CA3172841A1 - Substituted macrocyclic compounds and related methods of treatment - Google Patents

Substituted macrocyclic compounds and related methods of treatment Download PDF

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Publication number
CA3172841A1
CA3172841A1 CA3172841A CA3172841A CA3172841A1 CA 3172841 A1 CA3172841 A1 CA 3172841A1 CA 3172841 A CA3172841 A CA 3172841A CA 3172841 A CA3172841 A CA 3172841A CA 3172841 A1 CA3172841 A1 CA 3172841A1
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CA
Canada
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
formula
another embodiment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3172841A
Other languages
English (en)
French (fr)
Inventor
Lewis D. Pennington
Younggi Choi
Hoan Huynh
Brian M. Aquila
Ingo Andreas Mugge
Yuan HU
James R. Woods
Brian Kenneth Raymer
Jorg Martin BENTZIEN
Jonathan Ward LEHMANN
Michael R. Hale
Srinivasa Karra
Roman A. Valiulin
Daljit MATHARU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
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Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc filed Critical Alkermes Inc
Publication of CA3172841A1 publication Critical patent/CA3172841A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3172841A 2020-12-21 2021-12-21 Substituted macrocyclic compounds and related methods of treatment Pending CA3172841A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063128404P 2020-12-21 2020-12-21
US63/128,404 2020-12-21
US202163190937P 2021-05-20 2021-05-20
US63/190,937 2021-05-20
PCT/US2021/064483 WO2022140316A1 (en) 2020-12-21 2021-12-21 Substituted macrocyclic compounds and related methods of treatment

Publications (1)

Publication Number Publication Date
CA3172841A1 true CA3172841A1 (en) 2022-06-30

Family

ID=80050560

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3172841A Pending CA3172841A1 (en) 2020-12-21 2021-12-21 Substituted macrocyclic compounds and related methods of treatment

Country Status (10)

Country Link
US (2) US12006330B2 (enExample)
EP (1) EP4263555A1 (enExample)
JP (1) JP2024501641A (enExample)
KR (1) KR20230127254A (enExample)
CN (1) CN116615427B (enExample)
AU (1) AU2021409403A1 (enExample)
CA (1) CA3172841A1 (enExample)
IL (1) IL303848A (enExample)
MX (1) MX2023005338A (enExample)
WO (1) WO2022140316A1 (enExample)

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AU2022281345A1 (en) * 2021-05-26 2023-11-30 Alkermes, Inc. Substituted fused bicyclic macrocyclic compounds and related methods of treatment
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Also Published As

Publication number Publication date
KR20230127254A (ko) 2023-08-31
US20220194958A1 (en) 2022-06-23
AU2021409403A1 (en) 2023-05-25
IL303848A (en) 2023-08-01
AU2021409403A9 (en) 2025-03-20
JP2024501641A (ja) 2024-01-15
CN116615427B (zh) 2025-07-04
CN116615427A (zh) 2023-08-18
US20240368182A1 (en) 2024-11-07
EP4263555A1 (en) 2023-10-25
WO2022140316A1 (en) 2022-06-30
US12006330B2 (en) 2024-06-11
MX2023005338A (es) 2023-05-22

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