CN117062844A - 与cd19和cd22结合的双特异性嵌合抗原受体 - Google Patents

与cd19和cd22结合的双特异性嵌合抗原受体 Download PDF

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Publication number
CN117062844A
CN117062844A CN202280021455.4A CN202280021455A CN117062844A CN 117062844 A CN117062844 A CN 117062844A CN 202280021455 A CN202280021455 A CN 202280021455A CN 117062844 A CN117062844 A CN 117062844A
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陈岩
阮珍娜
赵克浩
张克明
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Eperi Biopharmaceutical Co ltd
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Eperi Biopharmaceutical Co ltd
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4212—CD22, BL-CAM, siglec-2 or sialic acid binding Ig-related lectin 2
    • A—HUMAN NECESSITIES
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2319/00—Fusion polypeptide
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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CN202280021455.4A 2021-01-22 2022-01-21 与cd19和cd22结合的双特异性嵌合抗原受体 Pending CN117062844A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163140752P 2021-01-22 2021-01-22
US63/140,752 2021-01-22
PCT/US2022/013231 WO2022159653A2 (en) 2021-01-22 2022-01-21 Bispecific chimeric antigen receptors binding to cd19 and cd22

Publications (1)

Publication Number Publication Date
CN117062844A true CN117062844A (zh) 2023-11-14

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CN202280021455.4A Pending CN117062844A (zh) 2021-01-22 2022-01-21 与cd19和cd22结合的双特异性嵌合抗原受体

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US (1) US20240082402A1 (enExample)
EP (1) EP4281470A4 (enExample)
JP (1) JP2024504162A (enExample)
KR (1) KR20230137948A (enExample)
CN (1) CN117062844A (enExample)
AU (1) AU2022209703A1 (enExample)
CA (1) CA3208935A1 (enExample)
IL (1) IL304554A (enExample)
WO (1) WO2022159653A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114729013B (zh) * 2019-08-21 2025-01-17 艾佩斯瑞生物制药公司 抗cd22抗体及其用途
WO2024096522A1 (ko) * 2022-10-31 2024-05-10 재단법인 아산사회복지재단 Cd22에 결합하는 항체, 이를 포함하는 이중특이적 항체, 키메라 항원 수용체, 항체 약물 복합체 및 이의 용도
CN116462770B (zh) * 2023-04-18 2024-03-08 科弈(浙江)药业科技有限公司 Cd19的人源化抗体和一种表达双特异性嵌合抗原受体的car-t细胞及其应用
KR20250174161A (ko) * 2024-06-04 2025-12-12 한국과학기술연구원 엔도글린 및 메소테린 이중 항원 표적 car 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015340056A1 (en) * 2014-10-27 2017-05-25 Agency For Science, Technology And Research Anti-TIM-3 antibodies
MX2017012939A (es) * 2015-04-08 2018-05-22 Novartis Ag Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.
TWI717375B (zh) * 2015-07-31 2021-02-01 德商安美基研究（慕尼黑）公司 Ｃｄ７０及ｃｄ３抗體構築體
CN118581122A (zh) * 2018-09-26 2024-09-03 莱蒂恩技术公司 用于用抗cd19/cd22免疫治疗来治疗癌症的组合物和方法
JP2022531113A (ja) * 2019-04-30 2022-07-06 ギガジェン，インコーポレイティッド 組換えポリクローナルタンパク質およびその使用方法
AU2020331963A1 (en) * 2019-08-19 2022-03-03 Elpis Biopharmaceuticals Anti-CD19 antibodies and uses thereof
CN114729013B (zh) * 2019-08-21 2025-01-17 艾佩斯瑞生物制药公司 抗cd22抗体及其用途

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Publication number Publication date
EP4281470A2 (en) 2023-11-29
WO2022159653A2 (en) 2022-07-28
JP2024504162A (ja) 2024-01-30
CA3208935A1 (en) 2022-07-28
WO2022159653A3 (en) 2023-04-13
AU2022209703A1 (en) 2023-08-17
AU2022209703A9 (en) 2025-03-06
EP4281470A4 (en) 2024-11-27
IL304554A (en) 2023-09-01
WO2022159653A8 (en) 2023-02-16
US20240082402A1 (en) 2024-03-14
KR20230137948A (ko) 2023-10-05

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