CN102670729A - Preparation method for cistanche tubulosa and American ginseng compound capsule - Google Patents
Preparation method for cistanche tubulosa and American ginseng compound capsule Download PDFInfo
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- CN102670729A CN102670729A CN2012101503155A CN201210150315A CN102670729A CN 102670729 A CN102670729 A CN 102670729A CN 2012101503155 A CN2012101503155 A CN 2012101503155A CN 201210150315 A CN201210150315 A CN 201210150315A CN 102670729 A CN102670729 A CN 102670729A
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- extract
- cistanche tubulosa
- panacis quinquefolii
- american ginseng
- radix panacis
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Abstract
The invention provides a preparation method for a cistanche tubulosa and American ginseng compound capsule. The cistanche tubulosa and American ginseng compound capsule comprises the following raw materials: 100-300g of cistanche tubulosa extract, 100-250g of American ginseng extract, 50-150ml of alcohol and 2-6g of magnesium stearate. The preparation method comprises the following steps of: respectively sieving the cistanche tubulosa extract and the American ginseng extract for 80-100 meshes; putting in a mixer and stirring for 40-50 minutes; then, adding 90-120ml of 65-85 percent alcohol to soften the extracts; sieving the softened extracts for 10-20 meshes; putting in a drying oven; drying at the temperature of 45-70 DEG C; sieving for 10-20 meshes when moisture content is 2-10 percent to obtain qualified particles; adding the magnesium stearate to the particles and evenly mixing to obtain total particles; and filling into capsules to obtain a finished product. The oral dose of the finished product is 0.4g per capsule. The cistanche tubulosa and American ginseng compound capsule is taken one each time and two times a day, and the quality guarantee period is 24 months.
Description
Technical field
The present invention relates to the reasonable compatibility and the processing of Chinese crude drug, especially the extract with Cistanche Tubulosa and Radix Panacis Quinquefolii is combined into capsule, and is both easy to carry edible, can produce diseases prevention preferably, health-care effect again.
Background technology
Along with improving constantly of quality of the life, people constantly increase for the demand of health product.Rhythm of life is fast, and work load is heavy, makes people's body and mind feel tired more easily, and the immunity degradation phenomenon is general, and therefore alleviating physical fatigue, raising immunity health product also constantly enlarge in the market share of China's health products trade.Alleviating physical fatigue class health product are mainly with Radix Ginseng in the market, taurine, and Air Bladder pseudosciaenae seu Acipenser, Radix Puerariae, Gallus Domesticus, Cornu Cervi Pantotrichum, Fructus Jujubae etc. are raw material; Anti-fatigue product mainly contains egg albumen powder, spirulina, propolis etc.
Cistanche Tubulosa has another name called greatly and rues, and in Shennong's Herbal, Herba Cistanches is classified as top gradely, and " main five kinds of strain and seven kinds of impairment, invigorating middle warmer remove stem invasion by pathogenic cold burning pain, support the five internal organs, reinforcing YIN-essence, benefiting essence-blood " is reinforcing the kidney and supporting YANG, life essence-filling, marrow-benefitting, the famous and precious Chinese crude drug that blood enriching and dryness moistening, happy color are prolonged life.Cistanche Tubulosa is one of Herba Cistanches kind of recording of Chinese Pharmacopoeia, and main product is (area, South Sinkiang), Inner Mongol in Xinjiang, and its sweet-salty is warm in nature; Return kidney, large intestine channel, but kidney-replenishing, benefiting essence-blood; Loosening bowel to relieve constipation, it is infertile to be used for sexual impotence, soreness of the waist and knees; Muscles and bones is unable, and the dryness of the intestine constipation have the good reputation of " desert Radix Ginseng "; But the kidney invigorating and essence nourishing blood, for by the loss of suffering from a deficiency of the kidney, the fatigue that asthenia of essence and blood, disorder of QI and blood cause has better action, has the effect of enhancing immunity." book on Chinese herbal medicine converge with speech " record Herba Cistanches be " support the gate of vitality, nourishing kidney gas, the medicine of replenishing vital essence and blood are the agent of flat benefits also, and temperature and not hot is mended and not high, warm up and not dry, slide and do not let out, so the name of Herba Cistanches is arranged ".Describe in " doctor rock gas " " aerial root also belongs to kidney in kidney, thus day ' the kidney improving inspiration by invigorating kidney-QI, its breath deeply, but Herba Cistanches the kidney invigorating and essence nourishing blood, for by the loss of suffering from a deficiency of the kidney, the fatigue that asthenia of essence and blood, disorder of QI and blood cause has better action, has the effect of enhancing immunity.
Radix Panacis Quinquefolii: sweet in the mouth, little hardship, cool in nature, GUIXIN, lung, kidney channel have the function of boosting qi and nourishing yin, pathogenic fire purging relieving restlessness, nourishing the stomach to promote the production of body fluid.The traditional Chinese medical science is thought, the gas person, the people at all also." doctor Quan Chubian ": " people's life and death, the full gas that relies.Gas gathers then gives birth to, the strong then health of gas, weakness of QI then a little less than, gas looses then dead." gas is the material base of keeping the human life activity, can excite and promote the physiological function of histoorgans such as each internal organs, meridians." doctor's rock gas ": " aerial root also belongs to kidney in kidney, so day ' the kidney improving inspiration by invigorating kidney-QI, its breath is deep." kidney behaviour the congenital foundation, deficiency of kidney-QI, deficiency of vital energy body fluid deficiency, then fatigue and asthenia." book on Chinese herbal medicine is new again " record Radix Panacis Quinquefolii " control the deficiency of vital energy and breathe out to breathe heavily, lose blood, impairment caused by overstrain, controlling nocturnal emission with astringent drugs is calmed the nerves, and produces all empty "." Records of Tradition Chinese and Western Medicine in Combination " record Radix Panacis Quinquefolii " can subsidize edema caused by disorder of QI, and ability tonification blood system ".The West participates in the kidney channel invigorating primordial QI, and kidney qi is abundant, takes the photograph and receives normally, and in healthy energy was deposited, heresy can not be done, and is applicable to fatigue symptoms such as the lazy speech of the deficiency of vital energy, extremity asthenia.
Literature search discloses: be mostly oral liquid and wine with the Herba Cistanches Related product on the market, the total glycosides capsule of Herba Cistanches glue, Herba Cistanches Cognex etc. are also arranged; Mostly be buccal tablet and oral formulations with the Radix Panacis Quinquefolii Related product, capsule product is also arranged, regulate the immunity class.
The Chinese medicine composition of the present invention's development comprises Cistanche Tubulosa extract and Radix Panacis Quinquefolii extract, and alleviating physical fatigue is organically combined with improving immunity function, has realized the stiffening effect of combination drug, certainly leads to rich market sale prospect.
Summary of the invention
The objective of the invention is to: the complex capsule of the Herba Cistanches Radix Panacis Quinquefolii that provides has alleviating physical fatigue, the diseases prevention that improves immunity, the building body effect of health care.
Order of the present invention is achieved in that a kind of method for preparing of Herba Cistanches Radix Panacis Quinquefolii complex capsule, and raw material is made up of 100-300g Cistanche Tubulosa extract, 100-250g Radix Panacis Quinquefolii extract, 50-150ml ethanol, 2-6g magnesium stearate; Cistanche Tubulosa extract, Radix Panacis Quinquefolii extract are crossed the 80-100 mesh sieve respectively, place mixer to stir, time 40-50 minute, add the soft system extract of 65-85% ethanol 90-120ml again; Soft system extract is crossed the 10-20 mesh sieve, place baking oven, dry under 45-70 ℃ of condition; When moisture 2%-10%, cross the 10-20 mesh sieve, get qualified granule; Add the magnesium stearate mix homogeneously to granule, get total particle, load capsule and get product.
Described method for preparing, the oral dose of finished capsule product are the 0.4g/ grain, and each 1, every day 2 times, the shelf-life is 24 months.
Described method for preparing, Cistanche Tubulosa extract is provided by Hetian DCM Medicine Biological Technology Co., Ltd.; Radix Panacis Quinquefolii extract is provided by the grand biotech inc of a specified duration in Jilin.
Medical mechanism of the present invention: the Herba Cistanches water extract can significantly improve the phagocytic percentage and the phagocytic index of macrophage, can make by prednisone to suppress low nonspecific immunity functional rehabilitation also can be strengthened mouse macrophage to certain level phagocytic function.It is active that the smart powder of Cistanche Tubulosa can improve body free radical scavenging enzyme SOD, thereby reduce the damage of radical pair body, so delaying senility function is arranged.
Utilize Radix Panacis Quinquefolii extract: Radix Panacis Quinquefolii belongs to immunopotentiating agent, has BA widely, and main effective ingredient is polysaccharide, saponin etc.Radix Panacis Quinquefolii can be stocked, improve mice aerobic capacity and sports load adaptability, thereby reach the antifatigue health care through raising mouse movement endurance, increase Mouse Liver glycogen.Modern pharmacological research confirms that the effective ingredient stem and leaf of Radix Panacis Quinquefolii total glycosides of Radix Panacis Quinquefolii has anti-hypoxia, antifatigue effect preferably.Experimental study discloses the stem and leaf of Radix Panacis Quinquefolii total glycosides can obviously prolong the mice normobaric hypoxia time-to-live, and can resist the oxygen consumption of isoproterenol; Can obviously improve the immunocompetence of deficiency of YIN mice due to the hydrocortisone, have the human body immunity improving ability, the effect of strengthening the body resistance.
The present invention's design mixes Cistanche Tubulosa extract with Radix Panacis Quinquefolii extract, the complex capsule of preparation has the elite of two kinds of materials concurrently, effectively alleviating physical fatigue and the effect of enhancing immunity disease-prevention health; Suitable crowd's fatiguability person and immunocompromised person so stronger illness prevention and fitness effect is arranged, show technological progress.
Description of drawings
The present invention combines accompanying drawing to be described further.
Accompanying drawing is the capsular process flow diagram of preparation;
As shown in the figure; Be arranged in order by flow process: Herba Cistanches extract and Radix Panacis Quinquefolii extract → mixed powder → wet granular → dried granule → qualified granule (adding magnesium stearate) → total particle → encapsulated → finished product.
The specific embodiment
The present invention combines embodiment to be described further.
Embodiment
Cistanche Tubulosa extract, Radix Panacis Quinquefolii extract are crossed 100 mesh sieves respectively, get 200g respectively, 160g places mixer, room temperature, normal pressure mixed 40 minutes; Add again 65% ethanol 100ml softening extract, will soften to such an extent that extract is crossed 20 mesh sieves, place drip pan to be dried to moisture 5% for 65 ℃; Cross 20 mesh sieves, get qualified granule, add magnesium stearate 2g mix homogeneously to granule; Get total particle, employing is waved granulation machine (YK-160) filling capsule and is got product.
The significant composition conformance with standard of this product is seen table 1.
Significant composition of table 1 and component content index
| Significant composition | Index |
| Total saponins (in the ginsenoside Re), g/100g >;= | 3.9 |
| Echinacoside, g/100g >;= | 6.0 |
| Verbascoside, g/100g >;= | 1.8 |
The physical and chemical index conformance with standard of this product is seen table 2.
Table 2 physical and chemical index
| Project | Index |
| Plumbous (in Pb), mg/kg<= | 1.5 |
| Arsenic (in As), mg/kg<= | 1.0 |
| Hydrargyrum (in Hg), mg/kg<= | 0.3 |
| Gamma Hexaochlorocyclohexane, mg/kg<= | 0.1 |
| Clofenotane, mg/kg<= | 0.1 |
| Moisture, %<= | 9.0 |
| Ash, %<= | 9.0 |
| Disintegration, min<= | 60 |
The microbiological indicator conformance with standard of this product is seen table 3.
Table 3 microbiological indicator
| Project | Index |
| Total plate count, cfu/g<= | 1000 |
| Coliform, MPN/100g<= | 40 |
| Mycete, cfu/g<= | 25 |
| Yeast, cfu/g<= | 25 |
| Pathogenic bacterium (Salmonella, shigella, Hemolytic streptococcus, staphylococcus aureus) | Must not detect |
The sense organ of this product requires conformance with standard, sees table 4.
Table 4 organoleptic indicator
| Project | Requirement |
| Color and luster | Capsule 's content is brown fine granularity powder |
| Flavour and abnormal smells from the patient | The distinctive abnormal smells from the patient of these article, mildly bitter flavor, free from extraneous odour |
| Form | Hard capsule, appearance is complete bright and clean |
| Impurity | Capsule 's content does not have macroscopic exogenous impurity |
In sum: this product is that quality, food safety aspect have all obtained confirming of national technical specification, and also obtained the approval of consumer, enterprise will produce great economic benefit.
The present invention selects for use waves granulation machine (YK-160), is produced by Changzhou great river drying equipment factory.
These health product of the present invention meet the regulation of GB 7718, GB/191 and Ministry of Public Health " health food sign regulation ".
Claims (3)
1. the method for preparing of a Herba Cistanches Radix Panacis Quinquefolii complex capsule, it is characterized in that: raw material is made up of 100-300g Cistanche Tubulosa extract, 100-250g Radix Panacis Quinquefolii extract, 50-150ml ethanol, 2-6g magnesium stearate; Cistanche Tubulosa extract, Radix Panacis Quinquefolii extract are crossed the 80-100 mesh sieve respectively, place mixer to stir, time 40-50 minute, add the soft system extract of 65-85% ethanol 90-120ml again; Soft system extract is crossed the 10-20 mesh sieve, place baking oven, dry under 45-70 ℃ of condition; When moisture 2%-10%, cross the 10-20 mesh sieve, get qualified granule; Add the magnesium stearate mix homogeneously to granule, get total particle, load capsule and get product.
2. method for preparing according to claim 1 is characterized in that: the oral dose of finished product is the 0.4g/ grain, and each 1, every day 2 times, the shelf-life is 24 months.
3. method for preparing according to claim 1, it is characterized in that: Cistanche Tubulosa extract is provided by Hetian DCM Medicine Biological Technology Co., Ltd.; Radix Panacis Quinquefolii extract is provided by the grand biotech inc of a specified duration in Jilin.
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|---|---|---|---|
| CN2012101503155A CN102670729A (en) | 2012-05-16 | 2012-05-16 | Preparation method for cistanche tubulosa and American ginseng compound capsule |
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| CN2012101503155A CN102670729A (en) | 2012-05-16 | 2012-05-16 | Preparation method for cistanche tubulosa and American ginseng compound capsule |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105749099A (en) * | 2016-03-30 | 2016-07-13 | 三株福尔制药有限公司 | Probiotic fermented traditional Chinese medicine composition for treating gastric cancer and preparation method and application thereof |
Citations (7)
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|---|---|---|---|---|
| CN1282602A (en) * | 1999-07-29 | 2001-02-07 | 北京天施康医药科技发展有限公司 | Antifatigue capsule |
| CN1466958A (en) * | 2002-07-08 | 2004-01-14 | 张小平 | Anti-consenescence anti-fatigue health-product containing pure plant extracts |
| CN1562131A (en) * | 2004-04-17 | 2005-01-12 | 江西青春康源医药有限公司 | Kidney tonifying oral liquid made of American ginseng and cordyceps |
| WO2006134409A2 (en) * | 2005-06-13 | 2006-12-21 | Jaszberenyi Csaba Jozsef | Synergistic prebiotic compositions |
| WO2008149689A1 (en) * | 2007-06-01 | 2008-12-11 | Kobayashi Pharmaceutical Co., Ltd. | Composition having antioxidative activity |
| CN101444558A (en) * | 2008-12-09 | 2009-06-03 | 天津市弗兰德医药科技发展有限公司 | Desertliving cistanche herb extract pellet and preparation method thereof |
| CN101524409A (en) * | 2009-03-31 | 2009-09-09 | 北京康比特体育科技股份有限公司 | Chinese medicine composition used for improving the level of serum testosterone and preparing method thereof |
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2012
- 2012-05-16 CN CN2012101503155A patent/CN102670729A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1282602A (en) * | 1999-07-29 | 2001-02-07 | 北京天施康医药科技发展有限公司 | Antifatigue capsule |
| CN1466958A (en) * | 2002-07-08 | 2004-01-14 | 张小平 | Anti-consenescence anti-fatigue health-product containing pure plant extracts |
| CN1562131A (en) * | 2004-04-17 | 2005-01-12 | 江西青春康源医药有限公司 | Kidney tonifying oral liquid made of American ginseng and cordyceps |
| WO2006134409A2 (en) * | 2005-06-13 | 2006-12-21 | Jaszberenyi Csaba Jozsef | Synergistic prebiotic compositions |
| WO2008149689A1 (en) * | 2007-06-01 | 2008-12-11 | Kobayashi Pharmaceutical Co., Ltd. | Composition having antioxidative activity |
| CN101444558A (en) * | 2008-12-09 | 2009-06-03 | 天津市弗兰德医药科技发展有限公司 | Desertliving cistanche herb extract pellet and preparation method thereof |
| CN101524409A (en) * | 2009-03-31 | 2009-09-09 | 北京康比特体育科技股份有限公司 | Chinese medicine composition used for improving the level of serum testosterone and preparing method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105749099A (en) * | 2016-03-30 | 2016-07-13 | 三株福尔制药有限公司 | Probiotic fermented traditional Chinese medicine composition for treating gastric cancer and preparation method and application thereof |
| CN105749099B (en) * | 2016-03-30 | 2019-09-13 | 三株福尔制药有限公司 | A kind of probiotics fermention Chinese medicine composition and its preparation method and application for treating gastric cancer |
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Application publication date: 20120919 |