CN1209978C - Nutritive health-care food for supplementing nucleic acid and its preparing process - Google Patents
Nutritive health-care food for supplementing nucleic acid and its preparing process Download PDFInfo
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Abstract
The present invention relates to nutritive health-care food for supplementing nucleic acid, which is mainly prepared from the components of the proportion by weight: 0 to 40% of DNA protamine, 1 to 30% of RNA protein, 10 to 15% of vitamin, and less than 15% of trace element. The present invention has the advantages that nucleic acid can be promptly supplemented to bodies, various diseases are prevented, delay aging is delayed, and organism health is maintained; DNA and RNA are selected from natural nucleic acid and are convenient to digest and absorb after eating, different types of nutritive nucleic acid health-care foods are produced according to the requirements of people in each age group, and the present invention has the advantages of high safety and reliability, no side effect and convenient eating.
Description
The present invention relates to a kind of food, be meant the nutritional supplementation health food that contains nucleic acid and the preparation method of this food especially.
According to the viewpoint of nutrition, protein, fat, sugar, mineral matter, vitamin and cellulose are human body indispensable six big nutrients.Recently scientists confirms and is accepted by people gradually: in cell metabolism procedure, synthesizing of the hereditary information indicator protein matter of DNA in the nucleic acid (DNA), the ribonucleic acid in the nucleic acid (RNA) then carries out the synthetic of protein according to the hereditary information of DNA.Therefore, nucleic acid is human requisite the 7th kind of nutrient.The picked-up deficiency of nucleic acid can cause a series of aging phenomenon:
1, due to cell division, the proliferation slows:
1. skin aging-dry skin, chap, lax, wrinkle, chloasma;
2. stomach aging-digestion, absorption function descends, and chronic diarrhea, constipation take place;
3. blood aging-anaemia, white blood cell minimizing, immunocompetence reduction, thrombopenia etc.;
4. regeneration function reduction-fracture, The wound refused to heal restore, because of disease non-viable non-apoptotic cells such as hepatitis are regenerated slowly;
5. sperm generation ability reduction-hyposexuality, male sterility;
6. depauperation, (children see more) has a delicate constitution;
7. fat (basic metabolism is low, and fat metabolism is bad etc.).
2, due to genic defence, reparation function and antioxidative functional reduce:
1. carcinogenic danger strengthens;
2. cause the generation of the heart, cerebrovascular disease because of artery sclerosis;
3. the initiation potential of diabetes strengthens;
4. quicken other aging phenomenon.
3, (RNA acid meeting content in brain cell is higher) due to the neural parasthenia:
1. failure of memory;
2. the generation of senile dementia;
3. Parkinson's disease, sudden deafness, epilepsy and other neural seizure of disease.
Before 20 years old, people's liver is synthetic active.The nucleic acid of necessary amount can be supplied with by synthesizing of liver.With advancing age, the function of liver can weaken gradually, therefore as far as possible reasonably goes picked-up to be very important from food.The flange gram doctor of the U.S. recommends should absorb every day 1-1.5 gram nucleic acid to people, contains 1.5-2 gram nucleic acid in the excreta that Japanese scholar has also confirmed to be grown up every day.Health adult with 50 kilograms of body weight is an example, need nucleic acid 2 grams every day, and can only replenish less than 1 gram by daily common diet, contain nucleic acid in egg, the milk hardly, be rich in most the sardine of nucleic acid with regard to the limit, people all only edible sardine on the one also only contains 50 milligrams nucleic acid in its 100 gram, if then need eat 2000 grams and can get 1 gram nucleic acid.Just not saying can eat a large amount of like this fishes every day, even may, also can be because of other ADs of initiation such as fat of while excess intake.
Main purpose of the present invention is to provide a kind of nutritive health-care food for supplementing nucleic acid, this nutritive nucleic acid health food instant, the timely nucleic acid deficiency in the added body, delay the aging phenomenon of above-mentioned discovery effectively, prevent various ADs, begin to recover the youthful vigor of health from cell, reach the purpose of good health and a long life.
Another object of the present invention is to provide a kind of preparation method of nutritive health-care food for supplementing nucleic acid, particularly from fish spermary (or pluck tissue), extract the technology of natural acid.
A kind of nutritive nucleic acid health food provided by the invention includes following composition:
DNA nucleoprotamine (or natural acid), RNA albumen, vitamin group and trace element, the shared weight ratio of various compositions is:
DNA nucleoprotamine 17%-40%,
RNA albumen 1-30%,
Comprise ascorbic vitamin group 10-15%,
Trace element＜15%,
The auxiliary material surplus.
DNA nucleoprotamine in the nutritive health-care food for supplementing nucleic acid of the present invention is taken from fish spermary (or extracting) from the animal viscera tissue, RNA albumen is food yeast extract (or refining low-molecular-weight nucleotides), the food yeast that adopts is a brewer's yeast at present, the following technology of extraction process of DNA nucleoprotamine (or natural acid):
1. various fish spermaries (or pluck tissue) are made powder through freeze drying;
2. refining: powder is mixed the back backflow heat with hydrous ethanol, hydrous ethanol is by ethanol: water: contain the protective agent of sulfydryl=85%: 11%: 4% and form, heating and temperature control stirred 1 hour at 88 ℃, was cooled to then below 25 ℃;
3. above-mentioned solid, liquid mixture are made wet product (solid portion) and liquid part through centrifuge and decanter separation, wherein liquid partly is discarded object, and recyclable ethanol wherein is in order to avoid pollute;
4. the product of wetting are carried out heated-air drying, drying under reduced pressure, temperature is controlled at below 60 ℃, and after the ethanol evaporation, the loss on drying of product is below 7%, and the ethanol of product remains in below 1%;
5. packed products.
DNA nucleoprotamine, RNA albumen (or refining low-molecular-weight nucleotides) and other nutritional labeling of extracting is processed into the nutritive nucleic acid health food of sheet or other state through combination process.
Accompanying drawing one extraction process flow chart
According to " functional evaluation program and the detection method of health food ", nutritive nucleic acid of the present invention is replenished health food to be detected, prove that this nutritive nucleic acid replenishes health food and has anti-fatigue effect, immunoloregulation function, improves memory function and deferring senility, its concrete outcome is as follows:
(1) fatigue function: per os gave the nucleic acid health-care tablet of various dose after 30 days, compare with control group, middle dosage group (0.5g/kg.bw) swimming time improves 83% (P＜0.05), the blood urine cellulose content reduces by 13% (P＜0.01), and hepatic glycogen content improves 25% (P＜0.05); High dose group (1.5g/kg.bw) swimming time improves 78% (P＜0.05), and the blood urine cellulose content reduces by 11% (P＜0.05), and the 0min Serum lactic acid content has reduced by 23% (P＜0.001) after the swimming. Conclusion is: middle and high dosage nucleic acid health-care tablet has obvious anti-fatigue effect.
(2) immunoloregulation function: per os gave the nucleic acid health-care tablet of various dose after 30 days, compared with control group, and the antibody-producting cell quantity of low dose group (0.25g/kg.bw) improves 5% (P＜0.05); The thymus gland of middle dosage group (0.5g/kg.bw)/body weight ratio improves 16% (P＜0.05), swelling degree of the paw improves 32% (P＜0.05), antibody-producting cell quantity improves 6% (P＜0.01), and HC50 improves 97% (P＜0.01); The thymus gland of high dose group (1.5g/kg.bw)/body weight ratio improves 23% (P＜0.05), and swelling degree of the paw improves 47% (P＜0.01). Conclusion is: nucleic acid health-care tablet of the present invention has the adjusting immunologic function.
(3) improve memory function:
1. test through human body test-meal in 30 days, score difference before and after the subscale score that sensing memory, associative memory and figure after the test freed recall and the test, memory quotient and total scale score and value added, this nutritive health-care food for supplementing nucleic acid test-meal group all is significantly higher than control group (P＜0.05), and the test-meal group is than testing front improved degree significantly better than control group. Illustrate that this nutritive health-care food for supplementing nucleic acid is improved the effect of person in middle and old age experimenter's memory.
2. through animal experiment, this nutritive health-care food for supplementing nucleic acid of gavage is one month result show, the number of animals that is shocked by electricity in the step down test, basic, normal, high dosage group compare with control group that there were significant differences; The middle and high dosetest group of mistake number is lower than control group, and prolongation of latency. Above-mentioned difference has statistical significance (P＜0.05); Reach home in the water maze test required time and wrong number, each dosetest group is lower than control group, significant difference statistically (P＜0.05). This result shows that this nutritive health-care food for supplementing nucleic acid also is improved the effect of animal memory.
(4) deferring senility: per os gives the nucleic acid health food 58 days of aged mouse various dose, compare with the blank group: low dose group (0.25g/ day/kg.bw) myocardial lipofuscin content 39% (P＜0.05), serum activity of SOD improves 8% (P＜0.05); Middle dosage group (0.5g/ day/kg.bw) myocardial lipofuscin content 43% (P＜0.05), whole blood glutathione peroxidase activity units improves 19% (P＜0.01); High dose group (1.5g/ day/kg.bw) myocardial lipofuscin content 31% (P＜0.05). Body weight is without significant difference before and after the experiment. Compare with the blank group (tested material concentration 0%), the female fruit bat maximum life span of tested material concentration 0.033% prolongs 4% (P＜0.001), and average life span has prolonged 6% (P＜0.001); The Male Drosophila maximum life span prolongs 5% (P＜0.001), and average life span prolongs 5% (P＜0.01). The female fruit bat half death time of tested material concentration 0.1% prolongs 5 days, and maximum life span has prolonged 6% (P＜0.001), and average life span prolongs 10% (P＜0.001); Male Drosophila is counted death time prolongation 4 days, and maximum life span has prolonged 7% (P＜0.001), and average life span prolongs 6% (P＜0.001). The female fruit bat half death time of tested material concentration 0.3% prolongs 6 days, and maximum life span has prolonged 8% (P＜0.001), and average life span prolongs 13% (P＜0.001); The Male Drosophila half death time prolongs 4 days, and maximum life span has prolonged 10% (P＜0.001), and average life span prolongs 9% (P＜0.001). The female fruit bat maximum life span of tested material concentration 0.9% has prolonged 5% (P＜0.001), and average life span prolongs 7% (P＜0.001); The Male Drosophila half death time prolongs 5 days, and maximum life span prolongs 6% (P＜0.001), and average life span prolongs 8% (P＜0.001). The conclusion that draws thus is: basic, normal, high dosage nutritive health-care food for supplementing nucleic acid has deferring senility.
Owing to possess the memory function of improvement and deferring senility, nutritive health-care food for supplementing nucleic acid of the present invention can be used for preventing senile dementia.
Summarize above each side, the advantage of nutritive health-care food for supplementing nucleic acid of the present invention is: the nucleic acid that 1. can in time remedy in the body is not enough, and the various diseases that prevents nucleic acid for want of to cause delays senility, begin to recover the youthful vigor of health from cell, reach the purpose of good health and a long life; 2. adopt the fish that can catch in a large number to do raw material, extracted nucleic acid from its spermary, guaranteed the abundant source of nucleic acid, and taken from digestion and absorption after natural nucleic acid is more convenient for eating; 3. adopt the medicine compatibility method of a certain amount of vitamin C and nucleic acid and usefulness, effectively prevented the generation of hyperuricemia; 4. for each age group people's demand, the difference of making " cut the garment according to the figure, take what one needs " stresses the nutritive nucleic acid health products of face, and is safe and reliable, has no side effect, edible very convenient.
Several different embodiment of the present invention are provided below.
Embodiment 1: a kind of health care nucleic acid food, and its composition and content are as follows:
Component content (%)
DNA nucleoprotamine 33.34%
RNA albumen 2%
Vitamin C 13.34%
Vitamin A 0.02%
Cobastab
10.05%
Cobastab
20.05%
Cobastab
60.05%
Cobastab
12Trace
Vitamin E 0.16%
Nicotinic acid 0.16%
Calcium pantothenate 0.5%
Folic acid 0.01%
Calcium 5%
Auxiliary material 10%
Above composition accounts for about 65% of gross weight, and surplus is supplemented to 100% with powdered glucose.
Embodiment 2: a kind of super health care nucleic acid food, and its composition and content are as follows:
Component content (%)
DNA nucleoprotamine 25%
RNA protein 16 .67%
DHA 13.89％
Vitamin C 13.34%
Vitamin A 0.02%
Cobastab
10.14%
Cobastab
20.14%
Cobastab
60.11%
Cobastab
12Trace
The vitamin D trace
Nicotinic acid 0.42%
Calcium pantothenate 0.42%
Folic acid 8.88%
Calcium 5%
Zinc 0.20%
Copper 0.014%
The selenium trace
Above composition accounts for about 84% of gross weight, and surplus is an auxiliary material.
This super health care nucleic acid is tablet, is mainly used in the prevention senile dementia.
Embodiment 3: a kind of IQ nucleic acid food, and mainly contain RNA nucleic acid and VC, and be added with DHA and vitamin group, concrete composition and content are as follows:
Component content (%)
RNA protein 25 %
DHA 30％
Vitamin C 25%
Cobastab group＜0.5%
Calcium≤18%
The auxiliary material surplus
This IQ nucleic acid food tablet can perfect the growth of brain and whole body, improves memory, and the title of " myelencephalon is a neurotrophic agents " is arranged, and is suitable for children especially and the teenager takes for a long time.
