the skin lesion part, is convenient to use and high in safety, and plays an important role in treating inflammatory exudative skin diseases such as eczema and the like.
Description
Technical Field
The invention relates to the field of medicines, in particular to a traditional Chinese medicine composition for detoxifying and relieving itching.
Background
Eczema is a chronic, recurrent, itchy skin disease, the incidence of which increases year by year worldwide, severely affecting human health and quality of life. The clinical characteristics of eczema include severe itching, erythema, pimple or herpes, edema, blister exudation, repeated disease duration, easy recurrence and chronic trend in the acute stage. 80% of eczema patients are accompanied by itching, severe itching can excite scratching, and skin infection is easy to accompany, thereby generating vicious circle and causing difficulties for local and systemic treatment. Specific causes and mechanisms of eczema remain hot spots of research in the medical community to date. In recent years, with the development of society, the incidence of this disease has been increasing year by year in a fast-paced and high-pressure life state. Therefore, prevention and effective treatment of eczema have become one of the problems to be studied and solved in the medical community.
At present, modern medicine mainly treats eczema by antihistamine medicines, antiallergic medicines, glucocorticoids and the like. Antihistaminic and antiallergic drugs often only achieve the purpose of relieving symptoms, and glucocorticoid can rapidly control symptoms in a short term, but can cause various adverse reactions such as skin atrophy, hormone-dependent dermatitis and the like after long-term use, and can cause skin damage deterioration after drug withdrawal, thus being easy to generate drug dependence.
The eczema is thought to be caused by wind evil, damp evil and heat evil accumulated in the skin striae and muscle surface, and damp heat accumulated in the skin is damaging yin blood, so the ancient books of the traditional Chinese medicine are called 'wet sore', 'immersion sore', 'embroidery ball wind' and the like. The external treatment method of the traditional Chinese medicine has the obvious characteristics and advantages of integral syndrome differentiation, treatment of both symptoms and root causes, small adverse reaction, wide applicable crowd and the like, can directly apply the medicine to the skin damage part, can reduce the use of systemic medicine, has high safety, and has important roles in the treatment of inflammatory exudative skin diseases such as eczema and the like.
At present, the report of the traditional Chinese medicine formula for effectively treating acute and chronic eczema is less, so that the traditional Chinese medicine formula for treating acute and chronic eczema is further developed from the field of traditional Chinese medicines, and the medicine with low side effect is a technical problem to be solved urgently.
Disclosure of Invention
In order to solve the technical problems, the invention comprises the following aspects:
the first aspect of the invention provides a traditional Chinese medicine composition for detoxifying and relieving itching, which is prepared from 1-8 parts by weight of sweet wormwood, 1-8 parts by weight of purslane, 1-8 parts by weight of biota orientalis, 1-8 parts by weight of senecio scandens and 1-6 parts by weight of peppermint.
Preferably, the traditional Chinese medicine composition is prepared from 3-6 parts by weight of sweet wormwood herb, 3-6 parts by weight of purslane, 3-6 parts by weight of biota orientalis, 3-6 parts by weight of senecio scandens and 2-5 parts by weight of mint.
More preferably, the traditional Chinese medicine composition is prepared from 6 parts by weight of sweet wormwood herb, 6 parts by weight of purslane, 6 parts by weight of biota orientalis, 6 parts by weight of climbing groundsel herb and 5 parts by weight of peppermint.
Preferably, the Chinese medicinal composition further comprises pharmaceutically acceptable auxiliary materials.
Preferably, the Chinese medicinal composition is an external preparation.
Preferably, the traditional Chinese medicine composition is in the form of patch, ointment, cream or gel.
More preferably, the traditional Chinese medicine composition is in a gel form.
Preferably, the preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing herba Artemisiae Annuae, herba Portulacae, folium Platycladi, herba Senecionis Scandentis and herba Menthae, adding deionized water 4-6 times of the total weight of the Chinese medicinal materials, heating and reflux extracting for 1-2 hr, filtering the extractive solution, concentrating the filtrate under reduced pressure to give medicinal liquid 1-2 times of the total weight of the Chinese medicinal materials, optionally adding pharmaceutically acceptable adjuvants, and making into Chinese medicinal composition.
