CN117298217A - Instant ginseng without excessive internal heat and preparation method thereof - Google Patents
Instant ginseng without excessive internal heat and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/50—Methods involving additional extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention provides an instant ginseng without excessive internal heat and a preparation method thereof, belonging to the technical field of ginseng processing. The preparation method of the instant ginseng without excessive internal heat comprises the following steps: mixing Ginseng radix, bulbus Lilii, herba Menthae, radix Ophiopogonis, poria and Glycyrrhrizae radix, ultrasonic treating in ethanol solution, and removing ethanol to obtain medicinal liquid; drying Ginseng radix at low temperature, adsorbing the medicinal liquid, and vacuum freeze drying to obtain instant Ginseng radix without excessive internal heat; the ginseng is whole ginseng. In the invention, ginseng is monarch, lily, peppermint and dwarf lilyturf tuber are ministerial, poria cocos is assistant, liquorice is guide, and the medicines are combined to have the effect of tonifying qi. The invention adopts the whole ginseng, has ornamental value, the dwarf lilyturf tuber, the Indian buead and the liquoric root can improve the bitter taste of the ginseng, the peppermint gives a new taste, and the vacuum freeze drying technology can improve the slag feel of the instant ginseng, so that the instant ginseng is easy to be accepted by consumers. The ginseng prepared by the method still has excellent tonifying effect, and can achieve the effect of preventing excessive internal heat.
Description
Technical Field
The invention relates to the technical field of ginseng processing, in particular to an instant ginseng without excessive internal heat and a preparation method thereof.
Background
The Chinese medicinal material Ginseng radix is a qi invigorating medicine, and is dried root and rhizome of Ginseng radix of Araliaceae. The ginseng has rich pharmacological components and high medicinal value, and the fleshy root is a tonic, is suitable for regulating blood pressure, recovering heart function, neurasthenia, and asthenia, and has the effects of eliminating phlegm, invigorating stomach, promoting urination, and exciting. For a long time, ginseng has been widely used as a tonic drug for various functional foods or therapeutic health products. However, excessive doses or long-term intake of ginseng can cause a series of "excessive internal heat" symptoms such as epistaxis, canker sores, sleep disorders, etc. Ginseng is decocted to obtain decoction for administration, or is used by chewing, stewing, soaking in wine or cooking soup. As the ginseng contains ginsenoside, the ginseng has obvious bitter taste and slag feeling when being chewed.
At present, the processing of ginseng is limited to slicing ginseng and then drying to obtain ginseng slices, and the ginseng slices can be taken only by soaking water later, so that the ginseng slices can not be taken immediately, and a user can possibly get excessive internal heat. The fresh cut ginseng slices are prepared into honey slices, and the taste and the efficacy of the ginseng cannot be optimized. Therefore, a need exists for a processing method of instant ginseng without excessive internal heat, which ensures that the prepared ginseng has good taste and good qi tonifying effect.
Disclosure of Invention
The invention aims to provide an instant ginseng without excessive internal heat and a preparation method thereof, and the prepared ginseng has the characteristics of no excessive internal heat and good taste.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a preparation method of instant ginseng without excessive internal heat, which comprises the following steps: mixing Ginseng radix, bulbus Lilii, herba Menthae, radix Ophiopogonis, poria and Glycyrrhrizae radix, ultrasonic treating in ethanol solution, filtering, and distilling the filtrate under reduced pressure to remove ethanol to obtain medicinal liquid; drying the ginseng subjected to ultrasonic treatment at low temperature, adsorbing the liquid medicine, and performing vacuum freeze drying to obtain the instant ginseng without excessive internal heat; the ginseng is whole ginseng.
Preferably, the lily, peppermint, dwarf lilyturf tuber, poria cocos and liquorice are all powder, and the particle size is 150-250 meshes.
