CN116615427B - 被取代的大环化合物及相关治疗方法 - Google Patents

被取代的大环化合物及相关治疗方法 Download PDF

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Publication number
CN116615427B
CN116615427B CN202180080848.8A CN202180080848A CN116615427B CN 116615427 B CN116615427 B CN 116615427B CN 202180080848 A CN202180080848 A CN 202180080848A CN 116615427 B CN116615427 B CN 116615427B
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another embodiment
ring
alkyl
alkylene
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CN116615427A (zh
Inventor
刘易斯·D·彭宁顿
崔永吉
黄霍安
布莱恩·M·阿奎拉
英戈·安德里亚斯·马格
胡元
詹姆斯·R·伍兹
布莱恩·肯尼斯·雷默
乔治·马丁·本齐恩
乔纳森·沃德·莱曼
迈克尔·R·霍尔
斯里尼瓦斯·卡拉
罗曼·A·瓦利林
达尔吉特·马塔鲁
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Alkermes Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202180080848.8A 2020-12-21 2021-12-21 被取代的大环化合物及相关治疗方法 Active CN116615427B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063128404P 2020-12-21 2020-12-21
US63/128,404 2020-12-21
US202163190937P 2021-05-20 2021-05-20
US63/190,937 2021-05-20
PCT/US2021/064483 WO2022140316A1 (en) 2020-12-21 2021-12-21 Substituted macrocyclic compounds and related methods of treatment

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CN116615427A CN116615427A (zh) 2023-08-18
CN116615427B true CN116615427B (zh) 2025-07-04

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EP (1) EP4263555A1 (enExample)
JP (1) JP2024501641A (enExample)
KR (1) KR20230127254A (enExample)
CN (1) CN116615427B (enExample)
AU (1) AU2021409403A1 (enExample)
CA (1) CA3172841A1 (enExample)
IL (1) IL303848A (enExample)
MX (1) MX2023005338A (enExample)
WO (1) WO2022140316A1 (enExample)

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KR20230127254A (ko) 2023-08-31
US20220194958A1 (en) 2022-06-23
AU2021409403A1 (en) 2023-05-25
CA3172841A1 (en) 2022-06-30
IL303848A (en) 2023-08-01
AU2021409403A9 (en) 2025-03-20
JP2024501641A (ja) 2024-01-15
CN116615427A (zh) 2023-08-18
US20240368182A1 (en) 2024-11-07
EP4263555A1 (en) 2023-10-25
WO2022140316A1 (en) 2022-06-30
US12006330B2 (en) 2024-06-11
MX2023005338A (es) 2023-05-22

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