Preferably, deionized water with the total weight of 5 times of the total weight of the traditional Chinese medicinal materials is added into the preparation method.
Preferably, the heating reflux extraction time in the preparation method is 1 hour.
Preferably, the filtrate is concentrated under reduced pressure until the weight of the liquid medicine is 1 time of the total weight of the added Chinese medicinal materials.
Preferably, the gel matrix with the prescription amount is weighed, distilled water with the prescription amount is added, the mixture is stirred and then is stood for overnight, the humectant is added after the mixture is completely swelled, the concentrated traditional Chinese medicine liquid is added after the mixture is fully and uniformly stirred, and the preparation is obtained.
Preferably, the gel comprises a gel matrix, a humectant and distilled water.
Preferably, the gel matrix is selected from one or more of carbomer, gelatin, chitosan or sodium alginate.
More preferably, the carbomer is carbomer 941.
Preferably, the humectant is selected from propylene glycol or glycerin.
Preferably, the weight ratio of the gel matrix to distilled water is 1 (100-200). More preferably, the weight ratio of the gel matrix to distilled water is 1 (150-180). Further preferably, the weight ratio of the gel matrix to distilled water is 1:170.
Preferably, the weight ratio of the humectant to distilled water is 1 (1-3). More preferably, the weight ratio of humectant to distilled water is 1 (1-2). Further preferably, the weight ratio of humectant to distilled water is 1:1.
Preferably, the weight percentage of the traditional Chinese medicine extract in the gel is 10-20%. More preferably, the weight percentage of the traditional Chinese medicine extract in the gel is 12-18%. Further preferably, the weight percentage of the traditional Chinese medicine extract in the gel is 16%.
Preferably, the gel comprises the above traditional Chinese medicine extract, carbomer 941, propylene glycol and distilled water. More preferably, the gel comprises 15-25g of the above Chinese medicine extract, 0.1-0.5g of carbomer 941, 30-80g of propylene glycol and 30-80g of distilled water. Further preferably, the gel comprises 20g of the above-mentioned Chinese medicine extract, 0.3g of carbomer 941, 50g of propylene glycol and 50g of distilled water.
The second aspect of the present invention provides a preparation method of the above-mentioned Chinese medicinal composition, comprising the following steps:
weighing herba Artemisiae Annuae, herba Portulacae, folium Platycladi, herba Senecionis Scandentis and herba Menthae, adding deionized water 4-6 times of the total weight of the Chinese medicinal materials, heating and reflux extracting for 1-2 hr, filtering the extractive solution, concentrating the filtrate under reduced pressure to give medicinal liquid 1-2 times of the total weight of the Chinese medicinal materials, optionally adding pharmaceutically acceptable adjuvants, and making into Chinese medicinal composition.
Preferably, deionized water with the total weight of 5 times of the total weight of the traditional Chinese medicinal materials is added into the preparation method.
Preferably, the heating reflux extraction time in the preparation method is 1 hour.
Preferably, the filtrate is concentrated under reduced pressure until the weight of the liquid medicine is 1 time of the total weight of the added Chinese medicinal materials.
Preferably, the gel matrix with the prescription amount is weighed, distilled water with the prescription amount is added, the mixture is stirred and then is stood for overnight, the humectant is added after the mixture is completely swelled, the concentrated traditional Chinese medicine liquid is added after the mixture is fully and uniformly stirred, and the preparation is obtained.
The third aspect of the invention provides application of the traditional Chinese medicine composition in preparation of medicines for treating eczema.
Preferably, the eczema is acute eczema or chronic eczema.
The fourth aspect of the invention provides an application of the traditional Chinese medicine composition in preparing medicines for reducing IL-4 content and/or improving INF-gamma content in serum.
Preferably, the invention provides application of the traditional Chinese medicine composition in preparation of medicines for improving IFN-gamma/IL-4 ratio in serum.
The traditional Chinese medicine raw materials selected by the invention have the following common pharmacological effects in the field:
sweet wormwood herb: cold in nature, bitter and pungent in flavor, enters liver and gallbladder meridians. Herba Artemisiae Annuae has effects of clearing heat and removing summer-heat, removing steaming, and preventing malaria, and can be used for treating summer-heat, yin deficiency, night fever, bone steaming, malaria, jaundice due to damp-heat.
Purslane: the traditional Chinese medicine composition has the effects of clearing heat and detoxicating, cooling blood and stopping bleeding, and is clinically used for treating enteritis, bacillary dysentery, furuncle swelling and toxicity, snake and insect bite, hemorrhoids gall, eczema, erysipelas, snake and insect bite, hematochezia, hemorrhoids, metrorrhagia and metrostaxis, acute dermatitis, subacute dermatitis, herpes zoster, postpartum and functional sub-functional bleeding, appendicitis and ancylostomiasis.
Platycladus orientalis leaves, with cold nature, bitter and astringent taste, enter lung meridian, liver meridian and spleen meridian. The cacumen Platycladi has effects of cooling blood, stopping bleeding, promoting hair growth, and blackening hair, and can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, hemorrhage, and blood heat alopecia.
All-grass of groundsel: cold in nature and bitter in flavor, enter liver meridian and lung meridian. The herba Senecionis Scandentis has effects of clearing heat and detoxicating, cooling blood and detumescence, removing liver fire for improving eyesight, killing parasites and relieving pain, and can be used for treating wind-heat type common cold, influenza, upper respiratory infection, acute tonsillitis, sore throat, pneumonia, lobar pneumonia, etc.
Peppermint: pungent in flavor, cool in nature, enters lung and liver meridians, dispels wind-heat, clears head and eyes, relieves sore throat, promotes eruption, soothes liver and moves qi; can be used for treating wind-heat type common cold, initial wind-warm syndrome, headache, conjunctival congestion, pharyngitis, aphtha, rubella, measles, chest distress and hypochondrium distention.
The clinical application method of the traditional Chinese medicine composition comprises the following steps:
150ml of freshly prepared traditional Chinese medicine extract in the embodiment of the invention is taken, 8 layers of gauze are soaked, the traditional Chinese medicine liquid is flatly applied to the affected part for 15 minutes each time of wet application, the residual liquid is wiped off by purified water after the wet application, the treatment is carried out for 2 times a day, and 4 weeks is a treatment course.
The invention has the technical effects that:
1. the traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility, and the inventor optimizes the traditional Chinese medicine composition with obvious eczema treatment effect, especially chronic eczema, by optimizing the components and content ratio of the traditional Chinese medicine.
2. The traditional Chinese medicine composition can directly act on the skin injury part, the potency of the medicine directly reaches the affected part, the use is convenient, the safety is high, and the traditional Chinese medicine composition plays an important role in treating inflammatory exudative skin diseases such as eczema and the like.
Detailed Description
The present invention will be further described with reference to examples, but the embodiments of the present invention are not limited thereto. The experimental methods used in the following examples are conventional methods unless otherwise specified.
Example 1
Weighing 36g of sweet wormwood herb, 36g of purslane, 36g of cacumen biotae, 36g of senecio scandens and 30g of mint, adding 900mL of deionized water, heating, refluxing and extracting for 1 hour, filtering the extracting solution, and concentrating the filtrate under reduced pressure to 200mL to obtain the traditional Chinese medicine extract 1. Weighing 0.3g of carbomer 941, adding 50g of distilled water, stirring, standing overnight, adding 50g of propylene glycol after complete swelling, fully and uniformly stirring, adding 20g of the prepared traditional Chinese medicine extract, and uniformly stirring to obtain the traditional Chinese medicine gel preparation 1.
