CN116712382B - Acne-removing essence and preparation method thereof - Google Patents
Acne-removing essence and preparation method thereof Download PDFInfo
- Publication number
- CN116712382B CN116712382B CN202310915164.6A CN202310915164A CN116712382B CN 116712382 B CN116712382 B CN 116712382B CN 202310915164 A CN202310915164 A CN 202310915164A CN 116712382 B CN116712382 B CN 116712382B
- Authority
- CN
- China
- Prior art keywords
- acne
- mixing
- extract
- parts
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010000496 acne Diseases 0.000 title claims abstract description 47
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 239000000284 extract Substances 0.000 claims abstract description 31
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 22
- 241001465754 Metazoa Species 0.000 claims abstract description 11
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000419 plant extract Substances 0.000 claims abstract description 11
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 11
- 239000000341 volatile oil Substances 0.000 claims abstract description 11
- 241000196324 Embryophyta Species 0.000 claims abstract description 10
- 239000003906 humectant Substances 0.000 claims abstract description 8
- 239000003381 stabilizer Substances 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims description 24
- 235000007650 Aralia spinosa Nutrition 0.000 claims description 12
- 241000949456 Zanthoxylum Species 0.000 claims description 12
- 239000011259 mixed solution Substances 0.000 claims description 12
- 241000255789 Bombyx mori Species 0.000 claims description 11
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 claims description 11
- 239000001738 pogostemon cablin oil Substances 0.000 claims description 11
- 229940051246 camellia oleifera leaf extract Drugs 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 7
- 239000002562 thickening agent Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 4
- 229940083957 1,2-butanediol Drugs 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
- 239000004386 Erythritol Substances 0.000 claims description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 2
- 230000003255 anti-acne Effects 0.000 claims description 2
- BMRWNKZVCUKKSR-UHFFFAOYSA-N butane-1,2-diol Chemical compound CCC(O)CO BMRWNKZVCUKKSR-UHFFFAOYSA-N 0.000 claims description 2
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 229960000541 cetyl alcohol Drugs 0.000 claims description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 2
- 229940009714 erythritol Drugs 0.000 claims description 2
- 235000019414 erythritol Nutrition 0.000 claims description 2
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 claims description 2
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims 1
- 241000186427 Cutibacterium acnes Species 0.000 abstract description 12
- 229940055019 propionibacterium acne Drugs 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 9
- 239000000203 mixture Substances 0.000 abstract description 6
- 244000178870 Lavandula angustifolia Species 0.000 abstract description 5
- 235000010663 Lavandula angustifolia Nutrition 0.000 abstract description 5
- 241000255791 Bombyx Species 0.000 abstract description 4
- 208000020154 Acnes Diseases 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 18
- 210000003491 skin Anatomy 0.000 description 17
- 238000012360 testing method Methods 0.000 description 16
- 239000011521 glass Substances 0.000 description 7
- 210000003780 hair follicle Anatomy 0.000 description 7
- 230000005764 inhibitory process Effects 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 230000002757 inflammatory effect Effects 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 230000001815 facial effect Effects 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 241000193403 Clostridium Species 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 150000004032 porphyrins Chemical class 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 240000001548 Camellia japonica Species 0.000 description 2
- 208000001126 Keratosis Diseases 0.000 description 2
- 240000002505 Pogostemon cablin Species 0.000 description 2
- 235000011751 Pogostemon cablin Nutrition 0.000 description 2
- 241000186429 Propionibacterium Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000010495 camellia oil Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 235000018597 common camellia Nutrition 0.000 description 2
- -1 coumarin compound Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000007933 dermal patch Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 235000021588 free fatty acids Nutrition 0.000 description 2
- 230000001530 keratinolytic effect Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000526900 Camellia oleifera Species 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010013700 Drug hypersensitivity Diseases 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- 108050009363 Hyaluronidases Proteins 0.000 description 1
- 229940124091 Keratolytic Drugs 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 241000555688 Malassezia furfur Species 0.000 description 1
- 206010054107 Nodule Diseases 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 244000089698 Zanthoxylum simulans Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002910 effect on acne Effects 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000036619 pore blockages Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 244000005714 skin microbiome Species 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940092665 tea leaf extract Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000004879 turbidimetry Methods 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229940013368 zanthoxylum bungeanum fruit extract Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of skin care products, and particularly relates to acne-removing essence and a preparation method thereof. The invention discloses acne-removing essence which comprises the following components: animal and plant extracts, plant essential oil, salicylic acid, humectant and stabilizer, wherein the animal and plant extracts comprise Bombyx Batryticatus extract, fructus Zanthoxyli extract, and folium Camelliae sinensis extract, and the plant essential oil comprises oleum herba Pogostemonis and oleum Lavandula Angustifolia. The composition disclosed by the invention can be matched with each other, inhibit the growth of propionibacterium acnes, reduce the occurrence probability of acnes and has obvious acne removing effect.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to acne-removing essence and a preparation method thereof.
