CN1415289A - Novel preparation of ethylenediamine tetraacetic acid ferro (EDTAferro) - Google Patents
Novel preparation of ethylenediamine tetraacetic acid ferro (EDTAferro) Download PDFInfo
- Publication number
- CN1415289A CN1415289A CN 02146594 CN02146594A CN1415289A CN 1415289 A CN1415289 A CN 1415289A CN 02146594 CN02146594 CN 02146594 CN 02146594 A CN02146594 A CN 02146594A CN 1415289 A CN1415289 A CN 1415289A
- Authority
- CN
- China
- Prior art keywords
- sodium iron
- iron ethylenediaminetetraacetate
- edta ferrum
- edta
- ferrum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
An EDTA iron medicine for preventing and treating iron-deficiency anemia is prepared from EDTA iron, vegetable butter powder, chocolate powder, lactose, glucose, mannitol, sorbitol, milk powder, citric acid, sweetening agent, VC and zinc gluconate.
Description
Invention field is a raw material with sodium iron ethylenediaminetetraacetate (EDTA ferrum), prepares novel sodium iron ethylenediaminetetraacetate (EDTA ferrum) novel formulation, is used for the field of compensating iron for human, prevention and treatment iron deficiency anemia.
Technical background sodium iron ethylenediaminetetraacetate (EDTA ferrum) is widely used in recent years as novel iron supplement agent.Yet along with the raising of people's living standard, people are to some medicines that need take for a long time, especially need the tonic medicine taken for a long time or the mouthfeel of functional food to require more and more higher in some human body life growth processes.The medicine of bad mouthfeel and functional food also make people produce anorexia psychology easily, make people refuse clothes, thereby also just can not ensure the curative effect of these medicines and functional food.Therefore, the mouthfeel that improves constantly these medicines and functional food is that each is engaged in the problem that the technical staff of this respect research should pay attention to very much in carrying out this respect preparation research.The inventor is according to the practical experience of new drug preparation research for many years, proposed this veriety should be followed " food mouthfeel " in preparation research research approach, studied multiple novel formulation with food mouthfeel according to this scheme inventor.The present invention uses sodium iron ethylenediaminetetraacetate (EDTA ferrum) to be crude drug, the novel formulation for preparing novel sodium iron ethylenediaminetetraacetate (EDTA ferrum) with food mouthfeel, as: sodium iron ethylenediaminetetraacetate (EDTA ferrum) chewable tablet, dry suspension, granule etc.
Goal of the invention is made chewable tablet, dry suspension, the granular preparation with " food mouthfeel " with sodium iron ethylenediaminetetraacetate (EDTA ferrum), be beneficial to people and when taking for a long time, do not produce the anorexia sense, guarantee the curative effect of iron supplement, prevention and the treatment iron deficiency anemia of sodium iron ethylenediaminetetraacetate (EDTA ferrum).
Sodium iron ethylenediaminetetraacetate (EDTA ferrum) and non-dairy creamer are found in the invention summary after deliberation, chocolate fruit powder, lactose, glucose, mannitol, sorbitol, milk powder, citric acid, add being reasonably combined of an amount of sweeting agent again and have good food mouthfeel, and be aided with vitamin C, zinc gluconate, the chewable tablet of the sodium iron ethylenediaminetetraacetate of making as adjuvant (EDTA ferrum), dry suspension, granule, help people and improve people's compliance when ferrum need be taken EDTA ferrum for a long time, thereby guarantee the benefit of EDTA ferrum for replenishing, the curative effect of prevention and treatment iron deficiency anemia.
The basic prescription and the preparation technology of detailed Description Of The Invention 1, EDTA ferrum dry suspension of the present invention:
Basic prescription:
EDTA ferrum 37.7g
Non-dairy creamer 2000～15000g
(or) sorbitol 0～6000g
(or) lactose 0～5000g
(or) glucose 0～1000g
(or) chocolate fruit powder 0～6000g
(or) cane sugar powder 0～3000g
(or) milk powder (defat or whole milk powder) 0～6000g
Vitamin C 10～500g
The maximum 300g of zinc gluconate
Sweet taste correctives (for example acesulfame potassium, stevioside, cyclamate etc.) is an amount of
Make 1000 bags (every bag of iron content 5mg)
Preparation technology:
As follows with the basic technology that above-mentioned basic prescription of the present invention prepares EDTA ferrum dry suspension:
The processing of ■ supplementary material and processing: all supplementary materials are crossed 100 orders or 200 mesh sieves respectively on request through after the assay was approved, should be pulverized in case of necessity.
■ takes by weighing above-mentioned principal agent and each adjuvant by recipe quantity, at first gets EDTA ferrum and vitamin C, sweet taste correctives earlier by the equivalent mixing method stirring and evenly mixing that progressively increases, and mixture and zinc gluconate is crossed once to sieve again and is mixed once.Add non-dairy creamer, or add sorbitol, lactose, glucose, or add chocolate fruit powder, cane sugar powder, the abundant mix homogeneously of milk powder.
■ is by the content of zinc gluconate and EDTA ferrum in the quality standard measurement granule of working out.
■ measures the content of moisture in the granule in 5%; Check microbial limit.Surpass as moisture, or microbial limit surpasses 80 ℃ of dryings of index (pressing two appendix regulations of Chinese Pharmacopoeia version in 2000 checks) 2～4 hours.
The ■ packing, promptly.
This product is pressed under two appendix IO items of Chinese Pharmacopoeia (version in 2000) and is checked, should meet the requirement of dry suspension.2, the basic prescription and the preparation technology of EDTA ferrum granule of the present invention:
Basic prescription:
EDTA ferrum 37.7g
Mannitol 0～4000g
Sucrose 0～5000g
Glucose 0～1000g
Vitamin C 10～500g
The maximum 300g of zinc gluconate
Polyvidone is an amount of
Make 1000 bags (every bag of iron content 5mg)
Preparation technology:
■ crosses 100 mesh sieves with EDTA ferrum.Each adjuvant except that polyvidone, vitamin C is crossed 100 mesh sieves.
■ takes by weighing supplementary material (sweet taste correctives according to concrete kind select appropriate amount) by recipe quantity and adopts the equivalent method mix homogeneously that progressively increases except that polyvidone, vitamin C.
■ gets polyvidone, with second alcohol and water preparation 10%PVP50% alcoholic solution.
■ is with 10%PVP50% alcoholic solution and former, the soft ability of adjuvant system that have mixed.
■ granulates with 16 mesh sieves, with wet granular 60 ℃～70 ℃ dryings 2～4 hours.
■ is with 16 mesh sieve granulate.
■ gets the vitamin C raw material, selects 14 orders～40 purpose vitamin C feed particles and above-mentioned granule mix homogeneously with 14 orders and 40 purpose screen clothes.
■ gets mixed granule and measures the EDTA iron content, carries out packing by recipe quantity and content, promptly.
This product is pressed under two appendix IN items of Chinese Pharmacopoeia (version in 2000) and is checked, should meet the requirement of granule.3, the basic prescription and the preparation technology of EDTA ferrum chewable tablet of the present invention:
Basic prescription:
EDTA ferrum 7.7g
Sorbitol 0～500g
Lactose 0～500g
Milk powder (defatted milk powder or whole milk powder) 0～500g
Citric acid 0～5g
Vitamin C 0～20g
The maximum 60g of zinc gluconate
Sweet taste correctives (for example acesulfame potassium, cyclamate etc.) is an amount of
Magnesium stearate an amount of (be generally prescription total amount about 0.4%)
Polyvidone is an amount of
Make 1000 (every iron content 1mg)
Preparation technology:
■ crosses 100 mesh sieves with EDTA ferrum.Each adjuvant except that polyvidone is crossed 100 mesh sieves.
