CN116785349A - Tightening composition, preparation method thereof, tightening liquid and preparation process thereof - Google Patents
Tightening composition, preparation method thereof, tightening liquid and preparation process thereof Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
The application relates to the technical field of female care, and particularly discloses a tightening composition, a preparation method thereof, a tightening liquid and a preparation process thereof. The tightening composition comprises a solvent and plant extracts, wherein the plant extracts account for 61.24% -82.46% of the tightening composition by mass, and the plant extracts at least comprise lime peel extracts, dogwood fruit extracts, pomegranate peel extracts and shizandra berry extracts. A method for preparing the compact composition comprises mixing the above materials. A tightening liquid comprises carbomer, butanediol, aminomethylpropanol, tightening composition, phenoxyethanol and water. A process for preparing the tightening liquid includes such steps as mixing carbomer with water to obtain the first content, mixing butanediol with tightening composition to obtain the second content, pouring the second content into the first content, and adding aminomethylpropanol and phenoxyethanol. The application has good effect of tightening and maintaining vagina.
Description
Technical Field
The application relates to the technical field of female nursing, in particular to a tightening composition and a preparation method thereof, and a tightening liquid and a preparation process thereof.
Background
The cause of vaginal relaxation in women involves several aspects, such as age, fertility, hormonal changes, etc., where vaginal relaxation due to fertility is particularly unavoidable. Postnatal women inevitably damage vaginal tissue during production, especially causing breaks in the elastic fibers in the vagina, damaging connective tissue in the inner wall of the vagina, leading to vaginal relaxation.
On the one hand, vaginal relaxation can reduce the resistance of the vagina to external pathogens, and harmful bacteria are more easily bred in the vagina, so that the risk of vaginal inflammation is caused. On the other hand, vaginal relaxation means that the contractility of the vagina is deteriorated, and a series of troubles such as vaginal blowing, urine leakage, decreased sexual desire, vaginal inflammation and the like are brought about in daily life.
In the prior art, the problem of vaginal relaxation is generally improved by physical means such as surgery, laser or injection filling, but the physical means have painful recovery period, are accompanied by the risk of complications, and cannot restore broken elastic fibers from root sources to restore the elasticity of the inner wall of the vagina. Therefore, there is still room for further improvement in the art for improving vaginal relaxation.
Disclosure of Invention
In order to solve the problem of vaginal relaxation, the application provides a tightening composition and a preparation method thereof, and a tightening liquid and a preparation process thereof. According to the application, in research, the tightening liquid added with the lime peel extract, the dogwood fruit extract, the pomegranate peel extract and the shizandra berry extract has unexpected promotion effect on the generation of Fibroblast Growth Factor (FGF), so that the proliferation and migration of fibroblasts on the inner wall of the vagina are promoted, a large number of fibroblasts are concentrated on the inner wall of the vagina to repair damaged elastic fibers, and the effects of recovering the elasticity of the inner wall of the vagina and improving the relaxation of the vagina can be achieved.
In a first aspect, the present application provides a tightening composition according to the following technical solution:
the tightening composition is characterized by comprising a solvent and a plant extract, wherein the plant extract accounts for 61.24-82.46% of the tightening composition by mass, and the plant extract at least comprises a lime peel extract, a dogwood fruit extract, a pomegranate peel extract and a shizandra berry extract.
In the technical scheme, the lime peel extract contains a large amount of vitamin C, has moisturizing effect on skin, can balance the pH value of the skin, helps collagen formation, and has good effects on skin repair. The Corni fructus extract has effects of scavenging various free radicals, resisting aging, inhibiting bacteria, and resisting sensitization. The pomegranate peel extract has broad-spectrum antibacterial effect and obvious inhibition effect on various bacteria and fungi. The schisandra chinensis extract has remarkable inhibiting effect on staphylococcus aureus and trichobacteria, has broad-spectrum antibacterial activity, and has remarkable inhibiting effect on various standard bacteria and drug-resistant bacteria.
According to the application, the lime peel extract, the dogwood fruit extract, the pomegranate peel extract and the shizandra berry extract are used as functional substances of the tightening composition, and on one hand, the plant extracts have good antibacterial and nourishing effects, can achieve the effect of mildly nourishing the vagina, inhibit the growth of harmful bacteria in the vagina and maintain the ecological balance in the vagina. On the other hand, the combination of the lime peel extract, the dogwood fruit extract, the pomegranate peel extract and the shizandra berry extract has a promoting effect on the generation of fibroblast growth factors, and the increase of the fibroblast growth factors promotes the proliferation and migration of the fibroblast cells, so that a large amount of the fibroblast cells are concentrated on the inner wall of the vagina, the synthetic elastic fibers are secreted, the damaged elastic fibers in the vagina are repaired, the contents of the elastic fibers and collagen in the inner wall of the vagina are increased, the elasticity of the inner wall of the vagina is recovered, the vaginal relaxation is improved, and the tightening of the vagina is realized.
Preferably, the lime peel extract accounts for 10-20% of the tightening composition in percentage by mass; the cornus officinalis fruit extract accounts for 40% -46% of the tightening composition; the pomegranate peel extract accounts for 10% -14% of the tightening composition; the schisandra chinensis extract accounts for 1% -2% of the tightening composition.
According to the technical scheme, the contents of the lime peel extract, the dogwood fruit extract, the pomegranate peel extract and the shizandra berry extract are limited, so that the lime peel extract, the dogwood fruit extract, the pomegranate peel extract and the shizandra berry extract can be better cooperated to promote the generation of fibroblast growth factors, the effects of recovering the elasticity of the inner wall of the vagina and mildly nourishing the inner wall of the vagina are achieved, and the compactness of the vagina is realized.
Preferably, the plant extract further comprises evodia rutaecarpa fruit extract and myrtle fruit extract.
According to the technical scheme, the fructus evodiae extract and the myrtle fruit extract are further added on the basis of the lime peel extract, the dogwood fruit extract, the pomegranate peel extract and the shizandra berry extract, so that the nourishing effect of the tightening composition on the inner wall of the vagina can be further improved, and the ecological balance in the vagina can be further maintained.
Preferably, the compacting composition comprises the following components in percentage by mass:
extract of lime peel: 10% -20%;
fructus Corni extract: 40% -46%;
pomegranate peel extract: 10% -14%;
schisandra chinensis extract: 1% -2%;
evodia rutaecarpa fruit extract: 0.2 to 0.4 percent;
myrtle fruit extract: 0.04 to 0.06 percent;
the balance being solvent.
According to the technical scheme, the contents of the components in the tightening composition are limited, so that the components of the tightening composition can be better cooperated with each other to play a role in tightening and nourishing the vagina.
Preferably, the solvent is 1, 3-propanediol.
In the technical scheme, the 1, 3-propylene glycol is selected as the solvent, so that the plant extract in the compact composition can be more uniformly distributed and dissolved in the solvent.
In a second aspect, the present application provides a method for preparing a tightening composition, which adopts the following technical scheme:
a method of preparing a tightening composition, as follows: mixing fructus Citri sinensis peel extract, corni fructus extract, pericarpium Granati extract, fructus Schisandrae extract, fructus evodiae extract, fructus Rhodomyrti extract, and solvent, and stirring to obtain compact composition.
In the technical scheme, the compact composition can be obtained by simply mixing the components, and the preparation method is simple and efficient and is suitable for industrial production.
In a third aspect, the present application provides a tightening solution, which adopts the following technical scheme:
the tightening liquid comprises the following components in percentage by mass: 1 to 2 percent of carbomer, 10 to 20 percent of butanediol, 1 to 2 percent of aminomethylpropanol, 20 to 30 percent of tightening composition, 0.2 to 0.5 percent of phenoxyethanol and the balance of water.
According to the technical scheme, the tightening composition is added into the tightening liquid, so that the prepared tightening liquid has a good effect of promoting the generation of fibroblast growth factors, damaged elastic fibers can be better repaired, the elasticity of the inner wall of the vagina is recovered, the inner wall of the vagina is nourished gently, and the tightening of the vagina is realized.
In a fourth aspect, the preparation process of the tightening liquid provided by the application adopts the following technical scheme:
the preparation process of the tightening liquid is characterized by comprising the following steps of:
step one: mixing carbomer and water, homogenizing, heating to 80-85 ℃, and uniformly stirring to obtain a first content; mixing and stirring the butanediol and the compact composition uniformly to obtain a second content;
step two: stirring and cooling the first content to 40-45 ℃, and slowly pouring the second content into the first content in a stirring state;
step three: adding aminomethyl propanol and phenoxyethanol, and stirring to obtain tightening solution.
