CN116650610A

CN116650610A - Pharmaceutical composition for treating diabetes

Info

Publication number: CN116650610A
Application number: CN202310194535.6A
Authority: CN
Inventors: 孙占荣
Original assignee: Individual
Current assignee: Individual
Priority date: 2023-03-03
Filing date: 2023-03-03
Publication date: 2023-08-29

Abstract

A pharmaceutical composition for treating diabetes is prepared from the following traditional Chinese medicine raw materials in parts by weight: 30-120 parts of astragalus membranaceus, 30-50 parts of codonopsis pilosula, 30-50 parts of roasted rhizoma polygonati, 60-120 parts of radix trichosanthis, 30-50 parts of wild arrowroot, 30-50 parts of rhizoma coptidis, 10-30 parts of rhizoma atractylodis, 30-80 parts of raw rhizoma dioscoreae, 10-30 parts of semen euryales, 5-20 parts of dried ginger, 30-60 parts of chicken gizzard-skin, 10-30 parts of raw pinellia ternate, 10-30 parts of silkworm larva, 10-30 parts of vinegar radix bupleuri, 10-30 parts of radix scutellariae, 10-30 parts of vinegar-nutgrass galingale rhizome, 10-30 parts of costustoot, 5-20 parts of fructus amomi, 30-80 parts of radix rehmanniae, 20-80 parts of wine sweet potato pulp, 20-50 parts of cortex moutan, 5-20 parts of leech, 15-30 parts of ligusticum chuanxiong, 10-30 parts of salted cortex phellodendri, 10-30 parts of cinnamon and 10 parts of cooked puerh tea.

Description

Pharmaceutical composition for treating diabetes

Technical Field

The application relates to the technical field of medicines, in particular to a pharmaceutical composition for treating diabetes.

Background

Diabetes is the disease name of traditional Chinese medicine, and is a syndrome characterized by polydipsia, diuresis, polyphagia, emaciation, fatigue and urinary sweetness. Modern medicine is considered a chronic metabolic disease. At present, the medicine considers that only hypoglycemic drugs can be used for maintaining the stability of blood sugar, and complications are reduced.

For example, the following problems are caused by the drugs used in western medicine therapy: 1. insulin: adverse reactions to insulin are: (1) Allergic reactions, patients with insulin may develop urticaria and angioneurotic oedema at the injection site; (2) a hypoglycemic reaction; (3) insulin resistance; (4) subcutaneous lipoatrophy or hyperplasia at the injection site; (5) ocular refractive disorders. 2. Sulfonylurea drugs: adverse reaction of sulfonylurea drugs: the occasional hypoglycemia can be diarrhea, nausea, vomiting, headache, stomach ache or discomfort, the less common and serious rash, jaundice, liver function damage, granulocytopenia (manifested as pharyngalgia, fever, infection), thrombocytopenia (manifested as bleeding, purpura) and the like. 3. Biguanides drugs: adverse reactions of biguanides are most common: gastrointestinal reactions, manifested by inappetence, nausea, vomiting, diarrhea, gastralgia, and metallic taste in the mouth. Sometimes patients have symptoms such as debilitation, tiredness, weight loss, dizziness, rash, etc. 4. Dietary glucose modulators: adverse reactions of dietary glucose modulators are: hypoglycemia, vision abnormality, gastrointestinal reaction, allergic rash, itching, urticaria, etc. Few patients develop elevated liver transaminases, which are mild and transient, with little withdrawal. 5. Thiazolidinedione insulin sensitizer: adverse reactions of thiazolidinedione insulin sensitizers include: (1) anemia; (2) cardiovascular system response; (3) neuropsychiatric system response; (4) a hypoglycemic reaction; (5) gastrointestinal reactions, and the like. 6. Non-insulin hypoglycemic hormonal drugs: the non-insulin hypoglycemic hormone medicines also have some adverse reactions, wherein nausea is the most common, severe hypoglycemia events are easy to occur within 3 hours after the use, and anorexia, vomiting, hypodynamia, dizziness and the like can also occur in patients.

The traditional Chinese patent medicines commonly used for treating diabetes mainly comprise the following components: (1) Xiaokewan; (2) Jiangtangshu; (3) Yuquan pills; (4) a hypoglycemic nail tablet; (5) manna diabetes capsules; (6) LIUWEIDIHUANG pill and MAIWEIDIHUANG pill; (7) herba dendrobii noctilucent pills; (8) a eyesight improving rehmannia pill; (9) ginseng astragalus hypoglycemic tablets; (10) Ke le Ning capsule; (11) Xiaokeling tablet; (12) Jinqi hypoglycemic tablets; (13) a sugar vein recovery granule; (14) an eighteen-ingredient myrobalan diuretic pill. Nevertheless, the efficacy of these traditional Chinese medicine preparations is still unsatisfactory.

Disclosure of Invention

In view of the above, there is a need for providing a pharmaceutical composition for treating diabetes with improved therapeutic effects.

Preferably, the astragalus root, the codonopsis pilosula, the rhizoma polygonati, the coptis chinensis, the kudzuvine root and the radix trichosanthis are used as monarch drugs, and the monarch drugs are used for tonifying qi of the five viscera, tonifying kidney and replenishing essence, strengthening spleen and strengthening foundation, promoting the production of body fluid to quench thirst and tonifying qi and blood so as to activate islet cells and restore the normal functions of the islets; the rhizoma atractylodis, chinese yam, gorgon fruit, dried ginger, chicken's gizzard-skin, raw pinellia tuber, stiff silkworm, vinegar-processed bupleurum, baical skullcap root, vinegar-processed nutgrass galingale rhizome, costustoot and villous amomum fruit are used as ministerial drugs, and the ministerial drugs are utilized to warm kidney, arrest semen, raise clear and lower turbid, dry dampness, invigorate spleen, sooth liver, regulate qi, enhance the transportation capability of intestines and stomach, invigorate the acquired and strengthen congenital, so that the intestines and stomach system recovers normal transportation function, dredges the whole body qi movement and promotes sugar metabolism; the dried rehmannia root, sweet potato pulp, cortex moutan, leech, szechuan lovage rhizome, amur corktree bark, cassia bark and cooked puerh tea are used as an adjuvant, the dried rehmannia root, sweet potato pulp, the cortex moutan, leech, szechuan lovage rhizome, amur corktree bark and cassia bark in the adjuvant are utilized to generate blood, promote blood circulation, cool blood, harmonize blood, remove meridian obstruction, remove deficiency fire, lead the fire to return to the origin, tonify liver and blood, tonify heart and spleen and kidney, strengthen kidney, so as to promote blood microcirculation, enable blood sugar to be directly supplied to cells, and the cooked puerh tea in the adjuvant is utilized to nourish stomach and liver, reduce blood fat and blood sugar and enhance the transportation and transformation capacity of intestines and stomach.

Preferably, the principal drugs are reused to achieve the whole prescription and improve the blood sugar reducing effect.

The beneficial effects are that: in the medicinal composition for treating diabetes, the three-jiao is conditioned by using the kudzuvine root, the astragalus root, the coptis root, the baical skullcap root, the bupleurum root, the vinegar-processed nutgrass galingale rhizome and the costustoot, so that the purposes of ascending and descending turbidity, dredging and regulating a water channel and regulating the whole body qi movement are achieved, and the problem of total metabolic circulation of a human body is further solved; the purposes of supplementing qi, generating blood, ascending and clearing away heat, tonifying kidney, generating sperm, strengthening spleen, regulating qi circulation, regulating stomach and intestine and improving the functions of transportation and transformation are achieved by utilizing astragalus, rhizoma polygonati, codonopsis pilosula, chinese yam, rhizoma atractylodis, chicken's gizzard-membrane, raw pinellia tuber, stiff silkworm, coptis chinensis, dried ginger, costustoot, fructus amomi, vinegar-processed bupleurum root, vinegar-processed nutgrass galingale rhizome, cinnamon and cooked puer tea to regulate the gastrointestinal system, so that the problems of sugar metabolism and the emotional diseases of liver depression and qi stagnation are solved; the purposes of promoting blood circulation, activating blood circulation, cooling blood, regulating blood circulation, removing obstruction in channels and purifying blood are achieved by utilizing dangshen, rhizoma polygonati, dried rehmannia root, sweet potato pulp, cortex moutan, ligusticum wallichii, leech, phellodendron bark and cinnamon to regulate a blood circulation system, so that the problems of blood microcirculation are solved, blood sugar is directly supplied to cells, blood sugar is reduced, complications are prevented, spleen and kidney are further achieved, and effects of simultaneous tonifying and yin-yang are achieved. Generally, 14 doses of the above pharmaceutical composition for treating diabetes are taken lightly, three more symptoms can disappear, the history of type II diabetes is treated for three months in ten years, and three more symptoms can disappear.

Drawings

FIG. 1 is a report of blood glucose tests before and after patient 1 took the pharmaceutical composition of the present application.

Figure 2 is a report of the blood glucose test before and after patient 2 took the pharmaceutical composition of the present application.

FIG. 3 is a report of the blood glucose test before and after patient 3 took the pharmaceutical composition of the present application.

FIG. 4 is a report of the blood glucose test before and after patient 4 took the pharmaceutical composition of the present application.

Figure 5 is a report of the blood glucose test before and after administration of the pharmaceutical composition of the present application to patient 5.

Detailed Description

In order to more clearly illustrate the technical scheme of the application, the pharmaceutical composition for treating diabetes of the application is further described in detail below by combining examples.

Wherein, the astragalus root, the pilose asiabell root, the rhizoma polygonati, the coptis root, the kudzuvine root and the radix trichosanthis are taken as monarch drugs, and the monarch drugs are utilized to tonify qi of the five viscera, tonify the kidney and replenish essence, strengthen the spleen and strengthen the foundation, promote the production of body fluid to quench thirst and tonify qi and blood so as to activate islet cells and restore the normal functions of the islets; the rhizoma atractylodis, chinese yam, gorgon fruit, dried ginger, chicken's gizzard-skin, raw pinellia tuber, stiff silkworm, vinegar-processed bupleurum, baical skullcap root, vinegar-processed nutgrass galingale rhizome, costustoot and villous amomum fruit are used as ministerial drugs, and the ministerial drugs are utilized to warm kidney, arrest semen, raise clear and lower turbid, dry dampness, invigorate spleen, sooth liver, regulate qi, enhance the transportation capability of intestines and stomach, invigorate the acquired and strengthen congenital, so that the intestines and stomach system recovers normal transportation function, dredges the whole body qi movement and promotes sugar metabolism; the dried rehmannia root, sweet potato pulp, cortex moutan, leech, szechuan lovage rhizome, amur corktree bark, cassia bark and cooked puerh tea are used as an adjuvant, the dried rehmannia root, sweet potato pulp, the cortex moutan, leech, szechuan lovage rhizome, amur corktree bark and cassia bark in the adjuvant are utilized to generate blood, promote blood circulation, cool blood, harmonize blood, remove meridian obstruction, remove deficiency fire, lead the fire to return to the origin, tonify liver and blood, tonify heart and spleen and kidney, strengthen kidney, so as to promote blood microcirculation, enable blood sugar to be directly supplied to cells, and the cooked puerh tea in the adjuvant is utilized to nourish stomach and liver, reduce blood fat and blood sugar and enhance the transportation and transformation capacity of intestines and stomach. Wherein, the monarch drug is reused to lead the whole prescription and improve the blood sugar reducing effect.

The following is an introduction of the efficacy of the individual drugs of the pharmaceutical composition for treating diabetes:

radix astragali: sweet and slightly warm. Enter spleen and lung meridians. It is suitable for deficiency of qi and blood, spontaneous perspiration, debilitation, anorexia, loose stool, chronic cough, short breath, and pyocutaneous disease. Pharmacological action: diuretic, antifatigue, metabolism promoting, antibacterial, blood sugar regulating, antiarrhythmic, blood pressure lowering, blood lipid reducing, radioprotective, antianemia preventing, liver protecting, antiaging, etc.

Radix codonopsis pilosulae: sweet in flavor and neutral in nature. Enter lung and spleen. Is suitable for spleen and lung qi deficiency, anorexia, fatigue, cough, asthma, deficiency of qi and blood, sallow complexion, palpitation, short breath, thirst due to body fluid deficiency, and internal heat and diabetes. Lazy speaking, weak limbs, poor appetite, qi deficiency, deficiency of both qi and fluid, deficiency of both qi and blood, and chlorosis due to blood deficiency. Pharmacological action: heart strengthening, shock resistance, fatigue resistance, hematopoietic function promotion, blood sugar reduction, anti-inflammatory, antiallergic, antitumor, hematopoietic system function promotion, etc.

Rhizoma polygonati: sweet in flavor and neutral in nature. Enter spleen, lung and kidney meridians. It is suitable for dry cough with little phlegm, chronic cough with no cure, soreness of waist and knees, premature graying hair, debilitation, and inappetence. Pharmacological action: antibacterial, immunity enhancing, coronary blood flow increasing, blood pressure lowering, blood sugar lowering, and antiaging effects.

Radix Puerariae: sweet and pungent in flavor, cold in nature and entering lung meridian and stomach meridian. Relieving muscle and fever, promoting eruption, promoting salivation, quenching thirst, and invigorating yang to arrest diarrhea. The main indications are: can be used for treating exterior syndrome fever, pain in neck and back, measles, fever, thirst, yin deficiency, thirst, diarrhea, and spleen deficiency.

Coptis root: sex flavor meridian tropism: bitter and cold. It enters heart, spleen and stomach, gallbladder and large intestine meridians. Is suitable for treating damp-heat dysentery, distention and fullness, emesis, hyperpyrexia, vexation, insomnia, conjunctival congestion, toothache, diabetes, eczema, carbuncle, and furuncle. Pharmacological action: antibacterial, antiarrhythmic, myocardial oxygen consumption reducing, acute inflammation resisting, gallbladder function promoting, diarrhea resisting, gastric secretion inhibiting, anticancer, and antiulcer effects.

Radix trichosanthis: sex taste: sweet, slightly bitter and slightly cold enter meridians: enter lung and stomach meridians. Efficacy: clearing heat and purging fire, promoting salivation and quenching thirst, moistening lung and resolving phlegm, and detumescence and pus discharge. The efficacy mainly treats: clearing heat and purging fire, promoting salivation and quenching thirst. Can be used for treating heat diseases such as fluid consumption, stomach heat, thirst, and diabetes. Moistening lung and resolving phlegm. Pharmacological action: radix Trichosanthis has immunity enhancing, anticancer, antiviral, and blood glucose regulating effects.

Rhizoma atractylodis: sex taste function and main indications: pungent and bitter, warm. Dry dampness, invigorate spleen, expel wind, dispel cold, improve eyesight. Can be used for treating abdominal distention, diarrhea, edema, tinea pedis, rheumatalgia, common cold due to wind-cold, sparrow eye night blindness. Pharmacological action: promoting gastrointestinal motility, resisting ulcer, inhibiting gastric acid secretion, reducing blood sugar, improving myocardial ischemia, resisting bacteria, protecting liver, inhibiting central nervous system, and resisting tumor.

Chinese yam: sweet and neutral in nature and taste, and enters spleen, lung and kidney meridians, and has the main effects of: it is mainly used for invigorating spleen qi, tonifying lung qi, invigorating kidney qi, relieving diarrhea, and stopping leukorrhagia in clinic. Pharmacological action: the Chinese yam can enhance the absorption capacity of small intestine, protect gastric mucosa, reduce blood sugar, resist oxidation and aging, has the functions of anesthesia, analgesia, anti-inflammation and bacteriostasis, and can reduce blood fat and resist tumors.

Gorgon fruit: sweet, astringent and flat. Enter spleen and kidney meridians. Has the effects of tonifying kidney, securing essence, strengthening spleen, relieving diarrhea, removing dampness and stopping leukorrhagia. The main indications are: 1. seminal emission and spermatorrhea. 2. Spleen deficiency chronic diarrhea. It can strengthen spleen and remove dampness, and astringe to check diarrhea. It can be used for treating spleen deficiency with excessive dampness, chronic diarrhea, 3, leukorrhagia; pharmacological action: has antioxidant, blood sugar reducing, analgesic, and kidney protecting effects. Antithrombotic efficacy.

Dried ginger: pungent in flavor and warm in nature, enters spleen meridian, stomach meridian, kidney meridian, heart meridian and lung meridian, has the effects of warming spleen and stomach to dispel cold, restoring yang to activate pulse and warming lung to remove fluid retention, is commonly used for treating epigastralgia, vomiting and diarrhea, micro-cold limbs and pulse, cold-retained fluid with cough and dyspnea, and is a main medicine for warming middle energizer. Pharmacological action: has slight irritation to digestive tract, and can enhance intestinal tension, rhythm and peristalsis, thereby promoting gastrointestinal digestion. Enhancing salivary secretion and digestion of starch. The rhizoma Zingiberis has effects in dilating blood vessel, promoting blood circulation, and tonifying heart. In addition, the dried ginger also has the functions of resisting bacteria and diminishing inflammation and promoting the immunity of organisms.

Endothelium corneum Gigeriae Galli: sex taste and meridian tropism: sweet and flat. Enter spleen, stomach, small intestine and bladder meridians. Efficacy: stomach invigorating, digestion promoting, nocturnal emission stopping, stranguria treating, and calculus removing effects. The main indications are: 1. the food stagnation is not eliminated, vomiting and diarrhea, infantile malnutrition 2, seminal emission, enuresis 3, stranguria with stone, distending and hypochondrium pain. Pharmacological action: digestive enzymes function, promote secretion of digestive juice, regulate gastrointestinal movement, reduce blood lipid, anticoagulate blood, improve hemorheology, promote excretion, reduce blood sugar, and resist hyperplasia of mammary glands, and is an essential drug for treating spleen and stomach transportation and transformation.

Raw pinellia ternate: pungent and warm. Is toxic. Enter spleen, stomach and lung meridians. Efficacy: eliminating dampness and phlegm, lowering adverse qi, relieving vomiting, relieving distension and fullness, and resolving hard mass; external use detumescence and pain relieving. Pharmacological action: has effects in relieving cough, relieving emesis, regulating gastrointestinal function, promoting bile flow, resisting cancer, and resisting early pregnancy.

Bombyx Batryticatus: salty, pungent and flat taste; it enters liver, lung and stomach meridians. Efficacy: calm wind and stop spasm, dispel wind and stop pain, dispel wind and stop itching, resolve phlegm and dissipate nodulation. The main indications are: can be used for treating convulsion, facial distortion, headache, conjunctival congestion, laryngopharynx swelling and pain, eruption, pruritus, scrofula, and phlegm nodule. Pharmacological action: reducing blood sugar, hypnotizing, anticonvulsant, anticoagulation, antibacterial and anticancer effects.

Vinegar bupleurum root: sex taste: bitter and slightly cold. Channel tropism: it enters liver and gallbladder meridians. Efficacy: relieving exterior and interior syndrome, soothing liver and raising yang. Can be used for treating common cold, fever, distending pain in chest and hypochondrium, menoxenia, prolapse of sub-organ, and rectocele. Pharmacological action: antipyretic, antiinflammatory, and immunostimulant effects.

Radix Scutellariae Baicalensis: sex flavor meridian tropism: bitter in flavor due to cold in nature, enters lung, gallbladder, spleen, large intestine and small intestine meridians. Efficacy: drying dampness, purging pathogenic fire, clearing heat, removing toxic substances, stopping bleeding, and preventing miscarriage. The function is as follows: is suitable for summer-heat and dampness, damp-heat distention and fullness, chest distress, vomiting, diarrhea, jaundice, high fever polydipsia, cough due to lung heat, carbuncle, sore and toxic swelling, and fetal irritability. Pharmacological action: antipathogenic, antiinflammatory, immunity regulating, antipyretic, tranquilizing, liver protecting, and gallbladder function promoting effects.

Vinegar rhizoma Cyperi: xin Wei it is bitter and sweet in flavor and neutral in nature. It enters lung meridian, liver meridian, spleen meridian, stomach meridian and triple energizer meridian. Efficacy: regulate qi and resolve depression, regulate menstruation and relieve pain. The main indications are: liver depression and qi stagnation, chest and hypochondrium pain, abdominal distention and pain, dyspepsia, irregular menstruation, amenorrhea and dysmenorrhea, cold hernia and abdominal pain, and breast pain. Pharmacological action: regulating menstruation, relieving pain, resisting bacteria, relieving fever, cooling, relieving inflammation, protecting bronchus, relieving emesis, tranquilizing, lowering blood pressure, tonifying heart, and slowing heart rate.

Radix aucklandiae: bitter in flavor, enters spleen, large intestine and triple energizer meridians. Has effects of activating qi-flowing, invigorating spleen, resolving food stagnation, and relieving pain, and can be used for treating chest pain, diarrhea, sudden deafness, snake and insect bite, nausea and emesis, etc. Pharmacological action: has effects in protecting gastric mucosa, relieving inflammation and pain, regulating gastrointestinal motility, promoting gallbladder function, inhibiting pathogenic microorganism, and resisting tumor.

Fructus Amomi: pungent and warm nature, enter spleen, stomach and kidney meridians. Efficacy: resolving dampness, stimulating appetite, warming spleen, relieving diarrhea, regulating qi-flowing, and preventing miscarriage. The main indications are: syndrome of damp obstruction of middle energizer, syndrome of qi stagnation of spleen and stomach, deficiency-cold of spleen and stomach, vomiting and diarrhea, vomiting of pregnancy and restlessness of fetal movement. Pharmacological action: enhancing gastrointestinal motility, promoting gastric secretion, lowering blood sugar, relieving ulcer, relieving diarrhea, promoting bile flow, relieving inflammation, inhibiting bacteria, and relieving pain.

Radix rehmanniae: sweet, bitter and cold. It enters heart, liver and kidney meridians. The functions are as follows: cooling blood, clearing heat, nourishing yin, tonifying kidney, promoting salivation, quenching thirst, and is commonly used for treating syndrome of heat entering nutrient-blood, bone-steaming tuberculosis heat, throat pain due to dryness, phlegm with blood, etc. Pharmacological action: has radioprotective, liver protecting, blood sugar lowering, heart strengthening, hemostatic, diuretic, and antifungal effects, and can be used for treating various diseases.

Sweet potato pulp: sour and astringent taste, mild nature, and efficacy of invigorating liver and kidney meridian: tonify liver and kidney, astringe and arrest spontaneous emission. The main indications are: deficiency of liver and kidney, soreness of waist and knees, spermatorrhea, enuresis, metrorrhagia, diabetes, and excessive sweating. Pharmacological action: fructus Corni has effects of lowering blood sugar, reducing blood lipid, enhancing immunity, resisting arrhythmia, resisting aging, resisting oxidation, relieving inflammation, relieving spasm, and resisting bacteria.

Cortex moutan radicis): pungent, bitter and cool in flavor. Channel tropism: mainly enter heart, liver and kidney meridians. Efficacy: clearing heat, cooling blood, harmonizing blood and removing blood stasis. The main indications are: heat entering blood system, spots, convulsion, cough, epistaxis, hematochezia, bone steaming and fever, night sweat due to yin deficiency, amenorrhea, abdominal mass, carbuncle, ulcer, traumatic injury, etc. Modern clinic is mainly used for treating hypertension or allergic rhinitis. Pharmacological action: clearing heat, activating blood, removing stasis, cooling blood, calming, hypnotizing, reducing blood pressure, resisting bacteria, dredging channels and relieving pain.

Leech: salty in property, has little toxicity, is liver meridian, mainly has the effects of activating blood, breaking blood and removing obstruction in collaterals, and can be used for treating hypertension, apoplexy, amenorrhea and traumatic injury clinically, and has pharmacological effects: has good curative effect on resisting cancer and preventing and treating cardiovascular and cerebrovascular diseases, and can also play an antithrombotic role.

Ligusticum wallichii: sex flavor meridian tropism: pungent taste and warm nature; enter liver, gallbladder and pericardium meridians. Is suitable for: 1. promoting blood circulation and activating qi-flowing, and treating menoxenia, amenorrhea, dysmenorrhea, puerperal abdominal pain, chest pain, abdominal mass, hypochondrium pain, traumatic injury, swelling and pain due to blood stasis and qi stagnation, limb numbness, and sore and ulcer swelling and pain; 2. dispelling wind and relieving pain, and treating headache and rheumatalgia. Pharmacological action: (1) an anti-vitamin E deficiency effect. (2) Ligustrazine can dilate coronary artery, increase coronary blood flow, improve blood oxygen supply to myocardium, and reduce oxygen consumption of myocardium. (3) Ligusticum wallichii can reduce the surface activity of blood platelets, inhibit the aggregation of blood platelets and prevent thrombosis. (4) Ligustrazine can dilate cerebral vessels, reduce vascular resistance, remarkably increase cerebral and limb blood flow, and improve microcirculation. (5) Ligusticum wallichii can accelerate absorption of local hematoma of fracture and promote porosis. (6) The neutral component of ferulic acid contained in rhizoma Ligustici Chuanxiong is promoted in small dose, and the large dose inhibits uterine smooth muscle. (7) The decoction of rhizoma Ligustici Chuanxiong has tranquilization effect on animal central nervous system, and has obvious and durable blood pressure lowering effect. (8) Ligusticum wallichii can inhibit a variety of bacilli. (9) Ligusticum chuanxiong Hort has antihistaminic and cholagogic effects.

Cortex Phellodendri: bitter and cold in nature. Efficacy: clearing heat and drying dampness, purging fire and removing steam, and detoxicating and treating sore. Can be used for treating damp-heat dysentery, jaundice, leukorrhagia, stranguria due to heat, tinea pedis, flaccidity, bone steaming, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, and eczema and pruritus. Salted phellodendron bark, cortex Phellodendri, radix Phellodendri, has the effect of nourishing yin to reduce pathogenic fire. Pharmacological action: has effects in resisting pathogenic microorganism, relieving inflammation, inhibiting immunity, lowering blood pressure, resisting oxidation, and resisting gout.

Cinnamon: pungent, sweet and severe heat property is attributed to kidney, spleen, heart and liver meridians. Efficacy: tonify fire and strengthen yang, dispel cold and alleviate pain, warm meridians and promote blood circulation, and activate fire to return to primordial energy. Can be used for treating various diseases caused by kidney-yang deficiency clinically. Can also be used for treating various diseases caused by cold coagulation stagnation. Pharmacological action: has the effects of dilating blood vessel, promoting blood circulation, increasing coronary blood flow and cerebral blood flow, relieving myocardial ischemia, inhibiting platelet aggregation, protecting gastric mucosa, resisting ulcer, tranquilizing mind, and relieving pain

Cooked puerh tea: mild in nature and brown-red. Efficacy: nourishing stomach, protecting stomach, warming stomach, regulating blood, reducing blood lipid, reducing blood glucose, lowering blood pressure, and resisting arteriosclerosis. Pharmacological action: 1. reducing blood lipid and weight; 2. Cancer prevention and anticancer; 3. nourishing and protecting stomach; 4. tooth care and tooth protection; 5. diminishing inflammation, sterilizing and treating dysentery; 6. anti-aging; 7, treating cardiovascular and cerebrovascular diseases, hypertension, coronary heart disease, high fat, diabetes, depression, leukoencephalopathy, parkinson disease, climacteric syndrome, osteoporosis, and intracranial tumor after operation.

The prescription and the dosage are the key of curing the disease in traditional Chinese medicine, and meanwhile, the application also reuses the monarch drug, breaks through the conventional dosage limit, uses the monarch drug with weight, and realizes the treatment effects of quick disease reduction, quick blood glucose reduction and short treatment course. The pharmaceutical composition for treating diabetes can be in the form of decoction, powder, tea and other conventional medicaments according to actual conditions. The application is further illustrated in decoction in powder form in the following examples to demonstrate the effectiveness of the application.

Example 1 please refer to fig. 1 at the same time:

Telephone: XXXXXX visit time: 2019, 5 months 2

Address: building No. 3-401 in XXX district XXX of Jin Fengou XXXX district of Ningxia Yinchuan

Work unit: ningxia XXXX company staff

Past history of disease: qi deficiency, cold limbs, love sweating.

Inquiry: complaints of: recently thirsty, especially loving to drink water, sweating is much, and examination finds that the blood sugar is higher and the blood sugar is 6.7 on an empty stomach. Thin stool, yellow urine, thin leucorrhea, and a large amount of urine. Poor appetite and insufficient sleep.

Inspection: yellow complexion, dark circles, dry and cracked lips, red tongue and thin and white tongue fur.

Smell diagnosis: the speaking sound is low, the people are weak and sweats are much.

And (5) diagnosis: the pulse is thin and weak.

Dialectical: deficiency of both qi and yin.

The treatment method comprises the following steps: tonify qi, nourish yin, and regulate yin and yang.

The prescription comprises the following components: 50 parts of astragalus membranaceus, 30 parts of codonopsis pilosula, 30 parts of roasted rhizoma polygonati, 60 parts of radix trichosanthis, 30 parts of wild pueraria, 20 parts of coptis chinensis, 10 parts of rhizoma atractylodis, 30 parts of raw yam, 10 parts of semen euryales, 5 parts of dried ginger, 30 parts of endothelium corneum gigeriae galli, 10 parts of raw pinellia ternate, 10 parts of silkworm larva, 10 parts of vinegar radix bupleuri, 10 parts of radix scutellariae, 10 parts of vinegar rhizoma cyperi, 10 parts of elecampane, 5 parts of fructus amomi, 30 parts of radix rehmanniae, 30 parts of wine sweet potato pulp, 20 parts of cortex moutan, 5 parts of leech, 15 parts of ligusticum wallichii, 10 parts of salted cortex phellodendri, 10 parts of cinnamon and 10 parts of cooked puer tea.

Doctor's advice: the 14 doses are decocted in water, and one dose is taken every day, and 250 ml is taken at half an hour after breakfast and supper. Smoke and wine are prohibited, and Xin Laila food is also provided.

Two diagnoses: the symptoms are relieved, but the people have much sweat, and fourteen doses are taken without changing the original prescription.

Three diagnoses: symptoms disappeared and blood glucose stabilized (fasting blood glucose 5.6). The three pairs of the powder are taken with water for one month, the treatment is consolidated, and the powder is taken with ten grams of warm boiled water twice a day.

Example 2 please refer to fig. 2 at the same time:

Telephone: XXXXXX visit time: 2020, 6 and 3

Address: ningxia Yinchuan XX district XX building 4-501

Work unit: XX property company staff

Past history of disease: qi and blood deficiency and blood stasis spots on the legs.

Inquiry: complaints: recently, thirst, dry mouth and frequent urination have occurred, and the examination has found that blood sugar is high and blood sugar is 6.5 on an empty stomach. The stool is not shaped.

White bands yellow. Restlessness. Can be eaten, and has stomach pain and swelling.

2. Inspection: emaciation, no spirit, fast walking, red tongue with yellow and greasy coating and blood stasis in sublingual veins.

3. Smell diagnosis: low speaking voice, weak qi and breath.

4. And (5) diagnosis: the left pulse is rapid, astringent and powerless.

Diagnosis: deficiency of both qi and yin and diabetes.

The treatment method comprises the following steps: has effects of invigorating qi, nourishing yin, promoting blood circulation, and removing blood stasis.

The prescription comprises the following components: 30 parts of astragalus membranaceus, 30 parts of codonopsis pilosula, 30 parts of roasted rhizoma polygonati, 60 parts of radix trichosanthis, 30 parts of wild pueraria, 20 parts of coptis chinensis, 10 parts of rhizoma atractylodis, 30 parts of raw rhizoma dioscoreae, 10 parts of semen euryales, 5 parts of dried ginger, 30 parts of endothelium corneum gigeriae galli, 10 parts of raw pinellia ternate, 10 parts of white stiff silkworm, 10 parts of vinegar radix bupleuri, 10 parts of radix scutellariae, 10 parts of vinegar rhizoma cyperi, 10 parts of radix aucklandiae, 5 parts of fructus amomi, 30 parts of radix rehmanniae, 20 parts of wine sweet potato pulp, 20 parts of cortex moutan, 10 parts of leech, 20 parts of rhizoma ligustici wallichii, 20 parts of salted cortex phellodendri, 10 parts of cinnamon and 10 parts of cooked puer tea

And (5) re-diagnosis: the symptoms are relieved, and the original prescription is not changed. And 14 doses were taken.

Three diagnoses: the hospital checks for fasting blood glucose 5.5. The three preparations are taken according to the original prescription by powdering and taking 10 g of warm water respectively in the morning and evening for consolidation therapy.

Example 3 please refer to fig. 3 at the same time:

Telephone: XXXXXX visit time: 2020, 6 th month and 6 th

Address: ningxia Yinchuan XX district

Occupation: company is always.

Past history of disease: deficiency of both the spleen and the kidney,

inquiry: complaints: the food has small meal, and after eating, the bellybutton is distended, the urine is frequent, the food has foam, has great taste and has the effect of fasting blood sugar of 6.8. White with taste and yellow color.

Inspection: the eyes have no spirit, fatigue and weakness, pale complexion, red tongue with yellow and greasy coating and tongue surface with ecchymosis.

Smell diagnosis: low speaking voice and heavy breath.

And (5) diagnosis: the left pulse is rapid and astringent.

Dialectical: spleen and kidney deficiency, damp turbidity stopping internally, and heat transforming into depression. Diagnosis: diabetes due to spleen and kidney deficiency.

The treatment method comprises the following steps: warming and invigorating spleen yang, strengthening spleen and removing dampness, ascending clear and descending turbid, and clearing heat and detoxicating.

The prescription comprises the following components: 50 parts of astragalus membranaceus, 30 parts of codonopsis pilosula, 30 parts of roasted rhizoma polygonati, 60 parts of radix trichosanthis, 30 parts of wild pueraria, 30 parts of coptis chinensis, 10 parts of rhizoma atractylodis, 30 parts of raw rhizoma dioscoreae, 10 parts of semen euryales, 5 parts of dried ginger, 30 parts of endothelium corneum gigeriae galli, 10 parts of raw pinellia ternate, 20 parts of white stiff silkworm, 15 parts of vinegar radix bupleuri, 15 parts of radix scutellariae, 15 parts of vinegar rhizoma cyperi, 10 parts of radix aucklandiae, 5 parts of fructus amomi, 30 parts of radix rehmanniae, 20 parts of wine sweet potato flesh, 20 parts of cortex moutan, 0 part of leech, 20 parts of rhizoma ligustici wallichii, 20 parts of salted cortex phellodendri, 10 parts of cinnamon and cooked puer tea

And (5) re-diagnosis: symptoms were reduced, fasting blood glucose 7.0. The original prescription is unchanged, and 14 doses are taken again.

Three diagnoses: the symptoms substantially disappeared. Fasting blood glucose 6.1. The original prescription is unchanged, and 14 doses are taken again.

Four diagnostic methods: the disorder disappeared. Stable blood sugar, fasting blood sugar 6.0. The original prescription is unchanged, and then three doses of powder are taken for consolidation treatment for one month, and the treatment is carried out in the morning and evening every day

Each time, ten grams of warm boiled water is taken after being infused with water each time.

Example 4 please refer to fig. 4 at the same time:

name: poplar XX birth time: sex number 20 6 months 1969: age of men: age of 48 years

Telephone: XXXXXX visit time: 2019, 10 th and 15 th

Address: ningxia Yinchuan XX work unit: the company's office is always in charge of,

inquiry: past history of disease: familial hereditary diabetes. Complaints: thirst, frequent urination, gastric fire, constipation, unstable blood sugar, and sometimes abdominal blood sugar of 7.8-16. Father dies from diabetes. The patients enjoy 62 years old, have ten years of diabetes, unstable blood sugar and sometimes have hypoglycemia, sometimes have seventeen or eight postprandial blood sugar, have serious constipation, have one stool every three or two days, and have foam urine.

Inspection: the emaciation is obvious, the tongue is red and has cracks, the sublingual vein is angry and tense, the tongue coating is yellow and greasy, the eye is black, and the tongue is fat.

Smell diagnosis: low sound and weak qi. Has the taste of rotten apples.

And (5) diagnosis: the left pulse is deep, astringent and weak.

Dialectical: deficiency of both yin and yang

Diagnosis: diabetes due to deficiency of both yin and yang.

The treatment method comprises the following steps: qi-tonifying, yin-nourishing, blood-activating, meridian-dredging, ascending and descending turbid urine, and yin-yin regulating

The prescription comprises the following components: 30 parts of astragalus membranaceus, 30 parts of codonopsis pilosula, 30 parts of roasted rhizoma polygonati, 80 parts of radix trichosanthis, 30 parts of wild arrowroot, 40 parts of coptis chinensis, 10 parts of rhizoma atractylodis, 30 parts of raw Chinese yam, 10 parts of semen euryales, 5 parts of dried ginger, 30 parts of endothelium corneum gigeriae galli, 10 parts of raw pinellia ternate, 20 parts of silkworm larva, 20 parts of vinegar-processed radix bupleuri, 20 parts of radix scutellariae, 10 parts of vinegar-processed nutgrass galingale rhizome, 10 parts of elecampane, 5 parts of fructus amomi, 30 parts of radix rehmanniae, 30 parts of wine sweet potato pulp, 30 parts of cortex moutan, 5 parts of leech, 20 parts of ligusticum wallichii, 20 parts of salted cortex phellodendri, 10 parts of cinnamon and cooked puer tea.

And (5) re-diagnosis: blood sugar no longer fluctuates, fasting blood sugar is about 7.8, the original prescription is not changed, and 14 pairs of the medicine are taken.

Three diagnoses: stable blood sugar, fasting blood sugar of 6.5, and improved above symptoms. The original prescription is not changed to take 14 doses.

Four diagnostic methods: the symptoms are basically eliminated, people are relatively mental, the fasting blood glucose is about 6.2, the original prescription is unchanged, and 14 doses are taken.

Five diagnostic methods: the basic symptoms disappear. Fasting blood glucose 5.3-6.0. Then, the seven pairs of powder preparation are grasped for consolidating the treatment for two months for a long time, and then telephone consultation is carried out: the basic symptoms of diabetes disappear, the quality of life is improved, and the blood sugar is stable.

Example 5 please refer to fig. 5:

Telephone: XXXXXX visit time: 2022, 5, 28

Address: ningxia Pingro county XX district working unit: the boss of the supermarket,

inquiry: history of past illness; hyperlipidemia, complaints: recently, thirst and frequent urination, 6.3 on fasting blood glucose, dry stool and yellow urine are detected. Wet weight, leg weight.

Inspection: the people have weakness, lack of essence, fat people, red tongue, yellow and greasy tongue coating and watery tongue surface. The tongue is inflated.

Smell diagnosis: the speaking sound is heavy and the breath is heavy. Heavy body taste.

Cutting: the pulse is deep, slippery and weak, dialectical: qi and yin are impaired, and spleen is not healthy.

The treatment method comprises the following steps: qi-tonifying and yin-nourishing, spleen-invigorating and diuresis-inducing effects

The prescription comprises the following components: 60 parts of astragalus membranaceus, 30 parts of codonopsis pilosula, 30 parts of roasted rhizoma polygonati, 60 parts of radix trichosanthis, 30 parts of wild pueraria, 20 parts of coptis chinensis, 20 parts of rhizoma atractylodis, 30 parts of raw Chinese yam, 10 parts of semen euryales, 5 parts of dried ginger, 30 parts of endothelium corneum gigeriae galli, 10 parts of raw pinellia ternate, 10 parts of silkworm larva, 10 parts of vinegar radix bupleuri, 10 parts of radix scutellariae, 10 parts of vinegar rhizoma cyperi, 10 parts of costustoot, 5 parts of fructus amomi, 30 parts of radix rehmanniae, 20 parts of wine sweet potato pulp, 20 parts of peony, 5 parts of leech, 15 parts of ligusticum wallichii, 20 parts of salted cortex phellodendri, 10 parts of cinnamon and cooked puer tea.

And (5) re-diagnosis: people also feel mental and relieve constipation. The original prescription is not changed and 14 doses are taken.

Three diagnoses: fasting blood glucose 5.6. The basic symptoms are relieved, and the three preparations are taken for one month in the morning and evening after powder preparation and consolidation treatment, and are taken with 10 g of warm water.

The foregoing disclosure is illustrative of the preferred embodiments of the present application, and is not to be construed as limiting the scope of the application, as it is understood by those skilled in the art that all or part of the above-described embodiments may be practiced with equivalents thereof, which fall within the scope of the application as defined by the appended claims.

Claims

1. A pharmaceutical composition for treating diabetes, which is characterized in that: the traditional Chinese medicine is prepared from the following traditional Chinese medicine raw materials in parts by weight: 30-120 parts of astragalus membranaceus, 30-50 parts of codonopsis pilosula, 30-50 parts of roasted rhizoma polygonati, 60-120 parts of radix trichosanthis, 30-50 parts of wild arrowroot, 30-50 parts of rhizoma coptidis, 10-30 parts of rhizoma atractylodis, 30-80 parts of raw rhizoma dioscoreae, 10-30 parts of semen euryales, 5-20 parts of dried ginger, 30-60 parts of chicken gizzard-skin, 10-30 parts of raw pinellia ternate, 10-30 parts of silkworm larva, 10-30 parts of vinegar radix bupleuri, 10-30 parts of radix scutellariae, 10-30 parts of vinegar-nutgrass galingale rhizome, 10-30 parts of costustoot, 5-20 parts of fructus amomi, 30-80 parts of radix rehmanniae, 20-80 parts of wine sweet potato pulp, 20-50 parts of cortex moutan, 5-20 parts of leech, 15-30 parts of ligusticum chuanxiong, 10-30 parts of salted cortex phellodendri, 10-30 parts of cinnamon and 10 parts of cooked puerh tea.

2. The pharmaceutical composition for treating diabetes of claim 1, wherein: the astragalus root, the codonopsis pilosula, the rhizoma polygonati, the coptis chinensis, the kudzuvine root and the radix trichosanthis are taken as monarch drugs, and the monarch drugs are utilized to tonify qi of the five viscera, tonify the kidney and replenish essence, strengthen the spleen and strengthen the body resistance, promote the production of body fluid to quench thirst and tonify both qi and blood so as to activate islet cells and restore the normal functions of the islets; the rhizoma atractylodis, chinese yam, gorgon fruit, dried ginger, chicken's gizzard-skin, raw pinellia tuber, stiff silkworm, vinegar-processed bupleurum, baical skullcap root, vinegar-processed nutgrass galingale rhizome, costustoot and villous amomum fruit are used as ministerial drugs, and the ministerial drugs are utilized to warm kidney, arrest semen, raise clear and lower turbid, dry dampness, invigorate spleen, sooth liver, regulate qi, enhance the transportation capability of intestines and stomach, invigorate the acquired and strengthen congenital, so that the intestines and stomach system recovers normal transportation function, dredges the whole body qi movement and promotes sugar metabolism; the dried rehmannia root, sweet potato pulp, cortex moutan, leech, szechuan lovage rhizome, amur corktree bark, cassia bark and cooked puerh tea are used as an adjuvant, the dried rehmannia root, sweet potato pulp, the cortex moutan, leech, szechuan lovage rhizome, amur corktree bark and cassia bark in the adjuvant are utilized to generate blood, promote blood circulation, cool blood, harmonize blood, remove meridian obstruction, remove deficiency fire, lead the fire to return to the origin, tonify liver and blood, tonify heart and spleen and kidney, strengthen kidney, so as to promote blood microcirculation, enable blood sugar to be directly supplied to cells, and the cooked puerh tea in the adjuvant is utilized to nourish stomach and liver, reduce blood fat and blood sugar and enhance the transportation and transformation capacity of intestines and stomach.

3. The pharmaceutical composition for treating diabetes of claim 2, wherein: the principal drugs are reused to achieve the whole recipe and improve the effect of reducing blood sugar.