CN117377522A - 用于捕集流体中的颗粒的声流体装置和方法 - Google Patents

用于捕集流体中的颗粒的声流体装置和方法 Download PDF

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Publication number
CN117377522A
CN117377522A CN202280033395.8A CN202280033395A CN117377522A CN 117377522 A CN117377522 A CN 117377522A CN 202280033395 A CN202280033395 A CN 202280033395A CN 117377522 A CN117377522 A CN 117377522A
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CN
China
Prior art keywords
channel
acoustic
fluid
particles
substrate
Prior art date
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Pending
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CN202280033395.8A
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English (en)
Chinese (zh)
Inventor
迈克尔·塞巴斯蒂安·格尔特
彼得·鲁彭
于尔格·杜阿利
斯文·潘克
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ETH Zurich
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ETH Zurich
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Publication date
Application filed by ETH Zurich filed Critical ETH Zurich
Publication of CN117377522A publication Critical patent/CN117377522A/zh
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28—Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • B01D21/283—Settling tanks provided with vibrators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/80—Employing electric, magnetic, electromagnetic or wave energy, or particle radiation
    • B01D2259/816—Sonic or ultrasonic vibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4094—Concentrating samples by other techniques involving separation of suspended solids using ultrasound

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Micromachines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN202280033395.8A 2021-05-06 2022-05-03 用于捕集流体中的颗粒的声流体装置和方法 Pending CN117377522A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21172430.7 2021-05-06
EP21172430.7A EP4085982A1 (en) 2021-05-06 2021-05-06 Acoustofluidic device and method for trapping particles in a fluid
PCT/EP2022/061881 WO2022233893A1 (en) 2021-05-06 2022-05-03 Acoustofluidic device and method for trapping particles in a fluid

Publications (1)

Publication Number Publication Date
CN117377522A true CN117377522A (zh) 2024-01-09

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CN202280033395.8A Pending CN117377522A (zh) 2021-05-06 2022-05-03 用于捕集流体中的颗粒的声流体装置和方法

Country Status (7)

Country Link
US (1) US20240253039A1 (cg-RX-API-DMAC7.html)
EP (2) EP4085982A1 (cg-RX-API-DMAC7.html)
JP (1) JP2024518382A (cg-RX-API-DMAC7.html)
KR (1) KR20240006602A (cg-RX-API-DMAC7.html)
CN (1) CN117377522A (cg-RX-API-DMAC7.html)
AU (1) AU2022268583A1 (cg-RX-API-DMAC7.html)
WO (1) WO2022233893A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115895883A (zh) * 2022-11-17 2023-04-04 北京理工大学 一种声流镊驱动的微小目标的移动和转动控制装置及方法
WO2026006856A1 (en) * 2024-06-25 2026-01-02 The Regents Of The University Of Colorado A Body Corporate High-throughput gravity-based multichannel separation assembly
WO2026011041A1 (en) * 2024-07-02 2026-01-08 The Charles Stark Draper Laboratory, Inc. Acoustic concentration of cells or particles in blood products

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4523682A (en) * 1982-05-19 1985-06-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Acoustic particle separation
US20080245709A1 (en) * 2007-04-09 2008-10-09 Gregory Kaduchak Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US20130043170A1 (en) * 2011-08-16 2013-02-21 Klint A. Rose Microfluidic ultrasonic particle separators with engineered node locations and geometries
US20140011240A1 (en) * 2012-03-15 2014-01-09 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
CN103667051A (zh) * 2013-12-20 2014-03-26 河南省医药科学研究院 用于肿瘤细胞分离的表面声波微流控芯片
US20200276579A1 (en) * 2018-12-03 2020-09-03 Duke University Acoustofluidic systems including acoustic wave generators for manipulating fluids, droplets, and micro/nano objects within a fluid suspension and related methods
CN112076808A (zh) * 2019-06-13 2020-12-15 安行生物技术有限公司 利用超高频声波控制溶液中的微粒移动的方法及设备
CN114308157A (zh) * 2021-12-27 2022-04-12 南京航空航天大学 一种基于局域谐振腔的动态可调声镊装置及其使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3488732B2 (ja) * 1992-12-02 2004-01-19 株式会社日立製作所 超音波処理装置
JP2700058B2 (ja) 1996-01-23 1998-01-19 工業技術院長 超音波を用いた非接触マイクロマニピュレーション方法
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
ES2326109B1 (es) * 2007-12-05 2010-06-25 Consejo Superior De Investigaciones Cientificas Microdispositivo de separacion y extraccion selectiva y no invasiva de particulas en suspensiones polidispersas, procedimiento de fabricacion y sus aplicaciones.
JP2012202789A (ja) * 2011-03-25 2012-10-22 Fujifilm Corp 測定装置
WO2014178782A1 (en) 2013-04-30 2014-11-06 Acousort Ab Microsystem and method to focus cells or particles using acoustophoresis
WO2015172095A1 (en) * 2014-05-08 2015-11-12 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
US10161926B2 (en) * 2015-06-11 2018-12-25 Flodesign Sonics, Inc. Acoustic methods for separation of cells and pathogens
WO2018005984A1 (en) * 2016-07-01 2018-01-04 Life Technologies Corporation Methods, systems and devices for concentration of particles
WO2020047504A2 (en) 2018-08-31 2020-03-05 The Charles Stark Draper Laboratory, Inc. Method and apparatus for high throughput high efficiency transfection of cells

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4523682A (en) * 1982-05-19 1985-06-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Acoustic particle separation
US20080245709A1 (en) * 2007-04-09 2008-10-09 Gregory Kaduchak Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US20130043170A1 (en) * 2011-08-16 2013-02-21 Klint A. Rose Microfluidic ultrasonic particle separators with engineered node locations and geometries
US20140011240A1 (en) * 2012-03-15 2014-01-09 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
CN103667051A (zh) * 2013-12-20 2014-03-26 河南省医药科学研究院 用于肿瘤细胞分离的表面声波微流控芯片
US20200276579A1 (en) * 2018-12-03 2020-09-03 Duke University Acoustofluidic systems including acoustic wave generators for manipulating fluids, droplets, and micro/nano objects within a fluid suspension and related methods
CN112076808A (zh) * 2019-06-13 2020-12-15 安行生物技术有限公司 利用超高频声波控制溶液中的微粒移动的方法及设备
CN114308157A (zh) * 2021-12-27 2022-04-12 南京航空航天大学 一种基于局域谐振腔的动态可调声镊装置及其使用方法

Also Published As

Publication number Publication date
WO2022233893A1 (en) 2022-11-10
EP4334011B1 (en) 2025-11-26
EP4085982A1 (en) 2022-11-09
KR20240006602A (ko) 2024-01-15
AU2022268583A1 (en) 2023-11-23
US20240253039A1 (en) 2024-08-01
EP4334011C0 (en) 2025-11-26
JP2024518382A (ja) 2024-05-01
EP4334011A1 (en) 2024-03-13

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