Background
The acne is a common skin disease, and the incidence of the acne is concentrated on teenagers and young people.
Acne is a chronic inflammation of the pilosebaceous glands, which is caused by the blockage of the hair follicles and sebaceous glands and the inability of sebum to flow normally, often occurs at sites where the sebaceous glands are dense, and causes various lesions such as acne, pimples, cysts, nodules, etc. Among them, bacteria are one of the important causative factors of acne, and include propionibacterium acnes, propionibacterium greedy, propionibacterium granatum and coccus (staphylococcus albus, staphylococcus aureus), pityrosporum ovale, etc., among which propionibacterium acnes is the most dominant pathogenic bacteria.
Propionibacterium acnes can produce bioactive extracellular enzymes such as lipases, proteases, hyaluronidases, etc., which on the one hand stimulate hair follicles by breaking down the free fatty acids produced by sebum, causing excessive keratinization of the sebaceous ducts of hair follicles; on the other hand, the generated polypeptide and free fatty acid can induce cell inflammation, so that the severity of acne is increased.
Acne can last for many years, causing the patient to either disfigure or leave a permanent scar, and can even severely affect the patient's mental growth.
Acne-removing cosmetics are popular as the most common and safe means for preventing and treating acne, are widely popular with consumers, and have various types of acne-removing raw materials at present and uneven product quality, and the acne-removing products usually contain a large amount of bactericidal and exfoliating components, so that the acne-removing cosmetics have a certain effect on acne treatment, but can generate irritation on application positions; there is therefore a need to develop an anti-acne composition containing less irritating bactericidal components.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide the acne-removing essence which can effectively inhibit the growth of skin bacteria, promote the metabolism of skin cuticle, has fewer chemical components and reduces skin irritation and a preparation method thereof.
The invention provides acne-removing essence for achieving the purpose, which comprises the following components in parts by mass:
0.6-1.1 parts of animal and plant extracts;
1.1-1.6 parts of plant essential oil;
0.6-1 part of salicylic acid;
3-5 parts of humectant;
0.01-0.08 part of stabilizer;
the animal and plant extract comprises stiff silkworm extract, pricklyash peel extract and camellia oleifera leaf extract;
The plant essential oil comprises patchouli oil and lavender oil.
Specifically, the mass ratio of the stiff silkworm extract to the pricklyash fruit extract to the camellia oleifera leaf extract is (2-3) 1 (20-30).
Specifically, the mass ratio of the patchouli oil to the lavender oil is 1 (10-15).
Specifically, the humectant is at least one of erythritol, 1, 2-butanediol, polyglycerol-10 and methyl propylene glycol.
Specifically, the composition also contains a thickener, wherein the content of the thickener is 0.1-0.6 part by mass;
more specifically, the thickener is at least one of carbomer, xanthan gum, cetyl alcohol, and magnesium aluminum silicate.
Specifically, the stabilizer is at least one of disodium EDTA, tetrasodium EDTA and octanoyl hydroxamic acid.
Specifically, the pH regulator is also contained, and the content of the pH regulator is less than or equal to 1.1 parts by mass.
The invention also provides a preparation method of the acne-removing essence, which comprises the following steps:
(1) Homogenizing and mixing humectant and part of solvent according to the formula amount to obtain a mixed solution A;
(2) Mixing animal and plant extracts, salicylic acid and part of solvent to obtain mixed solution B;
(3) Homogenizing and mixing the plant essential oil and part of solvent in the formula amount, adding the mixed solution A, the stabilizer and the mixed solution B during mixing, and adjusting the pH value to obtain the acne-removing essence.
Specifically, the rotation speed of the homogeneous mixing in the step (1) is set at 6000-7000rpm, and the mixing temperature is heated to 60-70 ℃;
mixing the step (2) at 120-200rpm for 1-1.5h;
The homogenizing mixing rotating speed in the step (3) is set at 15000-20000rpm, mixing is carried out at normal temperature, and the pH value is adjusted to be between 5 and 6.5.
In the invention, the following components are added:
The stiff silkworm extract contains rich proteins, polypeptides and amino acids, which are important components for forming skin and tissues, can promote healing of wounds left after acne injury, can accelerate growth and regeneration of epidermal cells, reduce formation of 'acne pits', and can improve firmness and elasticity of skin; the Bombyx Batryticatus extract also contains various chemical components such as fatty acid, flavonoid, nucleoside, steroid, coumarin compound, polysaccharide, etc., and has antioxidant, antiinflammatory, antibacterial effects.
The pricklyash peel extract is rich in volatile oil and various active ingredients, has a strong antibacterial effect, and can effectively inhibit bacterial growth in deep hair follicles; the active ingredients in the pricklyash peel extract have a certain anti-inflammatory effect, and can reduce inflammatory reaction and relieve pain and swelling; it contains flavonoid compounds, vitamin C, etc. and can neutralize free radical and protect cells from oxidative damage.
Under the joint coordination of the stiff silkworm extract, the pricklyash peel extract, the camellia oleifera leaf extract, the patchouli oil and the lavender oil, the fast reaction with propionibacterium acnes can be realized, the cell structure can be destroyed, and thus the sterilization effect can be realized. The coordination of the five components effectively inhibits the activity of microorganisms such as bacteria, can reduce the number of inflammatory signals sent by inflammatory mediators to a certain extent, and reduces the damage to skin caused by excessive release of the signals, thereby realizing acne removal.
Salicylic acid has a strong keratolytic ability and is commonly used as a shallow exfoliant in the treatment of acne. Salicylic acid can differentiate and shed keratinocytes, and due to its lipid solubility, it can penetrate pores and acne, inhibit bacterial growth and prevent pore blockage.
According to the invention, the stiff silkworm extract, the pricklyash peel extract and the oil tea leaf extract are mixed in a specific proportion, so that the whole combined system has low stimulation to human skin, and a milder acne removing system is obtained.
According to the research of the invention, the patchouli oil and the lavender oil are matched with each other in a specific proportion, so that the effects of inhibiting the conduction of inflammatory signals and the generation of secondary inflammatory mediators can be effectively achieved; meanwhile, the lavender oil and the patchouli oil can also strengthen the inhibition effect of the animal and plant extract on propionibacterium acnes.
When the essence is uniformly applied to an affected part, because of the fat-soluble property of salicylic acid and the similar compatibility principle of plant essential oil, the animal and plant extract of the invention is carried into skin hair follicles, so that antibacterial components act on propionibacteria to inhibit propionibacteria, and meanwhile, the plant essential oil can effectively inhibit the effects of inflammatory signal transduction and inflammatory medium generation, thereby reducing inflammatory reaction in skin and finally reducing the duration and intensity of inflammation. In addition, when the essence acts on the skin, the synthesis of collagen and elastin of the dermis of the skin is effectively stimulated, the renewal of the skin is accelerated, and the skin is also beneficial to resisting the invasion of bacteria; the method realizes the mild acne removal and skin color brightening.
The invention has the beneficial effects that:
1. The stiff silkworm extract, the pricklyash peel extract, the camellia oleifera leaf extract, the patchouli oil and the lavender oil are matched together to extend into hair follicles to effectively inhibit the growth of propionibacterium acnes, so that the occurrence probability of acnes is reduced.
2. The salicylic acid has stronger keratolytic effect, and the salicylic acid added in the invention has the effects of promoting the metabolism of the horny layer, accelerating the falling of the keratoses, avoiding the keratoses from being blocked in hair follicles and reducing the occurrence of acne inflammation.
Detailed Description
For a better understanding of the present invention, reference will now be made to the following description of specific examples, which are included in the terminology used to describe specific embodiments of the invention and are not intended to limit the scope of the invention.
In the invention, the following components are added:
The Bombyx Batryticatus extract is Bombyx Batryticatus (BOMBYX MORI) extract, with English name BOMBYX MORI EXTRACT, available from Shanxi Hongshikang biotechnology Co.
The pricklyash peel extract is pricklyash peel (ZANTHOXYLUM BUNGEANUM) extract, and has English name ZANTHOXYLUM BUNGEANUM FRUIT EXTRACT, and is purchased from Gansu Probiotics and biotechnology Co.
The tea-oil camellia leaf extract is tea-oil camellia (CAMELLIA OLEIFERA) leaf extract, the english name is CAMELLIA OLEIFERALEAF EXTRACT, purchased from volley biotechnology limited, lanzhou.
Patchouli OIL is patchouli (POGOSTEMON CABLIN) OIL, english name POGOSTEMON CABLIN OIL, CAS number 8014-09-3, available from Shanghai Yuan leaf Biotechnology Co.
The lavender OIL is lavender (LAVANDULA ANGUSTIFOLIA) OIL, the English name is LAVANDULAANGUSTIFOLIA (LAVENDER) OIL, the CAS number is 8000-28-0, and the lavender OIL is purchased from Shandong Seiya chemical Co., ltd.
The experimental methods of the following examples and comparative examples, in which specific conditions are not noted, are generally conducted under conventional conditions or under conditions recommended by the manufacturer. Percentages and parts are by weight unless otherwise indicated.
The preparation of examples and comparative examples comprises the following steps:
Step (1), weighing the raw materials according to the mass parts of the table 1; the stiff silkworm extract, the pricklyash peel extract and the camellia oleifera leaf extract are solid powder, and are mixed by a spiral stirring mixer in advance to obtain animal and plant extracts;
step (2), heating a part of deionized water to 70 ℃, adding weighed humectant and thickener into the part of deionized water, setting the rotating speed of a homogenizer at 7000rpm for carrying out homogenizing, dispersing and mixing to obtain a mixed solution A, wherein the rotating speed of the homogenizer is set within the range of 6000-7000rpm, and the mixing temperature is 60-70 ℃;
step (3), mixing the mixed extract of the step (1), salicylic acid and the other part of deionized water for 1.5 hours at the rotating speed of 200rpm to obtain a mixed solution B, wherein the rotating speed is set at 120-200rpm, and the mixing time is 1-1.5 hours;
And (4) carrying out homogenizing mixing on the weighed patchouli oil, the lavender oil and the rest deionized water at normal temperature and a rotating speed of 15000rpm, adding the mixed solution A, the stabilizer and the mixed solution B during mixing, and regulating the pH value to 6.5 by utilizing the pH regulator to obtain the acne-removing essence, wherein the rotating speed during homogenizing is 15000-20000rpm, and the pH value range of the acne-removing essence is 5-6.5.
Table 1 shows the components of each raw material and parts by weight of acne-removing essence
Note that: table 1 shows that the total parts by mass of the raw material components is 100 parts and that the blank indicates no addition.
Sample stability test:
1. Heat resistance test: the constant temperature incubator is adjusted to 40 ℃, 4 examples and 4 comparative examples prepared above are respectively used as 8 samples to be measured, three samples to be measured are taken and are respectively put into a transparent glass bottle, the sample loading amount is 20 ml/bottle, the samples are put into the constant temperature incubator after being sealed, the samples are taken out after three months, the temperature is restored to the room temperature, and the appearance change is observed.
2. Cold resistance test: and adjusting the constant temperature incubator to-10 ℃, taking the 4 prepared examples and 4 prepared comparative examples as 8 samples to be tested respectively, taking three samples to be tested each in a transparent glass bottle, sealing the transparent glass bottle, placing the transparent glass bottle in the constant temperature incubator after sealing, taking out the transparent glass bottle after three months, recovering the transparent glass bottle to room temperature, and observing the appearance change.
3. And (3) normal temperature test: the prepared 4 examples and 4 comparative examples are respectively used as 8 samples to be measured, three samples to be measured are taken and are filled in a transparent glass bottle, the filling amount is 20 ml/bottle, and after the samples are sealed and placed for 6 months at normal temperature, the appearance change of the samples is observed.
No phenomena such as precipitation and precipitation are observed in the heat resistance test, the cold resistance test and the normal temperature test, and the original appearance is maintained.
Human skin patch test:
The 4 examples and the 4 comparative examples prepared above were referred to the human skin patch experiments in 2022 cosmetic safety technical Specification.
Skin reactions were observed as standard at 30min (after the disappearance of the indentations), 24h and 48h, respectively, and the observations were recorded, see table 2.
TABLE 2 human safety test results
| Numbering device | 30min | 24h | 48h |
| Example 1 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 2 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 3 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 4 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Comparative example 1 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Comparative example 2 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Comparative example 3 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Comparative example 4 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
Sample in vitro inhibition test for propionibacterium acnes:
sample to be measured: examples 1-4, comparative examples 1-4, blank: sterile water.
The testing method comprises the following steps: inoculating a standard strain on the inclined plane of a clostridium enrichment medium added with agar powder, and performing anaerobic culture for 48-72 hours at 37+/-1 ℃; eluting the propionibacterium acnes by using 5mL clostridium enrichment medium, collecting eluent in a 10mL centrifuge tube, adjusting the concentration of bacterial liquid to 10 5～106 CFU/mL by using a turbidimetry method, and counting viable bacteria by using a plate method; pouring 18-20 mL clostridium enrichment agar culture is based on a disposable culture dish, and the pouring thickness is about 5-6 mm. After the flat plate is solidified, aseptically sucking 100 mu L of propionibacterium acnes bacterial liquid on the surface of a culture medium, and rapidly and uniformly coating the bacterial liquid by using an aseptic coating rod; placing sterilized oxford cups (circular stainless steel small tubes with inner diameter of 6mm, outer diameter of 8mm and height of 10 mm) on the coated culture medium, lightly pressing to ensure that the oxford cups are in contact with the culture medium without gaps, wherein each oxford cup is not less than 14mm from the edge of a flat plate, and the distance between the centers of every two oxford cups is not less than 30mm. About 200 mu L of samples to be tested are dripped into the oxford cup, each sample to be tested is subjected to 3 groups of parallel without overflowing, anaerobic culture is carried out for 48-72 hours at 37+/-1 ℃, and the result is observed.
The clear ring zone of inhibition was visually observed and the diameter of the zone of inhibition was measured with vernier calipers, after which 3 sets of parallel data were recorded and averaged.
The test results are shown in Table 3.
TABLE 3 antibacterial results
| Group of | Diameter of inhibition zone (mm) |
| Example 1 | 13.74 |
| Example 2 | 13.36 |
| Example 3 | 13.57 |
| Example 4 | 13.68 |
| Comparative example 1 | 12.23 |
| Comparative example 2 | 12.17 |
| Comparative example 3 | 11.59 |
| Comparative example 4 | 11.63 |
| Blank group | 0 |
Sample clinical test:
Detecting an object: 48 acne patients aged 20-35 years were randomly enrolled, and the group of acne patients was ranked as grade ii for acne. The subject excludes pregnant or intended pregnant subjects, and those who use immunosuppressants or antihistamines; patients who used other products for the treatment of facial acne within one month; patients with severe systemic diseases and those who are currently being administered systematically or who are sensitive to drug allergies.
Sample to be measured: examples 1 to 4 and comparative examples 1 to 4.
The detection process comprises the following steps: 5 days before the start of the test, the product with similar functions is deactivated. After the detection is started, facial cleaning is carried out in the morning and evening every day, the toner is sprayed, then 5ml of sample is used, the sample is uniformly smeared on the face, and the use is continued for 28 days.
1. Facial microbial activity
Images of the face of the test subject were collected by the VISIA, and porphyrin values of the face were analyzed using image analysis software, and the values on day 1 and day 28 were recorded.
Calculating the delta T formula: Δt=t 28-T1
T 28: average porphyrin values per group on day 28;
t 1: average porphyrin values per group on day 1.
2. Skin gloss
The face of the subject was measured using a skin luster meter, and the values on days 1 and 28 were recorded.
Calculating an DeltaL formula: Δl=l 28-L1
L 28: average gloss per group on day 28;
L 1: average gloss per group on day 1.
3. User feel
On day 28, the user was recorded as to whether the face was tight, uncomfortable, itchy, reddish and shiny, and vaccinia was apparent after using the sample.
The results of the sample clinical tests are shown in table 4.
TABLE 4 results of sample clinical testing
Analysis of test results:
As can be seen from table 3, the inhibition effect of examples 1-4 on propionibacterium acnes is obviously better than that of comparative examples 3 and 4, which shows that the acne-removing composition provided by the invention has excellent propionibacterium acnes inhibition capability; example 1 shows that the former has a better bacteriostatic effect than the latter, compared with comparative examples 1, 2, indicating that the specific ratio between the compositions of the invention has a better synergistic effect.
From Table 4, it can be seen that the acne-removing composition provided by the invention can effectively inhibit the growth of skin epidermic bacteria, reduce the occurrence of skin inflammation, promote the regeneration of skin horny layer, improve facial gloss, repair acne-damaged skin, and has remarkable acne-removing effect.
Claims (6)
1. The acne-removing essence is characterized by comprising the following components in parts by weight:
0.6-1.1 parts of animal and plant extracts;
1.1-1.6 parts of plant essential oil;
0.6-1 part of salicylic acid;
3-5 parts of humectant;
0.01-0.08 part of stabilizer;
the animal and plant extracts are stiff silkworm extract, pricklyash peel extract and camellia oleifera leaf extract;
the plant essential oil is patchouli oil and lavender oil;
The mass ratio of the stiff silkworm extract to the pricklyash peel extract to the camellia oleifera leaf extract is (2-3): 1 (20-30);
The mass ratio of the patchouli oil to the lavender oil is 1 (10-15);
The humectant is at least one of erythritol, 1, 2-butanediol, polyglycerol-10 and methyl propylene glycol;
the stabilizer is at least one of disodium EDTA, tetrasodium EDTA and octanoyl hydroxamic acid.
2. The acne-removing essence according to claim 1, further comprising a thickener, wherein the content of the thickener is 0.1 to 0.6 parts by mass.
3. The anti-acne concentrate of claim 2, wherein the thickener is at least one of carbomer, xanthan gum, cetyl alcohol, magnesium aluminum silicate.
4. The acne-removing essence according to claim 1, further comprising a pH regulator, wherein the content of the pH regulator is 1.1 parts by mass or less.
5. A method for preparing the acne-removing essence according to any one of claims 1 to 4, comprising the steps of:
(1) Homogenizing and mixing humectant and part of solvent according to the formula amount to obtain a mixed solution A;
(2) Mixing animal and plant extracts, salicylic acid and part of solvent to obtain mixed solution B;
(3) Homogenizing and mixing the plant essential oil and part of solvent in the formula amount, adding the mixed solution A, the stabilizer and the mixed solution B during mixing, and adjusting the pH value to obtain the acne-removing essence;
The solvent is deionized water.
6. The method according to claim 5, wherein the rotation speed of the homogeneous mixing in the step (1) is set at 6000 to 7000rpm, and the mixing temperature is heated to 60 to 70 ℃;
mixing the step (2) at 120-200rpm for 1-1.5h;
The homogenizing mixing rotating speed in the step (3) is set at 15000-20000rpm, mixing is carried out at normal temperature, and the pH value is adjusted to be between 5 and 6.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310915164.6A CN116712382B (en) | 2023-07-25 | 2023-07-25 | Acne-removing essence and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310915164.6A CN116712382B (en) | 2023-07-25 | 2023-07-25 | Acne-removing essence and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116712382A CN116712382A (en) | 2023-09-08 |
| CN116712382B true CN116712382B (en) | 2024-04-16 |
Family
ID=87871766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310915164.6A Active CN116712382B (en) | 2023-07-25 | 2023-07-25 | Acne-removing essence and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116712382B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491459A (en) * | 2016-12-22 | 2017-03-15 | 江西宜信堂医疗科技有限公司 | A kind of acne eliminating cream containing traditional Chinese medicine ingredients and preparation method thereof |
| CN109602686A (en) * | 2019-02-02 | 2019-04-12 | 西安力邦制药有限公司 | A kind of aqueous gelled cosmetic compositions and preparation method thereof |
-
2023
- 2023-07-25 CN CN202310915164.6A patent/CN116712382B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491459A (en) * | 2016-12-22 | 2017-03-15 | 江西宜信堂医疗科技有限公司 | A kind of acne eliminating cream containing traditional Chinese medicine ingredients and preparation method thereof |
| CN109602686A (en) * | 2019-02-02 | 2019-04-12 | 西安力邦制药有限公司 | A kind of aqueous gelled cosmetic compositions and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| "油茶叶提取物的5α-还原酶抑制活性及化学成分分析";崔心禹 等;《食品工业科技》;第42卷(第19期);97-98 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116712382A (en) | 2023-09-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN113332162B (en) | protamine-PDRN compound, composition and application in preparation of skin care product | |
| CN110638727B (en) | Infant hip-protecting composition and preparation method and application thereof | |
| CN113693979B (en) | Oil-control acne-removing composition and application thereof | |
| CN109260059B (en) | Essential oil composition with acne removing and skin repairing effects and application thereof | |
| CN113855718A (en) | Artemisia apiacea extract and application thereof | |
| CN107811926A (en) | A kind of oil control and acne removal gel | |
| CN111743830A (en) | Acne-removing composition and application thereof | |
| CN112426386A (en) | Oil-control acne-removing efficacy composition and gel | |
| CN112076133A (en) | Compound plant acne-removing composition and preparation method and application thereof | |
| CN113679765A (en) | Cortex dictamni extract and application thereof | |
| CN111888318A (en) | Skin repairing, whitening and acne removing mask and preparation method thereof | |
| WO2021143096A1 (en) | Whitening, acne-removing, blackhead-removing and anti-aging composition, and use and preparation thereof | |
| CN115337233B (en) | Gel mask with mild acne removing effect and preparation method thereof | |
| CN116712382B (en) | Acne-removing essence and preparation method thereof | |
| CN112773733A (en) | Acne-removing composition and preparation method of emulsion thereof | |
| CN117045523A (en) | High-content azelaic acid composition and preparation method thereof | |
| CN115414308A (en) | Acne removing composition as well as preparation method and application thereof | |
| CN115429738A (en) | Acne-removing repairing revitalizing essence and preparation method thereof | |
| CN113350255B (en) | Low-irritation antibacterial cosmetic and preparation method thereof | |
| JPH03236319A (en) | Skin drug for external use | |
| CN115919686A (en) | Skin soothing lotion for enhancing skin barrier and preparation method thereof | |
| CN112494392A (en) | Clean oil-in-water cosmetic composition and preparation method thereof | |
| CN110840799A (en) | Whitening, moisturizing, antibacterial and mosquito-repellent body lotion and preparation method thereof | |
| CN117323271B (en) | Acne-removing composition, and preparation method and application thereof | |
| CN115463048B (en) | Acne-removing and skin-refreshing essence and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |