CN117442512A

CN117442512A - Multifunctional bath composition and preparation method and application thereof

Info

Publication number: CN117442512A
Application number: CN202311603677.XA
Authority: CN
Inventors: 黄伟; 邓文云
Original assignee: Tisong Daily Chemical Products Guangzhou Co ltd
Current assignee: Tisong Daily Chemical Products Guangzhou Co ltd
Priority date: 2023-11-28
Filing date: 2023-11-28
Publication date: 2024-01-26

Abstract

The invention relates to a multi-effect bubble bath composition, a preparation method and application thereof, wherein the multi-effect bubble bath composition comprises an A component and a B component which are independently packaged; the component A comprises magnesium chloride, potassium chloride and calcium chloride; the component B comprises a humectant, an antibacterial polypeptide and vitamins. The A component in the multifunctional bath composition provided by the invention is a simulated dead sea salt component, has moisturizing effect on skin, plays an important role in normal physiological activities of human bodies, relieving fatigue, enhancing physical strength and the like, and the B component can further enhance the moisturizing effect of the composition through the cooperation of a humectant, an antibacterial polypeptide and vitamins, and can also have the effects of promoting metabolism in newcastle, conditioning skin, resisting bacteria and diminishing inflammation.

Description

Multifunctional bath composition and preparation method and application thereof

Technical Field

The invention belongs to the technical field of personal care, and particularly relates to a multifunctional bath composition, a preparation method and application thereof.

Background

With the increase of the working pressure of people and the acceleration of the life rhythm, sub-health problems are presented to more and more people. In daily life, people take medicines for relieving sub-health state, but the medicines are accompanied by side effects. The bath is a traditional bath mode for relieving fatigue, can promote metabolism, accelerate hormone secretion, and enable skin to become watery without side effects, so that the bath is more and more favored by people.

CN101129322 discloses a skin care multi-effect bathing powder containing natural herbal essence. The composition of the material is as follows: sodium salt mixture, tea saponin composite emollient, herbal essence powder, pearl powder, hydrochloric acid sterilizing and bacteriostat, and aromatherapy essential oil. The components in the bath powder provided by the bath powder can be degraded, the biodegradation rate can be close to 99%, the components of the bath powder can be effectively sterilized and antibacterial, the components of the bath powder can be rapidly dissolved in water, the bath powder has comprehensive synergistic effect, pharmacological effect and unique moisturizing effect, is soft and smooth, has lasting fragrance, can effectively promote skin blood circulation and metabolism, regulate skin physiological balance, whiten skin after bath, ruddy and tender, and can obviously inhibit and relieve body odor, dermatitis, prickly heat, eczema, skin itch and yang wet itch and inflammation caused by excessive sweat secretion on skin and sweat.

CN108159207a discloses a herbal medicine stone bath lotion, which is prepared from the following raw materials: 20% of medicinal stone, 9% of saffron, 9% of red paeony root, 9% of rhizoma atractylodis, 9% of red sage root, 9% of radix sophorae flavescentis, 9% of radix sileris and the balance of water. The invention optimizes the formulation of rare herbal medicines such as Yuan Yi medicinal stone and saffron, fully plays the synergistic effect of all the components, not only plays the roles of recovering the aging cells of the human body, but also has the good health care effects of promoting blood circulation, enhancing metabolism and removing waste in the body, and can better meet the physical characteristics and physical and psychological needs of modern people.

However, the bath product has no obvious skin care effect, and the traditional Chinese medicine components are expensive, so that the use cost of people is increased, and therefore, the development of a product for caring skin and maintaining physical health more effectively is urgently needed to meet the daily demands of people.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide a multi-effect bath composition, and a preparation method and application thereof.

In order to achieve the aim of the invention, the invention adopts the following technical scheme:

in a first aspect, the present invention provides a multi-functional bubble bath composition comprising separately packaged a and B components;

the component A comprises magnesium chloride, potassium chloride and calcium chloride;

the component B comprises a humectant, an antibacterial polypeptide and vitamins.