Preferably, the weight ratio of the ginseng to the lily to the mint to the dwarf lilyturf tuber to the tuckahoe to the liquorice is 35-45:15-25:10-15:15-25:10-15:5-10.
Preferably, the volume percentage of the ethanol solution is 50-60%.
Preferably, the mass volume ratio of the ginseng, the lily, the peppermint, the poria cocos, the dwarf lilyturf tuber and the liquorice to the ethanol solution is 1:2-4 g/mL.
Preferably, the temperature of the ultrasonic treatment is 40-50 ℃ and the time is 3-5 h.
Preferably, the low-temperature drying temperature is 40-50 ℃ and the time is 3-5 h.
Preferably, the pre-freezing temperature of the vacuum freeze drying is-40 to-35 ℃ and the time is 2 to 3 hours.
Preferably, the vacuum degree of the drying chamber for vacuum freeze drying is 50-60 Pa, the temperature is 40-50 ℃ and the time is 7-9 h.
The invention also provides the instant ginseng without excessive internal heat, which is obtained by the preparation method.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a preparation method of instant ginseng without excessive internal heat, which comprises the following steps: mixing Ginseng radix, bulbus Lilii, herba Menthae, radix Ophiopogonis, poria and Glycyrrhrizae radix, ultrasonic treating in ethanol solution, filtering, and distilling the filtrate under reduced pressure to remove ethanol to obtain medicinal liquid; drying the ginseng subjected to ultrasonic treatment at low temperature, adsorbing the liquid medicine, and performing vacuum freeze drying to obtain the instant ginseng without excessive internal heat; the ginseng is whole ginseng. The ginseng is used as a monarch drug for invigorating primordial qi, tonifying spleen and lung, promoting the production of body fluid and tranquillizing, lily, peppermint and dwarf lilyturf tuber are used as ministerial drugs for dispelling wind and heat, clearing heat and detoxicating, and reducing dryness of ginseng, poria cocos is used as ministerial drugs for invigorating spleen and stomach, promoting diuresis and excreting dampness, nourishing heart and tranquillizing, liquorice is used as an adjuvant drug for invigorating spleen and replenishing qi, clearing heat and detoxicating, and harmonizing drug property; the combination of the medicines has the effect of tonifying qi. In addition, the whole ginseng is processed without slicing, so that the ginseng has ornamental value; the mint is extracted by the invention and is used for the ginseng to have comfortable and fresh taste; after radix ophiopogonis, poria cocos and liquorice are extracted, sweet substances in the radix ophiopogonis, poria cocos and liquorice neutralize bitter taste of ginseng, so that the radix ophiopogonis, poria cocos and liquorice are easy to accept by consumers. In addition, the ginseng prepared by the preparation method still has excellent tonifying effect, and can achieve the effect of preventing excessive internal heat.
Detailed Description
The invention provides a preparation method of instant ginseng without excessive internal heat, which comprises the following steps: mixing Ginseng radix, bulbus Lilii, herba Menthae, radix Ophiopogonis, poria and Glycyrrhrizae radix, ultrasonic treating in ethanol solution, filtering, and distilling the filtrate under reduced pressure to remove ethanol to obtain medicinal liquid; drying the ginseng subjected to ultrasonic treatment at low temperature, adsorbing the liquid medicine, and performing vacuum freeze drying to obtain the instant ginseng without excessive internal heat; the ginseng is whole ginseng.
The ginseng is used as a monarch drug for invigorating primordial qi, tonifying spleen and lung, promoting the production of body fluid and tranquillizing, lily, peppermint and dwarf lilyturf tuber are used as ministerial drugs for dispelling wind and heat, clearing heat and detoxicating, and reducing dryness of ginseng is used as ministerial drugs for invigorating spleen and stomach, promoting diuresis and excreting dampness, nourishing heart and tranquillizing, and licorice is used as an adjuvant drug for invigorating spleen and replenishing qi, clearing heat and detoxicating and harmonizing drug property. The combination of the medicines has the effect of tonifying qi. Moreover, after the mint is extracted by the invention and used for ginseng, the mint has comfortable and fresh taste; after radix ophiopogonis, poria cocos and liquorice are extracted, sweet substances in the radix ophiopogonis, poria cocos and liquorice neutralize bitter taste of ginseng, so that the radix ophiopogonis, poria cocos and liquorice are easy to accept by consumers.
The ginseng is fresh ginseng and is derived from Changbai mountain ginseng.
The lily, peppermint, dwarf lilyturf tuber, poria cocos and liquorice are all preferably powder, and the particle size is preferably 150-250 meshes, more preferably 200 meshes; the weight ratio of the ginseng to the lily to the mint to the dwarf lilyturf tuber to the tuckahoe to the liquorice is preferably 35-45:15-25:10-15:15-25:10-15:5-10, and more preferably 40:20:13:20:13:8. The invention prepares the lily, the peppermint, the dwarf lilyturf tuber, the poria cocos and the liquorice into powder, and the effective components in the lily, the peppermint, the dwarf lilyturf tuber, the poria cocos and the liquorice are easier to dissolve in the solvent in the subsequent ultrasonic process.
The volume percentage of the ethanol solution is preferably 50-60%, more preferably 55%; the mass volume ratio of the ginseng, the lily, the peppermint, the poria cocos, the dwarf lilyturf tuber and the liquorice to the ethanol solution is preferably 1:2-4 g/mL, and more preferably 1:3g/mL.
The temperature of the ultrasonic treatment according to the present invention is preferably 40 to 50 ℃, more preferably 45 ℃, and the time is preferably 3 to 5 hours, more preferably 4 hours. According to the invention, the cellulose network in the ginseng epidermis can be loosened through ultrasonic treatment, so that the extraction of active ingredients is facilitated, the ginseng in the later stage is easier to dry, the dried ginseng is easier to be adsorbed by the liquid medicine, and the taste and quality of the instant ginseng are improved; and the effective components and sugar substances in the lily, peppermint, dwarf lilyturf tuber, poria cocos and liquorice powder can be more easily dissolved in the solvent, so that the extraction efficiency is improved.
The invention preferably carries out reduced pressure distillation on the filtrate to remove ethanol and obtain liquid medicine; the pressure of the reduced pressure distillation is preferably 15 to 20kPa, more preferably 18kPa, and the temperature is preferably 40 to 50 ℃, more preferably 45 ℃.
The low temperature drying temperature of the present invention is preferably 40 to 50 ℃, more preferably 45 ℃, and the time is preferably 3 to 5 hours, more preferably 4 hours. The invention carries out low-temperature drying on the ultrasonic-treated ginseng, and aims to absorb the liquid medicine for removing the ethanol and retain all the active ingredients of the medicine.
The pre-freezing temperature of the vacuum freeze drying is preferably-40 to-35 ℃, more preferably-38 ℃, and the time is preferably 2 to 3 hours, more preferably 2.5 hours; the vacuum degree of the drying chamber for vacuum freeze drying is preferably 50-60 Pa, more preferably 55Pa, the temperature is preferably 40-50 ℃, more preferably 45 ℃, and the time is preferably 7-9 h, more preferably 8h.
The invention completely adopts a low-temperature mode to treat the ginseng in the preparation process, and retains the effective components of the ginseng and other medicaments.
The invention also provides the instant ginseng without excessive internal heat, which is obtained by the preparation method.
The ginseng instant food is used for treating symptoms of qi and blood deficiency, is chewed by 3-9g per day, and has one treatment course every two weeks.
In the present invention, all raw material components are commercially available products well known to those skilled in the art unless specified otherwise.
