KR20240006602A - 유체에서 입자를 포획하기 위한 음향 유체 장치 및 방법 - Google Patents

유체에서 입자를 포획하기 위한 음향 유체 장치 및 방법 Download PDF

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Publication number
KR20240006602A
KR20240006602A KR1020237041983A KR20237041983A KR20240006602A KR 20240006602 A KR20240006602 A KR 20240006602A KR 1020237041983 A KR1020237041983 A KR 1020237041983A KR 20237041983 A KR20237041983 A KR 20237041983A KR 20240006602 A KR20240006602 A KR 20240006602A
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KR
South Korea
Prior art keywords
channel
acoustic
fluid
substrate
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237041983A
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English (en)
Korean (ko)
Inventor
마이클 세바스티앙 겔릿
피터 루펜
주르그 두얼
스벤 판케
Original Assignee
에테하 쭈리히
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에테하 쭈리히 filed Critical 에테하 쭈리히
Publication of KR20240006602A publication Critical patent/KR20240006602A/ko
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28—Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • B01D21/283—Settling tanks provided with vibrators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/80—Employing electric, magnetic, electromagnetic or wave energy, or particle radiation
    • B01D2259/816—Sonic or ultrasonic vibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4094—Concentrating samples by other techniques involving separation of suspended solids using ultrasound

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Micromachines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
KR1020237041983A 2021-05-06 2022-05-03 유체에서 입자를 포획하기 위한 음향 유체 장치 및 방법 Pending KR20240006602A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21172430.7 2021-05-06
EP21172430.7A EP4085982A1 (en) 2021-05-06 2021-05-06 Acoustofluidic device and method for trapping particles in a fluid
PCT/EP2022/061881 WO2022233893A1 (en) 2021-05-06 2022-05-03 Acoustofluidic device and method for trapping particles in a fluid

Publications (1)

Publication Number Publication Date
KR20240006602A true KR20240006602A (ko) 2024-01-15

Family

ID=76034419

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237041983A Pending KR20240006602A (ko) 2021-05-06 2022-05-03 유체에서 입자를 포획하기 위한 음향 유체 장치 및 방법

Country Status (7)

Country Link
US (1) US20240253039A1 (cg-RX-API-DMAC7.html)
EP (2) EP4085982A1 (cg-RX-API-DMAC7.html)
JP (1) JP2024518382A (cg-RX-API-DMAC7.html)
KR (1) KR20240006602A (cg-RX-API-DMAC7.html)
CN (1) CN117377522A (cg-RX-API-DMAC7.html)
AU (1) AU2022268583A1 (cg-RX-API-DMAC7.html)
WO (1) WO2022233893A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115895883A (zh) * 2022-11-17 2023-04-04 北京理工大学 一种声流镊驱动的微小目标的移动和转动控制装置及方法
WO2026006856A1 (en) * 2024-06-25 2026-01-02 The Regents Of The University Of Colorado A Body Corporate High-throughput gravity-based multichannel separation assembly
WO2026011041A1 (en) * 2024-07-02 2026-01-08 The Charles Stark Draper Laboratory, Inc. Acoustic concentration of cells or particles in blood products

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4523682A (en) * 1982-05-19 1985-06-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Acoustic particle separation
JP3488732B2 (ja) * 1992-12-02 2004-01-19 株式会社日立製作所 超音波処理装置
JP2700058B2 (ja) 1996-01-23 1998-01-19 工業技術院長 超音波を用いた非接触マイクロマニピュレーション方法
US8083068B2 (en) * 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
ES2326109B1 (es) * 2007-12-05 2010-06-25 Consejo Superior De Investigaciones Cientificas Microdispositivo de separacion y extraccion selectiva y no invasiva de particulas en suspensiones polidispersas, procedimiento de fabricacion y sus aplicaciones.
JP2012202789A (ja) * 2011-03-25 2012-10-22 Fujifilm Corp 測定装置
US8727129B2 (en) 2011-08-16 2014-05-20 Lawrence Livermore National Security, Llc. Microfluidic ultrasonic particle separators with engineered node locations and geometries
US9458450B2 (en) * 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
WO2014178782A1 (en) 2013-04-30 2014-11-06 Acousort Ab Microsystem and method to focus cells or particles using acoustophoresis
CN103667051A (zh) * 2013-12-20 2014-03-26 河南省医药科学研究院 用于肿瘤细胞分离的表面声波微流控芯片
WO2015172095A1 (en) * 2014-05-08 2015-11-12 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
US10161926B2 (en) * 2015-06-11 2018-12-25 Flodesign Sonics, Inc. Acoustic methods for separation of cells and pathogens
WO2018005984A1 (en) * 2016-07-01 2018-01-04 Life Technologies Corporation Methods, systems and devices for concentration of particles
WO2020047504A2 (en) 2018-08-31 2020-03-05 The Charles Stark Draper Laboratory, Inc. Method and apparatus for high throughput high efficiency transfection of cells
US11577241B2 (en) * 2018-12-03 2023-02-14 Duke University Acoustofluidic systems including acoustic wave generators for manipulating fluids, droplets, and micro/nano objects within a fluid suspension and related methods
WO2020249131A1 (zh) * 2019-06-13 2020-12-17 安行生物技术有限公司 利用超高频声波控制溶液中的微粒移动的方法及设备
CN114308157A (zh) * 2021-12-27 2022-04-12 南京航空航天大学 一种基于局域谐振腔的动态可调声镊装置及其使用方法

Also Published As

Publication number Publication date
WO2022233893A1 (en) 2022-11-10
EP4334011B1 (en) 2025-11-26
EP4085982A1 (en) 2022-11-09
CN117377522A (zh) 2024-01-09
AU2022268583A1 (en) 2023-11-23
US20240253039A1 (en) 2024-08-01
EP4334011C0 (en) 2025-11-26
JP2024518382A (ja) 2024-05-01
EP4334011A1 (en) 2024-03-13

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PA0105 International application

Patent event date: 20231205

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20250430

Comment text: Request for Examination of Application