Embodiment 4: beauty's nucleic acid is main component with the DNA nucleoprotein of dog salmon spermary extract, and is added with shark chondroitin (mucopolysaccharide), VC, VA, VB group of reaching beauty treatment, U.S. flesh effect from inside of human body etc., is combined into beauty food.Its concrete composition and content are:
Component content (%)
DNA nucleoprotamine 17%
RNA protein 17 %
Shark chondroitin 17%
Vitamin C 13%
Vitamin E 5%
Cobastab group 10%
Auxiliary material＜21%
The effect of above-mentioned various compositions is as follows:
DNA nucleoprotein-promotion cell division, new life.Skin is youthened;
RNA albumen-improve dry skin, chap, relax, occur wrinkle or chloasma;
The moisture-retaining capacity of shark chondroitin (mucopolysaccharide)-raising skin makes skin become bright-coloured tender and lovely;
Vitamin C-prevent, improve the generation of the aging and blackspot of skin;
Vitamin E, A, B group-the same.
Claims (3)
1, a kind of nutritive health-care food for supplementing nucleic acid, it is characterized in that containing the DNA nucleoprotamine, take from the food yeast extract RNA albumen, comprise ascorbic vitamin group and trace element, the shared weight ratio of various compositions is:
DNA nucleoprotamine 17%-40%,
RNA albumen 1-30%,
Comprise ascorbic vitamin group 10-15%,
Trace element＜15%,
Other auxiliary material surplus.
2, nutritive health-care food for supplementing nucleic acid according to claim 1 is characterized in that the DNA nucleoprotamine derives from fish spermary extract.
3, nutritive health-care food for supplementing nucleic acid according to claim 1 is characterized in that the extraction process of DNA nucleoprotamine may further comprise the steps:
1. various fish spermaries are made powder through freeze drying;
2. refining: powder is mixed the back backflow heat with hydrous ethanol, hydrous ethanol is by ethanol: water: contain the protective agent of sulfydryl=85%: 11%: 4% and form, heating and temperature control stirred 1 hour at 88 ℃, was cooled to then below 25 ℃;
3. above-mentioned solid, liquid mixture are made wet product solid portion and liquid part through centrifuge and decanter separation, wherein liquid partly is discarded object, and recyclable ethanol wherein is in order to avoid pollute;
4. the product of wetting are carried out heated-air drying, drying under reduced pressure, temperature is controlled at below 60 ℃, and after the ethanol evaporation, the loss on drying of the DNA nucleoprotamine that obtains is below 7%, and ethanol remains in below 1%.
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| CNB001228676A CN1209978C (en) | 2000-08-30 | 2000-08-30 | Nutritive health-care food for supplementing nucleic acid and its preparing process |
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| CNB001228676A CN1209978C (en) | 2000-08-30 | 2000-08-30 | Nutritive health-care food for supplementing nucleic acid and its preparing process |
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| CN1340302A CN1340302A (en) | 2002-03-20 |
| CN1209978C true CN1209978C (en) | 2005-07-13 |
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ID=4589373
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| CN110551747A (en) * | 2019-09-09 | 2019-12-10 | 河北医科大学 | Preparation method and use method of gene engineering nucleic acid factor paste for delaying skin aging |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4493725B1 (en) * | 2009-10-02 | 2010-06-30 | 株式会社 ファイナルフューチャーインターナショナル | Composition having lipolysis promoting action |
| JP4750213B1 (en) * | 2010-05-21 | 2011-08-17 | 株式会社 ファイナルフューチャーインターナショナル | Adiponectin production promoting composition |
| CN115737820A (en) * | 2022-11-15 | 2023-03-07 | 河北医科大学第二医院 | Medicine for improving cognitive impairment after epilepsy |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110551747A (en) * | 2019-09-09 | 2019-12-10 | 河北医科大学 | Preparation method and use method of gene engineering nucleic acid factor paste for delaying skin aging |
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Application publication date: 20020320 Assignee: Laifusaiyin Science and Technology Development Co Ltd, Beijing Assignor: Beijing life science biotech. Ltd. Contract record no.: 2012990000695 Denomination of invention: Nutritive health-care food for supplementing nucleic acid and its preparing process Granted publication date: 20050713 License type: Common License Record date: 20120921 |
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