CN116725917A - Acne-removing composition and preparation method and application thereof - Google Patents
Acne-removing composition and preparation method and application thereof Download PDFInfo
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- CN116725917A CN116725917A CN202310615449.8A CN202310615449A CN116725917A CN 116725917 A CN116725917 A CN 116725917A CN 202310615449 A CN202310615449 A CN 202310615449A CN 116725917 A CN116725917 A CN 116725917A
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- 206010000496 acne Diseases 0.000 title claims abstract description 118
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- 239000002904 solvent Substances 0.000 claims abstract description 18
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 69
- 239000000284 extract Substances 0.000 claims description 69
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an acne-removing composition, and a preparation method and application thereof. The acne removing composition comprises an antibacterial component, an oil control component, a acne mark removing component, an anti-inflammatory and soothing component, a repairing component, a supermolecular solvent and Neosolue TM Aqulio; aiming at the phase and mechanism of vaccinia formation, the multidimensional target spot inhibits the vaccinia. Firstly, the anti-inflammatory and soothing components are combined with the repairing components and the antibacterial componentsThe component is prepared by supermolecular solvent and Neosolue TM The Aqulio is delivered to the deep part of the acne muscles, so that the effects of dredging pores, relieving the acne gall, regulating grease secretion, removing red, repairing, fading acne marks and the like are achieved; finally, the skin Ao Ning with the bactericidal effect is compounded to accelerate the reestablishment of the microecological balance; finally, the aims of short-term anti-inflammatory, red removal and relief, long-term oil control, repair, acne mark removal and microecological balance are achieved, and thus the related problems of the acne muscles are improved.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to an acne-removing composition, and a preparation method and application thereof.
Background
Acne is also called acne, and is frequently found in adolescents, but androgens in the body fade slowly after puberty, and acne can be naturally relieved or healed. However, with the rapid development of society, people have increased life and work pressure, and have too much stimulation and stay up to eat food, so that acne appears on the face of more and more adults, and people feel a certain influence on mind and social interaction.
At present, the pathogenesis of acne is not completely studied, and it is generally considered that in vivo androgens (mainly testosterone) rise to convert 5 a-reductase of hair follicles and sebaceous glands into dihydrotestosterone with stronger activity, promote biochemical reaction, increase grease secretion, and meanwhile, sebaceous gland ducts and hair follicle cells are excessively keratinized to further seal the sebaceous gland ducts or hair follicle ducts, so that acne is formed and an anaerobic microenvironment favorable for the colonisation of propionibacterium acnes is formed. In anaerobic environment, propionibacterium acnes are propagated and proliferated in large quantity to generate lipolycemic enzyme, decompose sebum to generate free acid, stimulate hair follicle to cause inflammation, cause injury and rupture of hair follicle wall, and the accumulated sebum enters dermis, so that inflammatory reactions with unequal degrees around hair follicle are caused. Therefore, the more strongly the demand for skin care products with acne removal.
At present, the acne treatment scheme on the market mainly adopts tretinoin, antibiotics, hormone, salicylic acid, azelaic acid, fruit acid, pure plant extract, laser acne treatment scheme and the like in the acne treatment aspect, but has certain limitations. Tretinoin, antibiotics and hormone have good effect of treating acnes, but dependence can occur after long-term use, and the acnes can be repeated once the use is stopped; the acid product has larger irritation to skin, and if the acid product is used for a long time, the skin sensibility can be increased; the pure plant extract product has certain pertinence, is milder but takes effect slowly; the laser acne removal adopts a physical method to rapidly remove the acne, and cannot radically treat the acne. Most of acne removing products mainly take sterilization and anti-inflammation as main effects to treat the prophase of acne, and have less consideration on the repair of skin at the later stage and the elimination of acne marks.
Accordingly, there is a need for improvement and development in the art.
