CN116509759B

CN116509759B - Oily particle composition for coating active substance and external skin preparation

Info

Publication number: CN116509759B
Application number: CN202310776999.8A
Authority: CN
Inventors: 舒鹏; 李美停
Original assignee: Shenzhen Hujia Technology Co ltd
Current assignee: Shenzhen Hujia Technology Co ltd
Priority date: 2023-06-29
Filing date: 2023-06-29
Publication date: 2023-08-29
Anticipated expiration: 2043-06-29
Also published as: CN116509759A

Abstract

The application provides an oily particle composition for coating an active substance and an external skin preparation, wherein the composition comprises the following components: oily droplets and water; the oily liquid drop comprises an oily gel and a hydrophilically modified oily gel, and the oily liquid drop also comprises an oil-soluble active substance and skin-moistening grease; the water at least comprises an oleophilic modified aqueous gel; wherein the hydrophilic modified oily gel is an oily gel connected with polyethylene glycol groups, polypropylene glycol groups or polyglycerin groups; the lipophilic modified aqueous gel is acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer, and the cosmetic composition containing oily particles, which is difficult to aggregate, has good protection effect on active substances and excellent skin feel, is prepared by using the oily gel, the hydrophilic modified oily gel and the lipophilic modified aqueous gel in a matching way, and has wide market prospect.

Description

Oily particle composition for coating active substance and external skin preparation

Technical Field

The application relates to the field of cosmetics, in particular to an oily particle composition for wrapping an active substance and an external skin preparation.

Background

Methods for preparing cosmetics containing oily droplets are known, the main idea being: the oily gel is used for thickening the skin-moistening grease and the active grease to form oily liquid drops with spherical structures, and is matched with the aqueous gel, such as acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer used as the lipophilic modified aqueous gel or hydrophilic powder to prevent aggregation among the oily liquid drops.

After the lipophilic modified aqueous gel is dispersed in the water phase when not neutralized, the pH of the material is acidic, the hydrophilicity is weak, and the lipophilic modified aqueous gel is more distributed on the surfaces of oily liquid drops, so that oily liquid drops with better forms can be prepared, and oily particles are effectively prevented from being aggregated.

However, the acidic pH of the charge is detrimental to the preservation of the active added to the charge and tends to deactivate the active. After neutralization of the mass, it was found that the hydrophilicity of the lipophilically modified aqueous gel was increased such that its tendency to distribute on the surface of oily droplets was reduced and the oily droplets began to aggregate.

Disclosure of Invention

The application aims to solve the technical problems:

how to solve the problem of preventing the aggregation of oily droplets in the composition of oily droplets.

The technical means for solving the technical problems are as follows:

as a result of extensive studies, the inventors have unexpectedly found that the problem of oily droplet aggregation caused by the increased hydrophilicity of the acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer can be overcome by adding the hydrophilically modified oily gel. Specifically, the added hydrophilic modified oily gel tends to be distributed on the surface of the oily liquid drops and can play a role in supporting the structure of the oily liquid drops; in addition, the influence of the water phase environment on the oil-soluble active substances in the oily liquid drops can be slowed down, so that the oil-soluble active substances are better protected.

In one aspect of the present application, there is provided a composition comprising:

oily droplets and water;

the oily liquid drop comprises an oily gel and a hydrophilically modified oily gel, and the oily liquid drop also comprises an oil-soluble active substance and skin-moistening grease;

the water at least comprises an oleophilic modified aqueous gel; wherein, the liquid crystal display device comprises a liquid crystal display device,

the hydrophilic modified oily gel is an oily gel connected with polyethylene glycol groups, polypropylene glycol groups or polyglyceryl groups;

the oleophylic modified aqueous gel is acrylic acid (ester) or C10-30 alkanol acrylate cross-linked polymer.

In another aspect of the present application, there is provided a skin preparation for external use comprising at least the aforementioned composition.

