CN1172687C - Antifatigue capsule - Google Patents
Antifatigue capsule Download PDFInfo
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- CN1172687C CN1172687C CNB991111745A CN99111174A CN1172687C CN 1172687 C CN1172687 C CN 1172687C CN B991111745 A CNB991111745 A CN B991111745A CN 99111174 A CN99111174 A CN 99111174A CN 1172687 C CN1172687 C CN 1172687C
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Abstract
The present invention relates to a health capsule which comprises the following components according to the proportion by weight: 5 to 95 portions of L-carnitine, 5 to 95 portions of American ginseng extract and 5 to 60 portions of ribonucleic acid. The capsule is prepared by the following steps of material preparation, pulverization, drying, sieving, mixing, capsule filling, packaging, etc. The capsule has the function of fatigue resistance, has no toxicity, and does not contain medicines forbidden by the Olympic Committee.
Description
Technical field
The present invention relates to a kind of health composition.
Background technology
At present, health nutrient is a lot of on the market, but the health nutrient that can play a role in health care really is few, and this is because these health nutrients lack scientific formula, in addition have go back toxic side effect, influence the healthy of people.
Summary of the invention
The purpose of this invention is to provide a kind of anti-fatigue health-caring compositions, said composition has antifatigue effect, and human body is not had toxicity, side effect.
For achieving the above object, the present invention takes following technical scheme: the component of this anti-fatigue health-caring compositions and weight proportion are:
L-carnitine 5-95 parts by weight
Radix Panacis Quinquefolii extract 5-95 parts by weight
Nucleic acid 5-60 parts by weight
Radix Panacis Quinquefolii extract is to use Radix Panacis Quinquefolii through composition broken, that water is carried, ethanol precipitation, dry back prepare.
In above-mentioned composition, can also comprise following components in weight percentage,
Vitamin C 1-25 parts by weight
Vitamin E 1-20 parts by weight.
Can also include the filler of 5-95 parts by weight in above-mentioned composition, this filler is one or more in starch, microcrystalline Cellulose, the glucose.
Formula optimization scope of the present invention is that the weight proportion of each component in said composition is:
L-carnitine 13-15 parts by weight
Radix Panacis Quinquefolii extract 6-8 parts by weight
Nucleic acid 13-15 parts by weight
Filler is a starch, and starch is the 62-68 parts by weight.
Another preferable range of prescription of the present invention is that the weight proportion of each component in said composition is:
L-carnitine 15 parts by weight
Radix Panacis Quinquefolii extract 14 parts by weight
Nucleic acid 15 parts by weight
Vitamin C 20 parts by weight
Vitamin E 15 parts by weight
Filler is a starch, and starch is 21 parts by weight.
About the L-carnitine, in the beginning of this century, scientist separates from the muscle extract and has identified the L-carnitine.Experiment showed, that to some crowd the L-carnitine is the essential nutrients under a kind of specified conditions.Some tissues as cardiac muscle, skeletal muscle etc. need the L-carnitine, supply metabolic demand to carry out normal metabolism and to rely on from other tissue transhipment L-carnitine.The L-carnitine can promote fatty oxidation effectively, provide human body required energy.The L-carnitine participates in following metabolic process:
1, improve the endurance of human body,
2, make the fast quick-recovery in human body motion back,
3, promote the ripe and movable of sperm,
4, reduce plasma cholesterol.
Material content 〉=68% of the L-carnitine-L-tartrate that the present invention uses, L-carnitine-L-tartrate are used by the approval of Food Additives Used in China Professional Committee, have been loaded in No. 083 summary of China (95) food prison searching.
Radix Panacis Quinquefolii extract is to use Radix Panacis Quinquefolii through composition broken, that water is carried, ethanol precipitation, dry back prepare.Effective ingredient one Radix Panacis Quinquefolii Saponin in the Radix Panacis Quinquefolii can obviously increase the myocardial nutrition blood flow, resist myocardial ischemia, dwindle myocardial infarction area significantly, alleviate effect such as cardiac function and hemodynamics decays, increase coronary flow when blocking, thereby human body is had the endurance of raising, promotes the human body recovery to act on normally.
Nucleic acid is a class natural polymer, mainly is made up of ribonucleic acid (RNA) and DNA (deoxyribonucleic acid) (DNA).Confirm that after deliberation nucleic acid plays an important role in human body cell, it is hereditary information, nutrient substance, the energy carrier of cell, the basis of synthetic protein, so claim Source of life again.
Recent studies show that a people will finish normal physiological activity, needs every day just can satisfy the demands from external picked-up 1.5g nucleic acid.As nucleic acid intake deficiency, most people can suffer from the nucleic acid deficiency disease in varying degrees, thereby cause aging, pathological changes and the death of human body cell.Edible nucleic acid can promote myocardial metabolism, increases the hat blood flow, can promote gastrointestinal motility, improve digestion and absorption function, helps human body and improves endurance, sets up.Material content 〉=90%.
Ascorbic material content 〉=98% that the present invention uses.
Material content 〉=50% of the vitamin E that the present invention uses.
The starch that the present invention uses is food stage.
The specific embodiment
In order to show the antifatigue effect of anti-fatigue health-caring compositions of the present invention, anti-fatigue health-caring compositions of the present invention is given anti-Ins of Nutrition ﹠ Food Hygiene, the Academy of Medical Sciences by China mice is carried out the antifatigue effect experiment.
Wherein, every experiment is divided into 4 groups, i.e. matched group, and low dose group, middle dosage group, high dose group, each group is tried the agent amount and is respectively:
Low dose group 35.1mg/kg.bw, middle dosage group (MD) 117mg/kg.bw, high dose group (HD) 351mg/kg.bw is equivalent to 3 times of people's daily dose (11.7mg/kg.bw) respectively, and 10 times, 30 times.Matched group gives distilled water:
The preparation of sample solution:
Matched group: distilled water
Low dose group: take by weighing sample 175mg, be settled to 100ml, mixing with distilled water.
Middle dosage group: take by weighing sample 583mg, be settled to 100ml, mixing with distilled water.
High dose group: take by weighing sample 1750mg, be settled to 100ml, mixing with distilled water.
Sample is preparation temporarily before irritating stomach.It is 0.5ml/25g.bw that mice is irritated the stomach amount every day, continuous irrigation stomach 21 days.
Experimental technique and observation index:
1 mice swimming with a load attached to the body experiment:
The mice last was irritated behind the stomach 0.5 hour, was defined in depth of water 30cm by " program ", bear a heavy burden 5% swimming test of the swimming case that water temperature is 25 ± 0.5 ℃, and the record mice is from the swimming time of entry when power exhausts death.
2, blood urea nitrogen content: (mg/100ml);
The mice last was irritated behind the stomach 0.5 hour, and being defined in temperature by " program " is the 90min that swims in 30 ± 0.5 ℃ the water, and blood urea nitrogen content is measured in blood sampling.
3, hepatic glycogen content (mg/100g);
The mice last was irritated behind the stomach 0.5 hour, and being defined in temperature by " program " is the 90min that swims in 30 ± 0.5 ℃ the water, puts to death immediately, gets liver, measures hepatic glycogen content.
Pass through statistical analysis again: adopt the relatively difference between each variable of variance analysis, use the H check if homogeneity of variance or normality can not satisfy the requirement of variance analysis instead.
Experimental result is as follows:
1, the anti-fatigue health-caring composition powder is to the influence of mice swimming endurance:
Table 1 result represents to compare with matched group, though low, middle dosage group mice swimming time prolongs to some extent, but the difference (P＞0.05) on the statistics is not arranged, the mice swimming time of high dose group obviously prolongs, and there were significant differences (P＞0.05), and this result shows that the anti-fatigue health-caring composition powder of high dose has obvious potentiation to the mice swimming endurance.
The table 1 mice swimming with a load attached to the body time
Group number of animals (only) swimming time
a(min) p
Matched group 10 25.2 ± 20.9
Low dose group 10 32.4 ± 37.8＞0.05
Middle dosage group 10 44.9 ± 46.9＞0.05
High dose group 10 80.3 ± 44.7＜0.05
Annotate:
aX ± SD
2, the anti-fatigue health-caring composition powder is to the influence of mice blood urea nitrogen level:
The urea nitrogen levels of mouse movement bleeding from anus shown in table 2 result.Compare with matched group, high dose group mouse movement bleeding from anus urea nitrogen levels significantly reduces, and the significant difference (P＜0.05) on the statistics is arranged, and illustrates that the high dose group mice strengthens the adaptive capacity of violent load.
Table 2 mouse movement bleeding from anus urea nitrogen levels
Group number of animals (only) blood urea nitrogen content
a(mmol/L) p
Matched group 10 16.7 ± 1.9
Low dose group 10 17.0 ± 0.8＞0.05
Middle dosage group 10 16.7 ± 1.5＞0.05
High dose group 10 13.9 ± 0.04＜0.05
Annotate:
aX ± SD
3, the anti-fatigue health-caring composition powder is to the influence of Mouse Liver glycogen deposit:
The glycogen level of reserve behind the mouse movement shown in table 3 result.Compare with matched group, the hepatic glycogen level of reserve is apparently higher than matched group behind three dosage group mouse movements, significant difference (P＜0.05) is arranged on the statistics, show that the glycogen deposit is abundant behind three dosage group mouse movements, this anti-fatigue health-caring composition powder has the effect that improves glycogen metabolism.
The hepatic glycogen level of reserve behind table 3 mouse movement
Group number of animals (only) hepatic glycogen content
1(mmol/L) p
2
Matched group 10 2801.4 ± 250.5
Low dose group 10 3063.7 ± 259.8＜0.05
Middle dosage group 10 3334.8 ± 459.4＜0.05
High dose group 10 3469.6 ± 218.6＜0.05
Annotate:
1X ± SD,
2Compare with matched group
This experimental result shows, compare with matched group, the anti-fatigue health-caring composition powder of high dose group has remarkable effect to strengthening the mice swimming endurance, the blood urea nitrogen level is had remarkable reduction effect, and the anti-fatigue health-caring composition powder of three dosage groups is to the glycogen deposit effect of being significantly increased as energy.According to the criterion in " the health food function assessment assessment process and the method for inspection " of the promulgation of Ministry of Public Health health supervision department, can think that the anti-fatigue health-caring composition powder of high dose has antifatigue effect.
Anti-fatigue health-caring compositions of the present invention is carried out toxicological experiment and 30 days feeding trials through Capital University of Medical Sciences sanitary toxicology research department.Experimental result shows, anti-fatigue health-caring compositions of the present invention is not brought out the increase of micronuclear rates, (TA97a, TA98 are the frame shift type mutant to four kinds of strains, TAl00, TAl02 are base substitution type mutant) there is not a tangible induced mutation effect, to growth promoter, food use coefficient, the blood system of laboratory animal, the metabolism of liver, renal function and albumen, fat, sugar does not have obvious influence.Do not find toxic action.
Anti-fatigue health-caring compositions of the present invention detects through national analeptic and sport nutrition testing research center, testing result shows that anti-fatigue health-caring compositions of the present invention is not found stimulant, anesthetis, beta blocker, diuretic and the hormone medicine of International Olympic Committee's regulation forbidding in 1996.
Compositions of the present invention be through get the raw materials ready, pulverize, dry, sieve, mix, divide that encapsulated, packing, date printed, finished product are finished, the step of warehouse-in etc. makes.
Embodiment
Raw material by following weight is got the raw materials ready
15 kilograms of L-carnitines
14 kilograms of Radix Panacis Quinquefolii extracts
15 kilograms of nucleic acid
20 kilograms of vitamin Cs
15 kilograms of vitamin Es
21 kilograms of starch
Then with above-mentioned each raw material respectively after the CWF-2501 super micron mill is pulverized, in 101-4 type electric heating air-blowing drying machine under 50 ℃ of temperature conditions dry 30-120 minute, sieve at DPS-D1000 hanging type sieving machine, again after efficient V-Mixer of GHJ and the mixing of VHB250 type mixer, divide encapsulated, packing back date printed is put finished product in storage.
Anti-fatigue health-caring compositions of the present invention has anti-fatigue effect, is suitable for various mentality and physical labourer athlete.
Claims (6)
1, a kind of anti-fatigue health-caring compositions, it is characterized in that: its component and weight proportion are:
L-carnitine 5-95 parts by weight
Radix Panacis Quinquefolii extract 5-95 parts by weight
Nucleic acid 5-60 parts by weight
Radix Panacis Quinquefolii extract is to use Radix Panacis Quinquefolii through composition broken, that water is carried, ethanol precipitation, dry back prepare.
2, anti-fatigue health-caring compositions according to claim 1 is characterized in that, also comprises following components in weight percentage in above-mentioned composition:
Vitamin C 1-25 parts by weight
Vitamin E 1-20 parts by weight.
3, anti-fatigue health-caring compositions according to claim 1 is characterized in that: also include the filler of 5-95 parts by weight in the said composition, this filler is a starch, one or more in microcrystalline Cellulose, the glucose.
4, anti-fatigue health-caring compositions according to claim 2 is characterized in that: also include the filler of 5-95 parts by weight in the said composition, this filler is a starch, one or more in microcrystalline Cellulose, the glucose.
5, anti-fatigue health-caring compositions according to claim 3, it is characterized in that: the weight proportion of each component in said composition is:
L-carnitine 13-15 parts by weight
Radix Panacis Quinquefolii extract 6-8 parts by weight
Nucleic acid 13-15 parts by weight
Filler is a starch, and starch is the 62-68 parts by weight.
6, anti-fatigue health-caring compositions according to claim 4, it is characterized in that: the weight proportion of each component in said composition is:
L-carnitine 15 parts by weight
Radix Panacis Quinquefolii extract 14 parts by weight
Nucleic acid 15 parts by weight
Vitamin C 20 parts by weight
Vitamin E 15 parts by weight
Filler is a starch, and starch is 21 parts by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991111745A CN1172687C (en) | 1999-07-29 | 1999-07-29 | Antifatigue capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991111745A CN1172687C (en) | 1999-07-29 | 1999-07-29 | Antifatigue capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1282602A CN1282602A (en) | 2001-02-07 |
| CN1172687C true CN1172687C (en) | 2004-10-27 |
Family
ID=5274931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB991111745A Expired - Lifetime CN1172687C (en) | 1999-07-29 | 1999-07-29 | Antifatigue capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1172687C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670729A (en) * | 2012-05-16 | 2012-09-19 | 乌鲁木齐市生命核力高科有限公司 | Preparation method for cistanche tubulosa and American ginseng compound capsule |
-
1999
- 1999-07-29 CN CNB991111745A patent/CN1172687C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1282602A (en) | 2001-02-07 |
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| C14 | Grant of patent or utility model | ||
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Owner name: BEIJING POURKANG MEDICINE HIGH SCIENCE AND TECHNOL Free format text: FORMER OWNER: BEIJING TIANSHIKANG MEDICINE SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. Effective date: 20091204 |
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| TR01 | Transfer of patent right |
Effective date of registration: 20091204 Address after: Room 5, building 106, Fu Cheng Road middle school, 131 Fu Cheng Road, Beijing, Haidian District Patentee after: Beijing Puerkang Medical High Technology Co., Ltd. Address before: Beijing City, Haidian District Road No. 131 Fucheng Bai duizi Patentee before: Tianshikang Medical Science and Technology Development Co., Ltd., Beijing |
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| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20041027 |