The technical solutions of the present invention will be clearly and completely described in the following in connection with the embodiments of the present invention. It will be apparent that the described embodiments are only some, but not all, embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
Preparation of instant ginseng without excessive internal heat
(1) Pulverizing Bulbus Lilii, herba Menthae, radix Ophiopogonis, poria and Glycyrrhrizae radix respectively, and sieving with 200 mesh sieve; accurately weighing 20g of lily, 13g of peppermint, 20g of dwarf lilyturf tuber, 13g of poria cocos and 8g of liquorice, and a whole 40g of fresh ginseng; mixing the raw materials with 342mL of 55% ethanol solution by volume percent, and carrying out ultrasonic treatment for 4 hours at 45 ℃;
(2) Taking out Ginseng radix, filtering, and distilling the filtrate under reduced pressure at 45deg.C under 18kPa to obtain medicinal liquid;
(3) Drying the ultrasonic-treated ginseng at 45 ℃ for 4 hours, and absorbing the liquid medicine in the step (2);
(4) Pre-freezing radix Ginseng absorbing the medicinal liquid at-38deg.C for 2.5 hr, and drying at 45deg.C under 55Pa in a drying chamber for 8 hr to obtain instant radix Ginseng without excessive internal heat.
Example 2
Preparation of instant ginseng without excessive internal heat
(1) Pulverizing Bulbus Lilii, herba Menthae, radix Ophiopogonis, poria and Glycyrrhrizae radix respectively, and sieving with 150 mesh sieve; accurately weighing 25g of lily, 10g of peppermint, 25g of dwarf lilyturf tuber, 10g of poria cocos and 10g of liquorice, and a whole 35g of fresh ginseng; mixing the raw materials with 460mL of ethanol solution with the volume percentage of 50%, and carrying out ultrasonic treatment for 5h at 40 ℃;
(2) Taking out Ginseng radix, filtering, and distilling the filtrate under reduced pressure at 50deg.C and 15kPa to obtain medicinal liquid;
(3) Drying the ultrasonic-treated ginseng at 40 ℃ for 5 hours, and absorbing the liquid medicine in the step (2);
(4) Pre-freezing the ginseng absorbed with the liquid medicine at-40deg.C for 2 hr, and drying at 50deg.C under 60Pa in a drying chamber for 7 hr to obtain instant ginseng without excessive internal heat.
Example 3
Preparation of instant ginseng without excessive internal heat
(1) Pulverizing Bulbus Lilii, herba Menthae, radix Ophiopogonis, poria and Glycyrrhrizae radix respectively, and sieving with 250 mesh sieve; accurately weighing 15g of lily, 15g of peppermint, 15g of dwarf lilyturf tuber, 15g of poria cocos and 5g of liquorice, and a whole 45g of fresh ginseng; mixing the raw materials with 220mL of 60% ethanol solution by volume percent, and carrying out ultrasonic treatment for 5h at 40 ℃;
(2) Taking out Ginseng radix, filtering, and distilling the filtrate under reduced pressure at 40deg.C and 20kPa to obtain medicinal liquid;
(3) Drying the ultrasonic-treated ginseng at 50 ℃ for 3 hours, and absorbing the liquid medicine in the step (2);
(4) Pre-freezing the ginseng absorbing the liquid medicine at-35 ℃ for 3 hours, and drying for 9 hours in a drying chamber at 50Pa and 40 ℃ to obtain the instant ginseng without excessive internal heat.
Comparative example 1
No other medicinal materials are added compared with the example 1
(1) Mixing a whole 40g fresh ginseng with 120mL ethanol solution with the volume percentage of 55%, and carrying out ultrasonic treatment for 4 hours at 45 ℃;
(2) Taking out Ginseng radix, filtering, and distilling the filtrate under reduced pressure at 45deg.C under 18kPa to obtain medicinal liquid;
(3) Drying the ultrasonic-treated ginseng at 45 ℃ for 4 hours, and absorbing the liquid medicine in the step (2);
(4) Pre-freezing the ginseng absorbed with the liquid medicine at-38deg.C for 2.5 hr, and drying at 45deg.C under 55Pa in a drying chamber for 8 hr to obtain instant ginseng.
