CN117120090A - Hpk1拮抗剂和其用途 - Google Patents

Hpk1拮抗剂和其用途 Download PDF

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Publication number
CN117120090A
CN117120090A CN202280027804.3A CN202280027804A CN117120090A CN 117120090 A CN117120090 A CN 117120090A CN 202280027804 A CN202280027804 A CN 202280027804A CN 117120090 A CN117120090 A CN 117120090A
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CN
China
Prior art keywords
nitrogen
sulfur
oxygen
independently selected
partially unsaturated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN202280027804.3A
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English (en)
Chinese (zh)
Inventor
N·凯拉
I·林奈伊
S·沃德
G·威沙特
B·惠特克
W·辛科
S·沃茨
M·A·阿什韦尔
B·S·德拉巴尔
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Limbers Sutton Co
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Limbers Sutton Co
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Publication of CN117120090A publication Critical patent/CN117120090A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN202280027804.3A 2021-02-12 2022-02-11 Hpk1拮抗剂和其用途 Pending CN117120090A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163148857P 2021-02-12 2021-02-12
US63/148,857 2021-02-12
PCT/US2022/070627 WO2022174253A1 (en) 2021-02-12 2022-02-11 Hpk1 antagonists and uses thereof

Publications (1)

Publication Number Publication Date
CN117120090A true CN117120090A (zh) 2023-11-24

Family

ID=82837982

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280027804.3A Pending CN117120090A (zh) 2021-02-12 2022-02-11 Hpk1拮抗剂和其用途

Country Status (5)

Country Link
US (1) US12252488B2 (enExample)
EP (1) EP4291235A4 (enExample)
JP (1) JP2024506909A (enExample)
CN (1) CN117120090A (enExample)
WO (1) WO2022174253A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116063329A (zh) * 2021-10-29 2023-05-05 北京望实智慧科技有限公司 Hpk1抑制剂、制备方法及其用途

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116063329A (zh) * 2021-10-29 2023-05-05 北京望实智慧科技有限公司 Hpk1抑制剂、制备方法及其用途

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US12252488B2 (en) 2025-03-18
WO2022174253A1 (en) 2022-08-18
EP4291235A4 (en) 2025-01-08
US20230096641A1 (en) 2023-03-30
JP2024506909A (ja) 2024-02-15
EP4291235A1 (en) 2023-12-20

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