CN117425663B - 包含核酸寡聚物的组合物 - Google Patents

包含核酸寡聚物的组合物

Info

Publication number
CN117425663B
CN117425663B CN202280040815.5A CN202280040815A CN117425663B CN 117425663 B CN117425663 B CN 117425663B CN 202280040815 A CN202280040815 A CN 202280040815A CN 117425663 B CN117425663 B CN 117425663B
Authority
CN
China
Prior art keywords
nucleic acid
group
acid oligomer
formula
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202280040815.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN117425663A (zh
Inventor
森山悠也
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of CN117425663A publication Critical patent/CN117425663A/zh
Application granted granted Critical
Publication of CN117425663B publication Critical patent/CN117425663B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
CN202280040815.5A 2021-07-06 2022-06-28 包含核酸寡聚物的组合物 Active CN117425663B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021112316 2021-07-06
JP2021-112316 2021-07-06
PCT/JP2022/025692 WO2023282120A1 (ja) 2021-07-06 2022-06-28 核酸オリゴマーを含む組成物

Publications (2)

Publication Number Publication Date
CN117425663A CN117425663A (zh) 2024-01-19
CN117425663B true CN117425663B (zh) 2026-04-17

Family

ID=84801563

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280040815.5A Active CN117425663B (zh) 2021-07-06 2022-06-28 包含核酸寡聚物的组合物

Country Status (6)

Country Link
US (1) US20240300993A1 (https=)
EP (1) EP4368627A4 (https=)
JP (1) JP7806051B2 (https=)
KR (1) KR20240028416A (https=)
CN (1) CN117425663B (https=)
WO (1) WO2023282120A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4675778A1 (en) 2023-02-28 2026-01-07 SBTL Advanced Materials Co. Ltd. Stainless steel pouch film for secondary battery

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017115655A1 (ja) * 2015-12-28 2017-07-06 昭和電工株式会社 分離分析方法
WO2018212236A1 (ja) * 2017-05-16 2018-11-22 日産化学株式会社 オリゴヌクレオチドの製造方法
WO2020196890A1 (ja) * 2019-03-28 2020-10-01 味の素株式会社 ホスホロチオエート化部位を有するオリゴヌクレオチドの製造方法
WO2021024467A1 (ja) * 2019-08-08 2021-02-11 住友化学株式会社 一本鎖ｒｎａの製造方法
WO2021024465A1 (ja) * 2019-08-08 2021-02-11 住友化学株式会社 核酸分子の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
JPH07170981A (ja) * 1993-12-17 1995-07-11 Res Dev Corp Of Japan オリゴヌクレオチドの製造法
AU2005275801B2 (en) 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
US8138330B2 (en) * 2006-09-11 2012-03-20 Sigma-Aldrich Co. Llc Process for the synthesis of oligonucleotides
MX370398B (es) 2011-08-25 2019-12-11 Bonac Corp Compuesto de glicosido, metodo para producir tioeter, eter, metodo para producir eter, metodo para producir un compuesto de glicosido, metodo para producir acido nucleico.
EP3159407A1 (en) 2015-10-23 2017-04-26 Silence Therapeutics (London) Ltd Guide rnas, methods and uses
TWI729028B (zh) * 2015-11-17 2021-06-01 日商日產化學工業股份有限公司 寡核苷酸的製造方法
CN116063365A (zh) * 2015-12-16 2023-05-05 味之素株式会社 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸
LT3576753T (lt) * 2017-02-03 2024-07-25 Laboratoires Kôl Sterili emulsija, apimanti stabilų fosforotioato oligonukleotidą
KR102670605B1 (ko) 2018-04-24 2024-05-29 스미또모 가가꾸 가부시끼가이샤 아미다이트 화합물 및 그 화합물을 사용한 폴리뉴클레오티드의 제조 방법
CN115397831B (zh) * 2020-04-14 2026-02-24 住友化学株式会社 包含核酸寡聚物的组合物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017115655A1 (ja) * 2015-12-28 2017-07-06 昭和電工株式会社 分離分析方法
WO2018212236A1 (ja) * 2017-05-16 2018-11-22 日産化学株式会社 オリゴヌクレオチドの製造方法
WO2020196890A1 (ja) * 2019-03-28 2020-10-01 味の素株式会社 ホスホロチオエート化部位を有するオリゴヌクレオチドの製造方法
WO2021024467A1 (ja) * 2019-08-08 2021-02-11 住友化学株式会社 一本鎖ｒｎａの製造方法
WO2021024465A1 (ja) * 2019-08-08 2021-02-11 住友化学株式会社 核酸分子の製造方法

Also Published As

Publication number Publication date
CN117425663A (zh) 2024-01-19
EP4368627A4 (en) 2025-10-08
US20240300993A1 (en) 2024-09-12
JP7806051B2 (ja) 2026-01-26
WO2023282120A1 (ja) 2023-01-12
EP4368627A1 (en) 2024-05-15
KR20240028416A (ko) 2024-03-05
JPWO2023282120A1 (https=) 2023-01-12

Similar Documents

Publication Publication Date Title
KR102190852B1 (ko) 변형된 커플링 프로토콜을 이용하는 올리고머 화합물의 제조 방법
CN115397831B (zh) 包含核酸寡聚物的组合物
JP7719788B2 (ja) 核酸オリゴマーの製造方法
CN117425663B (zh) 包含核酸寡聚物的组合物
CN115362163B (zh) 核酸寡聚物的制造方法
JP7759323B2 (ja) 核酸オリゴマーの製造方法
JP7698631B2 (ja) 核酸オリゴマーの製造方法
EP4410770A1 (en) Production method for purified dichloroacetic acid
CN119403816A (zh) 寡核苷酸的制造方法
US20230322842A1 (en) Composition containing nucleic acid oligomer
CN120418262A (zh) 寡核苷酸的制造方法
WO2026071145A1 (ja) 核酸オリゴマーの製造方法
Park The Synthesis and Characterization Studies of Modified Nucleobase in PNA and DNA
EP4151597A1 (en) Inorganic porous substrate, inorganic porous support, and nucleic acid production method
CN115315430A (zh) 使用了链段型亚磷酰胺化合物的核酸合成法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant