CN116585243A - Moisturizing and soothing repairing composition and preparation method and application thereof - Google Patents
Moisturizing and soothing repairing composition and preparation method and application thereof Download PDFInfo
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- CN116585243A CN116585243A CN202310189331.3A CN202310189331A CN116585243A CN 116585243 A CN116585243 A CN 116585243A CN 202310189331 A CN202310189331 A CN 202310189331A CN 116585243 A CN116585243 A CN 116585243A
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 229940096857 opUNTia ficus-indica extract Drugs 0.000 description 1
- 229940082491 opUNTia ficus-indica flower extract Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 150000002987 phenanthrenes Chemical class 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Dermatology (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The application provides a moisturizing and soothing repairing composition, which comprises main functional components of dendrobium extract, aloe extract, radix sophorae flavescentis extract, ophiopogon root extract, cactus extract, ningxia wolfberry fruit extract and echinacea extract, wherein the extracts have rich active components such as alkaloids, flavonoids, isoflavones, polysaccharides, saponins, organic acids and the like, can jointly act on deep layers of skin, regenerate skin tissues and cells, and enable skin wounds to be healed, and the composition disclosed by the application has excellent moisturizing, soothing, repairing, antioxidant and elasticity increasing effects on the skin by utilizing the synergistic effect of the components.
Description
Technical Field
The application relates to the field of cosmetics, and IPC classification numbers relate to: A61K8/00, in particular to a moisturizing and soothing composition, a preparation method and application thereof.
Background
The skin is used as the largest organ of the human body, and has important protection effect on the human body; the stratum corneum keratin, intercellular substance, polysaccharides, etc. in the skin epidermis barrier together form an enclosure that resists the entry of external stimuli into the skin. However, the skin barrier dysfunction may be caused by factors such as increasing environmental pollution, poor eating habits, increasing mental stress, light stimulation of sunlight and electronic products, aging hormone changes, drug abuse, disease attraction, etc., and the skin may be susceptible to bad problems such as burning, stinging, itching, dermatitis, erythema, acne, scaling, aging dryness, etc. At present, the main method for treating the skin barrier disorder is moisturizing, the types of moisturizing agents in the market are various, but the simple skin moisturizing treatment can not treat the symptoms and root causes, the problem of skin surface inflammation can not be fundamentally solved, cosmetics with relieving and repairing effects are more and more favored by consumers, but the relieving and repairing components in the cosmetics are mostly added by means of hormone medicine components, the phenomena of intolerance or drug resistance of skin to the medicines possibly exist, the problem of skin barrier damage can not be effectively solved, and even the skin condition deterioration is aggravated.
Chinese patent CN106691975A discloses an anti-allergic moisturizing repair essence, which comprises trehalose, aloe vera gel, rosemary distillate, wall-broken pine pollen, wall-broken selenium-enriched yeast powder, glycerol, acetic acid and water, and can solve the allergic reaction of skin. Chinese patent CN115400060a discloses a preparation process of gentian extract, the gentian extract obtained by extraction has the effects of anti-inflammatory, soothing, calming and moistening skin, has the inhibition effect and antioxidant property on elastase, and prevents aging. However, the efficacy of the technology still has a certain improvement space.
Therefore, a composition which is mild, safe and non-irritating to the skin, has the characteristics of moisturizing, water locking, relieving and repairing, elasticity enhancing, raw material obtaining easiness, simple preparation process and the like needs to be researched, and the problem of skin damage is fundamentally solved.
Disclosure of Invention
In order to solve the technical problems, the application firstly provides the moisturizing and soothing repairing composition, the composition does not relate to the use of medicinal components, most of the effective components are from plant extracts, the skin is mild and has no stimulation, and the optimized composition components show excellent effects of moisturizing, soothing, repairing and the like through synergistic effects.
Further, the ingredients of the composition include a plant extract, an additive, and water; the additives include, but are not limited to, at least one of humectants, thickeners, solubilizers, preservatives, pH adjusters.
Further, the active ingredients of the composition include herba Dendrobii extract, ALOE VERA extract, radix Sophorae Flavescentis (SOPHORA FLAVESCENS) extract, radix Ophiopogonis (OPHIOPOGON JAPONICA) extract, and radix et caulis Opuntiae Dillenii (opuntiadil) extract.
Further, the composition comprises the following components:
component A: dendrobe extract, aloe extract, kuh-seng extract and additives;
component B: radix Ophiopogonis extract, radix et caulis Opuntiae Dillenii extract, radix Sophorae Flavescentis extract and additive.
Further, the component B accounts for 0.01% -99% of the total weight of the component A and the component B.
Further, the dendrobium extract is at least one selected from dendrobium nobile extract, dendrobium candidum extract, dendrobium chrysotoxum extract and dendrobium longum extract. Preferably Dendrobium nobile extract.
Further, the aloe extract is at least one selected from aloe vera extract, aloe ferox extract, aloe vera barbus extract. Preferably aloe vera extract.
