AU2022268583A1 - Acoustofluidic device and method for trapping particles in a fluid - Google Patents

Acoustofluidic device and method for trapping particles in a fluid Download PDF

Info

Publication number
AU2022268583A1
AU2022268583A1 AU2022268583A AU2022268583A AU2022268583A1 AU 2022268583 A1 AU2022268583 A1 AU 2022268583A1 AU 2022268583 A AU2022268583 A AU 2022268583A AU 2022268583 A AU2022268583 A AU 2022268583A AU 2022268583 A1 AU2022268583 A1 AU 2022268583A1
Authority
AU
Australia
Prior art keywords
channel
particles
acoustic
separating wall
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2022268583A
Other languages
English (en)
Inventor
Jürg Dual
Michael Sebastian GERLT
Sven Panke
Peter Ruppen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ETH Zurich
Original Assignee
ETH Zurich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ETH Zurich filed Critical ETH Zurich
Publication of AU2022268583A1 publication Critical patent/AU2022268583A1/en
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28—Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • B01D21/283—Settling tanks provided with vibrators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/80—Employing electric, magnetic, electromagnetic or wave energy, or particle radiation
    • B01D2259/816—Sonic or ultrasonic vibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4094—Concentrating samples by other techniques involving separation of suspended solids using ultrasound

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Micromachines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AU2022268583A 2021-05-06 2022-05-03 Acoustofluidic device and method for trapping particles in a fluid Pending AU2022268583A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21172430.7 2021-05-06
EP21172430.7A EP4085982A1 (en) 2021-05-06 2021-05-06 Acoustofluidic device and method for trapping particles in a fluid
PCT/EP2022/061881 WO2022233893A1 (en) 2021-05-06 2022-05-03 Acoustofluidic device and method for trapping particles in a fluid

Publications (1)

Publication Number Publication Date
AU2022268583A1 true AU2022268583A1 (en) 2023-11-23

Family

ID=76034419

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022268583A Pending AU2022268583A1 (en) 2021-05-06 2022-05-03 Acoustofluidic device and method for trapping particles in a fluid

Country Status (7)

Country Link
US (1) US20240253039A1 (cg-RX-API-DMAC7.html)
EP (2) EP4085982A1 (cg-RX-API-DMAC7.html)
JP (1) JP2024518382A (cg-RX-API-DMAC7.html)
KR (1) KR20240006602A (cg-RX-API-DMAC7.html)
CN (1) CN117377522A (cg-RX-API-DMAC7.html)
AU (1) AU2022268583A1 (cg-RX-API-DMAC7.html)
WO (1) WO2022233893A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115895883A (zh) * 2022-11-17 2023-04-04 北京理工大学 一种声流镊驱动的微小目标的移动和转动控制装置及方法
WO2026006856A1 (en) * 2024-06-25 2026-01-02 The Regents Of The University Of Colorado A Body Corporate High-throughput gravity-based multichannel separation assembly
WO2026011041A1 (en) * 2024-07-02 2026-01-08 The Charles Stark Draper Laboratory, Inc. Acoustic concentration of cells or particles in blood products