The multifunctional bubble bath composition provided by the invention has the advantages that the A component is a simulated dead sea salt component, a convection phenomenon of water penetration is formed on the skin epidermis, the water on the subcutaneous layer is induced to penetrate to the upper layer, the water-deficient skin can timely improve the humidity, meanwhile, the component can penetrate into the skin, is adsorbed on skin hair follicles, sweat glands and grease dirt with positive charges on the surface, dead skin cells and bacteria, the released nutritional component can be deeply absorbed into the skin after deep cleaning, the cell activity is improved, the important effects on normal physiological activities of a human body, fatigue relief, physical strength enhancement and the like are achieved, and the B component can further enhance the moisturizing effect of the composition through the cooperation of a humectant, an antibacterial polypeptide and vitamins, and can also have the effects of promoting metabolism in newcastle, conditioning the skin, whitening the skin, eliminating skin dryness and itching, resisting bacteria and inflammation, helping to eliminate acne, improving eczema and helping to treat acne.

Preferably, the component A comprises 40-70 parts by weight of magnesium chloride, 5-20 parts by weight of potassium chloride and 1-5 parts by weight of calcium chloride.

Preferably, the component B comprises 1-40 parts by weight of humectant, 1-50 parts by weight of antibacterial polypeptide and 0.1-15 parts by weight of vitamin.

Preferably, the humectant comprises any one or a combination of at least two of NMF-50, erythritol or hyaluronic acid.

Preferably, the humectant is a combination of NMF-50 and erythritol.

In the invention, the humectant adopts the combination of NMF-50 and erythritol, which not only improves the moisturizing effect of the composition, but also can reduce the irritation of the component A.

Preferably, the mass ratio of NMF-50 to erythritol is (1-3): 1-2.

Wherein "1-3" may be 1.2, 1.4, 1.6, 1.8, 2, 2.2, 2.4, 2.6, 2.8, etc.;

"1-2" may be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, etc.

Other specific point values in the numerical ranges are selectable, and will not be described in detail herein.

Preferably, the antimicrobial polypeptide comprises any one or a combination of at least two of lysozyme, nisin or cecropin.

Preferably, the antimicrobial polypeptide is a combination of lysozyme, nisin and cecropin.

The antibacterial polypeptide in the multifunctional bubble bath composition adopts the combination of lysozyme, nisin and cecropin, wherein the lysozyme breaks down beta-1, 4 glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in cell walls to decompose insoluble mucopolysaccharide on the cell walls into soluble glycopeptides, so that cell wall broken contents escape to dissolve bacteria, and the lysozyme can be directly combined with negatively charged viral proteins to form a complex with DNA, RNA and apoproteins to inactivate viruses; nisin can effectively kill pathogenic bacteria, bacteria and fungi, can inhibit most gram positive bacteria, and has strong inhibition effect on spores of bacillus; cecropin has broad-spectrum antibacterial effect. Has strong killing power to gram-positive bacteria and partial gram-negative bacteria, and has no toxicity to fungi and eukaryotic cells. The three have synergistic effect in terms of antibiosis and antiphlogosis, so that the antibiosis and antiphlogosis effects of the multi-effect bath composition can be improved, the infection risk of skin can be reduced, and the bath composition is safer and more reliable.

Preferably, the mass ratio of the lysozyme to the nisin to the cecropin is (1-2): 0.5-1.5): 1-2.

Wherein the first "1-2" may be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, etc.;

"0.5-1.5" may be 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, etc.;

the second "1-2" may be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, etc.

Preferably, the vitamins include B vitamins.

Preferably, the B vitamins include any one or a combination of at least two of vitamin B3, vitamin B6, or biotin.

Preferably, the component A further comprises any one or a combination of at least two of sodium chloride, magnesium bromide, silver chloride, zinc chloride, copper sulfate, dipotassium hydrogen phosphate or ferrous sulfate heptahydrate.

Preferably, the component A comprises, by weight, 40-70 parts of magnesium chloride, 5-20 parts of potassium chloride, 1-5 parts of calcium chloride, 1-10 parts of sodium chloride, 0.1-1 part of magnesium bromide, 0.0001-0.01 part of silver chloride, 0.01-0.1 part of zinc chloride, 0.01-0.1 part of copper sulfate, 0.01-0.1 part of dipotassium phosphate or 0.01-0.1 part of ferrous sulfate heptahydrate.