Example 2
18g of sweet wormwood herb, 54g of purslane, 36g of cacumen biotae, 36g of senecio scandens and 30g of peppermint are weighed, 900mL of deionized water is added, heating reflux extraction is carried out for 1 hour, the extracting solution is filtered, and the filtrate is concentrated to 200mL under reduced pressure, so that the traditional Chinese medicine extract 2 is obtained. Weighing 0.3g of carbomer 941, adding 50g of distilled water, stirring, standing overnight, adding 50g of propylene glycol after complete swelling, fully and uniformly stirring, adding 20g of the prepared traditional Chinese medicine extract, and uniformly stirring to obtain the traditional Chinese medicine gel preparation 2.
Example 3
Weighing 36g of sweet wormwood, 18g of purslane, 54g of cacumen biotae, 36g of senecio scandens and 30g of mint, adding 900mL of deionized water, heating, refluxing and extracting for 1 hour, filtering the extracting solution, and concentrating the filtrate under reduced pressure to 200mL to obtain the traditional Chinese medicine extract 3. Weighing 0.3g of carbomer 941, adding 50g of distilled water, stirring, standing overnight, adding 50g of propylene glycol after complete swelling, fully and uniformly stirring, adding 20g of the prepared traditional Chinese medicine extract, and uniformly stirring to obtain the traditional Chinese medicine gel preparation 3.
Example 4
Weighing 36g of sweet wormwood herb, 36g of purslane, 18g of cacumen biotae, 54g of senecio scandens and 30g of mint, adding 900mL of deionized water, heating, refluxing and extracting for 1 hour, filtering the extracting solution, and concentrating the filtrate under reduced pressure to 200mL to obtain the traditional Chinese medicine extract 4. Weighing 0.3g of carbomer 941, adding 50g of distilled water, stirring, standing overnight, adding 50g of propylene glycol after complete swelling, fully and uniformly stirring, adding 20g of the prepared traditional Chinese medicine extract, and uniformly stirring to obtain the traditional Chinese medicine gel preparation 4.
Comparative example 1 (Replacing of Qianli light into honeysuckle)
Weighing 36g of sweet wormwood herb, 36g of purslane, 36g of cacumen biotae, 36g of honeysuckle flower and 30g of peppermint, adding 900mL of deionized water, heating, refluxing and extracting for 1 hour, filtering the extracting solution, and concentrating the filtrate under reduced pressure to 200mL to obtain the traditional Chinese medicine extract 1 of the comparative example. Weighing 0.3g of carbomer 941, adding 50g of distilled water, stirring, standing overnight, adding 50g of propylene glycol after complete swelling, fully and uniformly stirring, adding 20g of the prepared traditional Chinese medicine extract, and uniformly stirring to obtain the traditional Chinese medicine gel preparation comparative example 1.
Comparative example 2 (substitution of cacumen Platycladi with Sanguisorbae)
Weighing 36g of sweet wormwood herb, 36g of purslane, 36g of garden burnet, 36g of senecio scandens and 30g of peppermint, adding 900mL of deionized water, heating, refluxing and extracting for 1 hour, filtering the extracting solution, and concentrating the filtrate under reduced pressure to 200mL to obtain the traditional Chinese medicine extract 2 of the comparative example. Weighing 0.3g of carbomer 941, adding 50g of distilled water, stirring, standing overnight, adding 50g of propylene glycol after complete swelling, fully and uniformly stirring, adding 20g of the prepared traditional Chinese medicine extract, and uniformly stirring to obtain the traditional Chinese medicine gel preparation comparative example 2.
