CN116650376A

CN116650376A - Herbal antibacterial shampoo preparation with anti-dandruff and antipruritic effects and preparation and use methods thereof

Info

Publication number: CN116650376A
Application number: CN202310647623.7A
Authority: CN
Inventors: 李现锋; 马道品; 王应琛; 蔡翠平; 赵飞; 徐云良
Original assignee: Zhongzhi Shandong Biotechnology Co ltd
Current assignee: Zhongzhi Shandong Biotechnology Co ltd
Priority date: 2023-05-31
Filing date: 2023-05-31
Publication date: 2023-08-29

Abstract

The invention discloses a herbal antibacterial shampoo preparation with anti-dandruff and antipruritic effects, and a preparation method and a use method thereof, belonging to the technical field of Chinese herbal medicine shampoo preparations. The preparation is prepared from pure Chinese herbal medicine plant extracts, raw materials of cacumen Platycladi, radix Scutellariae, radix Sophorae Flavescentis, radix Paeoniae and herba Menthae belong to medicinal grade, and the raw materials are combined to obtain a product with specific active ingredients, wherein the product does not contain any preservative. The preparation is based on the concept of 'whole, syndrome differentiation and synthesis' in traditional Chinese medicine, and has the main effects of cooling blood, stopping bleeding, promoting hair growth, blackening hair, cooling blood, promoting qi circulation, dispelling wind-damp and eliminating swelling toxin. The herb has bitter and cold nature, bitter and can dry dampness, cold and heat, clear heat and purge fire, detoxify and resist bacteria, has obvious external antibacterial and anti-bacterial effects, and has the effects of astringing yin and relieving sweat, suppressing liver yang, promoting eruption and relieving exterior syndrome, and resisting bacteria.

Description

Herbal antibacterial shampoo preparation with anti-dandruff and antipruritic effects and preparation and use methods thereof

Technical Field

The invention belongs to the technical field of Chinese herbal medicine shampoo preparations, and in particular relates to an herbal antibacterial shampoo preparation with anti-dandruff and antipruritic effects and a preparation method and a use method thereof.

Background

Under the influence of internal factors such as greasy diet, high anxiety and pressure and external factors such as frequent dyeing and scalding, inadequately nursing and the like, the hair health and scalp ecology of the national people are affected to different degrees, so that the problems such as dandruff, scalp itching, alopecia and the like become the most common hair trouble. Besides the common problems of dandruff, greasy hair and the like, the scalp is sensitive and dry, and meanwhile, the scalp is red and itchy; in the face of the endless scalp problem, consumers have developed a strong sense of scalp care products, and nearly nine-adult consumers know about scalp care products, most of which have been or are being used.

The current plagues include: more dandruff, greasy scalp, and thin and soft hair are popular scalp annoyances for consumers and are eager to seek improvement. In addition, the scalp is vulnerable, easy to break, itching and redness and the like.

The existing products are mostly products prepared from pure raw materials, for example: a scalp composition for scalp hair 1+1 cleaning and a preparation method thereof, the composition comprises water and the following components in parts by weight: disodium lauryl sulfosuccinate, cocamide MEA, cocamidopropyl betaine, glycerol, glyceryl stearate, propylene glycol, polyquaternium-7, acrylic copolymers, sodium chloride, PEG-120 methylglucdioleate, PEG-7 glycerocococoate, PPG-3 octyl ether, guar hydroxypropyl trimethyl ammonium chloride, polyquaternium-10, fragrances, plant functional components, preservatives, citric acid, panthenol, sodium hydroxide, DMDM hydantoin, menthol, witch hazel extract, aloe vera extract, nicotinamide, tocopheryl acetate, pyridoxine HCl, piroctone olamine, allantoin, and EDTA-disodium. The composition can effectively remove dirt and grease on scalp and promote hair follicle growth. However, the long-term use of purely chemical shampoos can affect the balance of the epidermis and the hair quality, further damage the scalp health, cause the generation of more dandruff, and also destroy the secretion performance of scalp cells.

Disclosure of Invention

The invention provides a herbal antibacterial shampoo preparation with anti-dandruff and antipruritic effects, which is prepared from pure Chinese herbal medicine plant extracts, wherein the sources of raw materials belong to medicinal grade, and the product with specific active ingredients is obtained after the raw materials are combined, and does not contain any preservative.

The second aim of the invention is to provide a herbal antibacterial shampoo with the efficacy of removing dandruff and relieving itching, which takes the whole, dialectical and comprehensive ideas of traditional Chinese medicine as guidance, and achieves the comprehensive, healthy and comprehensive anti-dandruff and antipruritic effects by stopping bleeding and cooling blood (blood heat recklessly flowing), growing and blackening hair, clearing heat and drying dampness (killing parasites and relieving itching, inhibiting bacteria and resisting bacteria), astringing yin and relieving sweat, stabilizing liver yang, promoting eruption and relieving exterior syndrome.

The third aim of the invention is to provide a preparation method of herbal antibacterial shampoo with anti-dandruff and antipruritic effects, which uses Chinese herbal medicine plants with Chinese characteristics and adopts the modern clinical technology of traditional Chinese medicine to obtain a pure natural product, thereby reducing the loss of active ingredients in the production process and being easy to store and transport.

The invention is realized by the following technical scheme:

an herbal antibacterial shampoo preparation with anti-dandruff and antipruritic effects is mainly prepared from the following raw materials in parts by weight:

20-40 parts of cacumen biotae extract, 20-40 parts of radix scutellariae extract, 10-30 parts of radix sophorae flavescentis extract, 3-15 parts of radix paeoniae alba extract and 3-15 parts of mint extract.

The compatibility of the above formula solves the scalp itch problem by analyzing the way: cooling blood, stopping bleeding, promoting hair growth, blackening hair, cooling blood, promoting qi circulation, dispelling pathogenic wind, removing dampness, and relieving swelling. The herb has bitter and cold nature, bitter and damp-eliminating property, heat-clearing and fire-purging property, detoxification and antibiosis, and has obvious external bacteriostasis and antibiosis effects. Astringing yin to stop sweating, and suppressing liver yang. Promoting eruption, relieving exterior syndrome, resisting bacteria and relieving pain.

Wherein, arborvitae She Bencao is taken as a monarch drug, and can cool blood and stop bleeding, promote hair growth and blacken hair, and the arborvitae twig can increase skin blood flow; has effects of inhibiting Staphylococcus aureus, escherichia coli and virus, and has certain antiseptic effect. The preparation has the effects of inhibiting sebum secretion, resisting inflammation in a broad spectrum, clearing heat and drying dampness, eczema and eczema, skin itch, scabies and leprosy, sterilizing and dispelling itch, and drying dampness and promoting diuresis. Paeonia lactiflora is taken as an adjuvant drug to astringe yin and arrest sweating, and calm liver yang; herba Menthae is used as a guiding drug for dispelling wind-heat, clearing head and eyes, promoting eruption, soothing liver, promoting qi circulation and relieving pain.

Preferably, the shampoo preparation is mainly prepared from the following raw materials in parts by mass:

30 parts of cacumen biotae extract, 30 parts of radix scutellariae extract, 20 parts of radix sophorae flavescentis extract, 10 parts of radix paeoniae alba extract and 10 parts of mint extract.

24 parts of cacumen biotae extract, 23 parts of radix scutellariae extract, 8 parts of radix sophorae flavescentis extract, 10 parts of radix paeoniae alba extract and 3 parts of mint extract.

The cacumen Platycladi extract has effects of preventing alopecia and inhibiting bacteria.

Radix Scutellariae extract has sebum secretion inhibiting effect, and also has antiallergic effect: the inhibition rate of 0.6mg/mL to histamine release is 75.6%; anti-inflammatory efficacy: the inhibition of the activation of luciferase and NF-B cell activity by the extract shows that the extract of radix scutellariae has the effects of inhibiting dermatitis and enhancing the resistance of skin, has anti-inflammatory property, can improve the immune function of skin and inhibit sebum secretion; the promotion of ceramide production by the extract shows that the extract can improve sebum composition and make skin more soft; and has effects in inhibiting sebum secretion, moistening skin, and promoting hair growth.

The kuh-seng extract has broad-spectrum anti-inflammatory activity, and has the functions of anti-allergy and anti-inflammatory: inhibition of interleukin IL-2 secretion by 100umol/L matrine 23%; inhibition of interleukin IL-6 secretion by 10ug/ml matrine 34.6%; inhibition of interleukin IL-8 secretion by 10ug/ml matrine 22%; antibacterial: the broad-spectrum antibacterial performance and MIC (antibacterial drug concept index) are 25-50mg/mL.

Paeonia lactiflora extract, paeoniflorin in Paeonia lactiflora has effects of relieving fever, relieving pain, and tranquilizing; polyphenols such as paeonol have effects of resisting platelet aggregation, resisting thrombosis, relieving myocardial ischemia, improving microcirculation, resisting oxidation, and regulating immunity. Paeonia lactiflora has antibacterial and antiallergic effects. Antibacterial: has inhibiting effect on various tinea bacteria, and can be used for preventing and treating tinea cutanea; the inhibition rate of 1% concentration to tooth decay bacteria is 100%; anti-inflammatory: 2.5g/kg paeoniflorin mouse test to inhibit interleukin IL-2 production by 34.4%;2.5g/kg paeoniflorin mouse test to inhibit interleukin IL-6 generation by 24.8%;2.5g/kg paeoniflorin mouse test promotes interleukin IL-10 generation by 80.2%; paeoniflorin inhibits NF-kB cell activity by 53.2%.

Herba Menthae extract has antibacterial, pore shrinking, and tanning effects. Antibacterial: the peppermint oil has antibacterial and bactericidal effects, and has good inhibition effects on bacillus subtilis, acne bacillus, staphylococcus saprophyticus, staphylococcus aureus and the like, for example, the MIC on bacillus subtilis is 0.5mg/mL. Other: can also be used as antioxidant, anti-inflammatory agent, allergy inhibitor, blood vessel enhancer, hair growth promoter, skin conditioner and humectant.

A preparation method of herbal antibacterial shampoo with anti-dandruff and antipruritic effects comprises:

respectively selecting raw materials of cacumen Platycladi, radix Scutellariae, radix Sophorae Flavescentis, radix Paeoniae and herba Menthae, respectively pulverizing, decocting, and filtering to obtain cacumen Platycladi extract, radix Scutellariae extract, radix Sophorae Flavescentis extract, radix Paeoniae extract and herba Menthae extract;

selecting the biota orientalis leaf extract, the baical skullcap root extract, the lightyellow sophora root extract, the Chinese herbaceous peony extract and the mint extract according to the corresponding parts by weight, mixing, concentrating and drying to obtain a finished product.

Preferably, the raw material is crushed and sieved by a 200-800 mesh sieve.

Preferably, the decoction temperature is 90-100 ℃.

Preferably, the number of times of decoction is 1-2 times;

the decoction time is 60-120 min/time.

Preferably, the concentration is carried out by a double-effect vacuum low-temperature concentration technology.

Preferably, the drying is carried out using a high-speed centrifugal drying spray technique.

A method for using herbal antibacterial shampoo with anti-dandruff and antipruritic effects comprises mixing shampoo with an amount of 0.3wt% -3wt% to clean scalp and/or hair; preferably 0.5wt%.

The herbal antibacterial shampoo preparation has effects of removing dandruff and relieving itching, has a certain inhibition effect on scalp bacteria and fungi, and has therapeutic effect on scalp eczema pustule caused by liver yang hyperactivity and yin deficiency and fire heat.

Compared with the prior art, the invention has at least the following technical effects:

the invention provides a herbal antibacterial shampoo preparation with the effects of removing dandruff and relieving itching, which is prepared from pure Chinese herbal medicine plant extracts, wherein the sources of raw materials belong to medicinal grade, and the product with specific active ingredients is obtained after the raw materials are combined, and does not contain any preservative.

(II) taking biota orientalis She Bencao as a monarch drug, cooling blood, stopping bleeding, generating hair, blackening hair and increasing skin blood flow by biota orientalis leaves; has effects of inhibiting Staphylococcus aureus, escherichia coli and virus, and has certain antiseptic effect. The preparation has the effects of inhibiting sebum secretion, resisting inflammation in a broad spectrum, clearing heat and drying dampness, eczema and eczema, skin itch, scabies and leprosy, sterilizing and dispelling itch, and drying dampness and promoting diuresis. Paeonia lactiflora is taken as an adjuvant drug to astringe yin and arrest sweating, and calm liver yang; herba Menthae is used as a guiding drug for dispelling wind-heat, clearing head and eyes, promoting eruption, soothing liver, promoting qi circulation and relieving pain.

The shampoo preparation has the main effects of cooling blood, stopping bleeding, promoting hair growth, blackening hair, cooling blood, promoting qi circulation, dispelling wind-damp and eliminating swelling and toxin. The herb has bitter and cold nature, bitter and damp-eliminating property, heat-clearing and fire-purging property, detoxification and antibiosis, and has obvious external bacteriostasis and antibiosis effects. Astringing yin to stop sweating, and suppressing liver yang. Promoting eruption, relieving exterior syndrome, resisting bacteria and relieving pain.

The shampoo preparation takes the whole, dialectical and comprehensive ideas of traditional Chinese medicine as guidance, and achieves the comprehensive, healthy and comprehensive anti-dandruff and antipruritic effects through stopping bleeding and cooling blood (blood heat recklessly flowing), growing and blackening hair, clearing heat and drying dampness (disinfestation and antipruritic, bacteriostasis and antibiosis), astringing yin and antiperspirant, suppressing liver yang, promoting eruption and relieving exterior syndrome.

And (V) the preparation method of the shampoo preparation adopts Chinese herbal medicine plants with Chinese characteristics, and adopts the modern clinical technology of traditional Chinese medicine to obtain a pure natural product, so that the loss of active ingredients is reduced in the production process, and the shampoo preparation is easy to store and transport.

Drawings

FIG. 1 is an initial state of an implementation use case;

fig. 2 shows a state of adding shampoo at 0.5wt% in example 3 for practical use.

Detailed Description

Embodiments of the present invention will be described in detail below with reference to the following examples, which are to be construed as merely illustrative and not limitative of the scope of the invention, but are not intended to limit the scope of the invention to the specific conditions set forth in the examples, either as conventional or manufacturer-suggested, nor are reagents or apparatus employed to identify manufacturers as conventional products available for commercial purchase.

Example 1:

the herbal antibacterial shampoo preparation with the anti-dandruff and antipruritic effects is prepared from the following raw materials in parts by weight:

200 g of cacumen biotae extract, 200 g of radix scutellariae extract, 100 g of radix sophorae flavescentis extract, 30 g of radix paeoniae alba extract and 30 g of mint extract.

Example 2:

400 g of cacumen biotae extract, 400 g of radix scutellariae extract, 300 g of radix sophorae flavescentis extract, 150 g of radix paeoniae alba extract and 150 g of herba menthae extract.

Example 3:

300 g of cacumen biotae extract, 300 g of radix scutellariae extract, 200 g of radix sophorae flavescentis extract, 100 g of radix paeoniae alba extract and 100 g of herba menthae extract.

Example 4:

240 g of cacumen biotae extract, 230 g of radix scutellariae extract, 80 g of radix sophorae flavescentis extract, 100 g of radix paeoniae alba extract and 30 g of mint extract.

The raw material is crushed and sieved by a 200-800 mesh sieve.

The decoction temperature is 90-100deg.C.

The decoction times are 1-2 times.

The decoction time is 60-120 min/time.

The concentration is treated by adopting a double-effect vacuum low-temperature concentration technology.

The drying is processed by adopting a high-speed centrifugal drying spray technology.

Experimental example:

based on example 3.

The formula configuration principle is as follows:

since there are many malassezia bacteria in hair follicles, hair loss is easy to cause, after primary inhibition and malassezia cleaning are carried out by utilizing cacumen biotae and radix sophorae flavescentis, the hair loss can be effectively relieved, the baicalein of the radix scutellariae can effectively relieve itching, resist bacteria and diminish inflammation and promote hair growth, and the baicalein has spectrum antibacterial effect, and has inhibition effects on staphylococcus aureus, streptococcus hemolyticus, pseudomonas aeruginosa and various skin disease fungi with different intensities, wherein the inhibition effect on staphylococcus aureus and pseudomonas aeruginosa is strongest.

The shampoo preparation prepared in the embodiment 3 can effectively relieve itching, diminish inflammation and sterilize (the antibacterial efficiency of malassezia reaches more than 95%), reduce grease, effectively care scalp, improve scalp health and reduce dandruff. The scalp is clean and fresh after being used for one month.

And (3) verifying: anti-dandruff properties

Each user divides the hair into two sides by the forehead hairline, and two different shampoos are randomly used on each side, and the usage amount of the two shampoos is the same. During the test period, 0.5wt% of the shampoo preparation product prepared in example 3 was added to the test group shampoo; the control group was not added and was a blank control.

The outer package of the shampoo is the same, and double-blind treatment is carried out. The scalp dandruff condition was observed after the test once every three to four days, and was observed more than four times (half a month) in succession.

And (3) observing and evaluating indexes: the anti-dandruff efficacy evaluation method adopts an adhesive dandruff ten-grade evaluation method, and the specific indexes are as follows:

(1) Level 0: no dandruff;

(2) 1-2 stages: small pieces of powdery gray rough scales;

(3) 3-4 stages: small to medium chips;

(4) 5-6 grades: large thin pieces loosely associated with the scalp;

(5) 7-8 stages: an adhesive chip;

(6) 9-10 grades: white to yellow thicker scales that adhere tightly to the scalp.

And II, verification: antipruritic property

During the test period, 0.5wt% of the shampoo preparation product prepared in example 3 was added to the test group shampoo; the control group was not added and was a blank control.

The outer package of the shampoo is the same, and double-blind treatment is carried out. The test was performed every three to four days, and after the test, the scalp itching was observed, and the test was performed four times or more (half a month).

The evaluation of the antipruritic effect is carried out together with the verification, and a subject self-evaluation method is adopted, and the conventional method generally carries out grading statistics according to the degree of itching, and is divided into itching and non-itching results for convenience.

After the test, taking example 3 therein as an example, the dandruff scoring table on the control side and the test side before and after use is shown in Table 1, and the total number of test persons is 10.

The numbers in table 1 are the number of people corresponding to the scoring progression, tested once every four days.

Table 1 results of anti-dandruff performance test

Table 1 data shows: the shampoo with the content of 0.5% can be used for rapidly and effectively removing dandruff, the anti-dandruff rate of the shampoo containing 0.5% of the herbal antibacterial shampoo for one time reaches 80%, and the anti-dandruff rate of the shampoo after repeated use can reach 90%.

Similarly, taking example 3 as an example, the statistics of the head itch symptoms of the control side and the test side before and after use are shown in table 2, the total number of the tested people is 10, the number in table 2 is the number of the corresponding items, and the test is carried out once every four days.

Table 2 antipruritic test results

Table 2 data shows: the shampoo added with 0.5% of the herbal antibacterial shampoo can obviously reduce the itching symptom, the itching relieving effective rate of the shampoo which is used once and contains 0.5% of the herbal antibacterial shampoo reaches 80%, and the itching relieving effective rate of the shampoo which is repeatedly used can reach 90%.

Specific implementation use cases:

take example 3 therein as an example. Figure 1 is a graph of the scalp surface and hair of a subject with a significant amount of dandruff prior to shampooing without the addition of 0.5% of the herbal bacteriostatic shampoo. Fig. 2 is a graph showing that all dandruff is removed after shampooing with the herbal bacteriostatic shampoo containing 0.5% and the anti-dandruff efficacy of the herbal bacteriostatic shampoo is visually demonstrated by comparing fig. 1 and fig. 2.

Description of use:

the herbal antibacterial shampoo is light yellow to yellow water-soluble liquid. Directly adding the water phase system at the temperature below 50 ℃ and the optimal applicable pH range: 4.5-7.0. To ensure the exertion of efficacy, the pH value of the product system is controlled within the range of the self acidity and alkalinity of the scalp as much as possible.

And (3) verification:

product detection report:

report number: 2206WH187-02;

detecting a sample: the shampoo was added in an amount of 0.5wt% based on the product prepared in example 3.

Sample number: 2206WH187-02; sample model/specification: 450mL; sample number: 3 bottles; sample state: yellow flowing liquid.

Production lot number: l22050802-2

Inspection item: evaluation of anti-dandruff efficacy of cosmetics

Judging the basis: laboratory method (HMC-WI-037 antibacterial property test of cosmetic dissolution antibacterial product)

Detection environment: temperature: 20-25 ℃, relative humidity: 40-70% RH, other conditions are all according to standard requirements.

Test results:

1. purpose and principle of the test

The dandruff problem is a large amount of desquamation phenomenon caused by the excessive proliferation of scalp keratinocytes, wherein malassezia is one of important factors for causing the production of dandruff, and the increase of the dandruff is a mild manifestation of seborrheic dermatitis of the scalp, and the condition of the excessive proliferation of the malassezia leads to serious oil production of the scalp and serious dandruff, which in turn promotes the proliferation of the malassezia. Thus, inhibiting or killing such microorganisms by adding anti-dandruff agents has a positive effect on inhibiting the growth of dandruff; and (3) taking malassezia as indicator bacteria, and performing anti-dandruff effect test evaluation on the shampoo product.

The test method is an in vitro method and is suitable for evaluating the efficacy of the declared anti-dandruff cosmetic.

2. Test index

3. Test method

Sample pretreatment, pretreatment of a test sample and a control sample, preparation of bacterial suspension, addition of the bacterial suspension into the test sample for action time, and cultivation in a biochemical incubator at 30 ℃ for 5d-10 d-5 d-10d, and then calculating the antibacterial rate of the sample.

4. Test results

5. Conclusion of the test

As can be seen from the above table, when the sample was diluted to 10% aqueous solution, malassezia furfur antibacterial rate: 10min98%, and shows that the sample has a certain anti-dandruff effect.

Finally, it should be noted that: the foregoing description is only of the preferred embodiments of the invention and is not intended to limit the scope of the invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The herbal antibacterial shampoo preparation with the anti-dandruff and antipruritic effects is characterized by being prepared from the following raw materials in parts by mass:

2. The herbal antibacterial shampoo preparation with the anti-dandruff and antipruritic effects as claimed in claim 1, wherein the shampoo preparation is mainly prepared from the following raw materials in parts by weight:

3. The herbal antibacterial shampoo preparation with the anti-dandruff and antipruritic effects as claimed in claim 2, wherein the shampoo preparation is mainly prepared from the following raw materials in parts by mass:

4. A method of preparing a herbal bacteriostatic shampoo with anti-dandruff and antipruritic effects according to any one of claims 1-3, comprising:

5. The method for preparing herbal antibacterial shampoo with anti-dandruff and antipruritic effects according to claim 4, wherein the raw materials are crushed and sieved with a 200-800 mesh sieve.

6. The method for preparing an herbal antibacterial shampoo with anti-dandruff and antipruritic effects according to claim 4, wherein the decoction temperature is 90-100deg.C;

the decoction times are 1-2 times.

7. The method for preparing an herbal antibacterial shampoo with anti-dandruff and antipruritic effects according to claim 4, wherein the decoction time is 60-120 min/time.

8. The method for preparing an herbal antibacterial shampoo with anti-dandruff and antipruritic effects according to claim 4, wherein the concentration is carried out by a double-effect vacuum low-temperature concentration technique.

9. The method of preparing herbal antibacterial shampoo with anti-dandruff and antipruritic effects according to claim 4, wherein the drying is performed by high-speed centrifugal drying spray technology.

10. A method of using a herbal bacteriostatic shampoo with anti-dandruff and antipruritic effects according to any one of claims 1-3, characterized in that said shampoo is added in an amount of 0.3% to 3% by weight for cleansing the scalp and/or hair; preferably 0.5wt%.