The magnesium chloride in the A component of the multi-functional bubble bath composition of the invention can be added in an amount of 42 parts, 45 parts, 48 parts, 50 parts, 52 parts, 55 parts, 58 parts, 60 parts, 62 parts, 65 parts or 68 parts, etc.;

the potassium chloride may be added in an amount of 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, or the like;

the addition amount of the calcium chloride can be 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts or 4.5 parts, etc.;

the addition amount of the sodium chloride can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts, etc.;

the magnesium bromide may be added in an amount of 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, or 0.9 parts, etc.;

the silver chloride may be added in an amount of 0.002 parts, 0.003 parts, 0.004 parts, 0.005 parts, 0.006 parts, 0.007 parts, 0.008 parts, 0.009 parts, or the like;

the zinc chloride may be added in an amount of 0.02 part, 0.03 part, 0.04 part, 0.05 part, 0.06 part, 0.07 part, 0.08 part, 0.09 part, or the like;

the addition amount of the copper sulfate may be 0.02 part, 0.03 part, 0.04 part, 0.05 part, 0.06 part, 0.07 part, 0.08 part, 0.09 part, or the like;

the dipotassium hydrogen phosphate can be added in an amount of 0.02 part, 0.03 part, 0.04 part, 0.05 part, 0.06 part, 0.07 part, 0.08 part or 0.09 part, etc.;

the addition amount of the ferrous sulfate heptahydrate can be 0.02 part, 0.03 part, 0.04 part, 0.05 part, 0.06 part, 0.07 part, 0.08 part, 0.09 part or the like.

Preferably, the component B further comprises any one or a combination of at least two of a soothing composition, a plant acaricide or an auxiliary agent.

Preferably, the component B comprises, by weight, 1-40 parts of a humectant, 1-50 parts of an antibacterial polypeptide, 0.1-15 parts of a vitamin, 0.1-10 parts of a soothing and repairing composition, 0.1-5 parts of a plant acaricide and 0-3 parts of an auxiliary agent.

The humectant in the component B of the multi-functional bubble bath composition of the invention can be added in an amount of 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts or 35 parts, etc.;

the addition amount of the antibacterial polypeptide can be 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts or 45 parts, etc.;

the addition amount of the vitamin may be 0.5 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, or the like;

the amount of the soothing composition added may be 0.5 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, or the like;

the plant acaricide can be added in an amount of 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts or 4.5 parts, etc.;

the addition amount of the auxiliary agent may be 0.1 part, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, or the like.

Preferably, the soothing composition comprises any one or a combination of at least two of dipotassium glycyrrhizinate, asiaticoside or oligopeptide.

Preferably, the soothing composition is a combination of dipotassium glycyrrhizinate, asiaticoside and oligopeptide.

As a preferred technical scheme of the invention, the multifunctional bath composition selects the combination of dipotassium glycyrrhizinate, asiaticoside and oligopeptide as the soothing and repairing component, and the three components cooperate to effectively repair the barrier function of skin, repair damaged cells better, reduce skin sensitivity and improve skin comfort.

Preferably, the mass ratio of dipotassium glycyrrhizinate, asiaticoside and oligopeptide is (1-2): 2-3): 0.1-1.

Wherein "1-2" may be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, etc.;

"2-3" may be 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, etc.;

"0.1-1" may be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, etc.

Preferably, the plant acaricide comprises any one or a combination of at least two of matrine, osthole or xanthoxylin.

Preferably, the auxiliary agent comprises any one or a combination of at least two of a preservative, an essence or an essential oil.

In a second aspect, the present invention provides a method of preparing a multi-functional bubble bath composition according to the first aspect, the method comprising:

(1) Mixing magnesium chloride, potassium chloride and calcium chloride to obtain a component A;

(2) Then the humectant, the antibacterial polypeptide and the vitamin are mixed to obtain the component B.

Preferably, the step (1) further comprises adding any one or a combination of at least two of sodium chloride, magnesium bromide, silver chloride, zinc chloride, copper sulfate, dipotassium hydrogen phosphate or ferrous sulfate heptahydrate.

Preferably, the humidity at the time of mixing in step (1) is < 75%, for example, the humidity may be 65%, 60%, 55%, 50%, 45% or 40%, etc.

Preferably, the step (2) further comprises adding any one or a combination of at least two of a soothing composition, a plant acaricide or an auxiliary agent when mixed.

Preferably, the a and B components are individually packaged.

In a third aspect, the present invention provides the use of a multi-functional bubble bath composition according to the first aspect in a bubble bath, the method of use comprising: the component A and the component B are added into water for use during bath;

preferably, the mass percentage of the A component in water is 0.1-3%, for example, 0.3%, 0.5%, 0.8%, 1%, 1.5%, 1.8%, 2%, 2.5% or 2.8%, etc.

Preferably, the mass ratio of the component A to the component B is 1 (0.1-1), and for example, the mass ratio can be 1:0.2, 1:0.3, 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9 or the like.

Compared with the prior art, the invention has the following beneficial effects:

the multifunctional bath composition provided by the invention has the advantages that the A component is a simulated dead sea salt component, a convection phenomenon of water penetration is formed on the skin epidermis, the water on the subcutaneous layer is induced to penetrate to the upper layer, the water-deficient skin can timely improve the humidity, meanwhile, the component can penetrate into the skin, is adsorbed on skin hair follicles, sweat glands and grease dirt with positive charges on the surface, dead skin cells and bacteria, the released nutritional component can be deeply absorbed into the skin after deep cleaning, the cell activity is improved, the important effects on normal physiological activities of a human body, fatigue relief, physical strength enhancement and the like are achieved, and the B component can further enhance the moisturizing effect of the composition through the cooperation of a humectant, an antibacterial polypeptide and vitamins, and can also have the effects of promoting metabolism, conditioning the skin, tendering the skin, eliminating skin dryness and itching, resisting bacteria and inflammation, helping to eliminate and improve eczema and help treat acne. Because the magnesium chloride, the potassium chloride, the calcium chloride and the like in the component A are easy to absorb moisture, and the component A and the component B are respectively and independently packaged, the active substances such as lysozyme, nisin, cecropin, asiaticoside and oligopeptide in the component B can be prevented from deteriorating and inactivating.

Detailed Description

In order to further describe the technical means adopted by the present invention and the effects thereof, the following describes the technical scheme of the present invention in combination with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

Example 1

The present example provides a multi-functional bubble bath composition comprising the following components:

the preparation method comprises the following steps:

(1) Mixing magnesium chloride, potassium chloride, calcium chloride, sodium chloride, magnesium bromide, silver chloride, zinc chloride, copper sulfate, dipotassium hydrogen phosphate and ferrous sulfate heptahydrate under the humidity of 50% to obtain a component A, and packaging by using a plastic bag;

(2) NMF-50, erythritol, lysozyme, nisin, cecropin, vitamin B3, vitamin B6, biotin, dipotassium glycyrrhizinate, asiaticoside, oligopeptide and matrine humectant are mixed at normal temperature to obtain a component B, and then the component B is packaged by an aluminum foil bag.

Example 2

the preparation method is described with reference to example 1.

Example 3

the preparation method is described with reference to example 1.

Example 4

The present example provides a multi-functional bath composition, which is characterized in that the raw materials for preparing the same as those of example 1 are characterized in that the component a does not include magnesium bromide, silver chloride, zinc chloride, copper sulfate, dipotassium hydrogen phosphate and ferrous sulfate heptahydrate, the reduced amount of which is added to sodium chloride, and the rest of the raw materials and the content thereof remain unchanged. The preparation method is described in example 1.

Example 5

The present example provides a multi-functional bath composition, which is characterized in that the component B does not include a soothing composition, the reduced amount of which is added to a humectant, and the ratio of NMF-50 to erythritol is kept unchanged, and the other raw materials and the content thereof are kept unchanged, as compared with the example 1. The preparation method is described in example 1.

Example 6

The present example provides a multi-functional bath composition, which is technically characterized in that the composition for soothing and repairing the B component does not include oligopeptides, the reduced amount thereof is distributed to dipotassium glycyrrhizinate and asiaticoside in a part ratio, and the remaining raw materials and the content thereof remain unchanged, as compared with the example 1. The preparation method is described in example 1.

Example 7

The present example provides a multi-functional bath composition, which is technically characterized in that the composition for soothing and repairing the B component does not include asiaticoside, the reduced amount thereof is distributed into dipotassium glycyrrhizinate and oligopeptides in a part ratio, and the remaining raw materials and the content thereof remain unchanged, as compared with the example 1. The preparation method is described in example 1.

Example 8

The present example provides a multi-functional bath composition, which is technically characterized in that the composition for soothing and repairing the B component does not include dipotassium glycyrrhizinate, the reduced amount of the composition is distributed into asiaticoside and oligopeptide according to the part ratio, and the rest of the raw materials and the content thereof remain unchanged, as compared with the example 1. The preparation method is described in example 1.

Example 9

The present example provides a multi-functional bath composition, which is technically characterized by the fact that the antibacterial polypeptide in component B does not include lysozyme, its reduced amount is proportionally distributed into nisin and cecropin in parts by weight, and the remaining raw materials and their contents remain unchanged. The preparation method is described in example 1.