Advantageous effects

The oily liquid drops in the composition system are not easy to aggregate, the skin feel of the composition is excellent, and the composition has good protection effect on active substances.

Drawings

The application also provides a drawing related to the technical scheme provided for explaining the technical scheme of the application. The drawings and description are only for the purpose of illustrating the application more clearly and should not be taken as limiting the scope of the application as claimed.

FIG. 1 shows a state in which aggregation occurs between oily droplets in a composition without adding a hydrophilically-modified oily gel agent thereto under an ambient temperature environment;

FIG. 2 shows a state in which no hydrophilically-modified oily gel is added to the composition and the body is oil-white in a low-temperature environment;

FIG. 3 shows a state in which no hydrophilically-modified oily gel is added to the composition in which oil is discharged around the oily liquid droplets under a high-temperature environment;

FIG. 4 shows the state of a composition having oil droplets of smaller particle size (with the addition of a hydrophilically modified oil gelling agent) in a high temperature environment;

fig. 5 shows a state of a composition having oil droplets of smaller particle diameter (added with a hydrophilically modified oil gel) in a normal temperature environment;

FIG. 6 shows the state of a composition having oil droplets of smaller particle size (with the addition of a hydrophilically modified oily gel) in a low temperature environment;

FIG. 7 shows the state of a composition having oil droplets with a larger particle diameter (added with a hydrophilically modified oil gelling agent) in a high temperature environment;

fig. 8 shows a state of a composition having oil droplets with a larger particle diameter (to which a hydrophilically modified oily gel agent is added) in a normal temperature environment;

fig. 9 shows the state of a composition having oil droplets with a larger particle diameter (to which a hydrophilically modified oily gel agent is added) in a low-temperature environment.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions of the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are not all embodiments.

Elements and features described in one embodiment of the application may be combined with elements and features shown in one or more other embodiments. It should be noted that the illustration and description of components and processes known to those of ordinary skill in the art, which are not relevant to the present application, have been omitted for clarity.

Definition of the definition

Herein, unless otherwise indicated, the term "%" means "% by mass".

Herein, unless otherwise indicated, "content" refers to the net content of the component in the composition.

Herein, unless otherwise indicated, the term "%" herein refers to based on the total mass of the composition of the present application.

In this context, all ranges defined refer to: including each specific range within a given range as well as combinations of sub-ranges between the given ranges. For example, a range of 1 to 5 specifically includes 1, 2, 3, 4 and 5, and also includes sub-ranges such as 2 to 5, 3 to 5, 2 to 3, 2 to 4, 1 to 4, etc.

In this context, the range of ratios refers to: including each specific ratio within a given range and combinations of sub-ranges between the given ranges.

Herein, the external skin preparation means any one or more forms commonly used in the field of skin care products or cosmetics including lotions, emulsions, foundations, hand creams, lotions, shampoos, conditioners, hair conditioners, styling agents, masks, soaps, facial washes and the like, which can be employed without affecting the technical effects of the preparation of the present application.

The present application provides a composition comprising at least:

oily droplets and water;

Optionally, the content of the oily gel is 1-30%; the content of the hydrophilic modified oily gel is 0.1-10%; the content of the lipophilic modified aqueous gel is 0.05-5%.

Optionally, the content of the oily gel is 1-10%; the content of the hydrophilic modified oily gel is 0.1-2%; the content of the lipophilic modified aqueous gel is 0.05-0.5%.

Optionally, the oily gel comprises one or more of castor oil/IPDI copolymer, propylene glycol di-ricinoleate/IPDI copolymer, and HDI/trimethylol hexyl lactone cross-linked polymer.

Optionally, the hydrophilically modified oily gel is a hydrophilically modified IPDI copolymer.

Optionally, the hydrophilically-modified oily gel is one or more of PEG-200 hydrogenated castor oil/IPDI copolymer, PPG-17/IPDI/DMPA copolymer, bis-PEG-15 polydimethylsiloxane/IPDI copolymer, PPG-35/PPG-51 glyceryl ether/IPDI cross-linked polymer, and glyceryl polyether-7 hydroxystearate/IPDI copolymer.