Disclosure of Invention
In order to improve the omnibearing efficacy of an acne-removing product, the invention aims to provide an acne-removing composition, a preparation method and application thereof, so as to solve the problem that the existing acne-removing composition cannot completely and efficiently remove acnes, and realize the aims of short-term anti-inflammatory, red-removing and relieving to long-term oil control, repair, acne mark removal and microecological balance, thereby improving the related problems of acne muscles.
The technical scheme of the invention is as follows:
in a first aspect of the present invention, there is provided an anti-acne composition, wherein the anti-acne composition comprises, in parts by weight: 0.05-0.1 part of pride, 5-12 parts of potassium azenoyl diglycolate, 1-3 parts of kuh-seng root extract, 0.01-2 parts of gentian extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract, 1-3 parts of licorice extract, 1-17 parts of purslane extract, 1-5 parts of glyceroglycosides, 1-45 parts of polyalcohols, 1-20 parts of supermolecular solvents and 1-20 parts of Neosolue TM -Aqulio。
Optionally, the polyol is at least one of butanediol and pentanediol.
Optionally, the supramolecular solvent is betaine citric acid.
Optionally, the acne-removing composition comprises the following components in parts by weight: 0.05-0.1 part of pride, 5-12 parts of potassium nonyldiglycolate, 1-3 parts of kuh-seng root extract, 0.01-2 parts of gentian extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract, 1-3 parts of licorice extract, 1-17 parts of purslane extract, 1-5 parts of glyceroglycosides, 1-45 parts of polyalcohols, 1-20 parts of betaine citric acid and 1-20 parts of Neosolue TM -Aqulio。
In a second aspect, the invention provides a method for preparing the acne-removing composition, which comprises the following steps: mixing 0.05-0.1 part of pride, 5-12 parts of potassium azenoyl diglycolate, 1-3 parts of radix sophorae flavescentis extract, 0.01-2 parts of radix gentianae extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract, 1-3 parts of licorice extract, 1-17 parts of purslane extract, 1-5 parts of glyceroglycosides, 1-45 parts of polyalcohol, 1-20 parts of supermolecular solvent and 1-20 parts of Neosolue TM -aqualio mixing, stirring to obtain the acne-removing composition.
Optionally, the preparation method of the acne-removing composition specifically comprises the following steps of:
mixing 0.05-0.1 part of Piaoning, 1-3 parts of kava extract, 1-20 parts of betaine citric acid and 1-25 parts of butanediol, and heating for dissolving to obtain solution 1;
sequentially mixing 1-5 parts of glyceroglycosides, 5-15 parts of pentanediol and 1-20 parts of Neosolue TM Aqualio is added to solution 1 and stirred ultrasonically to give solution 2;
mixing 20-50 parts of deionized water, 0.01-2 parts of gentian extract and 1-5 parts of butanediol, heating and dissolving, sequentially adding 1-3 parts of licorice extract, 1-3 parts of radix sophorae flavescentis extract and 1-3 parts of white willow bark extract, dissolving into light yellow liquid, adding 5-12 parts of potassium azedarachyl glycinate and 1-17 parts of purslane extract, and stirring to obtain solution 3;
adding the solution 2 into the solution 3, and stirring uniformly to obtain the acne-removing composition.
Optionally, the kuh-seng root extract, the gentian extract, the white willow bark extract, the kava extract, the licorice extract and the purslane extract are all obtained by extracting with betaine and citric acid.
In a third aspect, the invention provides an application of the acne-removing composition in preparing an acne-removing product.
Optionally, the acne removing product is an acne removing essence.