Comparative example 2
The specific embodiment was the same as in example 1, except that no ultrasonic treatment was performed and only the soaking in ethanol solution was performed for 4 hours.
Comparative example 3
The specific embodiment is the same as in example 1, except that step (4) is not included, and step (3) is to dry the sonicated ginseng at 45 ℃ for 4 hours, absorb the liquid medicine in step (2), and then dry the ginseng at 45 ℃ for 15 hours.
Comparative example 4
Sun-dried ginseng from Changbai mountain in Jilin Aodong.
Comparative example 5
Changbai mountain ginseng honey tablet (purchased from Taobao Jiujingtang flagship store).
Experimental example 1
Animal experiment
SD male rats with ages of 6-7 weeks and body weights of 200-220 g are selected and randomly divided into 7 groups of 20 rats. Blank, example 1, comparative example 2, comparative example 3, comparative example 4, and comparative example 5, respectively; the ginseng dosage of each group of SD rats is 0.5g/kg (except for blank groups, each group is dosed according to 4 times of the highest daily dose of adults prescribed in Chinese pharmacopoeia 2020); the blank group took equal quality physiological saline.
Each group of SD rats was fed free water, food, and feed in the same environment, and was continuously dosed for 4 weeks according to the above group. The mental state, hair color, drinking water feeding and the like of the rats are observed every 7 days (days 0, 7, 14, 21 and 28), the water content of the feces, the anus temperature and the saliva amount of the rats are monitored, the data with larger difference are removed, and other data are averaged. The specific results are shown in tables 1 to 3.
Wherein, the water content of the excrement adopts a drying weighing method: the weight of the rat stool before and after drying was measured separately, and the stool water content (%) = (weight before drying-weight after drying)/weight before drying was 100%.
The method for measuring the anal temperature comprises the following steps: after 1h of administration, the anal temperature was measured by a thermometer.
Saliva volume was collected by cotton ball wiping: after 1h of administration, the cotton balls are put into the oral cavity of the rat, wiped once up, down, left and right, and left for 3min, and the front and back mass of the cotton balls is measured to obtain saliva amount of the rat.
TABLE 1 fecal moisture content (%)
TABLE 2 anal temperatures (. Degree.C.) of rats of different groups and different times
| Group of | Day 0 | For 7 days | 14 days | 21 days | For 28 days |
| Blank group | 37.2 | 36.9 | 37.3 | 37.0 | 36.7 |
| Example 1 | 37.3 | 36.7 | 36.8 | 37.4 | 37.3 |
| Comparative example 1 | 36.9 | 37.4 | 37.7 | 38.0 | 38.5 |
| Comparative example 2 | 37.3 | 37.5 | 37.6 | 37.7 | 37.8 |
| Comparative example 3 | 37.4 | 36.9 | 37.3 | 37.0 | 37.2 |
| Comparative example 4 | 36.8 | 37.3 | 37.6 | 37.7 | 37.9 |
| Comparative example 5 | 37.0 | 36.8 | 37.4 | 37.5 | 37.5 |
TABLE 3 saliva amount (mg) of rats of different groups at different times
| Group of | Day 0 | For 7 days | 14 days | 21 days | For 28 days |
| Blank group | 9.8 | 10.5 | 13.8 | 10.7 | 12.5 |
| Example 1 | 10.6 | 10.8 | 12.7 | 13.0 | 14.8 |
| Comparative example 1 | 11.8 | 10.1 | 9.5 | 7.3 | 4.6 |
| Comparative example 2 | 9.7 | 9.5 | 8.1 | 7.6 | 5.7 |
| Comparative example 3 | 11.5 | 9.8 | 10.6 | 12.9 | 10.9 |
| Comparative example 4 | 9.9 | 9.5 | 7.8 | 6.9 | 5.3 |
| Comparative example 5 | 10.8 | 10.5 | 9.2 | 7.2 | 6.5 |
By observation, the rats in the blank group, the example 1 and the comparative example 3 had glossy endothelial hair in the experiment for 0-28 days, and had a mild and normal sex and a normal diet; the group 1 of comparative example can obviously observe dark fur, poor mental state and dry stool after 14 days, presents slight symptoms of excessive internal heat, has the condition of fur falling after 21 days, is irritable and dry stool, and presents obvious symptoms of excessive internal heat; comparative example 2, comparative example 4 and comparative example 5 exhibited slight symptoms of excessive internal heat on day 21, and symptoms of excessive internal heat were aggravated on day 28, but the symptoms of excessive internal heat were lighter than comparative example 1.