Optionally, the content ratio of the oily gel to the hydrophilically modified oily gel is 5-25:1.

Optionally, the content ratio of the hydrophilic modified oily gel to the lipophilic modified aqueous gel is 0.5-3:1.

Optionally, the average particle size of the oily liquid drops is 0.05-10 mm.

The application also discloses an external skin preparation which at least comprises any one of the compositions.

Compositions of the application

Oily liquid drop

The average particle diameter of the oily liquid droplets is preferably 0.05 to 10. 10 mm. Specifically, oily droplets having an excessively large average particle diameter are liable to aggregate, and an excessively small average particle diameter of the oily droplets does not provide a visual effect. The size of the oily liquid drops can be realized by adjusting the preparation process.

Oily gel

The oily gelling agent preferably comprises at least one of castor oil/IPDI copolymer, propylene glycol di-ricinoleate/IPDI copolymer, and HDI/trimethylol hexyl lactone cross-linked polymer.

The content of the oily gelling agent is preferably 1 to 30%. More preferably, the content of the oily gelling agent is preferably 1 to 10%. Specifically, the content of the oily gel may be 1% or 2% or 3% or 4% or 5% or 6% or 7% or 8% or 9% or 10%.

Oleophilic modified aqueous gel

The lipophilic modified aqueous gels are preferably acrylic acid (esters) based/C10-30 alkanol acrylate crosslinked polymers.

The content of the lipophilic modified aqueous gel is preferably 0.05 to 5%. More preferably, the content of the lipophilic modified aqueous gel is 0.05 to 0.5%. Specifically, the content of the oily gel may be 0.05 to 0.1% or 0.1 to 0.2% or 0.2 to 0.3% or 0.3 to 0.4% or 0.4 to 0.5%.

Hydrophilic modified oily gel

The hydrophilically modified oily gelling agent is preferably a hydrophilically modified IPDI copolymer. More preferably, the hydrophilically modified IPDI copolymer may include at least one of PEG-200 hydrogenated castor oil/IPDI copolymer, PPG-17/IPDI/DMPA copolymer, bis-PEG-15 polydimethylsiloxane/IPDI copolymer, PPG-35/PPG-51 glyceryl ether/IPDI cross-linked polymer, and glyceryl polyether-7 hydroxystearate/IPDI copolymer.

The content of the hydrophilically modified oily gel is preferably 0.1 to 10%. More preferably, the content of the lipophilic modified aqueous gel is 0.1 to 2%. In particular, the content of the hydrophilically modified oily gel may be 0.1% or 0.2% or 0.3% or 0.4% or 0.5% or 0.6% or 0.7% or 0.8% or 0.9% or 1% or 1.1% or 1.2% or 1.3% or 1.4% or 1.5% or 1.6% or 1.7% or 1.8% or 1.9% or 2%.

The content ratio of the oily gel to the hydrophilically modified oily gel is preferably 5 to 25:1. If the content ratio of the oily gel to the hydrophilically modified IPDI copolymer is less than 5:1, the particle size of the oily liquid drops is too small, the heat-resistant stability is poor, and the inactivation speed of the active substance is not different from that of the common emulsion. If the ratio of oily gel to hydrophilically modified oily gel is greater than 25:1, the composition of the application becomes too heavy and tacky in skin feel.

The content ratio of the hydrophilically modified oily gel to the hydrophilically modified aqueous gel is preferably 0.5 to 3:1. If the content of the hydrophilic modified oily gel is too small, oily liquid drops are easy to aggregate; if the content is too high, the use feeling is affected. Within this preferable range, oily droplets in the composition are less likely to aggregate and are excellent in skin feel.