The beneficial effects are that: the invention provides an acne-removing composition, which comprises an antibacterial component, an oil control and acne mark removal component, an anti-inflammatory and soothing component, a repairing component, a supermolecular solvent and Neosolue TM Aqulio; aiming at the phase and mechanism of vaccinia formation, the multidimensional target spot inhibits the vaccinia. Firstly, combining anti-inflammatory and soothing components with repairing components, enabling antibacterial components to be dissolved by supermolecule solvent and Neosolue TM The Aqulio is delivered to the deep part of the acne muscles, so that the effects of dredging pores, relieving the acne gall, regulating grease secretion, removing red, repairing, fading acne marks and the like are achieved; finally, the skin Ao Ning with the bactericidal effect is compounded to accelerate the reestablishment of the microecological balance; finally, the aims of short-term anti-inflammatory, red removal and relief, long-term oil control, repair, acne mark removal and microecological balance are achieved, and thus the related problems of the acne muscles are improved.
Drawings
Fig. 1 is a graph showing the trend of the number of people average acne.
FIG. 2 is a graph showing the trend of the average inflammatory papule number.
Fig. 3 is a graph showing the variation trend of the average number of the pustules.
Fig. 4 is a graph of the variation trend of the plllsbury grading score.
Fig. 5 is a graph showing the change trend of the a-value of the vaccinia (red-green).
Fig. 6 is a graph showing the change in size and volume of vaccinia.
Figures 7-11 are all graphs showing the human body test effect of the acne-removing essence.
Detailed Description
The invention provides an acne removing composition, a preparation method and application thereof, and aims to make the purposes, technical schemes and effects of the acne removing composition clearer and more definite, and the acne removing composition is further described in detail below. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Most of the current acne removing products mainly take sterilization and anti-inflammation as main effects to treat the early stage of acne, and have less consideration on the repair of later-stage skin and the elimination of acne marks. Aiming at the problems, the product with the effects of controlling oil, inhibiting bacteria, resisting inflammation, repairing and fading acne marks is important.
Specifically, the embodiment of the invention provides an acne-removing composition, which comprises the following components in parts by weight: 0.05-0.1 part of pride, 5-12 parts of potassium azenoyl diglycolate, 1-3 parts of kuh-seng root extract, 0.01-2 parts of gentian extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract, 1-3 parts of licorice extract, 1-17 parts of purslane extract, 1-5 parts of glyceroglycosides, 1-45 parts of polyalcohols, 1-20 parts of supermolecular solvents and 1-20 parts of Neosolue TM -Aqulio。
Wherein Pi Aoning and potassium nonyldiglycolate are used as antibacterial components; the kuh-seng root extract is used as an oil control and acne mark removal component; gentian extract, white willow bark extract, kava extract, licorice extract, purslane extract as anti-inflammatory soothing component; the glyceroglycosides and the polyalcohol are taken as repairing components.
The present example is directed to the stage and mechanism of vaccinia formation, and the multidimensional target inhibits vaccinia. Firstly, extracting plants by using a supermolecular solvent to obtain a plant extract with higher bioavailability and more stability (namely plant essence); next, the plant essence is combined with the glyceroglycosides and the potassium nonodiglycinate is extracted by a supermolecular solvent and Neosolue TM The Aqulio is delivered to the deep part of the acne muscles, so that the effects of dredging pores, relieving the acne gall, regulating grease secretion, removing red, repairing, fading acne marks and the like are achieved; the skin Ao Ning with the bactericidal effect is compounded, so that the reestablishment of the microecological balance is accelerated; finally, the aims of short-term anti-inflammatory, red removal and relief, long-term oil control, repair, acne mark removal and microecological balance are achieved, and thus the related problems of the acne muscles are improved. Namely, betaine citric acid and neonolue therein TM Aqualio can be used as a penetration enhancer to deliver the active ingredient deep into the vaccinia muscle.
In some embodiments, the polyol is at least one of butanediol, pentanediol. Wherein, the pentanediol is used as a preservative, the butanediol is used as a solvent on one hand, and is used as a humectant on the other hand.
In some embodiments, the supramolecular solvent is betaine citric acid.