As is apparent from the data of tables 1 to 3, the present invention can significantly reduce the symptoms of excessive internal heat caused by ginseng by using lily, peppermint, ophiopogon root, poria cocos and licorice.
Experimental example 2
Sensory test
(1) A sensory panel was composed of 10 professionally trained individuals, and the appearance, mouthfeel, and color of the ginseng according to examples 1-3 and comparative examples 1-5 were evaluated and summarized.
Examples 1-3 sensory evaluation of instant ginseng without excessive internal heat was substantially consistent: the whole ginseng has light yellow appearance, less folds, ornamental value, crisp taste, comfortable, fresh and slightly sweet taste in mouth and no slag feel.
Comparative example 1: the whole ginseng has light yellow appearance, less folds, ornamental value, crisp taste and no slag feel, but the ginseng has obvious earthy taste and bitter taste.
Comparative example 2: the whole ginseng has yellow appearance, less wrinkled parts, ornamental value, crisp taste, comfortable and fresh taste in mouth, but slightly bitter taste.
Comparative example 3: the appearance of the whole ginseng is yellow, the number of the wrinkled parts is large, the ornamental value is poor, and the whole ginseng has comfortable and fresh taste but has slag feeling.
Comparative example 4: the ginseng slice is white and yellow in middle, has light yellow epidermis, has no ornamental value, is slightly bitter in mouth, has slag feel and cannot be eaten immediately.
Comparative example 5: the ginseng honey slice is reddish brown, has no ornamental value, has sweet taste of honey when being eaten, and has slag feeling.
(2) 100 consumers conducted satisfaction surveys of the ginseng of examples 1-3 and comparative examples 1-5, respectively, on five grades of very satisfactory, general, unsatisfactory, very unsatisfactory, and the specific results are shown in Table 4.
Table 4A questionnaire for satisfaction of ginseng (%)
| Group of | Very satisfactory | Satisfactory satisfaction | In general | Dissatisfaction with | Is very unsatisfactory |
| Example 1 | 67 | 30 | 3 | 0 | 0 |
| Example 2 | 60 | 25 | 14 | 1 | 0 |
| Example 3 | 65 | 27 | 8 | 0 | 0 |
| Comparative example 1 | 30 | 30 | 25 | 10 | 5 |
| Comparative example 2 | 45 | 20 | 25 | 10 | 0 |
| Comparative example 3 | 21 | 29 | 26 | 15 | 9 |
| Comparative example 4 | 20 | 18 | 35 | 22 | 5 |
| Comparative example 5 | 30 | 27 | 30 | 12 | 1 |
The sensory and satisfaction degree of professionally trained personnel and consumers can obviously show that the instant ginseng without excessive internal heat obtained by the preparation method can obviously reduce the slag feel and the bitter taste of the ginseng, and the whole ginseng has ornamental value and is easy to be accepted by consumers.
Experimental example 3
150 women with ages of 30-40 years old and developed symptoms of deficiency of qi and blood (dizziness, hypodynamia, physical weakness, tiredness, low blood pressure and disease course of 1-3 years) are selected, and are equally divided into three groups, and the three groups of cases have no significant difference in age, disease course and the like before treatment, so that a subsequent clinical experiment can be carried out.