The performance of the acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer can be changed under different pH conditions, so that the distribution state of the acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer on the surface of oily liquid drops is directly influenced, and finally the oily liquid drops are aggregated, the hydrophilic group of the hydrophilic modified IPDI copolymer is relatively less influenced by the pH, and the situation of the aggregation of the oily liquid drops in the composition of the acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer singly can be improved by adding the hydrophilic modified oily gel.

The main function of the oily gel is to solidify grease and oil-soluble active substances to form a spherical structure, and the hydrophilic modified oily gel is similar to the oily gel in structure on one hand, and can assist the oily gel to form a uniform spherical structure; on the other hand, the hydrophilic modified oily gel contains hydrophilic groups, so that the hydrophilic modified oily gel is easier to exist on the surfaces of oily liquid drops, is easier to lock oily components in particles, and is also more beneficial to the protection effect of active substances.

In comparison to the addition of hydrophilic powders to the formulation, hydrophilic powders may be present in the aqueous phase in addition to the oily droplet surface, resulting in undesirable effects of the resulting oily droplets.

The thickening effect can be achieved by increasing the addition amount of the oily gel, but the amount of the oily gel to be added is large, so that the skin feel of the composition becomes sticky and heavy obviously.

Although the addition of solid fatty alcohol can improve the stability of particles to some extent when only a small amount of oily gel is used, the addition of solid fatty alcohol simultaneously brings a astringent feel and a heavy feel, and has a large influence on skin feel. In addition, solid fatty alcohols tend to spontaneously form lamellar liquid crystals in the aqueous phase, which can lead to migration of the solid fatty alcohols in the oily particles to the aqueous phase over time, a slow clouding of the entire composition, and poor stability and appearance.

Skin-moistening grease

The emollient oils preferably include vegetable oils, non-polar hydrocarbon oils, synthetic ester oils, and silicone oils. Examples of vegetable oils include olive oil, shea butter, coconut oil, sunflower seed oil, canola oil, jojoba seed oil, castor oil, wild soybean oil, camellia seed oil, and white pool seed oil. Examples of the nonpolar hydrocarbon oil include hydrogenated polyisobutene, squalane, hydrogenated polydecene, liquid paraffin, and petrolatum. Examples of synthetic ester oils include phytosterol/octyldodecanol lauroyl glutamate, tri (ethylhexanoate) glycerol, caprylic/capric triglyceride, isopropyl palmitate, dioctyl carbonate, ethylhexyl hydrogenated olive oleate, isopropyl myristate, pentaerythritol tetra (ethylhexanoate), isononyl isononanoate, and neopentyl glycol diheptanoate. Examples of the silicone oil include polydimethylsiloxane, phenyl trimethicone, cyclopentadimethicone, octyl polymethylsiloxane, and methylpolysiloxane.

The content of the emollient oil is preferably 5 to 50%. More preferably, the content of the emollient oil is 5 to 30%.

Active material

The active may comprise at least one of an oil soluble active and a water soluble active.

The oil soluble actives preferably include glabridin, retinol and its derivatives, ceramides, ascorbyl tetraisopalmitate, ascorbyl palmitate, ginseng seed oil and the like.

The water-soluble active substance preferably comprises water-soluble polypeptide, arbutin, alpha-manna, oat glucan, water-soluble vitamins, amino acid derivatives, plant extract, etc.

The content of active is preferably 0.1 to 20%. More preferably, the active content is 0.1 to 10%.

Water and its preparation method

The water is preferably ultrapure water, deionized water, rose water, lavender flower water, or the like.

The water content may be appropriately added according to the solubility of the components contained in the composition, the dosage form of the composition itself, the concentration, and the like.

Powder

The powder may be included in the present application, and the powder is preferably selected from inorganic powders such as talc, mica, kaolin, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, titanium dioxide, zinc oxide, etc., or organic powders such as polyamide spherical resin powder (nylon spherical powder), spherical polyethylene, crosslinked poly (meth) acrylic spherical resin powder, spherical polyester, crosslinked polystyrene spherical resin powder, spherical cellulose, etc. The powder may or may not be surface treated. The average particle diameter of the powder is not particularly limited in the present application.

The external skin preparation of the application

The external skin preparation can also comprise other functional substances besides the components, including at least one of skin conditioning agent, antioxidant, emulsifier, humectant, antiseptic, solubilizer, chelating agent and essence.

In the composition of the present application, the skin conditioner is not particularly limited. The skin conditioner is selected from hydroquinone, kojic acid, arbutin, ellagic acid, azelaic acid, malonyl diglycine, L-ascorbic acid and its derivatives, glycyrrhrizae radix extract, fructus Polygoni Cuspidati extract, sparassis crispa extract, alkoxysalicylic acid, rhizoma Polygoni Cuspidati extract, flos Sophorae Immaturus extract, curcuma rhizome extract, cortex Mori extract, fructus Phyllanthi extract, semen Pisi Sativi extract, aloin, etc.

The antioxidant is not particularly limited in the present application. The antioxidant is selected from butylhydroxytoluene, butylhydroxyanisole, propyl gallate, octyl gallate, dodecyl gallate, tertiary butylhydroquinone, tocopherol, ascorbyl palmitate, isopropyl citrate mixture, monoglyceride citrate, enoxolone, sodium sulfite, sodium bisulphite, sodium metabisulfite, cysteine, isoascorbic acid, thiourea, dilauryl thiomalonate, nordihydroguaiaretic acid, lipoic acid, alpha-tocopheryl acetate, carotenoids, phyllanthus tannin, ascorbic acid, glutathione, coenzyme Q10, etc.

The surfactant is not particularly limited in the present application. The surfactant may be an anionic surfactant, a cationic surfactant, a nonionic surfactant, an amphoteric surfactant, a natural surfactant, a fluorosurfactant, or the like.

The humectant is not particularly limited in the present application. The humectant is selected from glycerin, propylene glycol, butylene glycol, sorbitol polyether-20, amide humectant, glycerin polyether humectant, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, hydroxyethyl urea, erythritol, glycerin polyether-5 lactate, sodium hyaluronate, saccharide isomer, D-panthenol, polyethylene glycol, diglycerin, methacryloxyethyl phosphorylcholine, etc.

The preservative is not particularly limited in the present application. The preservative is selected from the group consisting of hydroxyphenyl esters and salts thereof, formaldehyde and formaldehyde donors, isothiazolinones, phenolic preservatives, acid preservatives, halide preservatives, quaternary ammonium compounds, alcohols, commonly used compound preservatives, natural preservatives, and the like.

The chelating agent is not particularly limited in the present application. For example, the chelating agent may be selected from ethylenediamine tetraacetic acid and its sodium salts, glycine, citric acid, succinic acid, and the like.

The essence is not particularly limited in the present application. For example, the essence may be sandalwood, jasmine, rose, sweet orange, vanilla essence, etc. The essence may also comprise essential oils, such as lime peel oil, bitter orange leaf/twig oil, pelargonium graveolens oil, rosa damascana flower oil, etc.

Experimental part

Samples (examples 1 to 9 and comparative examples 1 to 3) were prepared according to the formulations in tables 1 and 2, and subsequent experiments were performed.

The sample preparation process is as follows:

uniformly mixing the phase A raw materials, and heating to 80-90 ℃;

uniformly mixing the raw materials of the phase B, heating to 80-85 ℃, homogenizing for 3-5 min at a stirring speed of 3000 rpm until the materials are uniformly dispersed without particles;

adding phase A into phase B, keeping stirring speed at 30-45 r/min, preserving heat for 10min, and then starting to cool;

and (3) adding the phase C when the temperature is reduced to about 45 ℃, continuously mixing and stirring uniformly, continuously reducing the temperature to room temperature, and discharging to obtain the sample.

TABLE 1

TABLE 2

Sample testing

Skin feel test was performed on the samples of examples 1 to 9 and comparative examples 1 to 3 described above

The skin feel test is subjective, the score value range is 0-10, and 10 represents very satisfactory; 30 volunteers using skin care products are selected, the products are respectively scored after trial, and the statistical result is averaged.

Retinol storage Rate test was performed on the samples of examples 1 to 9 and comparative examples 1 to 3 described above

Detecting the content of retinol and derivatives in the sample, and obtaining data A; storing the sample at a constant temperature of 45 ℃ for 30 days, and then carrying out content detection again to obtain data B;

the retinol retention (30 days) was calculated as: b/a is 100%.

The results of the sample testing are shown in tables 3 and 4.

TABLE 3 Table 3

TABLE 4 Table 4

From the test results, it is clear that the hydrophilic modified oily gels are not added in both comparative example 1 and comparative example 2, the phenomenon of oily droplet aggregation occurs in the sample after the sample is left at normal temperature for 30 days (as shown in fig. 1), the phenomenon of oily droplet aggregation even oil exudation from the oily droplets occurs in the high-temperature and low-temperature environments, and the activity retention rate of the oil-soluble active substances and the appearance of the composition are seriously affected (the low-temperature environment is shown in fig. 2, and the high-temperature environment is shown in fig. 3). In comparative example 3, solid fatty alcohol was added to assist the oily gel to form a system with oily droplets, but the effect was very limited in high and low temperature environments, and the problem of oily droplet aggregation or system oil extraction was not solved.

Examples 1 to 9, to which the hydrophilically modified oily gels were added, gave good evaluations on skin feel, and also had significant advantages in terms of stability and retinol retention. The composition of the application has good skin feel and stability, and can effectively protect retinol and other oil-soluble active substances (the state of the composition with oily liquid drops with smaller particle size under high-temperature, normal-temperature and low-temperature environments is shown in figures 4-6, and the state of the composition with oily liquid drops with larger particle size under high-temperature, normal-temperature and low-temperature environments is shown in figures 7-9).

All other embodiments, which can be made by a person skilled in the art based on the embodiments of the application without any inventive effort, are intended to fall within the scope of the application.

Modifications of the technical solutions described in the above embodiments or equivalent substitutions of some technical features thereof may be made by those skilled in the art; these modifications or substitutions do not depart from the essence of the corresponding technical solutions from the protection scope of the technical solutions of the embodiments of the present application.

Claims

1. A composition characterized in that it comprises at least:

oily droplets and water;

the hydrophilic modified oily gel is one or more of PEG-200 hydrogenated castor oil/IPDI copolymer, PPG-17/IPDI/DMPA copolymer, bis-PEG-15 polydimethylsiloxane/IPDI copolymer, PPG-35/PPG-51 glyceryl ether/IPDI cross-linked polymer and glyceryl polyether-7 hydroxystearate/IPDI copolymer;

the oily gel comprises one or more of castor oil/IPDI copolymer, propylene glycol di-ricinoleate/IPDI copolymer and HDI/trimethylol hexyl lactone cross-linked polymer;

the oleophylic modified aqueous gel is acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer;

the content of the oily gel is 1-30%;

the content of the hydrophilic modified oily gel is 0.1-10%;

the content of the lipophilic modified aqueous gel is 0.05-5%.

2. The composition of claim 1, wherein:

the content of the oily gel is 1-10%;

the content of the hydrophilic modified oily gel is 0.1-2%;

the content of the lipophilic modified aqueous gel is 0.05-0.5%.

3. The composition of claim 1, wherein the ratio of the oily gel to the hydrophilically modified oily gel is from 5 to 25:1.

4. The composition of claim 1, wherein the content ratio of the hydrophilically modified oily gel to the hydrophilically modified aqueous gel is 0.5 to 3:1.

5. The composition of claim 1 wherein said oily droplets have an average particle size of from 0.05 to 10 mm.

6. A skin preparation for external use, characterized in that it comprises at least the composition according to any one of claims 1 to 5.