According to the technical scheme, the tightening liquid prepared by the process can keep active ingredients in the tightening composition to the greatest extent, so that the tightening composition is better matched with other components in the tightening liquid, and the tightening nourishing effect of the tightening liquid on vagina is further promoted.
Preferably, in the first step, the first content is obtained by homogenizing for 5-8 min at 2000-2200 r/min and stirring for 10-15 min at 200-220 r/min; stirring for 2-5 min at 200-220 r/min to obtain a second content;
in the second step, stirring is carried out for 10-15 min at the speed of 200-220 r/min;
in the third step, stirring is carried out for 10-15 min at the speed of 200-220 r/min.
According to the technical scheme, the fusion of the tightening composition and other components in the tightening liquid can be further promoted by limiting the process conditions, a synergistic effect is achieved, and the tightening and nourishing effect of the tightening liquid on the vagina is further improved.
In summary, the present application includes at least one of the following beneficial technical effects:
1. according to the application, the lime peel extract, the dogwood fruit extract, the pomegranate peel extract and the shizandra berry extract are used as functional substances of the tightening composition, and on one hand, the plant extracts have good antibacterial and nourishing effects, can achieve the effect of mildly nourishing the vagina, inhibit the growth of harmful bacteria in the vagina and maintain the ecological balance in the vagina. On the other hand, the combination of the lime peel extract, the dogwood fruit extract, the pomegranate peel extract and the shizandra berry extract has a promoting effect on the generation of fibroblast growth factors, and the increase of the fibroblast growth factors promotes the proliferation and migration of the fibroblast cells, so that a large amount of the fibroblast cells are concentrated on the inner wall of the vagina, the synthetic elastic fibers are secreted, the damaged elastic fibers in the vagina are repaired, the contents of the elastic fibers and collagen in the inner wall of the vagina are increased, the elasticity of the inner wall of the vagina is recovered, the vaginal relaxation is improved, and the tightening of the vagina is realized.
2. According to the application, the fructus evodiae extract and the myrtle fruit extract are further added on the basis of the lime peel extract, the dogwood fruit extract, the pomegranate peel extract and the shizandra berry extract, so that the nourishing effect of the tightening composition on the inner wall of the vagina can be further improved, and the ecological balance in the vagina can be further maintained.
3. According to the application, by adding the tightening composition into the tightening liquid, the prepared tightening liquid has a good effect of promoting the generation of fibroblast growth factors, can repair damaged elastic fibers better, recover the elasticity of the inner wall of the vagina, nourish the inner wall of the vagina gently, and realize the tightening of the vagina.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present application, the present application will be further described with reference to the following specific examples.
Example 1
A tightening composition comprises 10g of lime peel extract, 46g of dogwood fruit extract, 10g of pomegranate peel extract, 2g of shizandra berry extract, and 32g of solvent.
Wherein the solvent is 1, 3-propanediol.
Wherein the CAS number of the lime peel extract is 68916-04-1.
Wherein the CAS number of fructus Corni extract is 548-37-8.
Wherein the CAS number of the pomegranate peel extract is 65995-63-3.
Wherein the CAS number of the Schisandra chinensis extract is 98619-25-1.
The preparation method of the tightening composition comprises the following steps: mixing the extract of lime peel, the extract of dogwood fruit, the extract of pomegranate peel, the extract of shizandra berry and the solvent at normal temperature, and stirring at 200r/min for 15min to obtain the compact composition.
Example 2
A tightening composition, unlike example 1, comprises 20g of lime peel extract, 40g of dogwood fruit extract, 14g of pomegranate peel extract, 1g of schisandra fruit extract, 25g of solvent.
The preparation method of the tightening composition comprises the following steps: mixing the extract of lime peel, the extract of dogwood fruit, the extract of pomegranate peel, the extract of shizandra berry and the solvent at normal temperature, and stirring for 10min at 220r/min to obtain the compact composition.
Example 3
A tightening composition, unlike example 1, comprises 13g lime peel extract, 42g cornel extract, 12g pomegranate peel extract, 1.5g schisandra extract, 31.5g solvent.
Example 4
A tightening composition, unlike example 3, further comprises 0.2g of Evodia rutaecarpa extract, 0.06g of Myrtle extract, and the solvent content becomes 31.24g.
