CN107149577A - A kind of antipruritic emulsion of baby - Google Patents
A kind of antipruritic emulsion of baby Download PDFInfo
- Publication number
- CN107149577A CN107149577A CN201710328309.7A CN201710328309A CN107149577A CN 107149577 A CN107149577 A CN 107149577A CN 201710328309 A CN201710328309 A CN 201710328309A CN 107149577 A CN107149577 A CN 107149577A
- Authority
- CN
- China
- Prior art keywords
- antipruritic
- emulsion
- baby
- extract
- mass percent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of antipruritic emulsion of baby, in terms of mass percent concentration, including following components, natural extract 0.32 3.6%；Surfactant 2.1 8%；Oily raw material 4 20%；Water 70 92%.The present invention has advantages below and effect：Bite by mosquitos, eczema, allergy etc. can form gargalesthesia, and the essence of gargalesthesia is stimulation skin or mucous membrane after the allergic reaction of human body itself, human body release histamine, is delivered to by neural reflex in brain and forms gargalesthesia.The natural extract of the application can antibacterial, anti-inflammatory, reduction reflectivity, so as to play antipruritic effect, the formic acid of bite by mosquitos release can also be particularly neutralized when there is alkaloid in natural products, there is good antipruritic effect to the gargalesthesia of the formation such as bite by mosquitos, eczema, allergy, reached that spirituosity, gentle non-stimulated, natural extract are using safety, antipruritic effect be good, anti-inflammation effect.
Description
Technical field
The present invention relates to skincare product, more particularly to a kind of antipruritic emulsion of baby.
Background technology
The dermatological conditions that skin itching is a kind of only skin itching and damaged without primary cutaneous, mosquito in daily life
Bite etc. and to easily cause skin itching, redness, play bag etc..Infant's skin is very tender and lovely, and easily skin is scratched after bite by mosquitos
Skin.Antipruritic ointment and skin care item etc. have been related in the prior art, play itching-relieving action.
Such as the Chinese patent that application publication number is CN105106566A《A kind of antipruritic emulsifiable paste of anti-inflammation and sterilization and its preparation side
Method》Disclose a kind of antipruritic emulsifiable paste of anti-inflammation and sterilization, in contain following material：Aloe, Purple Perilla Seed Oil, evening primrose oil, golden small cup
Caul-fat, distilled water, APG type emulsifying agent SMONTANOV L, wheat source emulsifying agent MONTANOV82, peppermint extract solution, chrysanthemum indicum
Extract solution, Radix Sophorae Flavescentis extractive liquid, root bark of shaggy-fruited dittany extract solution, fruit of summer cypress extract solution, spina gleditsiae extract solution, frutus cnidii extract solution, ice crystal shape
Into agent, Carbopol 941, glycerine, 0.2% ethylparaben, 75% ethanol solution.
But there is problems with the antipruritic emulsifiable paste of above-mentioned anti-inflammation and sterilization：Contain ethanol in emulsifiable paste, ethanol has excitant,
Ethanol can stimulate the tender and lovely skin of baby, and easily be absorbed by infant skin, and growing for baby is even influenceed when serious.
The content of the invention
It is an object of the invention to provide a kind of antipruritic emulsion of baby, with the effect that not spirituosity, character are gentle.
The present invention above-mentioned technical purpose technical scheme is that：A kind of antipruritic emulsion of baby, with
Mass percent concentration meter, including following components, natural extract 0.32-3.6%；Surfactant 2.1-8%；Oily raw material
4-20%；Water 70-92%；The natural extract is pot marigold extract, golden yellow camomile extract, shrubby sophora extract, Huang
At least two in bark of a cork tree extract, common cnidium fruit P.E.
By using above-mentioned technical proposal, pot marigold extract is pot marigold petal extract, including lutein and corn
Flavine, pot marigold extract Central nervous has sedation, reduces reflex excitability.Secondly, pot marigold extract is included
Have antimicrobial component, particularly good to staphylococcus, streptococcus effect, various inflammation for skin, mucous membrane outside, play antibacterial,
Anti-inflammatory, antipruritic effect.
When being used for skin outside golden yellow camomile extract, antibacterial, antipruritic effect can be played.Shrubby sophora extract is from kuh-seng
A kind of alkaloid of middle extraction, including matrine, oxymatrine, ammothamnine, Anagyrine etc., there is heat-clearing and damp-drying drug,
The antipruritic effect of desinsection, there is good mitigation to skin itching.
The main component of cork tree extract is jamaicin, phellodendrine, magnoflorine etc., has different journeys to various pathogens
The inhibitory action of degree, is used to play a part of anti-inflammatory anti-itch on skin outside.Common cnidium fruit P.E is a kind of externally applied drug, with anti-
Punching, antimycotic effect.After selection at least two is compounded in above-mentioned natural extract, the work of Synergistic can be played
With with good antipruritic function.Secondly, antipruritic composition selects natural extract, gentle non-stimulated, uses safety.
Also include water, surfactant and oily raw material in the antipruritic emulsion of baby.Oily raw material is the base of a class cosmetics
Matter raw material, occupies larger specific gravity in the antipruritic emulsion of baby.The surfactant and water that are added in the antipruritic emulsion of baby simultaneously after,
Form emulsion after generation emulsification, the antipruritic emulsion of baby of acquisition not spirituosity, shape is gently non-stimulated, reduces to baby's flesh
The stimulation of skin, has reached the not gentle effect of spirituosity, shape.
The further setting of the present invention is：The natural extract include pot marigold extract, golden yellow camomile extract,
Matter of each component in the antipruritic emulsion of baby in shrubby sophora extract, cork tree extract, common cnidium fruit P.E, the natural extract
Measure percent concentration as follows, pot marigold extract 0.01-0.3%；Golden yellow camomile extract 0.01-0.3%；Shrubby sophora extract
0.1-1%；Cork tree extract 0.1-1%；Common cnidium fruit P.E 0.1-1%.
By using above-mentioned technical proposal, natural extract includes pot marigold extract, golden yellow camomile extract, hardship
Conopsea extraction, cork tree extract, common cnidium fruit P.E, can play a part of Synergistic after five kinds of natural extract mixing, carry
High the antipruritic of the antipruritic emulsion of baby, antibacterial, the effect of anti-inflammatory.
The further setting of the present invention is：In terms of mass percent concentration, include in the antipruritic emulsion of baby in following components
One or more, EDT A disodiums 0.01-0.3%；Dipotassium glycyrrhizinate 0.01-0.3%.
By using above-mentioned technical proposal, EDETATE SODIUM can as metal ion complexing agent, for complexing metal from
Son.After being added in the antipruritic emulsion of baby, the metal ion in natural extract can be complexed, the peace of the antipruritic emulsion of baby is improved
Quan Xing.Dipotassium glycyrrhizinate has the effects such as anti-inflammatory, antiallergy, moisturizing, is added in the antipruritic emulsion of baby, plays antianaphylactic work
With, it is to avoid the tender and lovely skin allergy of baby.
The further setting of the present invention is：In terms of mass percent concentration, include in the antipruritic emulsion of baby with the following group
One or more in point, menthol 0.1-0.5%；Sodium Hyaluronate 0.01-0.3%；Biological carbohydrate gum -1,0.5-2%；1,2-
Pentanediol 1-5%；Glycerine 1-10%.
By using above-mentioned technical proposal, menthol is a kind of organic compound, is main in peppermint and Peppermint essential oil
Composition, exists with the state of free and ester.Menthol act on the skin or mucous, play the role of it is refrigerant antipruritic, menthol with
Pot marigold extract, golden yellow camomile extract, shrubby sophora extract, cork tree extract, common cnidium fruit P.E synergy, are played
Strengthen the effect of antipruritic function.
Sodium Hyaluronate has the function of moisturizing, during in the antipruritic emulsion of baby, can improve the itching-relieving efficacies of menthol,
And wound healing can be promoted, play a part of recovering skin physiology function
The further setting of the present invention is：In terms of mass percent concentration, include in the antipruritic emulsion of baby with the following group
One or more in point, arginine 0.05-0.2%；Polyacrylic acid 0.05-0.2%.
By using above-mentioned technical proposal, arginine is a kind of amino acid, and arginine is added in the antipruritic emulsion of baby, energy
The function of Synergistic is played with hyaluronic acid, promotes skin wound and mucous membrane quickly to heal, the skin scratched due to itching
Can quickly it heal.Polyacrylic acid is colourless or weak yellow liquid, can form stable compound with metal ion such as calcium and magnesium etc..
The further setting of the present invention is：The surfactant includes following components and each component in baby's Alleviate Itching Galact
Mass percent concentration in liquid, cetyl glucoside 1-2%；Stearine 0.5-2%；Cetostearyl alcohol olive oil
Acid esters 0.3-2%；The smooth olive oleate 0.3-2% of sorb.
By using above-mentioned technical proposal, stearine hydrolysis is good, with very strong emulsifiability, while also simultaneous
The effects such as tool sterilization, scattered, decontamination.The smooth olive oleate of sorb is a kind of nonionic surfactant, is had to skin, eyes
Certain excitant.Cetostearyl alcohol olive oleate can also play a part of emulsification, but also have excitant to skin.
Therefore, cetyl glucoside is added in the antipruritic emulsion of baby, cetyl glucoside is a kind of green surface
Activating agent, with it is excellent emulsify, disperse, solubilising power, while can also reduce the excitant of other surfaces activating agent.Secondly,
Arginine also can further reduce the smooth olive oleate of sorb, the excitant of cetostearyl alcohol olive oleate so that stopping baby
Emulsion of itching excitant is small, and character is gentle.
The further setting of the present invention is：The component and each component that the oily raw material includes are in the antipruritic emulsion of baby
Mass percent concentration it is as follows, isononyl isononanoate 1-5%；(thylhexoic acid) ester of pentaerythrite four 1-5%；Cetostearyl alcohol
1-5%；Cetanol ethylhexoate 1-5%；Dimethyl silicone polymer 1-5%.
By using above-mentioned technical proposal, in oily raw material, pentaerythrite four (thylhexoic acid) ester as cosmetic base,
Character is sufficiently stable.Isononyl isononanoate is commonly called as silk oil, and viscosity is low, with good dispersive property, can play suppression baby
The effect of antipruritic emulsion greasy feeling.
Cetostearyl alcohol is a kind of dulcet white solid, plays a part of stable cosmetic gel, while spermaceti
Stearyl alcohol has the effect for suppressing greasy feeling, and dimethyl silicone polymer is nontoxic, generally accepted to be to skin and mucous membrane thing excitant
Safety.Isononyl isononanoate and cetostearyl alcohol are added in the antipruritic emulsion of baby, can be significantly inhibited greasy feeling, be used baby
It is salubrious without greasy feeling during antipruritic emulsion.
The further setting of the present invention is：In terms of mass percent concentration, include in the antipruritic emulsion of baby with the following group
One or more in point, cyclohexasiloxane 0.1-1%；Ring five dimethyl silicone polymer 0.1-1%.
By using above-mentioned technical proposal, cyclohexasiloxane and ring five dimethyl silicone polymer can play suppression greasy feeling
Effect, Synergistic can also be played a part of when both are used in conjunction with.
The further setting of the present invention is：In terms of mass percent concentration, include in the antipruritic emulsion of baby with the following group
Point, caprylic/capric triglyceride 3-10%.
By using above-mentioned technical proposal, caprylic/capric triglyceride is high salubrious tasteless grease, it is easy to inhaled by skin
Receive, make the antipruritic emulsion uniform and smooth of baby, it is nonirritant.
The further setting of the present invention is：In terms of mass percent concentration, include in the antipruritic emulsion of baby with the following group
One or more in point, phenmethylol 0.1-1%；Dehydroactic acid 0.1-0.6.
By using above-mentioned technical proposal, phenmethylol is fixastive, while also can be as limiting the use of preservative, dehydroactic acid is
A kind of low toxicity efficient antiseptic, after being added in the antipruritic emulsion of baby, extends the shelf life.
In summary, the invention has the advantages that：Using pot marigold extract, golden yellow camomile extract, hardship
The a variety of natural extracts of conopsea extraction, cork tree extract, common cnidium fruit P.E are compounded, and bite by mosquitos, eczema, allergy etc. can shapes
Into gargalesthesia, the essence of gargalesthesia is stimulation skin or mucous membrane after the allergic reaction of human body itself, human body release histamine, by nerve
Reflection, which is delivered in brain, forms gargalesthesia.The natural extract of the application can antibacterial, anti-inflammatory, reduction reflectivity, so as to play
Antipruritic effect, can also particularly neutralize the formic acid of bite by mosquitos release, to mosquito when there is alkaloid in natural products
Bite, the gargalesthesia of the formation such as eczema, allergy has good antipruritic effect, and antipruritic mesh is mainly reached by natural extract
, antipruritic, anti-inflammatory, good anti-bacterial effect, while not spirituosity, gentle non-stimulated.Second, using cetyl glucoside, glycerine
Stearate, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb are made as surfactant with excellent emulsification
With, meanwhile, cetyl glucoside and arginine collective effect reduce the excitant of surfactant；3rd, using different n-nonanoic acid
Different nonyl ester, pentaerythrite four (thylhexoic acid) ester, cetostearyl alcohol, cetanol ethylhexoate, dimethyl silicone polymer conduct
Greasy feeling can be suppressed after glyceride stock, addition cyclohexasiloxane, ring five dimethyl silicone polymer so that the antipruritic emulsion of baby is salubrious
Without greasy feeling；4th, add menthol, menthol with natural extract collective effect, improve itching-relieving efficacies while, peppermint
Alcohol interacts with Sodium Hyaluronate, arginine, promotes skin surface wound healing, has reached not spirituosity, gentle nothing
Stimulate, natural extract is using safety, antipruritic effect be good, anti-inflammation effect.
Embodiment
Specific embodiment is only explanation of the invention, and it is not limitation of the present invention, those skilled in the art
The modification without creative contribution can be made to the present embodiment as needed after this specification is read, but as long as in this hair
All protected in bright right by Patent Law.
Embodiment 1：A kind of antipruritic emulsion of baby, including natural extract, surfactant, oily raw material and water, naturally
Extract includes pot marigold extract, golden yellow camomile extract, shrubby sophora extract, cork tree extract, common cnidium fruit P.E.Baby
Each component standard Chinese title and INCI titles are shown in Table 1 in the antipruritic emulsion of youngster, and the mass percent concentration of each component is shown in Table 2.
The antipruritic emulsion preparation technology of baby is as follows, by water, natural extract input emulsification pot, dispersed with stirring to transparent,
It is heated to 70-75 DEG C；The surfactant and oily raw material input oil phase pot of formula ratio are weighed, 70-75 DEG C is heated, stirs molten
Solution, forms oil phase.Oil phase is added in emulsification pot, homogeneous, stirring, is cooled to 35 DEG C, discharging obtains the antipruritic emulsion of baby.
Embodiment 2：A kind of antipruritic emulsion of baby, is with the difference of embodiment 1, each component in the antipruritic emulsion of baby
Standard Chinese title and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
The extracting method of shrubby sophora extract：Take the kuh-seng of drying and crushing to be added in the acetone of 10 times of weight to soak 24 hours
Afterwards, the acetone solvent for soaking kuh-seng is heated to reflux 1.5-2 hours, then kuh-seng is pricked and is filtered to remove, filtrate is collected；Using super
Device is filtered, uses interception molecular weight for 5000-10000 membrane filtration filtrate, obtains secondary filtrate；Obtained secondary filtrate is put
Enter in Rotary Evaporators, steam solvent acetone, obtain shrubby sophora extract.
The extracting method of common cnidium fruit P.E：Fructus cnidii is taken, 60 mesh sieves were crushed, 45 DEG C of dryings are placed in after 5 hours
Stored for future use in drier.20g Common Cnidium Fruits are weighed, ultrasonic extraction under the conditions of 95% ethanol 200ml room temperatures (25 ± 1) is added
1 hour, it is filtrated to get the filtrate containing common cnidium fruit P.E.
Embodiment 3：A kind of antipruritic emulsion of baby, is with the difference of embodiment 1, each component in the antipruritic emulsion of baby
Standard Chinese title and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Embodiment 4：A kind of antipruritic emulsion of baby, is with the difference of embodiment 1, each component in the antipruritic emulsion of baby
Standard Chinese title and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Embodiment 5：A kind of antipruritic emulsion of baby, is with the difference of embodiment 1, each component in the antipruritic emulsion of baby
Standard Chinese title and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Embodiment 6：A kind of antipruritic emulsion of baby, is with the difference of embodiment 1, each component in the antipruritic emulsion of baby
Standard Chinese title and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
The antipruritic emulsion preparation technology of baby is as follows, and water, natural extract, EDETATE SODIUM, dipotassium glycyrrhizinate, input are emulsified
In pot, dispersed with stirring is heated to 70-75 DEG C to transparent；The surfactant and oily raw material input oil phase pot of formula ratio are weighed,
70-75 DEG C of heating, stirring and dissolving forms oil phase.Oil phase is added in emulsification pot, homogeneous, stirring is cooled to 35 DEG C, discharges,
Obtain the antipruritic emulsion of baby.
Embodiment 7：A kind of antipruritic emulsion of baby, is with the difference of embodiment 6, each component in the antipruritic emulsion of baby
Standard Chinese title and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Embodiment 8：A kind of antipruritic emulsion of baby, is with the difference of embodiment 7, each component in the antipruritic emulsion of baby
Standard Chinese title and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
The antipruritic emulsion preparation technology of baby is as follows, and water, natural extract, EDETATE SODIUM, dipotassium glycyrrhizinate, menthol are thrown
Enter to emulsify in pot, dispersed with stirring is heated to 70-75 DEG C to transparent；Weigh the surfactant and oily raw material input of formula ratio
Oil phase pot, heats 70-75 DEG C, stirring and dissolving forms oil phase.Oil phase is added in emulsification pot, homogeneous, stirring is cooled to 35
DEG C, discharging obtains the antipruritic emulsion of baby.
Embodiment 9：A kind of antipruritic emulsion of baby, with embodiment:8 difference is, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
The antipruritic emulsion preparation technology of baby is as follows, and water, natural extract, EDETATE SODIUM, dipotassium glycyrrhizinate, menthol are thrown
Enter to emulsify in pot, dispersed with stirring is heated to 70-75 DEG C to transparent；Weigh the surfactant and oily raw material input of formula ratio
Oil phase pot, heats 70-75 DEG C, stirring and dissolving forms oil phase.Oil phase is added in emulsification pot, homogeneous, stirring is cooled to 35
DEG C, discharging obtains the antipruritic emulsion of baby
Embodiment 10：A kind of antipruritic emulsion of baby, is with the difference of embodiment 9, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
The antipruritic emulsion preparation technology of baby is as follows, by water, natural extract, EDETATE SODIUM, Sodium Hyaluronate, glycyrrhizic acid two
In potassium, menthol input emulsification pot, dispersed with stirring is heated to 70-75 DEG C to transparent；Weigh the surfactant and oil of formula ratio
Matter raw material input oil phase pot, heats 70-75 DEG C, stirring and dissolving forms oil phase.Oil phase is added in emulsification pot, homogeneous is stirred
Mix, be cooled to 35 DEG C, discharging obtains the antipruritic emulsion of baby.
Embodiment 11：A kind of antipruritic emulsion of baby, is with the difference of embodiment 10, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Embodiment 12：A kind of antipruritic emulsion of baby, is with the difference of embodiment 11, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
The antipruritic emulsion preparation technology of baby is as follows, by water, natural extract, EDETATE SODIUM, Sodium Hyaluronate, glycyrrhizic acid two
Potassium, menthol, biological carbohydrate gum -1,1,2- pentanediols, glycerine input are emulsified in pot, and dispersed with stirring is heated to 70-75 to transparent
℃；The surfactant and oily raw material input oil phase pot of formula ratio are weighed, 70-75 DEG C is heated, stirring and dissolving forms oil phase.
Oil phase is added in emulsification pot, homogeneous, stirring, is cooled to 35 DEG C, discharging obtains the antipruritic emulsion of baby.
Embodiment 13：A kind of antipruritic emulsion of baby, is with the difference of embodiment 12, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Embodiment 14：A kind of antipruritic emulsion of baby, is with the difference of embodiment 13, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Embodiment 15：A kind of antipruritic emulsion of baby, is with the difference of embodiment 14, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
The antipruritic emulsion preparation technology of baby is as follows, by water, natural extract, EDETATE SODIUM, Sodium Hyaluronate, glycyrrhizic acid two
Potassium, menthol, biological carbohydrate gum -1,1,2- pentanediols, glycerine input are emulsified in pot, and dispersed with stirring is heated to 70-75 to transparent
℃；The surfactant and oily raw material input oil phase pot of formula ratio are weighed, 70-75 DEG C is heated, stirring and dissolving forms oil phase.
Oil phase is added in emulsification pot, homogeneous, stirring after oil phase is exhausted, is cooled to 45 DEG C, it is with suitable quantity of water that arginine is scattered equal
Even, input emulsification pot, homogeneous stirring is cooled to 35 DEG C, discharging obtains the antipruritic emulsion of baby.
Embodiment 16：A kind of antipruritic emulsion of baby, is with the difference of embodiment 14, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Embodiment 17：A kind of antipruritic emulsion of baby, is with the difference of embodiment 14, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
The antipruritic emulsion preparation technology of baby is as follows, by water, natural extract, EDETATE SODIUM, Sodium Hyaluronate, glycyrrhizic acid two
Potassium, menthol, biological carbohydrate gum -1,1,2- pentanediols, glycerine input are emulsified in pot, and dispersed with stirring is heated to 70-75 to transparent
℃；The surfactant and oily raw material input oil phase pot of formula ratio are weighed, 70-75 DEG C is heated, stirring and dissolving forms oil phase.