Further, the cactus extract is at least one selected from the group consisting of a cactus stem extract, a hydrolyzed Opuntia ficus-indica flower extract, an Opuntia ficus-indica extract stem extract, and an nopal flower extract. Preferably, it is an extract of the stems of Opuntia Dillenii.
Further, the composition comprises the following components in parts by weight:
component A: 0.01-6 parts of dendrobium extract, 0.01-10 parts of aloe extract, 0.01-5 parts of kuh-seng extract and 0-50 parts of A additive;
component B: 0.01-7 parts of ophiopogon root extract, 0.01-9 parts of cactus extract, 0.01-7 parts of kuh-seng extract and 0-50 parts of B additive;
the component B accounts for 0.01-99% of the total weight of the component A and the component B.
Preferably, the composition comprises the following components in parts by weight:
component A: 0.01-6 parts of dendrobium extract, 0.01-10 parts of aloe extract, 0.01-5 parts of kuh-seng extract and 0-50 parts of A additive;
component B: 0.01-7 parts of ophiopogon root extract, 0.01-9 parts of cactus extract, 0.01-7 parts of kuh-seng extract and 0-50 parts of B additive;
the weight ratio of the component A to the component B is (1-6): 1.
further, the component A also includes Lycium BARBARUM (Lycium BARBARUM) fruit extract and Echinacea purpurea (Echinacea purpurea) fruit extract.
In the study it was found that: the aloe extract can exert great moisturizing effect, but a certain amount of aloe-emodin may exist in the aloe extract, and although aloe-emodin Huang Subiao shows a certain antibacterial activity and immunosuppression effect, the research shows serious sensitization, and excessive use of the aloe extract may cause allergic reaction of part of strongly sensitive people; the inventor uses the extract of Lycium barbarum fruit and the extract of Echinacea purpurea in combination to complement the weakening of the effects of antioxidation, antibiosis and the like caused by the reduction of the content of the aloe extract. The use amount of the two components is reasonably controlled, and the composition added with the extract of the Ningxia wolfberry fruit and the extract of the Echinacea purpurea shows more excellent relieving and repairing effects through the synergistic effect of the components.
Preferably, component A comprises 0.01-2 parts by weight of extract of Lycium barbarum fruit and 0.01-1 part by weight of extract of Echinacea purpurea. The application discovers that the increase of the extract of the Ningxia wolfberry fruit and the extract of the purple coneflower can improve the antioxidation and the soothing activity of the composition in a certain range, but when the content of the extract of the Ningxia wolfberry fruit and the extract of the purple coneflower is excessive, the composition can not exert better efficacy, and the storage performance of the composition can be reduced, presumably because: firstly, the targeting action sites of the skin are limited, part of effective substances cannot be effectively combined with the skin, and secondly, part of vitamin E, beta-carotene and the like in the Ningxia wolfberry fruit extract are oxidized and inactivated in the later storage; in addition, the Echinacea purpurea extract contains abundant alkaloid and sesquiterpenes and other substances, and the substances have larger steric hindrance and polar functional groups, and when the substances are added in excessive amount, the substances not only influence the absorption of skin to functional components, but also generate larger acting force in the composition, so that the stability is reduced.
Further preferably, component A comprises 1-1.5 parts by weight of extract of Lycium barbarum fruit and 0.5-0.8 parts by weight of extract of Echinacea purpurea.
Further, the A additive comprises a humectant, a stabilizer and a thickener.
Further, the humectant is glycerin and/or glycol of C4-C6, and the addition amount of the humectant accounts for 50-75% of the total weight of the component A. In the components of cosmetics, alcohol substances are generally used as moisturizers, but the application discovers that the composition finally shows some differences in water locking effect, relieving and repairing effect and stability by using different alcohol molecules in the research; when only glycerin is used, although the penetrability of small molecular alcohol to skin is stronger, and the functional components can be carried to better achieve the deep-layer action of the skin, the small molecular glycerin can not well regulate and control the molecular distance among components such as polysaccharides, flavonoids, phenanthrenes, terpenes, phenols and the like in the system when being used as a connecting bridge of the effective components in the system due to the shorter molecular chain and more polar groups, and when being stored for a long time at low temperature, the composition is easy to generate the problems of excessively strong intermolecular acting force and excessively low molecular chain activity, so that the stability of the composition is reduced; when only C4-C6 diol is adopted, although the molecular chain length can increase the intermolecular distance of the effective components of the composition to a certain extent, the system stability and the moisturizing effect are improved, the rapid absorption and permeation effects of the skin on the effective components of the composition show poorer molecular chains (such as glycerol) and the effective time of the composition is slightly long; therefore, the application improves the efficacy performance and the stable storage performance of the composition when glycerin and C4-C6 glycol are compounded.
Further, the C4-C6 diol is at least one selected from butanediol, methyl propylene glycol, pentanediol and hexanediol.
In a preferred embodiment, the weight ratio of glycerol to C4-C6 glycol is (15-30): (2-7), more preferably (20-25): (3-5).
Further, the thickener is at least one selected from xanthan gum, carbomer, polyethylene glycol, cellulose, polyacrylate, alginate and cocodiethanolamide.
Further, the thickener is at least one selected from xanthan gum, polyethylene glycol, polyacrylate and alginate.
Preferably, the thickening agent is xanthan gum, and the addition amount of the thickening agent is 0.01-0.5% of the total weight of the component A; the addition of the xanthan gum is mainly used for improving the storage state of the component A and has a certain stabilizing effect; the xanthan gum swells when meeting water, but is not dissolved in water completely, but forms a globular insoluble body, because the xanthan gum has strong hydrophilicity, when meeting water, the surface layer expands into a micelle, and tissue moisture enters the inner layer, thus causing the problem of difficult dissolution; in the present application, if the stirring shear rate is increased to dissolve xanthan gum, the crosslinking action between long-chain active substances in the composition is cut off, which is detrimental to the stability of the components, and therefore, the amount of xanthan gum used needs to be controlled reasonably.
Further, the stabilizer is at least one selected from sodium hyaluronate, trehalose, phytic acid, ascorbic acid, glutathione and vitamins.
In a preferred embodiment, the stabilizer is trehalose added in an amount of 12-16% of the total weight of component a. In the present application, trehalose may further regulate the stability of the composition, on the one hand, probably because trehalose may form hydrogen bonds with other active ingredients, maintaining the spatial structure required for the stable state of the composition; it is also possible that the glass transition tendency may lead to the formation of an amorphous continuous phase, which reduces the denaturation of the functional molecules in the system. Only when the amount of trehalose added is appropriate, the efficacy performance and stability of the composition can be further improved.
Further, the B additive comprises a humectant and a stabilizer.
Further, when the humectant is glycerin and a C4-C6 glycol, glycerin, pentanediol, and hexanediol are preferable.
Further, the stabilizer is trehalose.
Further, the weight ratio of glycerin, pentanediol, hexanediol and trehalose is (15-30): (0.5-3.5): (1-4): (3-12).
In a preferred embodiment, the weight ratio of glycerin, pentanediol, hexanediol, and trehalose is 26:2:1.5:7.
further preferably, the composition comprises the following components in parts by weight:
component A: 2-5 parts of dendrobium extract, 1-3 parts of aloe extract, 1-2 parts of radix sophorae flavescentis extract, 0.8-1.6 parts of Ningxia wolfberry fruit extract, 0.5-1 part of echinacea extract, 20-30 parts of glycerol and/or C4-C6 glycol, 4-8 parts of trehalose and 0.05-0.1 part of xanthan gum;
component B: 0.01-7 parts of dwarf lilyturf tuber extract, 0.01-9 parts of cactus extract, 0.01-7 parts of lightyellow sophora root extract, 22-37 parts of glycerol and/or C4-C6 glycol and 3-12 parts of trehalose;
the weight ratio of the component A to the component B is (1-4): 1, preferably 7:3.
furthermore, the preparation method of the composition is not strictly defined, and the composition is uniformly mixed according to the corresponding mass ratio.
Further, the preparation method of the composition is selected from any one of a method one and a method two:
the first method is as follows: (1) Weighing herba Dendrobii, aloe, radix Sophorae Flavescentis, fructus Lycii in Ningxia, echinacea purpurea, radix Ophiopogonis, and radix et caulis Opuntiae Dillenii, mixing, and pulverizing to obtain powder composition; (2) mixing the powdery composition with deionized water according to a ratio of 1: soaking in the weight ratio of (15-30), heating, stirring, extracting, and collecting the stirring liquid; (3) Standing the stirring liquid, adopting a filter screen for rough filtration, decoloring, and filtering and purifying again; (4) concentrating the filtrate in vacuum; (5) Adding the additive A and the additive B into the concentrated solution according to the weight parts, supplementing the total weight to 100 parts by water, and uniformly stirring to obtain the composition.
The second method is as follows: s1, preparing a component A: (1) Weighing herba Dendrobii, aloe, radix Sophorae Flavescentis, fructus Lycii, and Echinacea purpurea, mixing, and pulverizing to obtain powder composition; (2) mixing the powdery composition with deionized water according to a ratio of 1: soaking in the weight ratio of (15-30), heating, stirring, extracting, and collecting the stirring liquid; (3) Standing the stirring liquid, adopting a filter screen for rough filtration, decoloring, and filtering and purifying again; (4) concentrating the filtrate in vacuum; (5) Adding the additive A into the concentrated solution according to parts by weight, and uniformly stirring to obtain the component A;
s2, preparing a component B: (1) Weighing radix Ophiopogonis, radix et caulis Opuntiae Dillenii, and radix Sophorae Flavescentis, mixing, and pulverizing to obtain powder composition; (2) mixing the powdery composition with deionized water according to a ratio of 1: soaking in the weight ratio of (15-30), heating, stirring, extracting, and collecting the stirring liquid; (3) Standing the stirring liquid, adopting a filter screen for rough filtration, decoloring, and filtering and purifying again; (4) concentrating the filtrate in vacuum; (5) Adding the additive B into the concentrated solution according to parts by weight, and uniformly stirring to obtain the component B;
s3, mixing the component A and the component B according to the corresponding mass ratio, and uniformly stirring.
Further, in the first and second methods, the particle size of the powdery mixture of the step (1) is 60 to 150 mesh, preferably 60 to 120 mesh.
Further, the soaking time in the step (2) is 40-90min, the heating temperature is 85-110 ℃, and the stirring time is 1-4h.
Preferably, the soaking time of the step (2) is 40-80min, the heating temperature is 90-100 ℃, and the stirring time is 1-3h.
Further, the extraction rate of the extract prepared by adopting the traditional Chinese medicine is 8-12%.
Further, the decoloring in the step (3) adopts at least one of macroporous resin adsorption, petroleum ether extraction, alcohol extraction and active carbon adsorption.
Preferably, the decoloring in the step (3) is activated carbon adsorption, the addition amount of the activated carbon is 1-5% of the mass of the filtrate, the decoloring temperature is 70-80 ℃, and the decoloring time is 0.5-1h.
Further, the step (3) is filtered and purified again to be: desalting the filtrate sequentially with cation resin and anion resin, and fine filtering with 400-700 mesh sieve.
Further, in the step (4), the vacuum concentration temperature of the filtrate is 65-70 ℃, and the concentration is carried out until the solid content is 6-8%.
Further, the application also provides the application of the composition in cosmetics, wherein the cosmetics comprise any one of water dosage form, emulsion dosage form, cream dosage form and gel type.
Further, the composition is added to the cosmetic in an amount of 0.1 to 30%, preferably 0.5 to 10%, more preferably 0.5 to 5% of the total mass of the cosmetic.
In one embodiment, the composition is applied to a soothing and repairing purified water, the soothing and repairing purified water comprising: 0.3-1% of polyacryl dimethyl taurine sodium, 0.1-0.4% of xanthan gum, 0.01-0.05% of EDTA disodium, 2-5% of glycerin, 1-3% of bis-PEG-18 methyl ether dimethyl silane and butylhydroxytoluene, 0.5-1.5% of methyl propylene glycol, 0.3-2% of 1, 2-hexanediol, 0.1-1% of p-hydroxyacetophenone, 1-8% of moisturizing and soothing composition, 0.1-0.9% of PEG-40 hydrogenated castor oil, 0-0.1% of auxiliary agent and 100% of water.
Advantageous effects
1. The main functional components of the composition are dendrobium extract, aloe extract, kuh-seng extract, dwarf lilyturf tuber extract, cactus extract, ningxia wolfberry fruit extract and echinacea extract, and the extracts have rich active components such as alkaloids, flavonoids, isoflavones, polysaccharides, saponins, organic acids and the like, can jointly act on deep layers of skin, regenerate skin tissues and cells and enable skin wounds to heal slowly, and the composition has excellent effects of moisturizing, soothing, repairing, resisting oxidation, increasing elasticity and the like on the skin by utilizing the synergistic effect of the components;
2. the application optimizes the components and the addition amount of the composition, can solve the problems of compatibility, oxidation inactivation and the like of various active substances, and ensures that the composition has excellent stability and storage performance;
3. the composition provided by the application has the main functional components of nature, is free from hormone medicine addition, and is mild and free from stimulation to skin.
4. The composition of the application has simple preparation method, is environment-friendly and can be biodegraded.
Drawings
Fig. 1: test results of experiments 1-5 with improved skin feel;
fig. 2: the essence water prepared in example 2 improves the test result pictures on the red area of the skin.
Detailed Description
Examples
Example 1
The present example provides a moisturizing, soothing and conditioning composition; the composition comprises the following components in parts by weight: 2.1 parts of dendrobium stem extract, 1.4 parts of aloe vera leaf extract, 2.55 parts of kuh-seng root extract, 0.84 part of Ningxia wolfberry fruit extract, 0.56 part of purple coneflower extract, 1.5 parts of radix ophiopogonis extract, 1.5 parts of cactus stem extract, 23.2 parts of glycerol, 2 parts of pentanediol, 1.29 parts of hexanediol and 6.3 parts of trehalose;
the preparation method of the composition comprises the following steps:
(1) Weighing the following raw materials in parts by weight: 21 parts of dendrobium stem, 14 parts of aloe vera leaf, 25.5 parts of kuh-seng root, 8.4 parts of Ningxia wolfberry fruit, 5.6 parts of purple coneflower, 15 parts of dwarf lilyturf tuber, 15 parts of Chinese caterpillar fungus cactus stem, 23.2 parts of glycerin, 2 parts of pentanediol, 1.29 parts of hexanediol and 6.3 parts of trehalose;
(2) Mixing stem of herba Dendrobii, aloe Vera leaf, radix Sophorae Flavescentis, fructus Lycii of Ningxia, echinacea purpurea, radix Ophiopogonis root, and stem of radix et caulis Opuntiae Dillenii, pulverizing to 60-120 mesh to obtain powder composition;
(3) The powdered composition and deionized water were mixed according to a 1: soaking for 60min at 20 weight ratio, heating and stirring at 100deg.C for 2 hr for extraction, stirring at 80r/min, and collecting stirring solution;
(4) Filtering the stirred solution by adopting a 100-mesh filter screen and a 200-mesh filter screen in turn after standing, adding active carbon accounting for 1% of the mass of the filtrate into the stirred solution, decoloring for 1h at 80 ℃, filtering the decolored solution by using the 200-mesh filter screen, sequentially passing the filtrate through cationic resin at a flow rate of 2.0t/h, desalting the filtrate by using anionic resin, collecting the filtrate, and finely filtering the filtrate by using a 500-mesh filter screen;
(5) Concentrating the filtrate under vacuum degree of 0.08MPa and temperature of 65-70deg.C until the solid content is 7%, and concentrating by about 3.7 times;
(6) Adding glycerol, pentanediol, hexanediol and trehalose into the concentrated solution according to parts by weight, supplementing the total weight of the composition to 100 parts by weight with water, and uniformly stirring to obtain the composition.
Example 2
The present example provides a moisturizing, soothing and conditioning composition; the composition comprises the following components in parts by weight:
component A: 3 parts of dendrobium stem extract, 2 parts of aloe vera leaf extract, 1.5 parts of kuh-seng root extract, 1.2 parts of Ningxia wolfberry fruit extract, 0.8 part of echinacea extract, 22 parts of glycerin, 2 parts of pentanediol, 2 parts of hexanediol, 6 parts of trehalose and 0.07 part of xanthan gum;
component B: 5 parts of radix ophiopogonis extract, 5 parts of cactus stem extract, 5 parts of radix sophorae flavescentis extract, 26 parts of glycerol, 2 parts of pentanediol, 1.5 parts of hexanediol and 7 parts of trehalose;
the weight ratio of the component A to the component B is 7:3.
the preparation method of the composition comprises the following steps:
s1, preparing a component A: the method comprises the following steps of (1) weighing the following raw materials in parts by weight: 30 parts of dendrobium stem, 20 parts of aloe vera leaf, 15 parts of kuh-seng root, 12 parts of Ningxia wolfberry fruit, 8 parts of purple coneflower, 23.2 parts of glycerin, 2 parts of pentanediol, 1.29 parts of hexanediol, 6 parts of trehalose and 0.07 part of xanthan gum;
(2) Mixing stem of herba Dendrobii, aloe Vera leaf, radix Sophorae Flavescentis, fructus Lycii of Ningxia, and Echinacea purpurea, and pulverizing to 100 mesh to obtain powder composition;
(3) The powdered composition and deionized water were mixed according to a 1: soaking for 60min at 20 weight ratio, heating and stirring at 100deg.C for 2 hr for extraction, stirring at 80r/min, and collecting stirring solution;
(4) Filtering the stirred solution by adopting a 100-mesh filter screen and a 200-mesh filter screen in turn after standing, adding active carbon accounting for 1% of the mass of the filtrate into the stirred solution, decoloring for 1h at 75 ℃, filtering the decolored solution by using the 200-mesh filter screen, sequentially passing the filtrate through cationic resin at a flow rate of 2.5t/h, desalting the filtrate by using anionic resin, collecting the filtrate, and finely filtering the filtrate by using a 500-mesh filter screen;
(5) Concentrating the filtrate under vacuum degree of 0.08MPa and temperature of 70deg.C until the solid content is 7%, and concentrating by about 3.7 times;
(6) Adding glycerol, pentanediol, hexanediol, trehalose and xanthan gum into the concentrated solution, and uniformly stirring to obtain the component A;
s2, preparing a component B: the steps (1) - (5) are consistent with the step (S1), and the raw materials of the component A are replaced by the raw materials of the component B (50 parts of dwarf lilyturf tuber extract, 50 parts of Chinese mugwort cactus stem extract, 50 parts of kuh-seng root extract, 26 parts of glycerin, 2 parts of pentanediol, 1.5 parts of hexanediol and 7 parts of trehalose);
s3, mixing the component A and the component B according to the corresponding mass ratio, and uniformly stirring.
Example 3
The present example provides a moisturizing, soothing and conditioning composition; the composition comprises the following components in parts by weight:
component A: 5 parts of dendrobium stem extract, 3 parts of aloe vera leaf extract, 2 parts of kuh-seng root extract, 0.8 part of Ningxia wolfberry fruit extract, 0.5 part of echinacea extract, 25 parts of glycerol, 3 parts of pentanediol, 3 parts of hexanediol, 8 parts of trehalose and 0.05 part of xanthan gum;
component B: 2 parts of radix ophiopogonis extract, 9 parts of cactus stem extract, 7 parts of radix sophorae flavescentis extract, 30 parts of glycerol, 3.5 parts of pentanediol, 4 parts of hexanediol and 12 parts of trehalose;
the weight ratio of the component A to the component B is 1:1.
the preparation method of the composition comprises the following steps:
s1, preparing a component A: the method comprises the following steps of (1) weighing the following raw materials in parts by weight: 50 parts of dendrobium stem, 30 parts of aloe vera leaf, 20 parts of radix sophorae flavescentis, 8 parts of Ningxia wolfberry fruit, 5 parts of purple coneflower, 25 parts of glycerin, 3 parts of pentanediol, 3 parts of hexanediol, 8 parts of trehalose and 0.05 part of xanthan gum;
(2) Mixing stem of herba Dendrobii, aloe Vera leaf, radix Sophorae Flavescentis, fructus Lycii of Ningxia, and Echinacea purpurea, and pulverizing to 120 mesh to obtain powder composition;
(3) The powdered composition and deionized water were mixed according to a 1:15, soaking for 90min, heating and stirring at 110 ℃ for 1h for extraction, wherein the stirring speed is 90r/min, and collecting the stirring liquid;
(4) Filtering the stirred solution by adopting a 100-mesh filter screen and a 200-mesh filter screen in turn after standing, adding active carbon accounting for 3% of the mass of the filtrate into the stirred solution, decoloring for 0.5h at 80 ℃, filtering the decolored solution by using the 200-mesh filter screen, sequentially passing the filtrate through cationic resin at a flow rate of 2.0t/h, desalting the filtrate by using anionic resin, collecting the filtrate, and finely filtering the filtrate by using a 500-mesh filter screen;
(5) Concentrating the filtrate under vacuum degree of 0.08MPa and 65 deg.C until the solid content is 6%, and concentrating by about 3.3 times;
(6) Adding glycerol, pentanediol, hexanediol, trehalose and xanthan gum into the concentrated solution, and uniformly stirring to obtain the component A;
s2, preparing a component B: the steps (1) - (5) are consistent with the step (S1), and the raw materials of the component A are replaced by the raw materials of the component B (20 parts of dwarf lilyturf tuber extract, 90 parts of Chinese mugwort cactus stem extract, 70 parts of kuh-seng root extract, 30 parts of glycerol, 3.5 parts of pentanediol, 4 parts of hexanediol and 12 parts of trehalose);
s3, mixing the component A and the component B according to the corresponding mass ratio, and uniformly stirring.
Example 4
The present example provides a moisturizing, soothing and conditioning composition; the composition comprises the following components in parts by weight:
component A: 2 parts of dendrobium stem extract, 1 part of aloe vera leaf extract, 1 part of kuh-seng root extract, 1.6 parts of Ningxia wolfberry fruit extract, 1 part of echinacea extract, 20 parts of glycerin, 1 part of pentanediol, 1 part of hexanediol, 4 parts of trehalose and 0.08 part of xanthan gum;
component B: 7 parts of radix ophiopogonis extract, 7 parts of cactus stem extract, 3 parts of radix sophorae flavescentis extract, 15 parts of glycerol, 0.5 part of pentanediol, 1 part of hexanediol and 3 parts of trehalose;
the weight ratio of the component A to the component B is 4:1.
the preparation method of the composition comprises the following steps:
s1, preparing a component A: the method comprises the following steps of (1) weighing the following raw materials in parts by weight: 20 parts of dendrobium stem, 10 parts of aloe vera leaf, 10 parts of radix sophorae flavescentis, 16 parts of Ningxia wolfberry fruit, 10 parts of echinacea, 20 parts of glycerin, 1 part of pentanediol, 1 part of hexanediol, 4 parts of trehalose and 0.08 part of xanthan gum;
(2) Mixing stem of herba Dendrobii, aloe Vera leaf, radix Sophorae Flavescentis, fructus Lycii of Ningxia, and Echinacea purpurea, and pulverizing to 80 mesh to obtain powder composition;
(3) The powdered composition and deionized water were mixed according to a 1:30, soaking for 90min, heating and stirring at 100deg.C for 4 hr for extraction, stirring at a speed of 100r/min, and collecting the stirring solution;
(4) Filtering the stirred solution by adopting a 100-mesh filter screen and a 200-mesh filter screen in turn after standing, adding active carbon accounting for 5% of the mass of the filtrate into the stirred solution, decoloring for 1h at 70 ℃, filtering the decolored solution by using the 200-mesh filter screen, sequentially passing the filtrate through cationic resin at a flow rate of 3.0t/h, desalting the filtrate by using anionic resin, collecting the filtrate, and finely filtering the filtrate by using a 500-mesh filter screen;
(5) Concentrating the filtrate under vacuum degree of 0.08MPa and temperature of 70deg.C until solid content is 8%, and concentrating by about 4.2 times;
(6) Adding glycerol, pentanediol, hexanediol, trehalose and xanthan gum into the concentrated solution, and uniformly stirring to obtain the component A;
s2, preparing a component B: the steps (1) - (5) are consistent with the step (S1), and the raw materials of the component A are replaced by the raw materials of the component B (70 parts of dwarf lilyturf tuber extract, 70 parts of Chinese mugwort cactus stem extract, 30 parts of kuh-seng root extract, 15 parts of glycerol, 0.5 part of pentanediol, 1 part of hexanediol and 3 parts of trehalose);
s3, mixing the component A and the component B according to the corresponding mass ratio, and uniformly stirring.
Comparative example 1
Substantially identical to example 2, except that: the weight ratio of the component A to the component B is 5:0.
comparative example 2
Substantially identical to example 2, except that: the weight ratio of the component A to the component B is 3:7.
comparative example 3
Substantially identical to example 2, except that: the weight ratio of the component A to the component B is 0:5.
the performance test method comprises the following steps:
the composition of the embodiment and the following components are compounded into a primary product, and the specific components are as follows: 0.3 part of polyacryl dimethyl taurine sodium, 0.5 part of hexanediol, 0.5 part of p-hydroxyacetophenone and 5 parts of composition. Experiment 1 used the composition of comparative example 1, experiment 2 used the composition of example 2, experiment 3 used the composition of example 3, experiment 4 used the composition of comparative example 2, and experiment 5 used the composition of comparative example 3.
1. Skin moisture content test: by means of a probeThe CM825 measures the skin moisture content value at each test point, three times per test zone, and averages. Skin moisture content change rate= (moisture content after use-moisture content before use)/moisture content before use x 100%; before each test, the test was performed for 1 day, 7 days, and 14 days (i.e., D0 and D1. D7, D14) and calculating the corresponding moisture improvement rate in the testThe test results are shown in Table 1.
2. Transepidermal water loss test: by means of a probeTMHex measures the percutaneous moisture loss values TEWL (g/m) at each test point 2 (h) testing each test area three times, and taking an average value; calculation ofThe test results are shown in Table 2.
3. Skin erythema index a value: the skin Image shooting instrument VISIA-CR is used for shooting standard white light and UV standard images, and the analysis system Image-Proplus is used for analyzing the facial pore area ratio and the red area a value. The test results are shown in Table 3.
4. Inhibition of hyaluronidase activity: hyaluronidase (HAase) is a participant in type I allergic reaction (immediate type allergic reaction), and studies show that Hyaluronidase has strong correlation with inflammation and relaxation, and many antiallergic drugs have strong effects of inhibiting Hyaluronidase activity. The method adopts the hyaluronidase in-vitro inhibition method to measure the efficacy of relieving and repairing the composition. Hyaluronidase in vitro inhibition assay: clean tubes were taken and 0.5mL hyaluronidase solution and 0.1mL,0.25mmol/LCaCl were added to each tube 2 Placing the test tube in a 37 ℃ incubator for heat preservation and culture for 20min; adding 0.5mL of a sample liquid to be detected with a certain concentration, and continuing to perform heat preservation culture at 37 ℃ for 20min; then adding 0.5mL of sodium hyaluronate solution, placing in a 37 ℃ incubator for heat preservation for 30min, then taking out, and placing for 5min at normal temperature; 0.1mL of 0.4mol/L NaOH solution and 0.5mL of ethyl acetate were addedHeating the acyl acetone solution in boiling water in a water bath for 15min, and immediately cooling with ice water for 5min; adding 1.0mL of an Escherichia reagent, diluting with 3.0mL of absolute ethanol, standing for 20min for color development, and measuring the absorbance value by a spectrophotometer; hyaluronidase inhibition ratio (%) = [ (a-B) - (C-D)]/(A-B). Times.100%; wherein: a is the absorbance value of the control solution (acetic acid buffer solution is used instead of sample solution); b is the absorbance value of the blank control solution (acetic acid buffer solution is used for replacing the sample solution and enzyme solution); c is the absorbance value of the tested sample solution; d is the absorbance value of the blank solution of the sample (acetic acid buffer solution is used for replacing enzyme solution). The test results are shown in Table 4.
5. Test experiment for skin feel improvement: the experiment numbers are shown in Table 5; the number of the subjects is 14, the subjects are healthy Asian population, the skin type is not limited, and the skin is normal. Skin feel evaluation for experiments A-C, using scoring, scores 1-5, higher scores indicate: the more sticky the sense of greasiness; the better the moisture retention, the better the brightness; the better the smoothness is, the better the moistening feeling is, and the better the elasticity after absorption is; the worse the sense of heaviness, the average of the obtained data is taken, and the test result is shown in fig. 1.
6. Stability test: the composition was placed in different environments, such as-20deg.C, 25deg.C, 50deg.C, and the appearance (turbidity, precipitation, flocculation, etc.) and color (color change) of the product were continuously observed at 7d, 14d, 30d, 60d, 90d, respectively, to determine the stability. If a certain group has obvious adverse phenomena such as substance precipitation, color change or bad smell in the observation and test process, judging that the stability of the group is unqualified, and stopping the observation of the stability of the group. The results prove that: the stability test of the examples was acceptable.
7. Efficacy test of formulation application: the composition of example 2 was applied to soothing and repairing purified water, and the specific ingredients are shown in Table 6; the reference test method comprises the following steps: the T/ZHCA003-2018 cosmetic influence the water loss test method of the epidermis, the T/TDCA003-2021 cosmetic tightening efficacy test method, the T/ZHCA005-2019 cosmetic influence the skin elasticity test method to test the efficacy of the soothing and repairing purified water, and the test results are shown in Table 7; red area improvement test pictures are shown in fig. 2. Performance test results:
TABLE 1
TABLE 2
| Experiment number | D1 | D7 | D14 |
| Experiment 1 | -11.76470588 | -24.06417112 | -23.90374332 |
| Experiment 2 | -5.165496489 | -13.22051824 | -19.26605505 |
| Experiment 3 | -3.383458647 | -10.839599 | -17.10526316 |
| Experiment 4 | -5.593667546 | -10.7881498 | -16.74500588 |
| Experiment 5 | -5.696969697 | -7.151515152 | -8.606060606 |
TABLE 3 Table 3
TABLE 4 Table 4
| Composition number | Hyaluronidase inhibition% |
| Example 2 | 48 |
| Example 3 | 54 |
| Comparative example 1 | 11 |
| Comparative example 2 | 62 |
| Comparative example 3 | 68 |
TABLE 5
TABLE 6
TABLE 7
Claims (10)
1. A moisturizing and soothing composition is characterized in that the active ingredients of the composition comprise dendrobe extract, aloe extract, kuh-seng extract, ophiopogon root extract and cactus extract.
2. The composition according to claim 1, wherein the components of the composition in parts by weight comprise:
component A: 0.01-6 parts of dendrobium extract, 0.01-10 parts of aloe extract, 0.01-5 parts of kuh-seng extract and 0-50 parts of A additive;
component B: 0.01-7 parts of ophiopogon root extract, 0.01-9 parts of cactus extract, 0.01-7 parts of kuh-seng extract and 0-50 parts of B additive;
the component B accounts for 0.01-99% of the total weight of the component A and the component B.
3. The composition of claim 2, wherein component a further comprises an extract of lycium barbarum and an extract of echinacea.
4. The composition of claim 2, wherein component a comprises 0.01-2 parts by weight of extract of lycium barbarum and 0.01-1 part by weight of extract of echinacea.
5. The composition of claim 2, wherein the a additive comprises a humectant, a stabilizer, and a thickener, wherein the humectant is glycerin and/or a C4-C6 glycol; the stabilizer is at least one selected from sodium hyaluronate, trehalose, phytic acid, ascorbic acid, glutathione and vitamins.
6. The composition of claim 5, wherein the weight ratio of glycerin to C4-C6 glycol is (15-30): (2-7).
7. The composition of claim 2, wherein the B additive comprises a humectant and a stabilizer, the humectant being glycerin, pentanediol, and hexanediol.
8. A method of preparing the composition of claim 3, wherein the method is selected from any one of method one and method two:
the first method is as follows: (1) Weighing herba Dendrobii, aloe, radix Sophorae Flavescentis, fructus Lycii in Ningxia, echinacea purpurea, radix Ophiopogonis, and radix et caulis Opuntiae Dillenii, mixing, and pulverizing to obtain powder composition; (2) mixing the powdery composition with deionized water according to a ratio of 1: soaking in the weight ratio of (15-30), heating, stirring, extracting, and collecting the stirring liquid; (3) Standing the stirring liquid, adopting a filter screen for rough filtration, decoloring, and filtering and purifying again; (4) concentrating the filtrate in vacuum; (5) Adding the additive A and the additive B into the concentrated solution according to the weight parts, supplementing the total weight to 100 parts by water, and uniformly stirring to obtain the composition;
the second method is as follows: s1, preparing a component A: (1) Weighing herba Dendrobii, aloe, radix Sophorae Flavescentis, fructus Lycii, and Echinacea purpurea, mixing, and pulverizing to obtain powder composition; (2) mixing the powdery composition with deionized water according to a ratio of 1: soaking in the weight ratio of (15-30), heating, stirring, extracting, and collecting the stirring liquid; (3) Standing the stirring liquid, adopting a filter screen for rough filtration, decoloring, and filtering and purifying again; (4) concentrating the filtrate in vacuum; (5) Adding the additive A into the concentrated solution according to parts by weight, and uniformly stirring to obtain the component A;
s2, preparing a component B: (1) Weighing radix Ophiopogonis, radix et caulis Opuntiae Dillenii, and radix Sophorae Flavescentis, mixing, and pulverizing to obtain powder composition; (2) mixing the powdery composition with deionized water according to a ratio of 1: soaking in the weight ratio of (15-30), heating, stirring, extracting, and collecting the stirring liquid; (3) Standing the stirring liquid, adopting a filter screen for rough filtration, decoloring, and filtering and purifying again; (4) concentrating the filtrate in vacuum; (5) Adding the additive B into the concentrated solution according to parts by weight, and uniformly stirring to obtain the component B;
s3, mixing the component A and the component B according to the corresponding mass ratio, and uniformly stirring.
9. The method of preparing a composition according to claim 8, wherein the soaking time of step (2) is 40-90min, the heating temperature is 85-110 ℃, and the stirring time is 1-4h.
10. Use of a composition according to any one of claims 1 to 7 in cosmetics.
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