Example 5
A tightening composition, unlike example 3, further comprises 0.4g of Evodia rutaecarpa extract, 0.04g of Myrtle extract, and the solvent content becomes 31.06g.
Example 6
A tightening composition is different from example 5 in that the Evodia rutaecarpa extract is replaced with Evodia rutaecarpa extract in equal amount.
Example 7
A tightening composition is different from example 5 in that the myrtle fruit extract is replaced with the peony extract in equal amount.
Comparative example 1
A tightening composition, different from example 3, in which the extract of lime peel was replaced with the extract of lime flower in equal amounts.
Comparative example 2
A tightening composition is different from example 3 in that the extract of cornel fruit is replaced with the extract of evodia rutaecarpa in equal amount.
Comparative example 3
A tightening composition, different from example 3, was replaced by an equivalent amount of pomegranate seed extract.
Comparative example 4
A tightening composition is different from example 3 in that the extract of Schisandra chinensis is replaced with the extract of Asparagus cochinchinensis in equal amounts.
Application example 1
A tightening liquid comprising 56.8g of water, 1g of carbomer, 20g of butanediol, 2g of aminomethylpropanol, 0.2g of phenoxyethanol, 20g of a tightening composition.
Wherein the tightening composition was derived from example 1.
Wherein the CAS number of the aminomethylpropanol is 124-68-5.
The preparation process of the tightening liquid comprises the following steps:
step one: mixing carbomer and water, homogenizing at 2200r/min for 5min, heating to 85deg.C, and stirring at 220r/min for 10min to obtain first content; mixing butanediol and the tightening composition, and stirring at 220r/min for 2min to obtain a second content;
step two: stirring and cooling the first content to 45 ℃, slowly pouring the second content into the first content in a stirring state of 220r/min, and stirring for 10min;
step three: adding aminomethyl propanol and phenoxyethanol, stirring for 10min at 220r/min to obtain tightening solution.
Application example 2
A tightening liquid, unlike application example 1, comprises 56.5g of water, 2g of carbomer, 10g of butanediol, 1g of aminomethylpropanol, 0.5g of phenoxyethanol, and 30g of a tightening composition.
Wherein the tightening composition was derived from example 1.
The preparation process of the tightening liquid comprises the following steps:
step one: mixing carbomer and water, homogenizing at 2000r/min for 8min, heating to 80deg.C, and stirring at 200r/min for 15min to obtain first content; mixing butanediol and the tightening composition, and stirring at 200r/min for 5min to obtain a second content;
step two: stirring and cooling the first content to 40 ℃, slowly pouring the second content into the first content in a stirring state of 200r/min, and stirring for 15min;
step three: adding aminomethyl propanol and phenoxyethanol, stirring at 200r/min for 15min to obtain tightening solution.
Application example 3
Unlike application example 1, the tightening liquid was derived from example 2.
Application example 4
Unlike application example 1, the tightening liquid was derived from example 3.
Application example 5
Unlike application example 1, the tightening liquid was derived from example 4.
Application example 6
Unlike application example 1, the tightening liquid was derived from example 5.
Application example 7
Unlike application example 1, the tightening liquid was derived from example 6.
Application example 8
Unlike application example 1, the tightening liquid was derived from example 7.
Application example 9
Unlike application example 6, the tightening liquid was replaced with triethanolamine in the same amount with aminomethylpropanol.
Comparative application example 1
A tightening liquid was different from application example 1 in that the tightening composition was derived from comparative example 1.
Comparative application example 2
A tightening liquid was different from application example 1 in that the tightening composition was derived from comparative example 2.
Comparative application example 3
A tightening liquid was different from application example 1 in that the tightening composition was derived from comparative example 3.
Comparative application example 4
A tightening liquid was different from application example 1 in that the tightening composition was derived from comparative example 4.
Experiment 1
And (3) detecting the content of fibroblast growth factors: the effect of the tightening composition on the fibroblast growth factor content of the female mouse vagina was verified.
Female Kunming mice (8-9 months retired species) were purchased from Peking Vitolith laboratory animal technologies Inc.
Mouse Fibroblast Growth Factor (FGF) ELISA assay kit (cat# XZK 20221160) was purchased from Shanghai Xuanzekang BioCo.