In some embodiments, the acne-removing composition consists of the following components in parts by weight: 0.05-0.1 part of pride, 5-12 parts of potassium nonyldiglycolate, 1-3 parts of kuh-seng root extract, 0.01-2 parts of gentian extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract, 1-3 parts of licorice extract, 1-17 parts of purslane extract, 1-5 parts of glyceroglycosides, 1-45 parts of polyalcohols, 1-20 parts of betaine citric acid and 1-20 parts of Neosolue TM -Aqulio。
Pi Aoning, also known as Quaternary ammonium salt-73. Propionibacterium acnes can resist the conventional bactericide, but due to the special action mechanism of Piao and Propionibacterium acnes, other bacteria and various fungi can be inhibited to a certain extent by extremely low dosage, the microecological balance is conditioned, the random growth of acnes is inhibited, and the acne symptoms are improved.
Potassium nonodiacyl diglycolate: the azelaic acid derivative is a well-known azelaic acid derivative, and the azelaic acid potassium azelate obtained after structural modification can be easily added into a formula, so that the azelaic acid derivative has better permeability, is much less in irritation, can inhibit skin grease secretion and strip waste cutin, has good grease secretion regulating effect, has stronger whitening effect, can effectively eliminate inflammation and lighten acne marks.
Kava pepper extract: kava is a perennial upright shrub of Piperaceae, and the roots and rhizomes can be used as medicines. The main medicinal components are kavalactone, kavain and the like. The kava extract has skin penetration effect, and can inhibit fungi, diminish inflammation, relieve pain, inhibit testosterone 5α -reductase activity, prevent excessive sebum secretion, and reduce acne.
Purslane extract: the purslane contains rich flavonoid substances and polysaccharide, so that the purslane has good antibacterial, anti-inflammatory and analgesic effects, can relieve skin sensitivity, inhibit the generation and release of allergic media and inflammatory factors, and reduce the damage of foreign matters to the skin.
Kuh-seng root extract: the main active ingredient of the kuh-seng extract is matrine, has broad-spectrum antibacterial property, can balance grease secretion, dredge and astringe pores, lighten acne marks and promote the growth and repair of damaged skin.
Gentian extract: the medicinal and cosmetic preparation has effects in promoting blood circulation, improving cell activity, promoting metabolism, and resisting oxidation and inflammation.
Licorice extract: the Glycyrrhrizae radix extract can be used in cosmetics for caring skin, relieving inflammation, removing red, repairing and eliminating acne marks. The Glycyrrhrizae radix extract has effects of reducing melanin synthesis, enhancing skin immunity, resisting inflammation, reducing oxidation speed, preventing skin sensitization, and soothing skin.
White willow bark extract: white willow bark extract, also known as natural aspirin, has salicin and dextran as main active components. Salicin is an oxidase inhibitor, and can be changed into salicylic acid after metabolism, and because it contains plant flavone, it is milder than salicylic acid when directly applied to skin. The salicin has effects of removing cutin and acne, mildly removing dead skin cells on skin surface, accelerating aging skin cell shedding, regulating skin cutin layer physiological activity, and making skin uniform and lustrous.
Glycerol glucoside: is a glycoside compound formed by connecting glucosyl and glycerol through glycosidic bonds, is taken as revitalization grass essence, and can unlock aquaporin, strengthen cell activity and repair skin.
Betaine citric acid: betaine citric acid has the effects of moisturizing and water locking of betaine, and simultaneously has the effects of diminishing inflammation and sterilizing of citric acid, and betaine citric acid can accelerate cutin renewal, improve pore corner plug blockage and promote metabolism and growth of skin cells. Under the NaDESs (natural eutectic solvent) supermolecular system, the solubility of other effective components can be greatly improved due to the amphiphilicity of the supermolecular solvent, the permeation is efficiently promoted, the skin cell channels are rapidly opened, and smooth and healthy skin is created.
Neosolue TM Aqulio: the lipid between adjacent cells can be temporarily opened by affecting the lipid of the stable structure between the keratinocytes, and meanwhile, the hydrophilic part of the structure can help the permeation of the water-soluble active ingredients, so that the absorption effect of the skin is improved.