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4523682A (en) * 1982-05-19 1985-06-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Acoustic particle separation
JP3488732B2 (ja) * 1992-12-02 2004-01-19 株式会社日立製作所 超音波処理装置
JP2700058B2 (ja) 1996-01-23 1998-01-19 工業技術院長 超音波を用いた非接触マイクロマニピュレーション方法
US8083068B2 (en) * 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
ES2326109B1 (es) * 2007-12-05 2010-06-25 Consejo Superior De Investigaciones Cientificas Microdispositivo de separacion y extraccion selectiva y no invasiva de particulas en suspensiones polidispersas, procedimiento de fabricacion y sus aplicaciones.
JP2012202789A (ja) * 2011-03-25 2012-10-22 Fujifilm Corp 測定装置
US8727129B2 (en) 2011-08-16 2014-05-20 Lawrence Livermore National Security, Llc. Microfluidic ultrasonic particle separators with engineered node locations and geometries
US9458450B2 (en) * 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
WO2014178782A1 (en) 2013-04-30 2014-11-06 Acousort Ab Microsystem and method to focus cells or particles using acoustophoresis
CN103667051A (zh) * 2013-12-20 2014-03-26 河南省医药科学研究院 用于肿瘤细胞分离的表面声波微流控芯片
WO2015172095A1 (en) * 2014-05-08 2015-11-12 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
US10161926B2 (en) * 2015-06-11 2018-12-25 Flodesign Sonics, Inc. Acoustic methods for separation of cells and pathogens
WO2018005984A1 (en) * 2016-07-01 2018-01-04 Life Technologies Corporation Methods, systems and devices for concentration of particles
WO2020047504A2 (en) 2018-08-31 2020-03-05 The Charles Stark Draper Laboratory, Inc. Method and apparatus for high throughput high efficiency transfection of cells
US11577241B2 (en) * 2018-12-03 2023-02-14 Duke University Acoustofluidic systems including acoustic wave generators for manipulating fluids, droplets, and micro/nano objects within a fluid suspension and related methods
WO2020249131A1 (zh) * 2019-06-13 2020-12-17 安行生物技术有限公司 利用超高频声波控制溶液中的微粒移动的方法及设备
CN114308157A (zh) * 2021-12-27 2022-04-12 南京航空航天大学 一种基于局域谐振腔的动态可调声镊装置及其使用方法

Also Published As

Publication number Publication date
WO2022233893A1 (en) 2022-11-10
EP4334011B1 (en) 2025-11-26
EP4085982A1 (en) 2022-11-09
CN117377522A (zh) 2024-01-09
KR20240006602A (ko) 2024-01-15
US20240253039A1 (en) 2024-08-01
EP4334011C0 (en) 2025-11-26
JP2024518382A (ja) 2024-05-01
EP4334011A1 (en) 2024-03-13

Similar Documents

Publication Publication Date Title
EP4334011B1 (en) Acoustofluidic device and method for trapping particles in a fluid
JP5642684B2 (ja) 定在超音波により懸濁液から粒子を分離するための装置と方法
US9701955B2 (en) Acoustophoretic separation technology using multi-dimensional standing waves
Feng et al. On-chip rotational manipulation of microbeads and oocytes using acoustic microstreaming generated by oscillating asymmetrical microstructures
EP2903715A2 (en) Acoustophoretic separation technology using multi-dimensional standing waves
Qiu et al. Enhancement of acoustic energy density in bulk-wave-acoustophoresis devices using side actuation
Harley et al. Enhanced acoustic streaming effects via sharp-edged 3D microstructures
Shields IV et al. Fabrication and operation of acoustofluidic devices supporting bulk acoustic standing waves for sheathless focusing of particles
Fuchsluger et al. Acoustofluidic particle trapping in a structured microchannel using lateral transducer modes
Zhu et al. High-throughput acoustofluidic microchannels for single cell rotation
JP2013072876A (ja) 流体媒体中の粒子の質量検出用のデバイス及び方法
Ozcelik et al. Fundamentals and applications of acoustics in microfluidics
JP2024518382A5 (cg-RX-API-DMAC7.html)
Liu et al. Trapping of particles by the leakage of a standing wave ultrasonic field
Johansson et al. Surface acoustic wave-induced precise particle manipulation in a trapezoidal glass microfluidic channel
Zhang et al. An integratible acoustic micropump based on the resonance of on-substrate sharp-edge micropillar arrays
Schwarz Rotation of particles by ultrasonic manipulation
Liu et al. A new strategy to capture single biological micro particles at the interface between a water film and substrate by ultrasonic tweezers
WO2006032048A2 (en) Separation of particle types using a non-uniform acoustic field
Leikam et al. Design Studies and Optimization of Acoustic Pressure in Acoustofluidic Cell Manipulation Platforms
Guo et al. Ultrasonic particle trapping in microfluidic devices using soft lithography
Talebjedi Developing an acoustic-based microfluidics micro/nano scale particle separation and manipulation platform with application for extracellular vesicle isolation
Fuchsluger et al. Acoustic particle manipulation along three orthogonal directions in laser engraved microfluidic channels
Hu et al. Ultrasonic collection of small particles by a tapered metal strip
JP7819972B2 (ja) 粒子２次元音響収束装置及びそれを用いた音響濃縮装置