CN1171849C - 制备富马酸单甲酯的工艺 - Google Patents
制备富马酸单甲酯的工艺 Download PDFInfo
- Publication number
- CN1171849C CN1171849C CNB021003971A CN02100397A CN1171849C CN 1171849 C CN1171849 C CN 1171849C CN B021003971 A CNB021003971 A CN B021003971A CN 02100397 A CN02100397 A CN 02100397A CN 1171849 C CN1171849 C CN 1171849C
- Authority
- CN
- China
- Prior art keywords
- monomethyl
- monomethyl fumarate
- isomerization
- monomethyl maleate
- technology
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NKHAVTQWNUWKEO-UHFFFAOYSA-N fumaric acid monomethyl ester Natural products COC(=O)C=CC(O)=O NKHAVTQWNUWKEO-UHFFFAOYSA-N 0.000 title claims abstract description 57
- NKHAVTQWNUWKEO-NSCUHMNNSA-N monomethyl fumarate Chemical compound COC(=O)\C=C\C(O)=O NKHAVTQWNUWKEO-NSCUHMNNSA-N 0.000 title claims abstract description 32
- 229940005650 monomethyl fumarate Drugs 0.000 title claims abstract description 29
- 238000004519 manufacturing process Methods 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 38
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 27
- NKHAVTQWNUWKEO-IHWYPQMZSA-N methyl hydrogen fumarate Chemical compound COC(=O)\C=C/C(O)=O NKHAVTQWNUWKEO-IHWYPQMZSA-N 0.000 claims abstract description 25
- 238000006317 isomerization reaction Methods 0.000 claims abstract description 18
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000005516 engineering process Methods 0.000 claims abstract description 16
- 238000006243 chemical reaction Methods 0.000 claims abstract description 12
- 239000002904 solvent Substances 0.000 claims abstract description 10
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims abstract description 8
- 239000000126 substance Substances 0.000 claims abstract description 5
- 238000006136 alcoholysis reaction Methods 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 4
- 238000005119 centrifugation Methods 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 8
- 238000005265 energy consumption Methods 0.000 abstract 1
- 238000003912 environmental pollution Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 description 5
- 229960004419 dimethyl fumarate Drugs 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 235000019633 pungent taste Nutrition 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- VPMUCSPCTYROMB-UHFFFAOYSA-N C(C=CC(=O)O)(=O)OC.C(C=C/C(=O)O)(=O)OC Chemical compound C(C=CC(=O)O)(=O)OC.C(C=C/C(=O)O)(=O)OC VPMUCSPCTYROMB-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021003971A CN1171849C (zh) | 2002-01-21 | 2002-01-21 | 制备富马酸单甲酯的工艺 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021003971A CN1171849C (zh) | 2002-01-21 | 2002-01-21 | 制备富马酸单甲酯的工艺 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1363547A CN1363547A (zh) | 2002-08-14 |
CN1171849C true CN1171849C (zh) | 2004-10-20 |
Family
ID=4739343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB021003971A Expired - Lifetime CN1171849C (zh) | 2002-01-21 | 2002-01-21 | 制备富马酸单甲酯的工艺 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1171849C (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104177260B (zh) * | 2013-09-13 | 2016-04-20 | 广东东阳光药业有限公司 | 一种常用辅料的制备方法 |
CN115572225A (zh) * | 2022-08-29 | 2023-01-06 | 福建福瑞明德药业有限公司 | 一种硬脂富马酸钠的制备方法 |
-
2002
- 2002-01-21 CN CNB021003971A patent/CN1171849C/zh not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1363547A (zh) | 2002-08-14 |
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Legal Events
Date | Code | Title | Description |
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder |
Address after: 400063 Jiguan Shipanlong Industrial Zone, Nanan District, Chongqing Patentee after: Chongqing Mintai New Agricultural Science and Technology Development Group Co., Ltd. Address before: 400063 Jiguan Shipanlong Industrial Zone, Nanan District, Chongqing Patentee before: Mintai Perfume Chemical Co., Ltd., Chongqing |
|
CP01 | Change in the name or title of a patent holder | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation of Monomethyl Fumarate Effective date of registration: 20210219 Granted publication date: 20041020 Pledgee: Chongqing Branch of China Everbright Bank Co., Ltd Pledgor: CHONGQING MINTAI NEW AGROTECH DEVELOPMENT GROUP Co.,Ltd. Registration number: Y2021500000005 |
|
CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Granted publication date: 20041020 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220307 Granted publication date: 20041020 Pledgee: Chongqing Branch of China Everbright Bank Co.,Ltd. Pledgor: CHONGQING MINTAI NEW AGROTECH DEVELOPMENT GROUP Co.,Ltd. Registration number: Y2021500000005 |