Experimental example 1 Effect of the Chinese medicinal composition of the invention on the serum IL-4 and IFN-gamma content of chronic eczema model rats
1. Test method
80 rats were randomly divided into a blank group, a model group, the inventive examples 1-4 and the comparative examples 1-2, 10 each. 1 day before molding, except for blank groups, all test groups were dehaired with a shaver in the abdomen of the rat in an area of 2cm×2cm, and then sensitized with 50 μl of 5% dncb acetone solution in the dehaired area for 2 consecutive days, dehaired with an area of 3cm×3cm in the back of the rat for 5 days, and then excited with 100 μl of 0.1% dncb acetone solution in the dehaired area in the back of the rat for 6 days, and then excited with 1 time every 3 days for 4 consecutive times. Blank rats were subjected to depilation treatment on the abdomen and back, and distilled water was applied to the depilation area. On day 2 after the end of the excitation, the traditional Chinese medicine gel prepared in the examples 1-4 and the comparative examples 1-2 of the invention are smeared on the dehairing area on the back of the rat according to the dosage of 2g gel/kg body weight except for a blank group and a model group, and are administrated 1 time a day for 10 days continuously. After 12 hours from the last administration, the femoral artery of each rat in each test group was bled, centrifuged at 3000r/min for 15min, the supernatant was taken, and the content of IL-4 and IFN-gamma in the serum of each rat group was determined by ELISA.
2. Test results
The IL-4 and IFN-gamma content in serum of chronic eczema model rats after administration of the traditional Chinese medicine of the present invention is shown in Table 1 below.
Table 1 comparison of serum IL-4 and IFN-gamma levels in rats of each test group
| Test group | IL-4(pg/mL) | IFN-γ(pg/mL) |
| Blank group | 90.48±7.36 | 287.30±27.47 |
| Model group | 374.25±29.31 | 224.19±22.39 |
| Example 1 group | 120.57±10.92 | 417.44±31.24 |
| Example 2 group | 167.33±16.27 | 341.57±29.88 |
| Example 3 group | 174.22±18.90 | 336.59±30.62 |
| Example 4 group | 188.57±20.38 | 344.90±27.19 |
| Comparative example 1 group | 220.41±25.93 | 301.26±28.46 |
| Comparative example 2 group | 234.87±26.88 | 307.85±30.81 |
As can be seen from Table 1 above, compared with the blank group, the serum INF-gamma content of the rats in the model group is obviously reduced, the IL-4 content is obviously increased, the IFN-gamma/IL-4 ratio is reduced (the difference has statistical significance), and the unbalance of Th1/Th2 occurs. Compared with the model group and the comparative examples 1-2, the serum INF-gamma content of the rats in the examples 1-4 of the invention is obviously increased, the IL-4 content is obviously reduced, and the IFN-gamma/IL-4 ratio is increased (the difference has statistical significance), so that the balance of Th1/Th2 is promoted. Surprisingly, the traditional Chinese medicine preparation of the embodiment 1 of the invention has the highest range of IFN-gamma/IL-4 ratio in serum, and has an unexpected excellent effect. The test results show that the traditional Chinese medicine composition has the effects of treating eczema and reducing inflammatory response, and the action mechanism of treating chronic eczema is possibly related to regulating Th1 and Th2 cytokines.
Test example 2 clinical treatment cases of the Chinese medicinal composition of the present invention
Clinical curative effect observation shows that the detoxification antipruritic traditional Chinese medicine composition has obvious curative effect on skin diseases such as eczema dermatitis, contact dermatitis and the like, can effectively relieve symptoms such as redness, liquid seepage, itching and the like, and promotes skin injury healing. The following will illustrate some representative examples. If not specified, the wet dressing method of the traditional Chinese medicine in the case of the invention is specifically referred to in the section of clinical application method of the traditional Chinese medicine composition.
Case 1: li Mou female 30 years old, with a diagnosis of general erythema accompanied by itching for 5 years, was treated irregularly and was diagnosed as "eczema". The traditional Chinese medicine composition of the embodiment 1 of the application is applied to the affected part after being taken orally (10 mg/time, 1 time/day) and treated by the external mometasone furoate ointment (1 time/day), the skin injury is light and heavy, the skin injury is not healed repeatedly, and the affected part is wet-applied for 2 times a day for 3 weeks, so that the red spots and itching of the whole body are basically relieved.
Case 2: chen Mou it was diagnosed as "sweat herpes" in the case of men, 45 years old, who had repeated 5 months of diagnosis for herpes, blisters, liquid seepage and itching of both hands and feet. External halomipine ointment (2 times/day), oral cetirizine tablet (10 mg/time, 1 time/day) and the like, and the skin injury is repeated, and the traditional Chinese medicine composition of the embodiment 1 of the application is applied to the affected part after the treatment, and is wet-applied for 2 times per day for 4 weeks, so that the herpes and pruritus of hands and feet basically subside, and slight desquamation is left.
Case 3: a person who is 8 years old, who is a woman who is 8 years old, is diagnosed as "toxic dermatitis and contact dermatitis" because of local redness, liquid seepage and itching occurring 2 days after the right upper limb is contacted with unknown chemicals. The topical mometasone furoate soft extract has poor effect, and the oral cetirizine (10 mg/time, 1 time/day) is taken after the doctor makes a visit, and meanwhile, the traditional Chinese medicine composition of the embodiment 1 of the application is applied to the affected part in a wet way, 4 times a day for 5 days, and the red swelling, the liquid seepage and the itching of the right upper limb are basically resolved.
Case 4: cui Mou, women, 65 years old, were diagnosed as "contact dermatitis" by a 3-day visit of a local erythema and papule blister accompanied with itching after the external application of the wound ointment for right leg pain. External halomicin soft extract (2 times/day), oral desloratadine tablet (10 mg/time, 1 time/day), etc., the improvement of skin lesions is not obvious, the traditional Chinese medicine composition of the application example 1 is applied to the affected part after the treatment, the wet application is carried out for 2 times a day for 3 days, and red rash, pimple and blister itch of the right lower leg are basically resolved, and the color is remained and sinking.
Case 5: liu Mou it is indicated for women, 63 years old, for red swelling and fluid seepage of the right foot and lower limb accompanied by itching pain for 10 days, and is diagnosed as erysipelas and skin infection of lower limb. The penicillin antibiotics are applied to local hospitals for 7 days in a static drip mode, the ethacridine lactate solution is externally applied, the illness state is poor, the traditional Chinese medicine composition of the embodiment 1 of the application is applied to affected parts after the treatment, the wet compress is carried out for 2 times a day, the total time is 7 days, and the red swelling and the seepage of the right feet and lower limbs are basically controlled.
Although specific embodiments of the invention have been described, those skilled in the art will recognize that many changes and modifications may be made thereto without departing from the scope or spirit of the invention. Accordingly, the present invention is intended to embrace all such alterations and modifications that fall within the scope of the appended claims and equivalents thereof.
Claims (10)
1. A traditional Chinese medicine composition for detoxifying and relieving itching is characterized by being prepared from 1-8 parts by weight of sweet wormwood herb, 1-8 parts by weight of purslane, 1-8 parts by weight of cacumen biotae, 1-8 parts by weight of climbing groundsel herb and 1-6 parts by weight of peppermint.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is prepared from 3-6 parts by weight of sweet wormwood herb, 3-6 parts by weight of purslane herb, 3-6 parts by weight of biota orientalis, 3-6 parts by weight of senecio scandens and 2-5 parts by weight of peppermint.
3. The traditional Chinese medicine composition according to claim 2, wherein the traditional Chinese medicine composition is prepared from 6 parts by weight of sweet wormwood herb, 6 parts by weight of purslane, 6 parts by weight of biota orientalis, 6 parts by weight of senecio and 5 parts by weight of peppermint.
4. The traditional Chinese medicine composition according to any one of claims 1-3, further comprising pharmaceutically acceptable excipients.
5. The traditional Chinese medicine composition according to any one of claims 1 to 3, wherein the traditional Chinese medicine composition is an external preparation.
6. A Chinese medicinal composition according to any one of claims 1 to 3, in the form of a patch, ointment, cream, gel.
7. The method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 6, wherein the method comprises the following steps: weighing herba Artemisiae Annuae, herba Portulacae, folium Platycladi, herba Senecionis Scandentis and herba Menthae, adding deionized water 4-6 times of the total weight of the Chinese medicinal materials, heating and reflux extracting for 1-2 hr, filtering the extractive solution, concentrating the filtrate under reduced pressure to give medicinal liquid 1-2 times of the total weight of the Chinese medicinal materials, optionally adding pharmaceutically acceptable adjuvants, and making into Chinese medicinal composition.
8. Use of the Chinese medicinal composition according to any one of claims 1-6 in the preparation of a medicament for treating eczema.
9. The use according to claim 8, wherein the eczema is acute or chronic.
10. Use of the Chinese medicinal composition according to any one of claims 1-6 for the preparation of a medicament for reducing IL-4 content and/or increasing INF-gamma content in serum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311514327.6A CN117442653A (en) | 2023-11-14 | 2023-11-14 | Traditional Chinese medicine composition for detoxifying and relieving itching |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311514327.6A CN117442653A (en) | 2023-11-14 | 2023-11-14 | Traditional Chinese medicine composition for detoxifying and relieving itching |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117442653A true CN117442653A (en) | 2024-01-26 |
Family
ID=89594675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311514327.6A Pending CN117442653A (en) | 2023-11-14 | 2023-11-14 | Traditional Chinese medicine composition for detoxifying and relieving itching |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117442653A (en) |
-
2023
- 2023-11-14 CN CN202311514327.6A patent/CN117442653A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108992488A (en) | A kind of Chinese medicine that treating rhinitis chronic and preparation method | |
| JP7196192B2 (en) | Chinese herbal medicine composition, Chinese herbal medicine formulation and its preparation method and application | |
| KR20100079858A (en) | The new medicine for skin disease composed of mineral and medical herbs | |
| CN103877247A (en) | Medicine for treating bedsore and preparation method thereof | |
| CN106822321B (en) | Application of Curcuma water of traumatology in preparing medicine for treating keratosis pilaris | |
| CN109674945A (en) | The Chinese medicine composition and preparation method thereof of ulcer is cured in a kind of myogenic hemostasia and detumescence analgesic | |
| CN117442653A (en) | Traditional Chinese medicine composition for detoxifying and relieving itching | |
| CN101703667B (en) | Brown red medicament for treating traumatic injuries and preparation method thereof | |
| WO2022011881A1 (en) | Medication for preventing and treating hemorrhoids and use thereof | |
| CN111920883A (en) | External preparation for treating herpes zoster and preparation method thereof | |
| CN107569580B (en) | A topical Chinese medicinal composition for treating hemorrhoid, and its preparation method | |
| CN1061865C (en) | External-use Chinese medicine preparation for treating skin ulcer | |
| CN105031380A (en) | Drug for oral local anesthesia of pregnant woman and preparation method thereof | |
| CN115429859B (en) | Traditional Chinese medicine composition for treating skin itch diseases and preparation method and application thereof | |
| CN111358927B (en) | Pujiang medicinal composition and application thereof | |
| CN111743965B (en) | A medicine for treating hemorrhoid and ulcer with regenerated silicon | |
| CN112933122B (en) | Traditional Chinese medicine external medicine for treating recurrent oral ulcer | |
| CN108853293B (en) | Compound essential oil for treating hemorrhoids and preparation method and use method thereof | |
| CN105250433A (en) | External use traditional Chinese medicine ointment for treating haemorrhoids and preparing method of external use traditional Chinese medicine ointment | |
| CN111298045A (en) | External medicine for treating flat wart and preparation method thereof | |
| CN106138628A (en) | A kind of strong medicine ZHICHUANG GAO and preparation method thereof | |
| CN105106590A (en) | Medicine for treating allergic rhinitis | |
| KR20030043326A (en) | A composition for treating a sexual dysfunction | |
| CN113952430A (en) | Chinese herbal medicine compound preparation for treating eczema and using method thereof | |
| CN104147246A (en) | Instant medicine for treating chronic eczema and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |