CN116849219A - Pharmaceutical composition for preventing and treating macadimia nut borer - Google Patents
Pharmaceutical composition for preventing and treating macadimia nut borer Download PDFInfo
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- CN116849219A CN116849219A CN202310794746.3A CN202310794746A CN116849219A CN 116849219 A CN116849219 A CN 116849219A CN 202310794746 A CN202310794746 A CN 202310794746A CN 116849219 A CN116849219 A CN 116849219A
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- Prior art keywords
- preventing
- borer
- fipronil
- macadimia nut
- metaflumizone
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 9
- 239000005914 Metaflumizone Substances 0.000 claims abstract description 18
- 239000003814 drug Substances 0.000 claims abstract description 18
- MIFOMMKAVSCNKQ-HWIUFGAZSA-N Metaflumizone Chemical compound C1=CC(OC(F)(F)F)=CC=C1NC(=O)N\N=C(C=1C=C(C=CC=1)C(F)(F)F)\CC1=CC=C(C#N)C=C1 MIFOMMKAVSCNKQ-HWIUFGAZSA-N 0.000 claims abstract description 17
- UFNOUKDBUJZYDE-UHFFFAOYSA-N 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Chemical compound C1=NC=NN1CC(O)(C=1C=CC(Cl)=CC=1)C(C)C1CC1 UFNOUKDBUJZYDE-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000005757 Cyproconazole Substances 0.000 claims abstract description 14
- HVQHXBNMBZJPLK-UHFFFAOYSA-N 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-[(2-methylprop-2-en-1-yl)amino]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound CC(=C)CNC1=C([S+]([O-])C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl HVQHXBNMBZJPLK-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 239000005783 Fluopyram Substances 0.000 claims abstract description 6
- KVDJTXBXMWJJEF-UHFFFAOYSA-N fluopyram Chemical compound ClC1=CC(C(F)(F)F)=CN=C1CCNC(=O)C1=CC=CC=C1C(F)(F)F KVDJTXBXMWJJEF-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000003795 chemical substances by application Substances 0.000 abstract description 8
- 230000002195 synergetic effect Effects 0.000 abstract description 8
- 241000540188 Cryptophlebia ombrodelta Species 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 abstract description 4
- 241000218691 Cupressaceae Species 0.000 abstract description 4
- 239000005899 Fipronil Substances 0.000 abstract description 4
- 239000013043 chemical agent Substances 0.000 abstract description 4
- 238000013329 compounding Methods 0.000 abstract description 4
- 150000001875 compounds Chemical class 0.000 abstract description 4
- 229940013764 fipronil Drugs 0.000 abstract description 4
- 239000000575 pesticide Substances 0.000 abstract description 4
- 238000012827 research and development Methods 0.000 abstract description 3
- 239000005901 Flubendiamide Substances 0.000 description 9
- 241000607479 Yersinia pestis Species 0.000 description 9
- 238000012360 testing method Methods 0.000 description 6
- 241000238631 Hexapoda Species 0.000 description 5
- 206010059866 Drug resistance Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000000749 insecticidal effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 2
- PGOOBECODWQEAB-UHFFFAOYSA-N (E)-clothianidin Chemical compound [O-][N+](=O)\N=C(/NC)NCC1=CN=C(Cl)S1 PGOOBECODWQEAB-UHFFFAOYSA-N 0.000 description 2
- 239000005888 Clothianidin Substances 0.000 description 2
- NYPJDWWKZLNGGM-UHFFFAOYSA-N fenvalerate Chemical compound C=1C=C(Cl)C=CC=1C(C(C)C)C(=O)OC(C#N)C(C=1)=CC=CC=1OC1=CC=CC=C1 NYPJDWWKZLNGGM-UHFFFAOYSA-N 0.000 description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000010413 mother solution Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 241000426497 Chilo suppressalis Species 0.000 description 1
- 108010062745 Chloride Channels Proteins 0.000 description 1
- 102000011045 Chloride Channels Human genes 0.000 description 1
- 241000255777 Lepidoptera Species 0.000 description 1
- 241001414989 Thysanoptera Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229940125516 allosteric modulator Drugs 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- -1 bifentate Chemical compound 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- QQODLKZGRKWIFG-QSFXBCCZSA-N cyfluthrin Chemical compound CC1(C)[C@@H](C=C(Cl)Cl)[C@H]1C(=O)O[C@@H](C#N)C1=CC=C(F)C(OC=2C=CC=CC=2)=C1 QQODLKZGRKWIFG-QSFXBCCZSA-N 0.000 description 1
- 229960001591 cyfluthrin Drugs 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- XQUXKZZNEFRCAW-UHFFFAOYSA-N fenpropathrin Chemical compound CC1(C)C(C)(C)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 XQUXKZZNEFRCAW-UHFFFAOYSA-N 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229960000490 permethrin Drugs 0.000 description 1
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/04—Insecticides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Insects & Arthropods (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticide research and development, and particularly relates to a pharmaceutical composition for preventing and treating macadimia nut borers. The medicine composition for preventing and treating macadimia nut borer is prepared with fluopyram, butene fipronil or metaflumizone and cyproconazole in binary compounding. According to the invention, the cypress fipronil and the existing chemical agent are compounded, and the binary compound combination of the fluofuran, the butene fipronil or the metaflumizone and the cypress fipronil is screened, wherein the compound combination has a co-toxicity coefficient of more than 120 for macadamia nut borers, has a synergistic effect, can improve the control effect, and has important significance for developing the efficient agent for controlling the macadamia nut borers.
Description
Technical Field
The invention belongs to the technical field of pesticide research and development, and particularly relates to a pharmaceutical composition for preventing and treating macadimia nut borers.
Background
Macadimia nut borer (Cryptophlebia ombrodelta) is a pest that is harmful to macadimia nuts. The macadimia nut borer mainly takes larvae as harmful fruits, and the damage of the shells is drilled into the shells when the shells are not completely hardened in the young fruit stage, then the damage of the nuts is drilled into the shells, and small boreholes are visible in the peel, so that empty fruits or fallen fruits are caused. At present, chemical control is mainly used for the macadimia nut borer, for example: fenvalerate, bifentate, fenpropathrin, cyfluthrin, permethrin, and the like. However, with the long-term use of these agents, macadimia nut borers have different degrees of drug resistance, resulting in unsatisfactory control effects. Therefore, research and development of the high-efficiency medicament for preventing and treating the macadimia nut borers have important significance.
The cypress-flubendiamide is a medicament which is safe to aquatic organisms and has high insecticidal activity after the cypress-methyl is introduced into the bromaroflubendiamide. According to IRAC classification, the cypress-flubendiamide belongs to a gamma-aminobutyric acid (GABA) gate control chloride ion channel allosteric modulator, has the characteristics of high efficiency, low toxicity, wide insecticidal spectrum, good permeability, quick effect and long lasting period, can effectively prevent and treat pests such as lepidoptera, coleopteran, thysanoptera and the like, and has excellent insecticidal activity on rice stem borers. Although the cypress-flubendiamide has the above advantages, as a chemical agent, if it is used as a single ingredient for a long period of time, it is liable to cause the generation of pest resistance, reducing its controlling effect on pests. The cypress-flubendiamide is compounded with other existing chemical agents, and the formula with the synergistic effect is screened, so that the drug resistance risk of the single component using the cypress-flubendiamide can be reduced, and the pest control effect can be improved.
At present, no report on the compounding of fluopyram, butene-fipronil or metaflumizone and cyproconazole is yet known.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art.
Disclosure of Invention
The invention aims to provide a pharmaceutical composition for preventing and controlling macadimia nut borer, which can reduce the drug resistance risk of single component using the cypress-flubendiamide and can improve the pest prevention and control effect.
In order to achieve the above purpose, the present invention provides the following technical solutions:
the medicine composition for preventing and treating macadimia nut borer is prepared with fluopyram, butene fipronil or metaflumizone and cyproconazole in binary compounding.
Preferably, the mass ratio of the fluopyram to the cyproconazole is 1-30:5-1.
Preferably, the mass ratio of the butene-fipronil to the clothianidin is 1-20:10-1.
Preferably, the mass ratio of butene-fipronil to clothianidin is 5:1.
preferably, the mass ratio of metaflumizone to cyproconazole is 1-25:3-1.
Compared with the prior art, the invention has the following beneficial effects:
(1) According to the invention, the cypress fipronil and the existing chemical agent are compounded, and a binary compound formula of the fluofuran, the butene fipronil or the metaflumizone and the cypress fipronil is screened, wherein the compound formula has a co-toxicity coefficient of more than 120 for macadamia nut borers, has a synergistic effect, can improve the control effect, and has important significance for developing high-efficiency agents for controlling the macadamia nut borers.
(2) The medicament composition is prepared by compounding two active ingredients, can reduce the drug resistance risk of the single ingredient using the cypress-flubendiamide, can protect the cypress-flubendiamide to a certain extent, and prolongs the service life of the cypress-flubendiamide.
Detailed Description
The following description of the embodiments of the present invention will be apparent from the description of the embodiments of the present invention, which is provided in part, but not in whole. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, are intended to fall within the scope of the present invention.
Examples
1. Test agent
96% of flupirfenidone crude drug (Bayer Co., ltd.), 96% of butene-fipronil crude drug (large Lian Jiu letter crop science Co., ltd.), 98% of metaflumizone crude drug (Canon Heilong pesticide Co., ltd.), and 98.6% of cyproconazole crude drug (Changsha Jiaqiao biosciences Co., ltd.).
2. Test pest
The carpopodium borer collected from the macadimia nut is continuously fed for more than 5 generations in a laboratory. Feeding conditions: temperature 27±1 ℃, humidity 70%, photoperiod L: d= (15:9) h, and selecting healthy 2-year-old larvae with consistent sizes as test subjects.
3. Test methods (cf. NT/T1154.14-2008 pesticide laboratory bioassay test guidelines pesticide section 14: leaf dipping method).
3.1 preparation of medicament
After the test agent is dissolved, the test agent is diluted into a single-agent mother solution by using 0.1% Tween-80 aqueous solution, a plurality of groups of proportions are arranged, each single-agent mother solution and each group of proportion mixture are provided with 5 mass concentration gradients, and each mass concentration is 80mL.
3.2 treatment of pests
And (3) allowing the tested pests to enter the liquid medicine for 8s, sucking the excessive liquid medicine by using filter paper, and transferring the liquid medicine to the original feeding condition for feeding. For each treatment, 4 replicates, 20 replicates were immersed in the insect, and a solution treatment containing only 0.1% tween-80 was used as a blank.
3.3 investigation and calculation
24h post-inspectionChecking the death condition of test insects, respectively recording the total number of insects and the death number of insects, calculating the corrected death rate of each treatment, performing regression analysis, and calculating the LD of each treatment medicament 50 。
And calculating the co-toxicity coefficient (CTC value) of the mixture according to the grand cloud Peel method, and evaluating the synergistic effect of the mixture of the medicaments according to the co-toxicity coefficient (CTC), wherein CTC is less than or equal to 80 and is antagonistic, CTC is less than or equal to 120 and is additive, and CTC is more than or equal to 120 and is synergistic. The results are shown in tables 1-3.
In the above formula: p- -mortality in units of; k- -death number in head; n- -total number of insects treated in units of heads.
In the above formula: p (P) 1 -correct mortality in units of; p (P) t -mortality rate in units of treatment; p (P) 0 Blank mortality in%.
TABLE 1 results of indoor biological Activity of Fluopirofidone and Cycloproflumilast compounded against macadimia nut borer
| Medicament name and ratio | LD 50 (mg/L) | ATI | TTI | CTC |
| Fluopirofuranone | 18.2444 | 100.0000 | -- | -- |
| Cycloproflumilast | 0.7629 | 2391.4537 | -- | -- |
| Flupirfuranone 1: cycloproflumilast 5 | 0.6294 | 2898.6972 | 2009.5447 | 144.2465 |
| Flupirfuranone 1: cycloproflumilast 1 | 1.1562 | 1577.9623 | 1245.7268 | 126.6700 |
| Flupirfuranone 5: cycloproflumilast 1 | 2.3752 | 768.1206 | 481.9089 | 159.3912 |
| Flupirfuranone 10: cycloproflumilast 1 | 4.2390 | 430.3940 | 308.3140 | 139.5960 |
| Flupirfuranone 20: cycloproflumilast 1 | 6.8011 | 268.2566 | 209.1168 | 128.2807 |
| Flupirfuranone 30: cycloproflumilast 1 | 8.6769 | 210.2640 | 173.9179 | 120.8985 |
From Table 1, it is clear that the mass ratio of the flupirfenidone to the cyproconazole is 1-30:5-1, the co-toxicity coefficient of the macadamia nut borer is more than 120, and the synergistic effect is achieved.
TABLE 2 indoor biological Activity determination results of butene-fipronil and Cycloproflumilast Complex to Australian nut borer
As can be seen from table 2, the mass ratio of butene-fipronil to cyproconazole is 1-20: when the composition is compounded in the range of 10-1, the co-toxicity coefficient of the composition to the macadimia nut borers is more than 120, and the composition is synergistic. Especially when the mass ratio is 5:1, the co-toxicity coefficient reaches 515.7662, and the synergy is most remarkable.
Table 3 results of determining indoor biological Activity of metaflumizone and Cycloproflumilast in combination with macadimia nut borer
| Medicament name and ratio | LD 50 (mg/L) | ATI | TTI | CTC |
| Metaflumizone | 2.7212 | 100.0000 | -- | -- |
| Cycloproflumilast | 0.7629 | 356.6916 | -- | -- |
| Metaflumizone 1: cycloproflumilast 3 | 0.6909 | 393.8631 | 292.5187 | 134.6454 |
| Metaflumizone 1: cycloproflumilast 1 | 0.9801 | 277.6451 | 228.3458 | 121.5898 |
| Metaflumizone 5: cycloproflumilast 1 | 1.4716 | 184.9144 | 142.7819 | 129.5083 |
| Metaflumizone 10: cycloproflumilast 1 | 0.7947 | 342.4185 | 123.3356 | 277.6315 |
| Metaflumizone 20: cycloproflumilast 1 | 2.0117 | 135.2687 | 112.2234 | 120.5352 |
| Metaflumizone 25: cycloproflumilast 1 | 0.8208 | 331.5302 | 109.8728 | 301.7402 |
As shown in table 3, the mass ratio of metaflumizone to cyproconazole is 1-25:3-1, the co-toxicity coefficient of the macadamia nut borer is more than 120, and the synergistic effect is achieved.
The foregoing descriptions of specific exemplary embodiments of the present invention are presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain the specific principles of the invention and its practical application to thereby enable one skilled in the art to make and utilize the invention in various exemplary embodiments and with various modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (5)
1. The medicine composition for preventing and treating macadimia nut borer is characterized in that the effective components are compounded by fluopyram, butene fipronil or metaflumizone and cyproconazole in a binary mode.
2. The pharmaceutical composition for preventing and treating macadimia nut borer according to claim 1, wherein the mass ratio of the fluopyram to the cyproconazole is 1-30:5-1.
3. The pharmaceutical composition for preventing and treating macadimia nut borer according to claim 1, wherein the mass ratio of butene fipronil to cyproconazole is 1-20:10-1.
4. The pharmaceutical composition for preventing and treating macadimia nut borer according to claim 1, wherein the mass ratio of butene fipronil to cyproconazole is 5:1.
5. the pharmaceutical composition for preventing and treating macadimia nut borer according to claim 1, wherein the mass ratio of metaflumizone to cyproconazole is 1-25:3-1.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310794746.3A CN116849219A (en) | 2023-06-30 | 2023-06-30 | Pharmaceutical composition for preventing and treating macadimia nut borer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310794746.3A CN116849219A (en) | 2023-06-30 | 2023-06-30 | Pharmaceutical composition for preventing and treating macadimia nut borer |
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| Publication Number | Publication Date |
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| CN202310794746.3A Pending CN116849219A (en) | 2023-06-30 | 2023-06-30 | Pharmaceutical composition for preventing and treating macadimia nut borer |
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| CN (1) | CN116849219A (en) |
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