Oil phase is added in emulsification pot, homogeneous, stirring after oil phase is exhausted, is cooled to 45 DEG C, is disperseed polyacrylic acid with suitable quantity of water
Uniformly, in input emulsification pot, arginine is uniformly dispersed by homogeneous, stirring with suitable quantity of water, input emulsification pot, homogeneous stirring, cooling
To 35 DEG C, discharging obtains the antipruritic emulsion of baby.
Embodiment 18：A kind of antipruritic emulsion of baby, is with the difference of embodiment 14, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Embodiment 19：A kind of antipruritic emulsion of baby, is with the difference of embodiment 14, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
The antipruritic emulsion preparation technology of baby is as follows, by water, natural extract, EDETATE SODIUM, Sodium Hyaluronate, glycyrrhizic acid two
Potassium, menthol, biological carbohydrate gum -1,1,2- pentanediols, glycerine input are emulsified in pot, and dispersed with stirring is heated to 70-75 to transparent
℃；Weigh the surfactant of formula ratio, oily raw material, cyclohexasiloxane, ring five dimethyl silicone polymer, caprylic/capric sweet
Oily three esters input oil phase pot, heats 70-75 DEG C, stirring and dissolving forms oil phase.Oil phase is added in emulsification pot, homogeneous is stirred
Mix, after oil phase is exhausted, be cooled to 45 DEG C, polyacrylic acid is uniformly dispersed with suitable quantity of water, in input emulsification pot, homogeneous, stirring,
Arginine is uniformly dispersed with suitable quantity of water, input emulsification pot, homogeneous stirring；Phenmethylol, dehydroactic acid input emulsification pot, homogeneous,
Stirring, is cooled to 35 DEG C, discharging obtains the antipruritic emulsion of baby.
Embodiment 20：A kind of antipruritic emulsion of baby, is with the difference of embodiment 14, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Embodiment 21：A kind of antipruritic emulsion of baby, is with the difference of embodiment 14, each group in the antipruritic emulsion of baby
The quasi- Chinese of minute mark and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Comparative example 1：A kind of antipruritic emulsion of baby, is with the difference of embodiment 1, each component in the antipruritic emulsion of baby
Standard Chinese title and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Comparative example 2：A kind of antipruritic emulsion of baby, is with the difference of embodiment 1, each component in the antipruritic emulsion of baby
Standard Chinese title and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Comparative example 3：A kind of antipruritic emulsion of baby, is with the difference of embodiment 1, each component in the antipruritic emulsion of baby
Standard Chinese title and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Comparative example 4：A kind of antipruritic emulsion of baby, is with the difference of embodiment 1, each component in the antipruritic emulsion of baby
Standard Chinese title and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Comparative example 5：A kind of antipruritic emulsion of baby, is with the difference of embodiment 1, each component in the antipruritic emulsion of baby
Standard Chinese title and INCI titles are shown in Table 1, and the mass percent concentration of each component is shown in Table 2.
Antipruritic experiment：290 cavys are taken, 29 groups, every group 10 are randomly divided into.Wherein 1 group is blank control group, and remaining 28
Group corresponds to embodiment 1-21 and comparative example 1-7 respectively.
First 1 day of experiment, to instep shaving behind each group animal right side, numbering smears experimental drug, experimental drug in shaving region
For the antipruritic emulsion of baby in each embodiment and comparative example.3ml is administered in every cavy.Blank control group is not administered.Test the same day,
At coarse sandpaper scratch instep shaving, area 1cm2, then be administered once, it is coated at the shaving of instep, blank control group is not administered.
Each group starts in the histamine phosphate's solution of surface of a wound Chu Di 0.01%, every 0.05ml/ in 10min after last coating
It is secondary, it is 0.05ml/ every time hereafter every 3min according to 0.01%, 0.02%, 0.03%, 0.04% ... progressive concentration.Directly
It is itch-threshold to the histamine phosphate's total amount for occurring being given when cavy is turned one's head and licks right sufficient.And list experimental result in table 3.
Acute dermal toxicity is tested：To each embodiment and comparative example, reference《Cosmetics health specification》(Chinese people's republicanism
The Ministry of Public Health of state, in January, 2007) acute dermal toxicity experiment is carried out, and toxicity grading result is listed in table 3.
Skin irritation/corrosion test：To each embodiment and comparative example, reference《Cosmetics health specification》(middle Chinese
The Ministry of Public Health of people republic, in January, 2007) skin irritation/corrosion test is carried out, and skin irritatin strength grading result is existed
Listed in table 3.
Table 1
Table 2
Table 2- continues
Table 2- continues
Table 3
Claims (10)
1. a kind of antipruritic emulsion of baby, in terms of mass percent concentration, including following components,
The natural extract is pot marigold extract, golden yellow camomile extract, shrubby sophora extract, cork tree extract, cnidium monnieri
At least two in seed extract.
2. the antipruritic emulsion of a kind of baby according to claim 1, it is characterised in that：The natural extract includes pot marigold
It is each in extract, golden yellow camomile extract, shrubby sophora extract, cork tree extract, common cnidium fruit P.E, the natural extract
Mass percent concentration of the component in the antipruritic emulsion of baby is as follows,
3. the antipruritic emulsion of a kind of baby according to claim 1 or 2, it is characterised in that：In terms of mass percent concentration, baby
Include the one or more in following components in the antipruritic emulsion of youngster,
EDETATE SODIUM 0.01-0.3%；
Dipotassium glycyrrhizinate 0.01-0.3%.
4. the antipruritic emulsion of a kind of baby according to claim 1, it is characterised in that：It is described in terms of mass percent concentration
Include the one or more in following components in the antipruritic emulsion of baby,
5. the antipruritic emulsion of a kind of baby according to claim 1, it is characterised in that：It is described in terms of mass percent concentration
Include the one or more in following components in the antipruritic emulsion of baby,
Arginine 0.05-0.2%；
Polyacrylic acid 0.05-0.2%.
6. the antipruritic emulsion of a kind of baby according to claim 1, it is characterised in that：The surfactant is included with the following group
Point and mass percent concentration of each component in the antipruritic emulsion of baby,
7. the antipruritic emulsion of a kind of baby according to claim 1, it is characterised in that：The component that the oily raw material includes with
And mass percent concentration of each component in the antipruritic emulsion of baby is as follows,
8. the antipruritic emulsion of a kind of baby according to claim 7, it is characterised in that：It is described in terms of mass percent concentration
Include the one or more in following components in the antipruritic emulsion of baby,
Cyclohexasiloxane 0.1-1%；
Ring five dimethyl silicone polymer 0.1-1%.
9. the antipruritic emulsion of a kind of baby according to claim 1, it is characterised in that：It is described in terms of mass percent concentration
Include following components in the antipruritic emulsion of baby,
Caprylic/capric triglyceride 3-10%.
10. the antipruritic emulsion of a kind of baby according to claim 1, it is characterised in that：It is described in terms of mass percent concentration
Include the one or more in following components in the antipruritic emulsion of baby,
Phenmethylol 0.1-1%；
Dehydroactic acid 0.1-0.6%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710328309.7A CN107149577A (en) | 2017-05-11 | 2017-05-11 | A kind of antipruritic emulsion of baby |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710328309.7A CN107149577A (en) | 2017-05-11 | 2017-05-11 | A kind of antipruritic emulsion of baby |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107149577A true CN107149577A (en) | 2017-09-12 |
Family
ID=59794300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710328309.7A Pending CN107149577A (en) | 2017-05-11 | 2017-05-11 | A kind of antipruritic emulsion of baby |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107149577A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107811950A (en) * | 2017-12-06 | 2018-03-20 | 佛山微赢电子商务有限公司 | A kind of stern protection cream to baby's skin with nursing effect and preparation method thereof |
| CN108904409A (en) * | 2018-08-20 | 2018-11-30 | 广州旭升化工科技有限公司 | A kind of dedicated safety cream of baby skin protection |
| CN109549902A (en) * | 2019-01-16 | 2019-04-02 | 史德良 | It is a kind of to improve and treat eczema, allergy, saliva rash, diaper rash, the composite skin care product of intertrigo and its application |
| CN112402271A (en) * | 2020-11-28 | 2021-02-26 | 科玛化妆品(北京)有限公司 | Microcapsule-like precursor and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079214A (en) * | 2015-09-24 | 2015-11-25 | 皖南医学院 | Emulsion containing traditional Chinese medicine extracting solution and used for treating eczema and preparation method thereof |
| CN106138219A (en) * | 2016-07-01 | 2016-11-23 | 扬州中汇生物技术有限公司 | A kind of infant itching-relieving cream and preparation method thereof |
| CN106176344A (en) * | 2016-07-08 | 2016-12-07 | 浙江优全护理用品科技有限公司 | A kind of removing miliaria and relieving itching baby's wet tissue special and preparation method thereof |
-
2017
- 2017-05-11 CN CN201710328309.7A patent/CN107149577A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079214A (en) * | 2015-09-24 | 2015-11-25 | 皖南医学院 | Emulsion containing traditional Chinese medicine extracting solution and used for treating eczema and preparation method thereof |
| CN106138219A (en) * | 2016-07-01 | 2016-11-23 | 扬州中汇生物技术有限公司 | A kind of infant itching-relieving cream and preparation method thereof |
| CN106176344A (en) * | 2016-07-08 | 2016-12-07 | 浙江优全护理用品科技有限公司 | A kind of removing miliaria and relieving itching baby's wet tissue special and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107811950A (en) * | 2017-12-06 | 2018-03-20 | 佛山微赢电子商务有限公司 | A kind of stern protection cream to baby's skin with nursing effect and preparation method thereof |
| CN107811950B (en) * | 2017-12-06 | 2021-03-02 | 达威控股有限公司 | Hip-protecting cream with nursing effect on skin of baby and preparation method thereof |
| CN108904409A (en) * | 2018-08-20 | 2018-11-30 | 广州旭升化工科技有限公司 | A kind of dedicated safety cream of baby skin protection |
| CN109549902A (en) * | 2019-01-16 | 2019-04-02 | 史德良 | It is a kind of to improve and treat eczema, allergy, saliva rash, diaper rash, the composite skin care product of intertrigo and its application |
| CN112402271A (en) * | 2020-11-28 | 2021-02-26 | 科玛化妆品(北京)有限公司 | Microcapsule-like precursor and preparation method thereof |
| CN112402271B (en) * | 2020-11-28 | 2022-05-03 | 科玛化妆品(北京)有限公司 | Microcapsule-like precursor and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107149577A (en) | A kind of antipruritic emulsion of baby | |
| CN102695482A (en) | Wipe article comprising lotion composition comprising omega-6 fatty acid | |
| CN104800125A (en) | Nail polish and preparation method thereof | |
| US8668943B2 (en) | Hair care compositions for promoting hair growth and preventing hair loss | |
| US10993922B2 (en) | Topical skin care compositions | |
| CN106963691A (en) | A kind of antipruritic spraying of baby | |
| CN106726784B (en) | Natural organic shea butter nail-protecting cream and preparation method thereof | |
| US20200330543A1 (en) | A topical herbal healing formulation | |
| US20160296583A1 (en) | Methods and compounds for intensive skin repair and healing including active organic and synthetic compounds | |
| US11331263B2 (en) | Male cleanser and manufacturing method thereof | |
| DE202006019184U1 (en) | Moisturizing sea buckthorn skin care gel, useful to nourish and clean skin that is damaged by cancer therapy, comprises wax and fat; vitamin; vegetable hydrolate; moisturizing and anti-allergic active substance, pH-regulator and buffer | |
| Sonalkar et al. | Formulation and evaluation of polyherbal cosmetic cream | |
| CN105997645A (en) | Multi-moisturizing makeup removing lotion and preparation method thereof | |
| JP2015513558A (en) | Beauty composition | |
| EP2399648B1 (en) | Cosmetic composition and use of same | |
| Gadge et al. | Formulation and evaluation of polyherbal antidandruff shampoo | |
| KR20170016770A (en) | Cleansing composition for improving itch of hair and scalp | |
| AU2017239512A1 (en) | Skin care preparation and method of use | |
| US20230233448A1 (en) | Topical compositions for treating or preventing scars and methods for their use | |
| CN101422422A (en) | Sheep placental extract paste and manufacture method thereof | |
| RU2681851C1 (en) | Anti-burn means | |
| DE202006019185U1 (en) | Moisture aqueous sea buckthorn skin care preparation, useful to nourish and clean skin, which is damaged by cancer therapy, comprises waxes and fats, vitamins, plant hydrolates, moisturizing substances, material mixtures, and pH-regulators | |
| DE202014011069U1 (en) | Patches for the treatment of dermatitis | |
| CN116785349A (en) | Tightening composition, preparation method thereof, tightening liquid and preparation process thereof | |
| WO2023014640A1 (en) | Methods and compounds for natural organic intensive skin repair and healing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170912 |