■ takes by weighing supplementary material (sweet taste correctives according to concrete kind select appropriate amount) by recipe quantity and adopts the equivalent method mix homogeneously that progressively increases except that polyvidone, magnesium stearate, vitamin C.
■ gets polyvidone, with second alcohol and water preparation 10%PVP50% alcoholic solution.
■ is with 10%PVP50% alcoholic solution and former, the soft ability of adjuvant system that have mixed.
■ granulates with 20 mesh sieves, with wet granular 60 ℃～70 ℃ dryings 2～4 hours.
■ is with 20 mesh sieve granulate.Behind fine powder and vitamin C and the magnesium stearate mix homogeneously again with the granule mix homogeneously.
■ selects suitable mould tabletting, promptly.
This product is pressed under two appendix IA items of Chinese Pharmacopoeia (version in 2000) and is checked, should meet the requirement of chewable tablet.
The following examples are used to further specify the present invention, but do not mean that the present invention only limits to this.The preparation of embodiment 1 suspension type EDTA ferrum dry suspension:
Prescription is formed: EDTA ferrum 38.5g
Non-dairy creamer 5000g
Vitamin C 50g
Zinc gluconate 35g
Acesulfame potassium is an amount of
Make 1000 bags (every bag of iron content 5mg)
Preparation technology: with the preparation technology of above-mentioned EDTA ferrum dry suspension.
Characteristics: this product 1 bag is taken after mixing it with water with 20ml～30ml hot water, the solution suspendible shape that is creamy white, good mouthfeel.The preparation of embodiment 2 clear and bright type EDTA ferrum dry suspension:
Prescription is formed: EDTA ferrum 37.7g
Sorbitol 2000g
Lactose 2000g
Glucose 500g
Vitamin C 50g
Zinc gluconate 35g
Acesulfame potassium is an amount of
Make 1000 bags (every bag of iron content 5mg)
Preparation technology: with the preparation technology of above-mentioned EDTA ferrum dry suspension.
Characteristics: this product 1 bag is taken after mixing it with water with 20ml～30ml hot water, and solution is clear and bright shape, good mouthfeel.The preparation of embodiment 3 chocolate type EDTA ferrum dry suspension:
Prescription is formed: EDTA ferrum 37.7g
Chocolate fruit powder 2000g
Defatted milk powder 3000g
Cane sugar powder 1000g
Vitamin C 50g
Zinc gluconate 35g
Acesulfame potassium is an amount of
Make 1000 bags (every bag of iron content 5mg)
Preparation technology: with the preparation technology of above-mentioned EDTA ferrum dry suspension.
Characteristics: this product 1 bag is taken after mixing it with water with 20ml～30ml hot water, and solution is coffee-like suspendible shape, good mouthfeel.The preparation of embodiment 4 EDTA ferrum granules:
Prescription is formed: EDTA ferrum 37.7g
Mannitol 2000g
Sucrose 1000g
Glucose 500g
Vitamin C 50g
Zinc gluconate 35g
Polyvidone is an amount of
Make 1000 bags (every bag of iron content 5mg)
Preparation technology: with the preparation technology of above-mentioned EDTA ferrum granule.
Characteristics: this product 1 bag is taken after mixing it with water with 20ml～30ml hot water, and solution is clear and bright shape, good mouthfeel.The preparation of embodiment 5 EDTA ferrum chewable tablet:
Prescription is formed: EDTA ferrum 7.54g
Sorbitol 150g
Defatted milk powder 150g
Lactose 150g
Citric acid 2g
Vitamin C 10g
Zinc gluconate 7g
An amount of or the 1g of acesulfame potassium
Magnesium stearate an amount of (be generally prescription total amount about 0.4%)
Polyvidone is an amount of
Make 1000 (every iron content 1mg)
Preparation technology: with the preparation technology of above-mentioned EDTA ferrum chewable tablet.
Claims (7)
1, be raw material with sodium iron ethylenediaminetetraacetate (EDTA ferrum), add suitable adjuvant and make sodium iron ethylenediaminetetraacetate (EDTA ferrum) dry suspension, sodium iron ethylenediaminetetraacetate (EDTA ferrum) granule, sodium iron ethylenediaminetetraacetate (EDTA ferrum) chewable tablet, be used for the medical treatment and the healthcare field of compensating iron for human and treatment iron deficiency anemia.This series products is characterised in that this series products not only contains sodium iron ethylenediaminetetraacetate (EDTA ferrum), has simultaneously the pharmaceutics feature that meets the chewable tablet of explaining in two appendix I ruless of preparations of Chinese Pharmacopoeia (version in 2000), dry suspension, granule again.
2, according to the dried mixture of claim 1 preparation sodium iron ethylenediaminetetraacetate (EDTA ferrum), it is characterized in that: contain non-dairy creamer vitaminize C in the prescription of the dried mixture of sodium iron ethylenediaminetetraacetate (EDTA ferrum) and add zinc gluconate or chocolate fruit powder and add cane sugar powder vitaminize C with milk powder and add zinc gluconate or sorbitol and add lactose and add the combination that glucose vitaminize C adds zinc gluconate.
3, according to claim 1,2, the dried mixture of preparation sodium iron ethylenediaminetetraacetate (EDTA ferrum), its prescription feature is: sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 53～399 with the weight ratio of non-dairy creamer; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～159 with the weight ratio of sorbitol; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～133 with the weight ratio of lactose; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～27 with the weight ratio of glucose; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～159 with the weight ratio of chocolate fruit powder; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～80 with the weight ratio of cane sugar powder; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～159 with the weight ratio of milk powder; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0.27～13 with ascorbic weight ratio; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～8 with the weight ratio of zinc gluconate.
4, according to claim 1 preparation sodium iron ethylenediaminetetraacetate (EDTA ferrum) granule, it is characterized in that: contain the combination of mannitol, vitamin C, glucose, zinc gluconate, sucrose in the prescription of sodium iron ethylenediaminetetraacetate (EDTA ferrum) granule.
5, according to claim 1,4, preparation sodium iron ethylenediaminetetraacetate (EDTA ferrum) granule, its prescription feature is: sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～106 with the weight ratio of mannitol; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～27 with the weight ratio of glucose; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～133 with the weight ratio of sucrose; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0.27～13 with ascorbic weight ratio; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～8 with the weight ratio of zinc gluconate.
6, according to claim 1 preparation sodium iron ethylenediaminetetraacetate (EDTA ferrum) chewable tablet, it is characterized in that: contain the combination of sorbitol, lactose, milk powder, citric acid, vitamin C, zinc gluconate in the prescription of sodium iron ethylenediaminetetraacetate (EDTA ferrum) granule.
7, according to claim 1,6, preparation sodium iron ethylenediaminetetraacetate (EDTA ferrum) chewable tablet, its prescription feature is: sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～65 with the weight ratio of sorbitol; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～65 with the weight ratio of lactose; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～65 with the weight ratio of milk powder; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～2.6 with ascorbic weight ratio; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～8 with the weight ratio of zinc gluconate; Sodium iron ethylenediaminetetraacetate (EDTA ferrum) is 1: 0～0.65 with the weight ratio of citric acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02146594 CN1415289A (en) | 2002-10-28 | 2002-10-28 | Novel preparation of ethylenediamine tetraacetic acid ferro (EDTAferro) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02146594 CN1415289A (en) | 2002-10-28 | 2002-10-28 | Novel preparation of ethylenediamine tetraacetic acid ferro (EDTAferro) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1415289A true CN1415289A (en) | 2003-05-07 |
Family
ID=4751117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02146594 Pending CN1415289A (en) | 2002-10-28 | 2002-10-28 | Novel preparation of ethylenediamine tetraacetic acid ferro (EDTAferro) |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1415289A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100344326C (en) * | 2005-09-30 | 2007-10-24 | 北京康比特威创体育新技术发展有限公司 | Iron-supplementing preparation |
| CN101690590B (en) * | 2009-10-15 | 2012-06-27 | 南宁富莱欣生物科技有限公司 | Health-care food of iron zinc calcium tablets and production method thereof |
| CN103099787A (en) * | 2013-02-19 | 2013-05-15 | 青岛正大海尔制药有限公司 | Vitamin C dry suspension |
| CN111714470A (en) * | 2020-05-27 | 2020-09-29 | 天津瑞益瑞美生物技术有限公司 | Sustained-release ethylenediamine tetraacetic acid iron sodium premix for animals and preparation method thereof |
-
2002
- 2002-10-28 CN CN 02146594 patent/CN1415289A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100344326C (en) * | 2005-09-30 | 2007-10-24 | 北京康比特威创体育新技术发展有限公司 | Iron-supplementing preparation |
| CN101690590B (en) * | 2009-10-15 | 2012-06-27 | 南宁富莱欣生物科技有限公司 | Health-care food of iron zinc calcium tablets and production method thereof |
| CN103099787A (en) * | 2013-02-19 | 2013-05-15 | 青岛正大海尔制药有限公司 | Vitamin C dry suspension |
| CN103099787B (en) * | 2013-02-19 | 2014-06-25 | 青岛正大海尔制药有限公司 | Vitamin C dry suspension |
| CN111714470A (en) * | 2020-05-27 | 2020-09-29 | 天津瑞益瑞美生物技术有限公司 | Sustained-release ethylenediamine tetraacetic acid iron sodium premix for animals and preparation method thereof |
| CN111714470B (en) * | 2020-05-27 | 2022-04-08 | 天津瑞益瑞美生物技术有限公司 | Enteric-coated sodium iron ethylene diamine tetraacetate premix for livestock and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1233282C (en) | Bramble powder product preparing method | |
| CN1765224A (en) | Healthy caring roasted qingke barley flour and its production method | |
| CN102860468A (en) | Corn composite nutritive rice | |
| CN102860461A (en) | Konjac composite nutritive rice | |
| CN101057643A (en) | Rice with blood sugar reducing function | |
| CN100344326C (en) | Iron-supplementing preparation | |
| CN1714655A (en) | Ginkgo biscuit, rice biscuit and its producing method | |
| CN1067538C (en) | Health-care powder | |
| CN1275546C (en) | Fat reducing nutrient | |
| CN1415289A (en) | Novel preparation of ethylenediamine tetraacetic acid ferro (EDTAferro) | |
| CN106578945A (en) | Nutritive compound rice eaten by lying-in women and preparation method thereof | |
| CN1493208A (en) | Dietary fiber powder pouring boiling water for eating | |
| CN1795745A (en) | Longevity noodle prepared from nine corns | |
| CN108497316A (en) | Lower hyperlipidemia, hypertension, hyperglycemia nutritious food and its manufacturing method | |
| CN1097093A (en) | Cicer arietinum flour product and processing method thereof | |
| CN1415311A (en) | Novel preparation of ferrisodium pyrophosphate | |
| CN1669446A (en) | Bread premixing powder containing wheat germ powder | |
| CN1283269C (en) | Compound preparation of forest frog, and preparation method | |
| CN105580957A (en) | Method for producing corn tablet candy | |
| CN1258538A (en) | Health food made of silkworm for treating diabetes and hyperlipemia and its production process | |
| CN1718101A (en) | Tablets contg. bee-pollen and soybean ovolecithin, and its prodn. method | |
| CN1293831C (en) | Effervescent solid beverage of amino acid chelated calcium and its prepn | |
| CN113142367A (en) | Preparation method of shark chondroitin milk calcium tablet candy | |
| JP2004049102A (en) | Health food and method for producing the same | |
| CN1098852A (en) | Gaufrette series food and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |