JP2024518382A - 流体中の粒子を捕捉する音響流体デバイス及び方法 - Google Patents

流体中の粒子を捕捉する音響流体デバイス及び方法 Download PDF

Info

Publication number
JP2024518382A
JP2024518382A JP2023567991A JP2023567991A JP2024518382A JP 2024518382 A JP2024518382 A JP 2024518382A JP 2023567991 A JP2023567991 A JP 2023567991A JP 2023567991 A JP2023567991 A JP 2023567991A JP 2024518382 A JP2024518382 A JP 2024518382A
Authority
JP
Japan
Prior art keywords
channel
acoustic
fluid
particles
separation wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023567991A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024518382A5 (cg-RX-API-DMAC7.html
Inventor
セバスティアン ゲルト，ミヒャエル
ルッペン，ペーター
ドゥアル，ヨルグ
パンケ，スヴェン
Original Assignee
エーテーハー チューリヒ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エーテーハー チューリヒ filed Critical エーテーハー チューリヒ
Publication of JP2024518382A publication Critical patent/JP2024518382A/ja
Publication of JP2024518382A5 publication Critical patent/JP2024518382A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28—Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • B01D21/283—Settling tanks provided with vibrators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/80—Employing electric, magnetic, electromagnetic or wave energy, or particle radiation
    • B01D2259/816—Sonic or ultrasonic vibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4094—Concentrating samples by other techniques involving separation of suspended solids using ultrasound

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Micromachines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2023567991A 2021-05-06 2022-05-03 流体中の粒子を捕捉する音響流体デバイス及び方法 Pending JP2024518382A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21172430.7 2021-05-06
EP21172430.7A EP4085982A1 (en) 2021-05-06 2021-05-06 Acoustofluidic device and method for trapping particles in a fluid
PCT/EP2022/061881 WO2022233893A1 (en) 2021-05-06 2022-05-03 Acoustofluidic device and method for trapping particles in a fluid

Publications (2)

Publication Number Publication Date
JP2024518382A true JP2024518382A (ja) 2024-05-01
JP2024518382A5 JP2024518382A5 (cg-RX-API-DMAC7.html) 2025-04-25

Family

ID=76034419

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023567991A Pending JP2024518382A (ja) 2021-05-06 2022-05-03 流体中の粒子を捕捉する音響流体デバイス及び方法

Country Status (7)

Country Link
US (1) US20240253039A1 (cg-RX-API-DMAC7.html)
EP (2) EP4085982A1 (cg-RX-API-DMAC7.html)
JP (1) JP2024518382A (cg-RX-API-DMAC7.html)
KR (1) KR20240006602A (cg-RX-API-DMAC7.html)
CN (1) CN117377522A (cg-RX-API-DMAC7.html)
AU (1) AU2022268583A1 (cg-RX-API-DMAC7.html)
WO (1) WO2022233893A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115895883A (zh) * 2022-11-17 2023-04-04 北京理工大学 一种声流镊驱动的微小目标的移动和转动控制装置及方法
WO2026006856A1 (en) * 2024-06-25 2026-01-02 The Regents Of The University Of Colorado A Body Corporate High-throughput gravity-based multichannel separation assembly
WO2026011041A1 (en) * 2024-07-02 2026-01-08 The Charles Stark Draper Laboratory, Inc. Acoustic concentration of cells or particles in blood products

