CN116585217A - Retinol wrap, raw material and external skin preparation easier to be absorbed through skin - Google Patents

Retinol wrap, raw material and external skin preparation easier to be absorbed through skin Download PDF

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Publication number
CN116585217A
CN116585217A CN202310870369.7A CN202310870369A CN116585217A CN 116585217 A CN116585217 A CN 116585217A CN 202310870369 A CN202310870369 A CN 202310870369A CN 116585217 A CN116585217 A CN 116585217A
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China
Prior art keywords
retinol
wrap
matrine
solvent
oil
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Granted
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CN202310870369.7A
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Chinese (zh)
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CN116585217B (en
Inventor
周琪
舒鹏
王媛
王静
刘琴
黄河
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Shenzhen Hujia Technology Co ltd
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Shenzhen Hujia Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The application provides a retinol wrap, a raw material and an external skin preparation which are easier to be absorbed through skin, wherein the retinol wrap at least comprises the following components: retinol; matrine and solvent; intermolecular forces exist between the retinol and matrine. The retinol wrap disclosed by the application is not easy to separate out, has a stable and ordered structure and good stability, can protect the bioactivity of retinol while reducing the irritation of retinol, and can exert the maximum efficacy of retinol.

Description

Retinol wrap, raw material and external skin preparation easier to be absorbed through skin
Technical Field
The application relates to the field of cosmetics, in particular to a retinol wrap, a raw material and an external skin preparation which are easier to be absorbed through skin.
Background
Vitamin a includes two subtypes: VA-1 (retinol) and VA-2 (retinol and retinoic acid), retinol and retinol esters (retinol esters prepared by chemical reaction of vitamin A) are widely applied to anti-aging and anti-wrinkle products in recent years, and the effect is remarkable. Retinol is a fat-soluble alcohol substance, can regulate metabolism of epidermis and cutin, can reduce seborrhea, lighten pigment color spots, stimulate collagen production, reduce wrinkles, improve relaxation, help skin recover elasticity and smoothness, and is widely applied to anti-aging and anti-wrinkle products in recent years. Products in the cosmetic market are therefore based on the addition of retinol.
However, retinol and its derivatives are inferior in stability and easily degraded under ultraviolet, air, photo-thermal conditions, etc., because the side chain of the tetraene of retinol is particularly easily receiving energy of light waves, and ultraviolet rays easily transfer energy to it, so that the structure of the retinol is changed to lose bioactivity. In general, retinol palmitate is more stable than retinol but is thermodynamically unstable, and studies have shown that 2% of retinol palmitate degrades by 38% in an oil-in-water system at 4 ℃ for 7 days.
Disclosure of Invention
The application aims to solve the technical problems:
how to improve the stability of retinol.
The technical means for solving the technical problems are as follows:
through repeated researches, the inventor finds that the retinol coating can form an ordered structure after being mixed with matrine and a solvent, and has excellent stability. In addition, the retinol wrap has higher transdermal rate, and retinol can penetrate into the bottom layer of the skin to enable the skin to absorb better. The active loss of retinol after three weeks at 50 ℃ was only 4.2%.
In one aspect of the present application, there is provided a retinol wrap characterized in that it comprises at least: retinol; matrine; a solvent; intermolecular forces exist between the retinol and matrine.
In one aspect of the present application, a retinol wrap is provided, which comprises at least retinol; matrine; a solvent; the retinol wrap has at least the following hydrogen signals in the nuclear orvehaus effect spectrum:
(3.71-3.74,2.00-2.04) or (2.00-2.04,3.71-3.74);
(4.20-4.22,1.55-1.58) or (1.55-1.58,4.20-4.22);
(3.71-3.75,1.53-1.56) or (1.53-1.56,3.71-3.75).
In one aspect of the present application, there is provided the use of the aforementioned retinol wrap for the preparation of cosmetics or skin care products.
In one aspect of the present application, a cosmetic raw material is provided that includes at least the aforementioned retinol wrap.
In one aspect of the present application, there is provided a skin preparation for external use comprising at least the aforementioned retinol wrap.
In one aspect of the present application, a method for preparing a retinol wrap is provided, which is characterized by providing retinol, matrine, solvent and antioxidant;
mixing, heating and stirring matrine and a solvent under a light-shielding condition and an inert atmosphere, wherein the heating temperature is 40-60 ℃, the stirring speed is 600-750 r/min, and reacting for 2-4 hours to obtain an ionic liquid;
mixing and stirring retinol and the ionic liquid cooled to normal temperature under the light-shielding condition and inert atmosphere, wherein the stirring speed is 600-750 r/min, and stirring for 2-4 hours to obtain a primary liquid;
mixing the antioxidant with the primary liquid, and stirring for 0.5-1 h at a stirring speed of 600-750 r/min to obtain the retinol wrap. The beneficial effects are that:
the retinol wrap disclosed by the application is not easy to separate out, has a stable and ordered structure and good stability, and can protect the bioactivity of retinol while reducing the irritation of retinol.
The retinol wrap of the present application is well dissolved in the aqueous phase of cosmetics and is substantially unaffected by dissolved oxygen in water.
The retinol wrap disclosed by the application has good permeability, can assist retinol to penetrate into the bottom layer of skin, and can be better absorbed by skin to exert an excellent anti-aging effect.
Drawings
The application also provides a drawing related to the technical scheme provided for explaining the technical scheme of the application. The drawings and description are only for the purpose of illustrating the application more clearly and should not be taken as limiting the scope of the application as claimed.
FIG. 1 is a state diagram of the combination of retinol with different alkaloids and solvents, wherein sample (1) comprises retinol, betaine and malic acid, sample (2) comprises retinol, betaine and glycerol, sample (3) comprises retinol, L-carnitine and succinic acid, sample (4) comprises retinol, L-carnitine and BAIHUA seed oil, sample (5) comprises retinol, matrine and coconut oil, sample (6) comprises retinol, matrine and camellia seed oil, and sample (7) comprises retinol, matrine and prinsepia utilis royle oil; the retinol content in samples (1) to (7) was 10%;
fig. 2 is a state diagram of the samples (1) to (7) (2%) in fig. 1 after mixing with water (98%).
FIG. 3 is a two-dimensional nuclear magnetic pattern test result of the retinol wrap of the present application;
FIG. 4 is a graphical representation of the statistics of the relative amount of active in a retinol wrap according to the present application over time at various temperature conditions;
FIG. 5 is a graph showing the results of a transdermal test of a retinol wrap of the present application with a conventional retinol solution;
fig. 6 shows a retinol wrap prepared using different solvents, and in fig. 6, examples 5, 6, 7 and 8 are shown in order from the left.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions of the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are not all embodiments.
Elements and features described in one embodiment of the application may be combined with elements and features shown in one or more other embodiments. It should be noted that the illustration and description of components and processes known to those of ordinary skill in the art, which are not relevant to the present application, have been omitted for clarity.
Definition of the definition
Herein, unless otherwise indicated, the term "%" means "% by mass".
Herein, unless otherwise indicated, the term "%" herein refers to based on the total mass of the composition of the present application.
In this context, all ranges defined refer to: including each specific range within a given range as well as combinations of sub-ranges between the given ranges. For example, a range of 1 to 5 specifically includes 1, 2,3, 4 and 5, and also includes sub-ranges such as 2 to 5,3 to 5, 2 to 3,2 to 4,1 to 4, etc.
In this context, the range of ratios refers to: including each specific ratio within a given range and combinations of sub-ranges between the given ranges.
In this context, "intermolecular forces" include both weak electrostatic interactions caused by the permanent and momentary dipoles of the molecules, and hydrogen bonds. The intermolecular force can be determined by detecting whether a nuclear European Haohaus effect (Nuclear Overhauser Effect, NOE) exists between retinol and an ionic liquid consisting of matrine and coconut oil through a two-dimensional nuclear magnetic NOESY spectrogram.
Herein, the cosmetic raw material means any one or more forms commonly used in the field of skin care products or cosmetics including powdery raw materials, colloidal raw materials, oily raw materials, solvent raw materials, and the like, which can be employed without affecting the technical effects of the formulation of the present application.
Herein, the external skin preparation means any one or more forms commonly used in the field of skin care products or cosmetics including lotions, emulsions, foundations, hand creams, lotions, shampoos, conditioners, hair conditioners, styling agents, masks, soaps, facial washes and the like, which can be employed without affecting the technical effects of the preparation of the present application.
The application is that
The present application provides a retinol wrap comprising at least:
retinol;
matrine;
a solvent;
intermolecular forces exist between the retinol and matrine.
The present application also provides a retinol wrap comprising at least:
retinol;
matrine;
a solvent;
the retinol wrap has at least the following hydrogen signals in the nuclear orvehaus effect spectrum:
(3.71-3.74,2.00-2.04) or (2.00-2.04,3.71-3.74);
(4.20-4.22,1.55-1.58) or (1.55-1.58,4.20-4.22);
(3.71-3.75,1.53-1.56) or (1.53-1.56,3.71-3.75).
Optionally, the retinol wrap has at least the following hydrogen signals in the nuclear orvehaus effect spectrum:
(3.72-3.73,2.01-2.02) or (2.01-2.02,3.72-3.73);
(4.20-4.21,1.55-1.56) or (1.55-1.56,4.20);
(3.73-3.74,1.54-1.55) or (1.54-1.55,3.73-3.74).
Optionally, the solvent is at least one of coconut oil, peony seed oil, macadamia nut oil and prinsepia utilis royle oil.
Optionally, the solvent is at least one of coconut oil and prinsepia utilis royle oil.
Optionally, the retinol content is 0.01-15%.
Optionally, the matrine content is 25-60%, and the solvent content is 25-60%.
Optionally, the content ratio of matrine to solvent is 1:0.5-1.5.
Optionally, an antioxidant is also included, and the antioxidant is at least one of tocopherol, ascorbic acid and dibutyl hydroxy toluene.
The application also provides the use of any of the foregoing retinol wraps for the preparation of cosmetics or skin care products.
The application also provides a raw material for cosmetics, which at least comprises any one of the retinol wrappers.
The application also provides an external skin preparation which at least comprises any one of the retinol wrappers.
The application also provides a preparation method of the retinol wrap, which comprises the following steps:
providing retinol, matrine, a solvent and an antioxidant;
mixing, heating and stirring matrine and a solvent under a light-shielding condition and an inert atmosphere, and reacting for 2-4 hours to obtain an ionic liquid;
mixing and stirring retinol and the ionic liquid cooled to normal temperature for 2-4 hours under a light-shielding condition and an inert atmosphere to obtain a primary liquid;
mixing and stirring the antioxidant and the primary liquid for 0.5-1 h to obtain the retinol wrap.
Optionally, the solvent is at least one of coconut oil, peony seed oil, macadamia nut oil and prinsepia utilis royle oil.
Retinol wrap
The present application provides a retinol wrap comprising at least: retinol; matrine; a solvent; intermolecular forces exist between the retinol and matrine.
The ionic liquid composed of matrine and a proper solvent has good suitability with retinol, and retinol is fully dissolved in the ionic liquid without precipitation, and has good solubility and no turbidity after being mixed with water, as shown in figures 1 and 2.
The solvent is preferably selected from any one or more of coconut oil, peony seed oil, macadamia nut oil, prinsepia utilis royle oil. Through tests, when the solvent is prepared into coconut oil, peony seed oil, macadamia nut oil and prinsepia utilis royle oil, the retinol wrapping material has transparent appearance, good uniformity and full dissolution after being mixed with the aqueous solution.
The retinol content is preferably 0.01 to 15%. As a further preferred, the retinol content is preferably 0.01 to 12%. As a further preferred, the retinol content is preferably 0.01 to 10%. For example, specifically, the content of retinol is preferably 0.1 to 1%, or preferably 2%, or preferably 3%, or preferably 4%, or preferably 5%, or preferably 6%, or preferably 7%, or preferably 8%, or preferably 9%, or preferably 10%.
The matrine content is preferably 25-60%. Further preferably, the matrine content is 45-55%. Specifically, the content of matrine is preferably 25 to 30%, or preferably 30 to 35%, or preferably 35 to 40%, or preferably 40 to 45%, or preferably 45 to 50%, or preferably 50 to 55%, or preferably 55 to 60%.
The solvent is preferably selected from any one of coconut oil, peony seed oil, macadamia nut oil, prinsepia utilis royle oil. When the solvent is coconut oil, peony seed oil, macadamia nut oil and prinsepia utilis royle oil, the retinol wrap is more stable, and the problems of color change, layering, water dissolution and the like are not easy to occur. The content of the solvent is preferably 25 to 60%. Further preferably, the matrine content is 45-55%. Specifically, the content of matrine is preferably 25 to 30%, or preferably 30 to 35%, or preferably 35 to 40%, or preferably 40 to 45%, or preferably 45 to 50%, or preferably 50 to 55%, or preferably 55 to 60%.
Preferably, the content ratio of matrine to solvent is 1:0.5-1.5. Further preferably, the content ratio of matrine to solvent is 1:0.8-1.2. For example, specifically, the content ratio of matrine to solvent is 1:0.5, or the content ratio of matrine to solvent is 1:0.6, or the content ratio of matrine to solvent is 1:0.7, or the content ratio of matrine to solvent is 1:0.8, or the content ratio of matrine to solvent is 1:0.9, or the content ratio of matrine to solvent is 1:1, or the content ratio of matrine to solvent is 1:1.1, or the content ratio of matrine to solvent is 1:1.2, or the content ratio of matrine to solvent is 1:1.3, or the content ratio of matrine to solvent is 1:1.4, or the content ratio of matrine to solvent is 1:1.5. When the content ratio of matrine to solvent is 1:0.8-1.2, more retinol can be dissolved in the retinol wrap.
Antioxidants may preferably be included in the retinol wrap in an amount of 0.01 to 10%. Further preferably, the content of the antioxidant is 0.01 to 5%. The antioxidant may be selected from commonly used antioxidants such as vitamin C, tocopherol, dibutyl hydroxytoluene, etc., preferably the antioxidant is tocopherol.
Raw material for cosmetics or external skin preparation
The application also provides a raw material for cosmetics or an external skin preparation, wherein the raw material for cosmetics or the external skin preparation can comprise other functional substances besides retinol inclusion, and the raw material for cosmetics or the external skin preparation comprises at least one of skin conditioning agents, antioxidants, lipids, thickening agents, emulsifying agents, moisturizers, preservatives, solubilizers, chelating agents and essence.
In the composition of the present application, the skin conditioner is not particularly limited. The skin conditioner is selected from hydroquinone, kojic acid, arbutin, ellagic acid, azelaic acid, L-ascorbic acid and its derivatives, glycyrrhrizae radix extract, fructus Polygoni Tinctorii extract, hydrangea extract, alkoxysalicylic acid, rhizoma Polygoni Cuspidati extract, flos Sophorae Immaturus extract, curcuma rhizome extract, cortex Mori extract, fructus Phyllanthi extract, semen Pisi Sativi extract, aloin, etc.
The antioxidant is not particularly limited in the present application. The antioxidant may be selected from butylhydroxytoluene, butylhydroxyanisole, propyl gallate, octyl gallate, dodecanol gallate, tertiary butylhydroquinone, tocopherol, ascorbyl palmitate, a mixture of isopropyl citrate, monoglyceride citrate, canola, sodium sulfite, sodium bisulfite, sodium metabisulfite, cysteine, isoascorbic acid, thiourea, dilauryl thiomalonate, nordihydroguaiaretic acid, lipoic acid, alpha-tocopheryl acetate, carotenoids, phyllanthin, ascorbic acid, glutathione, coenzyme Q10, and the like.
The lipid is not particularly limited in the present application. The lipid is selected from the group consisting of vegetable oils, animal oils, mineral oils, lanolin and derivatives thereof. The lipid can be selected from waxes, such as animal wax, vegetable wax, and mineral wax. The lipid may be selected from fatty acids and fatty alcohols. The lipid may be selected from lipids used to synthesize the skin barrier.
The thickener is not particularly limited in the present application. The thickener is selected from acrylic polymer and its derivatives, carbomer polymer, acrylic acid (ester)/C 10 ～C 30 Alkanol acrylate copolymer, acrylate/C 10 ～C 30 Alkanoacrylate crosslinked copolymer, acrylic acid (ester) copolymer, polyacrylate-1 crosslinked polymer, acrylic acid/acrylamide nitrogen copolymer, acrylic acid (ester) type/steareth (20) methacrylate copolymer, acrylic acid (ester) type/beheneth (25) methacrylate copolymer, acrylic acid (ester) type/steareth-20 itaconate copolymer, acrylic acid (ester) type/aminoacrylate copolymer, acrylic acid (ester) type/vinyl isodecanoate crosslinked polymer, steareth (10) allyl ether/acrylic acid (ester) type copolymer acrylic copolymer sodium salt/mineral oil/PPG-1 tridecyl polyether-6, glycerol polymethacrylate and compound thereof, castor oil/IPDI copolymer, acrylamide copolymer compound, acrylamide/sodium acrylate copolymer compound, sodium/ammonium acryloyldimethyl taurate copolymer and compound thereof, PVM/MA decadiene crosslinked polymer, PEG-150/decyl alcohol/SMDI copolymer, polyquaternium-31 and polyquaternium-37 compound, polyethylene and polyethylene copolymer, polyethylene glycol, polyethylene oxide, PEG-120 methylglucdioleate, PEG-120 sorbitanTriisostearate, polyvinyl alcohol, PEG-150 pentaerythritol tetrastearate, trishydroxystearin, aluminum hydroxide/magnesium stearate, and the like.
The surfactant is not particularly limited in the present application. The surfactant may be an anionic surfactant, a cationic surfactant, a nonionic surfactant, an amphoteric surfactant, a natural surfactant, a fluorosurfactant, or the like.
The humectant is not particularly limited in the present application. The humectant may be selected from glycerin, propylene glycol, butylene glycol, sorbitol polyether-20, amide type humectant, glycerin polyether type humectant, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, hydroxyethyl urea, erythritol, glycerin polyether-5 lactate, sodium hyaluronate, saccharide isomer, D-panthenol, polyethylene glycol, diglycerin, methacryloxyethyl phosphorylcholine, etc.
The preservative is not particularly limited in the present application. The preservative can be selected from the group consisting of hydroxyphenyl esters and salts thereof, formaldehyde and formaldehyde donors, isothiazolinones, phenolic preservatives, acid preservatives, halide preservatives, quaternary ammonium compounds, alcohols, commonly used built preservatives, natural preservatives and the like.
The chelating agent is not particularly limited in the present application. For example, the chelating agent may be selected from ethylenediamine tetraacetic acid and its sodium salts, glycine, citric acid, succinic acid, and the like.
The essence is not particularly limited in the present application. For example, the essence may be sandalwood, jasmine, rose, sweet orange, vanilla essence, etc. The essence can also comprise essential oil, and can be lime peel oil, bitter orange leaf/twig oil, geranium oil, rosa damascena flower oil, etc.
Experimental part
Sample preparation
Adding coconut oil (about 22 g) into a reaction kettle under the dark condition and inert atmosphere, keeping stirring, adding matrine powder (about 22 g), heating and stirring, wherein the heating temperature is 40-60 ℃, the stirring speed is 600-750 r/min, and reacting for 2-4 h to obtain the ionic liquid.
After the matrine-coconut oil ionic liquid is cooled to room temperature (25 ℃), keeping an inert atmosphere and avoiding light, adding retinol (about 5 g) into the matrine-coconut oil ionic liquid, and stirring at the stirring speed of 600-750 r/min for 2-4 h to obtain a primary liquid.
Finally adding tocopherol (vitamin E) (about 2.5 g), stirring for dissolving, wherein the stirring speed is 600-750 r/min, and the stirring time is 0.5-1 h, so as to obtain the retinol wrap.
Sample detection
Two-dimensional nuclear magnetic analysis
And carrying out two-dimensional nuclear magnetic analysis (a two-dimensional nuclear magnetic NOESY spectrogram is shown in figure 3) on the prepared retinol inclusion.
From fig. 3, it can be clearly seen that there is a clear hydrogen signal between retinol and the ionic liquid composed of matrine and coconut oil (see the label in fig. 3), which indicates that there is a clear nuclear euclidean effect (Nuclear Overhauser Effect, NOE), and thus that there is intermolecular forces in the retinol inclusion, which has a more stable structure.
Stability test
The prepared retinol wrap was subjected to stability test, the test contents include sensory test, temperature test and active content test, and the test results are shown in tables 1 to 3 and fig. 4.
TABLE 1
TABLE 2
TABLE 3 Table 3
From the stability test results of tables 1 to 3 and fig. 4, it can be seen that the retinol wrap of the present application has good stability.
Examples 1 to 4 were tested according to the above test methods, the components of examples 1 to 4 are shown in Table 4, and the statistical results are shown in Table 5.
TABLE 4 Table 4
TABLE 5
Transdermal test
Experimental sample
Sample group: 0.1mL of the retinol wrap was taken and formulated into 1mL of retinol wrap (wherein the solvent was the receiving solution).
Control group: a receiving solution containing 0.01g of retinol material (purity 100%) and 1 mL.
Naturally thawing the isolated pigskin preserved in a low temperature refrigerator, soaking in physiological saline for 30 min, drying with filter paper, fixing between two diffusion cells with iron clamp, and adding 7.5 mL acceptor solution (physiological saline: ethanol=1:1) into the acceptor cell of the vertical diffusion cell.
The sample group and the control group of 1mL were slowly injected into the supply cell, respectively, and the upper port was sealed with a sealing film. When the permeation duration was 4, 6, 24 hours, 200. Mu.L of permeate was placed in an EP tube for HPLC on-machine testing. After each sampling, the receiving well was replenished with an equal amount of receiving liquid and the air bubbles in the well were removed. Repeated three times. The on-machine test data were counted and analyzed, and the results are shown in fig. 5.
As shown in FIG. 5, the retinol wrap of the present application has better transdermal property and skin has better absorption effect on the retinol wrap of the present application compared to retinol solution.
Description of the preferred embodiments
Samples of 2% strength retinol wrap (mixed with 98% water) were prepared according to the aforementioned method for preparing retinol wrap of the present application (example 5, example 6, example 7 and example 8). Wherein example 5 is a mixed solution of 2% retinol wrap (composition of retinol wrap is 10% retinol, 40% matrine, 45% coconut oil and 5% tocopherol) with 98% water. Example 6 is a mixed solution of 2% retinol wrap (composition of retinol wrap is 10% retinol, 40% matrine, 45% peony seed oil and 5% tocopherol) with 98% water. Example 7 is a mixed solution of 2% retinol wrap (the composition of retinol wrap is 10% retinol, 40% matrine, 45% macadamia nut oil and 5% tocopherol) with 98% water. Example 8 is a mixed solution of 2% retinol wrap (the composition of retinol wrap is 10% retinol, 40% matrine, 45% prinsepia utilis royle oil and 5% tocopherol) with 98% water. The exterior of the material bodies of examples 5 to 8 is shown in FIG. 6.
All other embodiments, which can be made by a person skilled in the art based on the embodiments of the application without any inventive effort, are intended to fall within the scope of the application.
Modifications of the technical solutions described in the above embodiments or equivalent substitutions of some technical features thereof may be made by those skilled in the art; these modifications or substitutions do not depart from the essence of the corresponding technical solutions from the protection scope of the technical solutions of the embodiments of the present application.

Claims (14)

1. A retinol wrap, characterized in that it comprises at least:
retinol;
matrine;
a solvent;
intermolecular forces exist between the retinol and matrine.
2. A retinol wrap, characterized in that it comprises at least:
retinol;
matrine;
a solvent;
the retinol wrap has at least the following hydrogen signals in the nuclear orvehaus effect spectrum:
(3.71-3.74,2.00-2.04) or (2.00-2.04,3.71-3.74);
(4.20-4.22,1.55-1.58) or (1.55-1.58,4.20-4.22);
(3.71-3.75,1.53-1.56) or (1.53-1.56,3.71-3.75).
3. The retinol wrap as defined in claim 2 wherein the retinol wrap has at least the following hydrogen signals in the nuclear euclidean effect spectrum:
(3.72-3.73,2.01-2.02) or (2.01-2.02,3.72-3.73);
(4.20-4.21,1.55-1.56) or (1.55-1.56,4.20);
(3.73-3.74,1.54-1.55) or (1.54-1.55,3.73-3.74).
4. A retinol wrap as in any one of claims 1-3 wherein the solvent is at least one of coconut oil, peony seed oil, macadamia nut oil, prinsepia utilis royle oil.
5. A retinol wrap as in any one of claims 1-3 wherein the solvent is at least one of coconut oil, prinsepia utilis royle oil.
6. A retinol wrap as in any of claims 1-3 wherein the retinol is present in an amount of 0.01-15%.
7. A retinol wrap as in any of claims 1-3 wherein the matrine is present in an amount of 25-60% and the solvent is present in an amount of 25-60%.
8. A retinol wrap as in any of claims 1-3 wherein the ratio of matrine to solvent is 1:0.5-1.5.
9. The retinol wrap as defined in claim 1, further comprising an antioxidant which is at least one of tocopherol, ascorbic acid, dibutyl hydroxy toluene.
10. Use of a retinol wrap as defined in any one of claims 1 to 9 for the preparation of cosmetics or skin care products.
11. Cosmetic raw material, characterized in that it comprises at least a retinol wrap as defined in any one of claims 1 to 9.
12. A skin preparation for external use, characterized in that it comprises at least a retinol wrap as defined in any one of claims 1 to 9.
13. A method of preparing a retinol wrap as defined in any one of claims 1 to 9, comprising the steps of:
providing retinol, matrine, a solvent and an antioxidant;
mixing, heating and stirring matrine and a solvent under a light-shielding condition and an inert atmosphere, and reacting for 2-4 hours to obtain an ionic liquid;
mixing and stirring retinol and the ionic liquid cooled to normal temperature for 2-4 hours under a light-shielding condition and an inert atmosphere to obtain a primary liquid;
mixing and stirring the antioxidant and the primary liquid for 0.5-1 h to obtain the retinol wrap.
14. The method of claim 13, wherein the solvent is at least one of coconut oil, peony seed oil, macadamia nut oil, prinsepia utilis royle oil.
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