The embodiment of the invention provides a preparation method of the acne-removing composition, which comprises the following steps: mixing 0.05-0.1 part of pride, 5-12 parts of potassium azenoyl diglycolate, 1-3 parts of radix sophorae flavescentis extract, 0.01-2 parts of radix gentianae extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract, 1-3 parts of licorice extract, 1-17 parts of purslane extract, 1-5 parts of glyceroglycosides, 1-45 parts of polyalcohol, 1-20 parts of supermolecular solvent and 1-20 parts of Neosolue TM -aqualio mixing, stirring to obtain the acne-removing composition.
In some embodiments, the preparation method of the acne-removing composition specifically comprises the following steps in parts by weight:
mixing 0.05-0.1 part of Piaoning, 1-3 parts of kava extract, 1-20 parts of betaine citric acid and 1-25 parts of butanediol, and heating for dissolving to obtain solution 1;
sequentially mixing 1-5 parts of glyceroglycosides, 5-15 parts of pentanediol and 1-20 parts of Neosolue TM Aqualio is added to solution 1 and stirred ultrasonically to give solution 2;
mixing 20-50 parts of deionized water, 0.01-2 parts of gentian extract and 1-5 parts of butanediol, heating and dissolving, sequentially adding 1-3 parts of licorice extract, 1-3 parts of radix sophorae flavescentis extract and 1-3 parts of white willow bark extract, dissolving into light yellow liquid, adding 5-12 parts of potassium azedarachyl glycinate and 1-17 parts of purslane extract, and stirring to obtain solution 3;
adding the solution 2 into the solution 3, and stirring uniformly to obtain the acne-removing composition.
In some embodiments, the kuh-seng extract, gentian extract, white willow bark extract, kava extract, licorice extract, purslane extract are all obtained using betaine citric acid extraction. The plant extract is extracted from betaine and citric acid, so that the bioavailability of the effective components of the extracted plant extract is higher and more stable.
The embodiment of the invention provides an application of the acne-removing composition in preparing an acne-removing product.
In some embodiments, the anti-acne product is an anti-acne concentrate.
The acne-removing composition of the embodiment can exert the effects of dissolving the angular embolism, controlling oil, inhibiting bacteria, resisting inflammation, relieving and removing red, repairing and fading acne marks, and realizes the functions of short-term anti-inflammation, red removal and relieving to long-term oil control, repairing and acne mark removal and microecological balance through omnibearing acne removal, thereby improving the related problems of acne muscles.
The invention is further illustrated by the following specific examples.
Comparative example 1
In a beaker, 0.05 part of Piaoning, 1 part of kava extract and 25 parts of butanediol were added, and the mixture was heated and dissolved to obtain solution 1. Sequentially adding 5 parts of glyceroglycosides, 5 parts of pentanediol and 10 parts of Neosolue TM Aqualio is added to solution 1 and sonicated and stirred well to give solution 2. And (3) taking another beaker, adding 31.95 parts of deionized water and 2 parts of gentian extract into the beaker, heating and dissolving the extracts, sequentially adding 2 parts of licorice extract, 1 part of radix sophorae flavescentis extract and 1 part of white willow bark extract, dissolving, adding 10 parts of potassium azedarach and 1 part of purslane extract, and uniformly stirring to obtain a solution 3. Adding the solution 2 into the solution 3, and stirring uniformly to obtain the acne-removing composition 1.
Comparative example 2
In a beaker, 0.05 part of pride, 1 part of kava extract, 25 parts of butanediol, 1 part of betaine citric acid were added and dissolved by heating to obtain solution 1. Sequentially adding 5 parts of glyceroglycosides, 5 parts of pentanediol and 10 parts of Neosolue TM Aqualio is added to solution 1 and sonicated and stirred well to give solution 2. Another beaker is taken, 31.95 parts of deionized water and 2 parts of gentian extract are added into the beaker, and after the gentian extract is heated and dissolved, 2 parts of gentian extract are added in turnDissolving Glycyrrhrizae radix extract, 1 part of radix Sophorae Flavescentis extract and 1 part of white willow bark extract, adding 10 parts of potassium azedarach and 1 part of herba Portulacae extract, stirring, and mixing to obtain solution 3. Adding the solution 2 into the solution 3, and stirring uniformly to obtain the acne-removing composition 2.
Comparative example 3
In a beaker, 0.05 part of pride, 1 part of kava extract, 3 parts of betaine citric acid and 12 parts of butanediol were added, and heated to dissolve to obtain solution 1. Sequentially mixing 5 parts of glyceroglycosides, 15 parts of pentanediol and 10 parts of Neosolue TM Aqualio is added to solution 1 and sonicated and stirred well to give solution 2. And (3) taking another beaker, adding 31.95 parts of deionized water, 2 parts of gentian extract and 3 parts of butanediol into the beaker, heating and dissolving the materials, sequentially adding 2 parts of licorice extract, 1 part of radix sophorae flavescentis extract and 1 part of white willow bark extract, dissolving the materials, adding 10 parts of potassium nonylbisglycinate and 1 part of purslane extract, and stirring the materials uniformly to obtain a solution 3. Adding the solution 2 into the solution 3, and stirring uniformly to obtain the acne-removing composition 3.
Example 1
In a beaker, 0.05 part of pride, 1 part of kava extract, 5 parts of betaine citric acid and 25 parts of butanediol were added, and heated to dissolve, to obtain solution 1. Sequentially adding 5 parts of glyceroglycosides, 5 parts of pentanediol and 10 parts of Neosolue TM Aqualio is added to solution 1 and sonicated and stirred well to give solution 2. And (3) taking another beaker, adding 31.95 parts of deionized water and 2 parts of gentian extract into the beaker, heating and dissolving the materials, sequentially adding 2 parts of licorice extract, 1 part of radix sophorae flavescentis extract and 1 part of white willow bark extract, dissolving the materials, adding 10 parts of potassium azedarach and 1 part of purslane extract, and uniformly stirring to obtain a solution 3. Adding the solution 2 into the solution 3, and stirring uniformly to obtain the acne-removing composition 4.
Example 2
In a beaker, 0.05 part of pride, 1 part of kava extract, 5 parts of betaine citric acid and 25 parts of butanediol were added, and heated to dissolve, to obtain solution 1. Sequentially mixing 2 parts of glyceroglycosides and 8 parts of glutaric acidAlcohol, 10 parts of Neosolue TM Aqualio is added to solution 1 and sonicated and stirred well to give solution 2. And (3) taking another beaker, adding 31.95 parts of deionized water and 2 parts of gentian extract into the beaker, heating and dissolving the materials, sequentially adding 2 parts of licorice extract, 1 part of radix sophorae flavescentis extract and 1 part of white willow bark extract, dissolving the materials, adding 10 parts of potassium azedarach and 1 part of purslane extract, and uniformly stirring to obtain a solution 3. Adding the solution 2 into the solution 3, and stirring uniformly to obtain the acne-removing composition 5.
Example 3
In a beaker, 0.05 part of pride, 1 part of kava extract, 5 parts of betaine citric acid and 12 parts of butanediol were added, and heated to dissolve to obtain solution 1. Sequentially mixing 5 parts of glyceroglycosides, 15 parts of pentanediol and 10 parts of Neosolue T M-Aqulio is added into the solution 1, and the solution is subjected to ultrasonic treatment and uniform stirring to obtain a solution 2. And (3) taking another beaker, adding 31.95 parts of deionized water, 2 parts of gentian extract and 3 parts of butanediol into the beaker, heating and dissolving the materials, sequentially adding 2 parts of licorice extract, 1 part of radix sophorae flavescentis extract and 1 part of white willow bark extract, dissolving the materials, adding 10 parts of potassium nonylbisglycinate and 1 part of purslane extract, and uniformly stirring to obtain a solution 3. Adding the solution 2 into the solution 3, and stirring uniformly to obtain the acne-removing composition 6.
Application examples 1-3 and application comparative examples 1-3 are acne-removing essence with the mass fraction of the acne-removing composition of 4% prepared by examples 1-3 and comparative examples 1-3, respectively.
The acne-removing essence is prepared from the following raw materials in parts by weight: 86.27 parts of deionized water, 0.8 part of DC2501, 2 parts of dipropylene glycol, 0.15 part of allantoin, 0.5 part of glyceroglycosides, 0.08 part of sclerotium gum, 4 parts of acne-removing composition, 4 parts of algae plant extract, 0.4 part of cymene, htsoft-56880.5 parts, 0.2 part of dipotassium glycyrrhizinate, 0.1 part of arginine and 1 part of ceramide.
The preparation method of the acne-removing essence comprises the following steps:
1. sequentially adding DC2501, dipropylene glycol, allantoin, glyceroglycosides and sclerotium gum with formula amount into deionized water for homogenizing, stirring uniformly, and heating for dissolving to obtain solution a;
2. stirring and cooling, sequentially adding the acne-removing 6, algae planting extract, cymene, 5668, dipotassium glycyrrhizinate, arginine and ceramide with the formula amount into the solution a obtained in the step 1, and uniformly stirring to obtain the acne-removing essence.
1. And (3) antibacterial effect test:
according to the test, bacteriostats with different concentrations are mixed and dissolved in an agar culture medium by adopting an agar dilution method, then bacteria are inoculated, and the lowest concentration of an antibacterial substance for inhibiting the growth of a tested bacterium is determined according to the growth of the bacteria. The minimum concentration that inhibits the growth of the test bacteria is the minimum inhibitory concentration (Minimal Inhibitory Concentration, MIC).
Table 1 antibacterial effect of the acne-removing composition
| Group of | Experimental strain | Minimum Inhibitory Concentration (MIC) |
| Example 3 | Propionibacterium acnes | 2％ |
From the above data, the minimum inhibitory concentration of the composition on propionibacterium acnes was 2%, demonstrating the antibacterial effect of the composition on acne.
2. Human body efficacy test:
the acne-removing essence prepared from the acne-removing composition of the preferred embodiment 3 is subjected to human body efficacy test:
test part: facial skin.
Test object: 30 acne subjects with mild, moderate and severe facial conditions were selected, aged 18-65 years.
The testing method comprises the following steps: marking the acne skin lesion part of the face of the subject by using a positioning film on site when the product is smeared for 0 day, and simultaneously and respectively counting the number of the whole face acne, inflammatory papules and pustules; then, a laboratory technician performs an Antera-3D acquisition image of the skin image analysis system; the subjects were again subjected to the skin image analysis system Antera-3D acquisition image on days 2, 5, 7, 14, 28 of the smear product.
The test results are shown in FIGS. 1-11, and it can be seen from FIGS. 1-11 that:
after using the acne-removing essence D28:
1. compared with a basic value, the acne average number is reduced by 26.09%, and the acne average number has a remarkable difference;
2. the average number of inflammatory papules is reduced by 33.06% compared with a basal value, and the number of inflammatory papules is remarkably different;
3. compared with a basic value, the average number of the pustules is reduced by 40.63 percent, and the difference is obvious;
4. the fraction of the plllsbury classification is reduced by 24.82% compared with the basic value, and the difference is significant;
5. the (red-green) a value of the vaccinia area was reduced by 24.10% compared to the basal value, with a significant difference;
6. the volume of the vaccinia is reduced by 80.95% compared with the basic value, and the volume of the vaccinia is obviously different.
7. Figures 7-11 are images taken of subjects at various times using anti-acne serum. Intuitively, it can be seen that the acne-removing essence has the effect of improving acnes.
The results show that the test sample has the acne-removing effect.
The results of the above tests are combined to demonstrate that the acne-removing composition of the embodiment can repair skin barrier, relieve skin inflammation and reduce redness caused by skin inflammatory reaction, and can be used in the field of skin barrier repair skin care products.
It is to be understood that the invention is not limited in its application to the examples described above, but is capable of modification and variation in light of the above teachings by those skilled in the art, and that all such modifications and variations are intended to be included within the scope of the appended claims.
Claims (9)
1. An acne-removing composition is characterized by comprising the following components in parts by weight: 0.05-0.1 part of pride, 5-12 parts of potassium azenoyl diglycolate, 1-3 parts of kuh-seng root extract, 0.01-2 parts of gentian extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract, 1-3 parts of licorice extract, 1-17 parts of purslane extract, 1-5 parts of glyceroglycosides, 1-45 parts of polyalcohols, 1-20 parts of supermolecular solvents and 1-20 parts of Neosolue TM -Aqulio。
2. The acne-removing composition according to claim 1, wherein the polyhydric alcohol is at least one of butylene glycol and pentylene glycol.
3. The acne-removing composition of claim 1, wherein the supramolecular solvent is betaine citric acid.
4. The acne-removing composition according to claim 1, wherein the acne-removing composition comprises the following components in parts by weight: 0.05-0.1 part of pride, 5-12 parts of potassium nonyldiglycolate, 1-3 parts of kuh-seng root extract, 0.01-2 parts of gentian extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract, 1-3 parts of licorice extract, 1-17 parts of purslane extract, 1-5 parts of glyceroglycosides, 1-45 parts of polyalcohols, 1-20 parts of betaine citric acid and 1-20 parts of Neosolue TM Aqualio, 20-50 parts deionized water.
5. A method for preparing the acne-removing composition according to any one of claims 1 to 4, comprising the steps of: mixing 0.05-0.1 part of pride, 5-12 parts of potassium nonyldiglycolate, 1-3 parts of radix Sophorae Flavescentis extract, 0.01-2 parts of radix Gentianae extract, 1-3 parts of white willow bark extract, 1-3 parts of kava pepper extract and 13 parts of licorice extract, 1-17 parts of purslane extract, 1-5 parts of glyceroglycosides, 1-45 parts of polyalcohol, 1-20 parts of supermolecular solvent and 1-20 parts of neonolue TM -aqualio mixing, stirring to obtain the acne-removing composition.
6. The method for preparing the acne-removing composition according to claim 5, wherein the method for preparing the acne-removing composition specifically comprises the following steps in parts by weight:
mixing 0.05-0.1 part of Piaoning, 1-3 parts of kava extract, 1-20 parts of betaine citric acid and 1-25 parts of butanediol, and heating for dissolving to obtain solution 1;
sequentially mixing 1-5 parts of glyceroglycosides, 1-15 parts of pentanediol and 1-20 parts of Neosolue TM Aqualio is added to solution 1 and stirred ultrasonically to give solution 2;
mixing 20-50 parts of deionized water, 0.01-2 parts of gentian extract and 1-5 parts of butanediol, heating and dissolving, sequentially adding 1-3 parts of licorice extract, 1-3 parts of radix sophorae flavescentis extract and 1-3 parts of white willow bark extract, dissolving into light yellow liquid, adding 5-12 parts of potassium azedarachyl glycinate and 1-17 parts of purslane extract, and stirring to obtain solution 3;
adding the solution 2 into the solution 3, and stirring uniformly to obtain the acne-removing composition.
7. The method of preparing an anti-acne composition according to claim 5, wherein the kuh-seng extract, gentian extract, white willow bark extract, kava extract, licorice extract, purslane extract are all obtained by extraction with betaine citric acid.
8. Use of the anti-acne composition of any one of claims 1-5 for the preparation of an anti-acne product.
9. The use according to claim 8, wherein the anti-acne product is an anti-acne concentrate.
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