Grouping: a group of chewing agents is prepared by chewing 3-9g of instant ginseng of the embodiment 1 of the invention per day; a group of instant ginseng of comparative example 1 is chewed, 3-9g per day; the final group takes the honeyed sheet of ginseng in the Changbai mountain of comparative example 5, 1-2 sheets per day. The results of the drug effect and the excessive internal heat were counted after 60 days of administration for the three groups, as shown in Table 5.
Diagnostic decision criteria:
the effect is shown: the symptoms of dizziness, hypodynamia and fatigue are eliminated, the physique is recovered, and the blood pressure is in a normal range;
the method is effective: symptoms of dizziness, hypodynamia and fatigue symptom are improved before treatment;
invalidation: the symptoms were the same as before treatment and did not improve.
Symptoms of excessive internal heat: one or more symptoms of dry lips, bitter and dry mouth, fever throughout the body and dry stool appear, and are judged by combining pulse conditions.
TABLE 5 Effect of different ginseng on deficiency of Qi and blood
| Group of | Display effect (example) | Effective (example) | Invalidation (example) | Internal heat (example) |
| Example 1 | 39 | 10 | 1 | 0 |
| Comparative example 1 | 30 | 17 | 3 | 15 |
| Comparative example 5 | 20 | 22 | 8 | 6 |
As shown in Table 5, the total effective rate of the instant ginseng of the present invention is 98%, which is significantly higher than that of comparative example 5, indicating that the instant ginseng of the present invention has significant qi and blood tonifying effects. In addition, after the instant ginseng is taken, the symptom of excessive internal heat does not appear. The instant ginseng provided by the invention has the advantages that the taste is improved, the drug effect is ensured, and the effect of preventing excessive internal heat is achieved.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.
Claims (10)
1. A preparation method of instant ginseng without excessive internal heat is characterized by comprising the following steps: mixing Ginseng radix, bulbus Lilii, herba Menthae, radix Ophiopogonis, poria and Glycyrrhrizae radix, ultrasonic treating in ethanol solution, filtering, and distilling the filtrate under reduced pressure to remove ethanol to obtain medicinal liquid; drying the ginseng subjected to ultrasonic treatment at low temperature, adsorbing the liquid medicine, and performing vacuum freeze drying to obtain the instant ginseng without excessive internal heat;
the ginseng is whole ginseng.
2. The preparation method according to claim 1, wherein the lily, peppermint, ophiopogon root, poria cocos and licorice are all powder, and the particle size is 150-250 meshes.
3. The preparation method according to claim 1 or 2, wherein the weight ratio of ginseng, lily, peppermint, ophiopogon root, poria cocos and licorice is 35-45:15-25:10-15:15-25:10-15:5-10.
4. The method according to claim 1, wherein the volume percentage of the ethanol solution is 50-60%.
5. The preparation method according to claim 1, wherein the mass-volume ratio of the ginseng, lily, peppermint, poria cocos, ophiopogon root and licorice to the ethanol solution is 1:2-4 g/mL.
6. The method according to claim 1, wherein the ultrasonic treatment is carried out at a temperature of 40 to 50 ℃ for a time of 3 to 5 hours.
7. The method according to claim 1, wherein the low-temperature drying is performed at a temperature of 40 to 50 ℃ for 3 to 5 hours.
8. The method according to claim 1, wherein the pre-freezing temperature in the vacuum freeze-drying is-40 to-35 ℃ for 2 to 3 hours.
9. The method according to claim 1, wherein the vacuum degree of the vacuum freeze-drying chamber is 50 to 60Pa, the temperature is 40 to 50 ℃ and the time is 7 to 9 hours.
10. Instant ginseng without excessive internal heat obtained by the preparation method according to any one of claims 1 to 9.
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