Example 10

The present example provides a multi-functional bath composition, which is technically characterized by the fact that the antibacterial polypeptide in component B does not include nisin, the reduced amount thereof is distributed to lysozyme and cecropin in a part ratio, and the remaining raw materials and the content thereof remain unchanged, as compared with example 1. The preparation method is described in example 1.

Example 11

The present example provides a multi-functional bath composition, which is technically characterized by the difference between the preparation raw materials and example 1, wherein the antibacterial polypeptide in the B component does not include cecropin, the reduction amount is distributed into lysozyme and nisin according to the part ratio, and the rest raw materials and the content thereof are kept unchanged. The preparation method is described in example 1.

Example 12

This example provides a multi-functional bath composition whose manufacturing materials are technically distinguished from example 1 only in that the humectant in the B-component does not include NMF-50, its reduced amount is added to erythritol, and the remaining materials and their contents remain unchanged. The preparation method is described in example 1.

Example 13

This example provides a multi-functional bath composition whose manufacturing materials are technically distinguished from example 1 only in that the humectant in the B-component does not include erythritol, its reduced amount is added to NMF-50, and the remaining materials and their contents remain unchanged. The preparation method is described in example 1.

Comparative example 1

This comparative example provides a multi-functional bath composition which is technically distinguished from example 1 only in that it does not include the a component, other raw materials and their contents remain unchanged. The preparation method is described in example 1.

Comparative example 2

This comparative example provides a multi-functional bath composition which is technically distinguished from example 1 only in that it does not include the B component, other raw materials and their contents remain unchanged. The preparation method is described in example 1.

Comparative example 3

This comparative example provides a multi-functional bath composition which is technically distinguished from example 1 only in that the magnesium chloride is not included in the a-component, the reduction amount thereof is increased to potassium chloride and calcium chloride in a part ratio, and the other raw materials and the contents thereof remain unchanged. The preparation method is described in example 1.

Comparative example 4

This comparative example provides a multi-functional bath composition which is technically distinguished from example 1 only in that the a component does not include potassium chloride, the reduction of which is increased to magnesium chloride and calcium chloride in parts by weight, and the other raw materials and their contents remain unchanged. The preparation method is described in example 1.

Comparative example 5

This comparative example provides a multi-functional bath composition which is technically distinguished from example 1 only in that the a component does not include calcium chloride, the reduction of which is increased to magnesium chloride and potassium chloride in parts by weight, and the other raw materials and their contents remain unchanged. The preparation method is described in example 1.

Comparative example 6

This comparative example provides a multi-functional bath composition which is technically distinguished from example 1 only in that the B component does not include an antimicrobial polypeptide, the reduced amount of which is added to the humectant and the vitamin in a part ratio, and the other raw materials and their contents remain unchanged. The preparation method is described in example 1.

Comparative example 7

This comparative example provides a multi-functional bath composition which is technically distinguished from example 1 only in that the B component does not include vitamins, the reduction of which is increased in parts to the humectant and the antimicrobial polypeptide, the other materials and their contents remain unchanged. The preparation method is described in example 1.

Test example 1: skin irritation evaluation:

the specific method comprises the following steps: the samples of examples 1 to 13 and comparative examples 3 to 7 (mass ratio of the A component to the B component was 1:1) were prepared as a 3% aqueous solution, the samples of comparative examples 1 to 2 were prepared as a 3% aqueous solution, and 40 volunteers (20 men and women) were used as test subjects, and the samples were each tested.

(1) The test was performed using a 24h closed patch test. Measuring 0.020mL of the aqueous solution into a spot tester respectively, and setting a blank control group (without adding any substances);

(2) After the inner side of the arm of the subject is cleaned, the spot tester added with the sample is applied to the selected position of the inner side of the arm of the subject by using a non-stimulated adhesive tape, and is uniformly applied to the skin by slightly pressing the finger after being applied for 24 hours. Ordering the subject to keep the spot paste part dry within 24 hours, avoiding fierce exercise, scratching the spot test part, long-time sunlight irradiation and the like;

(3) After 24 hours, the tester is removed and marked, after 30 minutes, the isobaric mark is disappeared, the judgment is carried out under sufficient light, and the return visit observation is carried out within 24 hours and 48 hours respectively.

The identification criteria for skin irritation test are shown in table 1:

TABLE 1

Grade	(symbol)	Authentication criteria
			0	-	Negative reaction: no irritation and erythema
1	±	Suspicious reaction: mild erythema
			2	+	Weak positive reaction: erythema (red spot)
3	++	Strong positive reaction: erythema, papule and blister
			4	+++	Very strong positive reaction: severe edema, large foam

The test results are shown in table 2:

TABLE 2

As can be seen from the test results in Table 2, the synergistic combination of the component A and the component B in the multi-functional bath composition provided by the invention has no irritation and no positive reaction to skin, which means that the product provided by the invention is safe and mild, and in comparative example 2, the component A only causes erythema reaction, which means that the component A is easy to cause skin sensitivity, so that the combination of the component A and the component B can make the product milder.

Test example 2

Antibacterial performance test:

test sample: the samples of examples 1 to 13 and comparative examples 3 to 7 (mass ratio of the A component to the B component was 1:1) were prepared as a 3% aqueous solution, and the samples of comparative examples 1 to 2 were prepared as a 3% aqueous solution.

The test method comprises the following steps: with reference to QB/T2738-2005, the test species were Candida albicans (ATCC 10231), pseudomonas aeruginosa (ATC 15442) and Staphylococcus aureus (ATCC 27217).

The test results are shown in table 3:

TABLE 3 Table 3

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As can be seen from the data in Table 3, the multifunctional bath composition provided by the invention has remarkable antibacterial and antiseptic effects, and lysozyme, nisin and cecropin have a certain synergistic effect on improving the antibacterial effect of the product, and meanwhile, the formula composition of the component A also influences the antibacterial effect of the product.

Test example 3

Percutaneous moisture loss test

Test instrument: skin surface moisture loss tester (C & K, tewameter TM300, germany);

test sample: samples of examples 1-4, 12-13 and comparative examples 1-5 were prepared.

The test principle is as follows: the test probe of the skin surface moisture loss tester uses a specially designed cylindrical cavity vehicle probe with two open ends to form a relatively stable test small environment on the skin surface, and the moisture loss condition of the skin surface is measured by measuring the water vapor pressure gradient at different two points, which is formed by the water loss of the stratum corneum near the epidermis (within about 1 cm), through two groups of temperature and humidity sensors and directly measuring the water content evaporated through the epidermis. In g/hm ² . In particular, the amount of percutaneous moisture loss, the less moisture loss, indicates better skin barrier function;

the subject: selecting 110 subjects, selecting subjects with dry forearm skin, incorporating a moisture value of less than 45, randomly dividing into 11 groups of 10 persons each, and bathing each group once a day by using the multi-effect bath compositions of examples 1-4, 12-13 and comparative examples 1-5 (bath water composition: the samples of examples 1-4, 12-13 and comparative examples 3-5 (mass ratio of component A and component B is 1:1) are configured as 2% aqueous solutions, and the samples of comparative examples 1-2 are configured as 2% aqueous solutions);

test part: inner measurement of the forearm;

the test results are shown in table 4:

TABLE 4 Table 4

As can be seen from the test results of Table 4, the water loss was reduced to 18g/hm after 4 weeks using the multi-functional bubble bath compositions of examples 1-3 of the present invention ² The following is given. As is clear from the comparison of examples 1 and 4 and comparative examples 3 to 5, the moisture retention effect can be improved by compounding the components in the A component of the present invention; while examples 12-13, compared to example 1, demonstrate that the compatibility of NMF-50 with erythritol effectively improves moisturizing ability.

Test example 4

Clinical sleep test

210 female volunteers 20-40 years old were selected, randomly divided into 21 groups of 10 persons each, wherein 20 groups were bathed once per day with the multi-efficacy bath compositions of examples 1-13 and comparative examples 1-7 (bath water composition: the samples of examples 1-13 and comparative examples 3-7 (mass ratio of A component to B component 1: 1) were prepared as 2% aqueous solutions, the samples of comparative examples 1-2 were prepared as 2% aqueous solutions), the remaining group was blank (without any bath product), 15 days was a course of treatment, statistical efficacy was obtained for two courses of treatment, no sleep aid and no health care was taken during the period, and the change in sleep time was measured using millet bracelet, and the apparatus was capable of measuring deep sleep time and indirectly used to evaluate sleep improvement.

The specific test results are shown in table 5:

TABLE 5

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From the test data in Table 5, the sleep time of volunteers was increased by more than 60min after 15 days and more than 90min after 14 days when the multi-functional bath composition of the present invention was continuously used. Therefore, the A component and the B component in the bath composition are matched with each other, so that the bath composition has a synergistic effect, can further improve the effects of soothing the nerves and aiding sleep, can improve sleep after long-term use, can improve sleep quality, and can further improve sub-health state.

The applicant states that the present invention is illustrated by the above examples as a multi-functional bubble bath composition, and a method of making and using the same, but the present invention is not limited to, i.e., does not mean that the present invention must be practiced in dependence upon the above examples. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of raw materials for the product of the present invention, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present invention and the scope of disclosure.

The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solution of the present invention within the scope of the technical concept of the present invention, and all the simple modifications belong to the protection scope of the present invention.

In addition, the specific features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations are not described further.

Claims

1. A multi-functional bath composition, characterized in that the multi-functional bath composition comprises an a component and a B component which are independently packaged;

2. The multi-functional bath composition according to claim 1, wherein the a component comprises, in parts by weight, 40-70 parts of magnesium chloride, 5-20 parts of potassium chloride and 1-5 parts of calcium chloride;

3. The multi-efficacy bath composition according to claim 1 or 2, characterized in that the humectant comprises any one or a combination of at least two of NMF-50, erythritol or hyaluronic acid;

preferably, the humectant is a combination of NMF-50 and erythritol;

preferably, the mass ratio of NMF-50 to erythritol is (1-3): 1-2.

4. A multi-efficacy bubble bath composition according to any one of claims 1-3 characterized in that the antimicrobial polypeptide comprises any one or a combination of at least two of lysozyme, nisin or cecropin;

preferably, the antimicrobial polypeptide is a combination of lysozyme, nisin and cecropin;

preferably, the mass ratio of the lysozyme to the nisin to the cecropin is (1-2): 0.5-1.5): 1-2;

preferably, the vitamins include B vitamins;

5. The multi-functional bath composition of any one of claims 1-4, wherein the a component further comprises any one or a combination of at least two of sodium chloride, magnesium bromide, silver chloride, zinc chloride, copper sulfate, dipotassium hydrogen phosphate, or ferrous sulfate heptahydrate;

preferably, the component A comprises, by weight, 40-70 parts of magnesium chloride, 5-20 parts of potassium chloride, 1-5 parts of calcium chloride, 1-10 parts of sodium chloride, 0.1-1 part of magnesium bromide, 0.0001-0.01 part of silver chloride, 0.01-0.1 part of zinc chloride, 0.01-0.1 part of copper sulfate, 0.01-0.1 part of dipotassium phosphate and 0.01-0.1 part of ferrous sulfate heptahydrate.

6. The multi-efficacy bath composition according to any one of claims 1 to 5, characterized in that the B component further comprises any one or a combination of at least two of a soothing composition, a botanical acaricide or an adjuvant;

7. The multi-efficacy bath composition according to claim 6, characterized in that the soothing composition comprises any one or a combination of at least two of dipotassium glycyrrhizinate, asiaticoside or oligopeptides;

preferably, the soothing composition is a combination of dipotassium glycyrrhizinate, asiaticoside and oligopeptide;

preferably, the mass ratio of dipotassium glycyrrhizinate, asiaticoside and oligopeptide is (1-2): 2-3): 0.1-1;

preferably, the plant acaricide comprises any one or a combination of at least two of matrine, osthole or xanthoxylin;

8. The method of preparing a multi-functional bubble bath composition according to any one of claims 1-7, comprising:

9. The method of preparing a multi-functional bath composition according to claim 8, wherein the step (1) further comprises adding any one or a combination of at least two of sodium chloride, magnesium bromide, silver chloride, zinc chloride, copper sulfate, dipotassium hydrogen phosphate, or ferrous sulfate heptahydrate when mixing;

preferably, the humidity at the time of mixing of step (1) is < 75%;

preferably, the step (2) further comprises adding any one or a combination of at least two of a soothing composition, a plant acaricide or an auxiliary agent when mixed;

preferably, the a and B components are individually packaged.

10. Use of a multi-functional bubble bath composition according to any one of claims 1-7 in a bubble bath, characterized in that the method of application is: the component A and the component B are added into water for use during bath;

preferably, the mass percentage of the component A in water is 0.1-3%;

preferably, the mass ratio of the component A to the component B is 1 (0.1-1).