Experimental samples: the compacting compositions of examples 1-3 and comparative examples 1-4.
The experimental method comprises the following steps: after 24 mice were acclimatized for 7d, the mice were randomly divided into 8 groups of 3 mice each, with a control group of 1 and an experimental group of 7. Vaginal administration of mice was started after 7 d: the medicine is administrated once daily, the dose is 0.2mL each time, 0.2mL of experimental sample (without bubbles) is sucked by a 0.25mL syringe (without needle core) and slowly pushed into the vagina of a female mouse, then the female mouse is put back into a cage, the medicine is continuously administrated for 7d, and the administration of the control group is 0.2mL of 1, 3-propanediol.
And (3) detecting the content of the fibroblast growth factor: mice were sacrificed at 8d, vaginal tissue was dissected, blotted dry with filter paper after glass fat, and PBS phosphate buffer saline (0.01 mol/L) was added with a mass ratio of tissue to buffer of 1:9, preparing a tissue homogenate mixture of PBS. Grinding the tissue homogenate mixture by a homogenizer, centrifuging by a centrifuge, taking supernatant, detecting the content of the mouse fibroblast growth factor (pg/mL) by using the supernatant of the mouse fibroblast growth factor ELISA detection kit, and taking an average value of experimental results as shown in table 1.
Experiment 2
And (3) pH value measurement: the pH values of the compacts of each application example and comparative application example were measured by using a Lei Ci PHS-3CpH tester, and the experimental results are shown in Table 2.
Experiment 3
The experimental object: 130 women who are born all over the country at ages of 27-35 have trouble such as vaginal blowing, urine leakage, decreased sexual desire, vaginal inflammation and normal endocrine.
The experimental method comprises the following steps: 130 test persons were equally divided into 13 groups of 10 persons each, and the tightening liquid 14d of each application example and comparative application example was continuously used once a day.
1. And (3) respectively adopting a Lei Ci PHS-3CpH value tester to measure the pH value of the vaginal secretion of the experimenter before the use of the first 1d and before the use of the second 15d, wherein the normal pH value of the vaginal secretion of the female is between 3.8 and 4.5. The results of the experiments were averaged and are shown in Table 2.
2. The experimenter evaluated the tightening effect, the mild effect, and the maintenance effect of the tightening solution at 15 d. Tightening effect: no effect or no effect is hardly perceived as 0 to 10 minutes, the vaginal tightening is perceived as 11 to 20 minutes, and the vaginal tightening is obviously perceived as 21 to 30 minutes; mild effect: the stimulus intensity is 0-10 minutes, and the slight stimulus intensity is 11-20 minutes; the feeling of stimulation is difficult to be perceived or no feeling of stimulation is 21-30 minutes; the maintenance effect is as follows: the dry odor is 0 to 10 minutes, the tight odor is 11 to 20 minutes, the wet odor is 21 to 30 minutes, and the experimental results are averaged, as shown in Table 2.
Table 1:
table 2:
by combining examples 1 to 3, comparative examples 1 to 4 and Table 1, it is possible to obtain a compact composition comprising, as functional substances, extracts of lime peel, cornel fruit, pomegranate peel and shizandra berry, which has excellent fibroblast growth promoting effect and vagina compacting effect. The applicant specifically analyzes that the compound of the lime peel extract, the dogwood fruit extract, the pomegranate peel extract and the shizandra berry extract has specificity, has unexpected promotion effect on the generation of fibroblast growth factors, and the increase of the fibroblast growth factors promotes the proliferation and migration of the fibroblasts, so that a large number of the fibroblasts are concentrated on the inner wall of the vagina, secrete synthetic elastic fibers, repair the damaged elastic fibers in the vagina, increase the content of the elastic fibers and collagen in the inner wall of the vagina, recover the elasticity of the inner wall of the vagina, improve the vaginal relaxation, realize the tightening of the vagina, and further achieve the effect of good tightening and maintaining the vagina by being assisted with the effects of the four plant extracts.
By combining application examples 5 to 6, application example 3 and Table 2, it can be obtained that the tightening liquid added with the lime peel extract, the dogwood fruit extract, the pomegranate peel extract, the shizandra berry extract, the evodia fruit extract and the myrtle fruit extract has better effect of tightening and maintaining vagina. The specific analysis of the inventor proves that the plant extracts have good antibacterial and nourishing effects, and the evodia rutaecarpa extract and myrtle fruit extract can enhance the matching effect of the plant extracts, so that the nourishing effect of the tightening composition on the inner wall of the vagina is further improved, and the ecological balance in the vagina is further maintained.
By combining application examples 6, 7-9 and Table 2, it can be obtained that the tightening liquid containing lime peel extract, dogwood fruit extract, pomegranate peel extract, shizandra berry extract, evodia rutaecarpa fruit extract, myrtle fruit extract and aminomethylpropanol has good effect of regulating the pH value of vaginal secretion. The inventor specifically analyzes that the aminomethyl propanol is added into the tightening liquid as a neutralizing agent, has good effect of regulating the pH value of the tightening liquid, so that the pH value of the tightening liquid is acidic, and is more suitable for being used in the intravaginal environment, while the lime peel extract, the dogwood fruit extract, the pomegranate peel extract, the shizandra berry extract, the evodia fruit extract and the myrtle fruit extract are added into the tightening liquid as plant extracts, especially the evodia fruit extract and the myrtle fruit extract enhance the matching effect of the plant extracts, and the aminomethyl propanol is added, so that the tightening liquid has the best combination effect, and the unexpected outstanding effect of regulating the pH value of vaginal secretion is reflected, thereby further regulating the intravaginal environment, further maintaining the ecological balance of the intravaginal environment, and further improving the tightening and maintaining effect of the tightening liquid on the vagina.
The present embodiment is only for explanation of the present application and is not to be construed as limiting the present application, and modifications to the present embodiment, which may not creatively contribute to the present application as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present application.
Claims (8)
1. The tightening composition is characterized by comprising a solvent and a plant extract, wherein the plant extract accounts for 61.24% -82.46% of the tightening composition in mass percent, and the plant extract at least comprises a lime peel extract, a dogwood fruit extract, a pomegranate peel extract and a shizandra berry extract.
2. The tightening composition according to claim 1, wherein the lime peel extract accounts for 10% -20% of the tightening composition in mass percent; the cornus officinalis fruit extract accounts for 40% -46% of the tightening composition; the pomegranate peel extract accounts for 10% -14% of the tightening composition; the schisandra chinensis extract accounts for 1% -2% of the tightening composition.
3. The tightening composition of claim 1, wherein the plant extract further comprises evodia rutaecarpa extract, myrtle extract.
4. A compacting composition according to claim 3, characterised in that it comprises, in mass percent:
extract of lime peel: 10% -20%;
fructus Corni extract: 40% -46%;
pomegranate peel extract: 10% -14%;
schisandra chinensis extract: 1% -2%;
evodia rutaecarpa fruit extract: 0.2% -0.4%;
myrtle fruit extract: 0.04% -0.06%;
the balance being solvent.
5. A method of preparing the tightening composition of claim 3 or 4, characterized by the following: mixing fructus Citri sinensis peel extract, corni fructus extract, pericarpium Granati extract, fructus Schisandrae extract, fructus evodiae extract, fructus Rhodomyrti extract, and solvent, and stirring to obtain compact composition.
6. A tightening liquid containing the tightening composition according to any one of claims 1 to 4, characterized by comprising the following components in mass percent: 1% -2% of carbomer, 10% -20% of butanediol, 1% -2% of aminomethylpropanol, 20% -30% of a tightening composition, 0.2% -0.5% of phenoxyethanol and the balance of water.
7. A process for preparing a tightening fluid according to claim 6, comprising the steps of:
step one: mixing carbomer and water, homogenizing, heating to 80-85 ℃, and uniformly stirring to obtain a first content; mixing and stirring the butanediol and the compact composition uniformly to obtain a second content;
step two: stirring and cooling the first content to 40-45 ℃, and slowly pouring the second content into the first content in a stirring state;
step three: adding aminomethyl propanol and phenoxyethanol, and stirring to obtain tightening solution.
8. The process for preparing a tightening liquid according to claim 7, wherein in the first step, the first content is obtained by homogenizing for 5-8 min at 2000-2200 r/min and stirring for 10-15 min at 200-220 r/min; stirring for 2-5 min at 200-220 r/min to obtain a second content;
stirring for 10-15 min at 200-220 r/min;
and thirdly, stirring for 10-15 min at 200-220 r/min.
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