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0747259A (ja) * 1992-12-02 1995-02-21 Hitachi Ltd 超音波による流体中の微粒子処理装置
US20080245745A1 (en) * 2007-04-09 2008-10-09 Ward Michael D Acoustic concentration of particles in fluid flow
US20100323342A1 (en) * 2007-12-05 2010-12-23 Gonzalez Gomez Maria Iciar Micro-device and method for selective and non-invasive separation and extraction of particles in polydispersed suspensions, manufacturing process and applications thereof
JP2012202789A (ja) * 2011-03-25 2012-10-22 Fujifilm Corp 測定装置
US20130043170A1 (en) * 2011-08-16 2013-02-21 Klint A. Rose Microfluidic ultrasonic particle separators with engineered node locations and geometries
WO2016201385A2 (en) * 2015-06-11 2016-12-15 Flodesign Sonics, Inc. Acoustic methods for separation cells and pathogens
JP2017515669A (ja) * 2014-05-08 2017-06-15 フローデザイン ソニックス， インコーポレイテッド 圧電要素変換器アレイを伴う音響泳動デバイス
JP2019530850A (ja) * 2016-07-01 2019-10-24 ライフ テクノロジーズ コーポレーション 粒子を濃縮するための方法、システム、および装置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4523682A (en) * 1982-05-19 1985-06-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Acoustic particle separation
JP2700058B2 (ja) 1996-01-23 1998-01-19 工業技術院長 超音波を用いた非接触マイクロマニピュレーション方法
US8083068B2 (en) * 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US9458450B2 (en) * 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
WO2014178782A1 (en) 2013-04-30 2014-11-06 Acousort Ab Microsystem and method to focus cells or particles using acoustophoresis
CN103667051A (zh) * 2013-12-20 2014-03-26 河南省医药科学研究院 用于肿瘤细胞分离的表面声波微流控芯片
WO2020047504A2 (en) 2018-08-31 2020-03-05 The Charles Stark Draper Laboratory, Inc. Method and apparatus for high throughput high efficiency transfection of cells
US11577241B2 (en) * 2018-12-03 2023-02-14 Duke University Acoustofluidic systems including acoustic wave generators for manipulating fluids, droplets, and micro/nano objects within a fluid suspension and related methods
WO2020249131A1 (zh) * 2019-06-13 2020-12-17 安行生物技术有限公司 利用超高频声波控制溶液中的微粒移动的方法及设备
CN114308157A (zh) * 2021-12-27 2022-04-12 南京航空航天大学 一种基于局域谐振腔的动态可调声镊装置及其使用方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0747259A (ja) * 1992-12-02 1995-02-21 Hitachi Ltd 超音波による流体中の微粒子処理装置
US20080245745A1 (en) * 2007-04-09 2008-10-09 Ward Michael D Acoustic concentration of particles in fluid flow
US20100323342A1 (en) * 2007-12-05 2010-12-23 Gonzalez Gomez Maria Iciar Micro-device and method for selective and non-invasive separation and extraction of particles in polydispersed suspensions, manufacturing process and applications thereof
JP2012202789A (ja) * 2011-03-25 2012-10-22 Fujifilm Corp 測定装置
US20130043170A1 (en) * 2011-08-16 2013-02-21 Klint A. Rose Microfluidic ultrasonic particle separators with engineered node locations and geometries
JP2017515669A (ja) * 2014-05-08 2017-06-15 フローデザイン ソニックス， インコーポレイテッド 圧電要素変換器アレイを伴う音響泳動デバイス
WO2016201385A2 (en) * 2015-06-11 2016-12-15 Flodesign Sonics, Inc. Acoustic methods for separation cells and pathogens
JP2019530850A (ja) * 2016-07-01 2019-10-24 ライフ テクノロジーズ コーポレーション 粒子を濃縮するための方法、システム、および装置

Also Published As

Publication number Publication date
WO2022233893A1 (en) 2022-11-10
EP4334011B1 (en) 2025-11-26
EP4085982A1 (en) 2022-11-09
CN117377522A (zh) 2024-01-09
KR20240006602A (ko) 2024-01-15
AU2022268583A1 (en) 2023-11-23
US20240253039A1 (en) 2024-08-01
EP4334011C0 (en) 2025-11-26
EP4334011A1 (en) 2024-03-13

Similar Documents

Publication Publication Date Title
JP5642684B2 (ja) 定在超音波により懸濁液から粒子を分離するための装置と方法
EP4334011B1 (en) Acoustofluidic device and method for trapping particles in a fluid
US9701955B2 (en) Acoustophoretic separation technology using multi-dimensional standing waves
Lenshof et al. Acoustofluidics 5: Building microfluidic acoustic resonators
Oberti et al. Manipulation of micrometer sized particles within a micromachined fluidic device to form two-dimensional patterns using ultrasound
Hu Ultrasonic micro/nano manipulations: principles and examples
JP7232246B2 (ja) ポリマーチップにおける音響泳動操作のための方法および装置
Qiu et al. Enhancement of acoustic energy density in bulk-wave-acoustophoresis devices using side actuation
Zhang et al. Acoustic streaming and microparticle enrichment within a microliter droplet using a Lamb-wave resonator array
Fuchsluger et al. Acoustofluidic particle trapping in a structured microchannel using lateral transducer modes
Shields IV et al. Fabrication and operation of acoustofluidic devices supporting bulk acoustic standing waves for sheathless focusing of particles
JP2013072876A (ja) 流体媒体中の粒子の質量検出用のデバイス及び方法
JP2024518382A5 (cg-RX-API-DMAC7.html)
JP6758719B2 (ja) 多目的音響浮揚トラップ
Liu et al. A new strategy to capture single biological micro particles at the interface between a water film and substrate by ultrasonic tweezers
Johansson et al. Surface acoustic wave-induced precise particle manipulation in a trapezoidal glass microfluidic channel
Gralinski et al. Non-contact acoustic trapping in circular cross-section glass capillaries: a numerical study
Cui et al. Augmented longitudinal acoustic trap for scalable microparticle enrichment
Schwarz Rotation of particles by ultrasonic manipulation
Hu Ultrasonic Nano/Microfabrication, Handling, and Driving
Guo et al. Ultrasonic particle trapping in microfluidic devices using soft lithography
Fuchsluger et al. Acoustic particle manipulation along three orthogonal directions in laser engraved microfluidic channels
Hu et al. Ultrasonic collection of small particles by a tapered metal strip
CN115066489A (zh) 使用晶种粒子的增强声学粒子处理
JP7819972B2 (ja) 粒子２次元音響収束装置及びそれを用いた音響濃縮装置

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250417

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20250417

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20260310

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20260317

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20260617

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20260807