CN116549563A - Traditional Chinese medicine composition for soothing liver and promoting bile flow as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for soothing liver and promoting bile flow as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine ointment, and particularly relates to a traditional Chinese medicine composition for soothing liver and promoting bile flow, and a preparation method and application thereof. The traditional Chinese medicine composition for soothing liver and promoting bile flow provided by the invention comprises the following components: radix Platycodi, notoginseng radix, folium Mori, herba Huichhorniae, atractylodis rhizoma, alismatis rhizoma, radix rehmanniae Preparata, rhizoma Polygonati Odorati, ganoderma, cortex Lycii and fructus Lipuidambaris. The traditional Chinese medicine composition has obvious effects of soothing liver, promoting bile flow and treating liver and gall diseases; the preparation method comprises preparing the raw materials into Chinese medicinal powder and plant essential oil, and mixing. The ointment adopts the administration mode of acupoint application, combines the rapid permeation effect of the essential oil of the traditional Chinese medicine, and the effective components can directly enter the channels and collaterals and the microcirculation of the human body through the skin of the acupoints, so as to reach the whole body and rapidly absorb the effective components. The acupoint application mode bypasses the first pass effect of the liver, the metabolism and the excretion of the kidney and the gastrointestinal inactivation, protects the liver and the kidney and reduces the toxicity damage.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine ointment, and particularly relates to a traditional Chinese medicine composition for soothing liver and promoting bile flow, and a preparation method and application thereof.
Background
At present, the treatment methods for the problems of liver stasis and qi stagnation, soothing liver and regulating qi, clearing fat and improving eyesight, enhancing liver evacuation capability, metabolizing liver toxin, promoting secretion of alcohol dehydrogenase and acetaldehyde dehydrogenase and the like mainly adopt the modes of oral administration of Chinese and western medicine preparations such as tablets, decoction, pills, capsules and the like, and the administration modes need to be absorbed into blood through gastrointestinal digestion and absorption, so that the first pass effect of liver, kidney metabolism and excretion and gastrointestinal inactivation are easy to occur, so that the dosage entering the systemic circulation is reduced, the utilization rate of the medicine is reduced, and meanwhile, the burden of intestines and stomach, liver and kidney is increased.
However, since it is difficult for the common traditional Chinese medicine ointment to directly reach the focus of the liver and gall through the skin of the body surface of the liver and gall, the traditional Chinese medicine ointment for treating the liver and gall problems is still blank at present.
Disclosure of Invention
In order to solve the technical problems, a traditional Chinese medicine composition for soothing liver and promoting bile flow and a preparation method and application thereof are provided.
In the first aspect, the traditional Chinese medicine composition for soothing liver and promoting bile flow comprises the following raw materials in parts by weight: 10-30 parts of platycodon grandiflorum, 10-30 parts of pseudo-ginseng, 10-30 parts of mulberry leaf, 10-30 parts of Huichun grass, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of rhizoma alismatis, 5-10 parts of prepared rehmannia root, 5-10 parts of polygonatum odoratum, 5-10 parts of lucid ganoderma, 10-20 parts of cortex lycii radicis and 10-20 parts of fructus liquidambaris.
By adopting the technical scheme, the ganoderma lucidum is taken as a monarch drug; rhizoma alismatis and prepared rehmannia root are ministerial drugs; rhizoma Atractylodis Macrocephalae and rhizoma Polygonati Odorati as adjuvant drugs; herba Huichi, fructus Lipuidambaris, cortex Lycii, radix Platycodi, notoginseng radix and folium Mori as guiding drug; the drug effect of the drug with the combined action can be exerted to the maximum extent.
A Chinese medicinal composition for dispersing stagnated liver qi and promoting bile flow comprises medicinal powder and medicinal oil,
powder: 10-30 parts of platycodon grandiflorum, 10-30 parts of pseudo-ginseng, 10-30 parts of mulberry leaf, 10-30 parts of Huichun grass, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of rhizoma alismatis and 5-10 parts of prepared rehmannia root;
the medicinal oil is prepared from the following raw materials: 5-10 parts of radix polygonati officinalis, 5-10 parts of lucid ganoderma, 10-20 parts of cortex lycii radicis and 10-20 parts of fructus liquidambaris.
Wherein, in the medicinal powder, the particle size of the traditional Chinese medicine obtained by crushing the raw materials is 0.1-1.0 μm;
extracting the raw materials in the medicinal oil by supercritical carbon dioxide extraction to obtain plant essential oil, namely medicinal oil; specifically, the extraction temperature is 50-100 ℃, the extraction pressure is 20-25MPa, and the extraction time is 5-6h.
Preferably, the raw material components comprise, in parts by weight: 20 parts of platycodon grandiflorum, 20 parts of pseudo-ginseng, 20 parts of mulberry leaf, 20 parts of Huichun grass, 7 parts of bighead atractylodes rhizome, 7 parts of rhizoma alismatis, 7 parts of prepared rehmannia root, 7 parts of radix polygonati officinalis, 7 parts of lucid ganoderma, 15 parts of cortex lycii radicis and 15 parts of fructus liquidambaris.
In a second aspect, the preparation method of the traditional Chinese medicine composition for soothing liver and promoting bile flow adopts the following technical scheme:
a preparation method of a traditional Chinese medicine composition for soothing liver and promoting bile flow comprises the following steps: pulverizing radix Platycodi, notoginseng radix, folium Mori, herba Huichi, atractylodis rhizoma, alismatis rhizoma, and radix rehmanniae Preparata into Chinese medicinal powder, extracting plant essential oil from rhizoma Polygonati Odorati, ganoderma, cortex Lycii, and fructus Lipuidambaris, and mixing the Chinese medicinal powder and plant essential oil thoroughly to obtain the Chinese medicinal composition for dispersing stagnated liver qi and promoting bile flow.
By adopting the technical scheme, the traditional Chinese medicine powder is compatible, the bighead atractylodes rhizome is used as a monarch drug, the rhizoma alismatis and the prepared rehmannia root are used as ministerial drugs, the Huichun grass is used as adjuvant drugs, and the platycodon grandiflorum, the pseudo-ginseng and the mulberry leaf are used as conductant drugs; essential oil compatibility, namely ganoderma lucidum is a monarch drug, polygonatum is a ministerial drug, fructus liquidambaris is an adjuvant drug, and cortex lycii radicis is a conductant drug; the traditional Chinese medicine ointment is prepared by mixing, the essential oil has strong penetrability, the pores are relaxed, yi Shun passes through the channels to reach the liver and gall parts in the corresponding viscera and six fu organs, and the effect of the traditional Chinese medicine powder is matched, so that the medicine effect is maximally acted on the liver and gall parts, and the focus can be rapidly and effectively treated and recovered.
Preferably, the preparation method of the traditional Chinese medicine powder comprises the following steps:
(1) Weighing platycodon grandiflorum, pseudo-ginseng, mulberry leaf, huichun grass, bighead atractylodes rhizome, rhizoma alismatis and prepared rehmannia root according to parts by weight, cleaning and airing;
(2) Freeze-drying the medicinal materials in the step (1) at (-20) - (-40) deg.C for 20-30h;
(3) And (3) carrying out low-temperature ultrafine grinding on the medicinal materials frozen in the step (2), wherein the grinding temperature is 0- (-10) DEG C, the grinding time is 30-60min, and the traditional Chinese medicine powder with the particle size of 0.1-1.0 mu m is selected.
Preferably, in the step (2), the freezing temperature is-30 ℃, and the freezing time is 25 hours.
Preferably, in the step (3), the crushing temperature is-5 ℃, and the crushing time is 45min.
Preferably, the preparation method of the plant essential oil comprises the following steps:
cleaning and airing rhizoma polygonati officinalis, ganoderma lucidum, cortex lycii radicis and fructus liquidambaris according to parts by weight, slicing and crushing, extracting volatile oil by a supercritical carbon dioxide extraction method at 50-100 ℃ under 20-25MPa for 5-6 hours, and obtaining plant essential oil of the rhizoma polygonati officinalis, ganoderma lucidum, cortex lycii radicis and fructus liquidambaris.
Preferably, the extraction temperature is 75 ℃, the extraction pressure is 22MPa, and the extraction time is 5.5h.
In a third aspect, an application adopts the following technical scheme:
the traditional Chinese medicine ointment is used as an ointment patch for soothing liver and promoting bile flow.
Preferably, the plaster is applied to an acupoint combination;
the acupoint combination is selected from one or more acupoints of Chaomen, shimen, with pulse, yongquan and Taixi.
The traditional Chinese medicine paste prepared by the invention is applied by the following steps: the plaster is stuck on corresponding acupuncture points (one or more of Chaomen, shimen, with pulse, yongquan and Taixi) for 8-24 hours to be replaced once.
The invention has the characteristics and beneficial effects that:
1. adopts the extraction process of Chinese medicinal materials to maximize the medicinal effect. The method is characterized in that a part of Chinese medicinal materials are selected to extract plant essential oil, and the other part of Chinese medicinal materials are prepared into Chinese medicinal fine powder according to the characteristics of cold, cool, warm, heat four nature, pungent, sweet, sour, bitter and salty five flavors of different Chinese medicinal materials and the mode of being more beneficial to human body absorption, and then the plant essential oil and the Chinese medicinal fine powder are mixed to prepare the Chinese medicinal composition, so that the effects of each Chinese medicinal material can be exerted to a greater extent.
2. Adopts double compatibility, and the prescription is more compact. The first layer is formed by combining all traditional Chinese medicinal materials according to monarch, minister, assistant and guide in the whole formula; the second layer, in the preparation process of plant essential oil and traditional Chinese medicine fine powder, also respectively compatibility of the traditional Chinese medicine materials in two extraction modes according to monarch, minister, assistant and guide, so that the formula is more reasonable, the interaction among various medicinal materials is more sufficient, and the effects can be exerted in a layering way after acting on a human body, and the preparation method is stable and durable.
3. Adopts Chinese medicinal essential oil, improves purity, and enhances osmotic force. The plant essential oil is extracted and refined by using modern technological means, and on the basis of not violating the aim of 'pure natural herbal essence', the extract essence has higher concentration, stronger penetrability and quicker drug effect, and the active ingredient achieves the effect of multiple times of common aromatic essential oil. Meanwhile, the selected Chinese medicinal essential oils act with each other, but not the single plant essential oil, so that the whole formula essential oil can bring more vigor, half and multiple functions.
4. The acupoint application administration mode is adopted, the menstruation is entered, and the effect is achieved quickly and safely. According to the meridian principle, the traditional Chinese medicine composition adopts an administration mode of acupoint application, combines the rapid permeation effect of the essential oil of the traditional Chinese medicine, and the active ingredients can directly enter the meridian and the microcirculation of the human body through the skin of the acupoint, so that the traditional Chinese medicine composition can reach the whole body, and the active ingredients can be rapidly absorbed, thus the traditional Chinese medicine composition is instant. The acupoint application mode bypasses the first pass effect of the liver, the metabolism and the excretion of the kidney and the gastrointestinal inactivation, protects the liver and the kidney, reduces the toxicity damage and can be used by both men and women, the old and the young. Meanwhile, the Chinese medicinal plaster for external application can maintain constant blood concentration and relatively reduce individual differences of patients; can prolong the acting time of the medicine and reduce the administration times and the total dosage; can improve the treatment effect of the medicine; in addition, the external application is a convenient administration mode, and patients can self-administer according to the doctor's advice, and also can terminate administration at any time.
The clinical use effect of the traditional Chinese medicine composition shows that the traditional Chinese medicine composition has the following beneficial effects: has definite treatment effect, quick response and no toxic or side effect, can be applied for 9-18 days, can effectively relieve liver stasis and qi stagnation of a patient, can be used together with medicaments for protecting liver and the like, can synergistically improve the effects of clearing fat and improving eyesight, soothing liver and regulating qi, and can metabolize liver toxins, and can effectively improve light and medium fatty liver and liver stasis and liver blockage; can be used by drinkers at any time, and can promote secretion of alcohol dehydrogenase and acetaldehyde dehydrogenase, enhance liver drainage ability, and reduce damage of substances such as alcohol to liver. In addition, the invention has the characteristics of easily available raw materials, simple preparation method, convenient use and the like.
Detailed Description
The following is a description of the traditional Chinese medicine ointment for soothing liver and promoting bile flow, and the preparation method and application thereof. For simplicity of description, this document does not exhaust all the alternative technical features and embodiments included in the present invention, so that those skilled in the art should understand that any technical features and embodiments in this example do not limit the scope of protection of the present invention, and this scope of protection includes any alternative technical features and embodiments that all those skilled in the art do not take into consideration. Specifically, any embodiment obtained by replacing any technical feature in the present invention or combining any two or more technical features provided by the present invention with each other shall fall within the scope of the present invention. The specific techniques and conditions are not identified in the examples, and the reagents or apparatus used, or the manufacturer is not identified in accordance with the techniques and conditions described in the literature in this field or in accordance with the product specifications, are conventional products commercially available.
Example 1
Taking 10 parts of platycodon grandiflorum, 10 parts of pseudo-ginseng, 10 parts of mulberry leaf, 10 parts of Huichun grass, 5 parts of bighead atractylodes rhizome, 5 parts of rhizoma alismatis and 5 parts of prepared rehmannia root, cleaning and airing; freeze drying at-20deg.C for 20 hr, micronizing the frozen materials at 0deg.C for 30min, and sieving to obtain powder with particle diameter of 0.1-1 μm; taking 5 parts of polygonatum odoratum, 5 parts of ganoderma lucidum, 10 parts of cortex lycii radicis and 10 parts of fructus liquidambaris, cleaning, airing, slicing, crushing, extracting volatile oil by a supercritical carbon dioxide extraction method at the extraction temperature of 50 ℃ and the extraction pressure of 20MPa for 5 hours, and obtaining plant essential oil of the polygonatum odoratum, ganoderma lucidum, cortex lycii radicis and fructus liquidambaris; mixing the Chinese medicinal powder and plant essential oil to obtain Chinese medicinal paste, and applying the Chinese medicinal paste onto paste carrier or making the Chinese medicinal paste into granule with particle diameter of 3-5cm, and applying to obtain topical Chinese medicinal paste.
Example 2
20 parts of platycodon grandiflorum, 20 parts of pseudo-ginseng, 20 parts of mulberry leaf, 20 parts of Huichun grass, 7 parts of bighead atractylodes rhizome, 7 parts of rhizoma alismatis and 7 parts of prepared rehmannia root, cleaning and airing, performing freeze drying treatment, performing low-temperature ultrafine grinding on the frozen medicinal materials at the freezing temperature of minus 30 ℃ for 25 hours, performing grinding at the grinding temperature of minus 5 ℃ for 45 minutes, and screening the Chinese medicinal powder with the particle size of 0.1-1 mu m; 7 parts of polygonatum odoratum, 7 parts of ganoderma lucidum, 15 parts of cortex lycii radicis and 15 parts of fructus liquidambaris, and after cleaning, airing, slicing and crushing, extracting volatile oil by a supercritical carbon dioxide extraction method at the extraction temperature of 75 ℃, the extraction pressure of 22.5MPa and the extraction time of 5.5 hours, thus obtaining the plant essential oil of the polygonatum odoratum, ganoderma lucidum, cortex lycii radicis and fructus liquidambaris. Mixing the Chinese medicinal powder and plant essential oil to obtain Chinese medicinal paste, and applying the Chinese medicinal paste onto paste carrier or making the Chinese medicinal paste into granule with particle diameter of 3-5cm, and applying to obtain topical Chinese medicinal paste.
Example 3
30 parts of platycodon grandiflorum, 30 parts of pseudo-ginseng, 30 parts of mulberry leaf, 30 parts of Huichun grass, 10 parts of bighead atractylodes rhizome, 10 parts of rhizoma alismatis and 10 parts of prepared rehmannia root, cleaning, airing, performing freeze drying treatment, freezing at-40 ℃ for 30 hours, performing low-temperature superfine grinding on the frozen medicinal materials at-10 ℃ for 60 minutes, and screening the Chinese medicinal powder with the particle size of 0.1-1 mu m; 10 parts of polygonatum odoratum, 10 parts of ganoderma lucidum, 20 parts of cortex lycii radicis and 20 parts of fructus liquidambaris, cleaning, airing, slicing, crushing, extracting volatile oil by a supercritical carbon dioxide extraction method at the extraction temperature of 100 ℃ under the extraction pressure of 25MPa for 6 hours, and obtaining the plant essential oil of the polygonatum odoratum, ganoderma lucidum, cortex lycii radicis and fructus liquidambaris. Mixing the Chinese medicinal powder and plant essential oil to obtain Chinese medicinal paste, and applying the Chinese medicinal paste onto paste carrier or making the Chinese medicinal paste into granule with particle diameter of 3-5cm, and applying to obtain topical Chinese medicinal paste.
Clinical efficacy observation test.
A total of 10 volunteer patients with liver and gall disease were recruited, 6 men and 4 women; age under 45 years old 2, 45-55 years old 4, 55-70 years old 2, and over 70 years old 2. The traditional Chinese medicine composition is applied for 1-3 months after the application of the traditional Chinese medicine composition for 1-5 years in the course of disease, the mild patients are close to the recovery, and various symptoms of the severe patients are obviously improved. Of 10 patients, the treatment by application is close to healing, which is 4 cases and accounts for 40%; the improvement cases are 5 cases, accounting for 50 percent, and the total effective rate is 90 percent.
Case (B)
1. He Mou female, 35 years old
He Mou from the time of hospital examination, the liver is slightly enlarged, the total cholesterol value is 6.72mmol/L, the triglyceride value is 2.03mmol/L, and the whole body is hypodynamia.
In a conditioning mode, under the condition that no other medicament is used, after the external application Chinese medicinal ointment prepared by the invention is only applied for 18 days, the fatty liver is obviously improved, the total cholesterol value is 5.01mmol/L, the triglyceride value is 1.57mmol/L, and the physical strength is gradually recovered.
2. Cui Mou Male, 45 years old
Cui Mou it is indicated that alcoholic liver injury is caused by long-term excessive drinking, liver pain is accompanied by emesis, glutamic-pyruvic transaminase value is 79.8U/L, glutamic-pyruvic transaminase value is 114U/L, and indirect bilirubin value is 12.2umol/L and exceeds normal value.
In the conditioning mode, under the condition that other medicaments are not used, only the external application Chinese medicinal ointment prepared by the invention is applied for 1 day, and then the vomiting condition is stopped; after being applied for 9 days, the liver is not painful; after 18 days of application, the glutamic pyruvic transaminase value is 43.3U/L, the glutamic pyruvic transaminase value is 57.7U/L, the indirect bilirubin value is 8.9umol/L, and the liver function is gradually recovered.
3. Wang Mou Male, 52 years old
In the examination of certain hospitals in Beijing city, the value of the glutamine transaminase is 736.8U/L, the value of the glutamic-pyruvic transaminase is 140.94U/L, the value of the glutamic-oxaloacetic transaminase is 95U/L, and the value of the triglyceride is 2.46mmol/L.
In a conditioning mode, under the condition that other medicaments are not used, after the external application Chinese medicinal paste prepared by the invention is only applied for 27 days, the glutamine transaminase is reduced to 255.6U/L, the glutamic-pyruvic transaminase is 58U/L, the glutamic-pyruvic transaminase is 39U/L, and the triglyceride value is 1.55mmol/L.
4. Lin Mou Male, 52 years old
The alcoholic liver injury is caused by long-term drinking, liver area pain, yellow eyes are stained, the glutamic-pyruvic transaminase value is 98.3U/L, the glutamic-pyruvic transaminase value is 121U/L, the total bilirubin value is 58.2umol/L, the total cholesterol value is 7.54mmol/L, and the triglyceride value is 3.28mmol/L, which are all beyond the normal value.
The conditioning mode is that under the condition that other medicaments are not used, the pain in the liver area is obviously relieved after the traditional Chinese medicine ointment for external application prepared by the invention is only applied for 3 days; after being applied for 9 days, the liver area of the forest is not painful any more, and the yellow dyeing condition of eyes is obviously reduced; after 27 days of application, the glutamic pyruvic transaminase value is 38.3U/L, the glutamic pyruvic transaminase value is 51.1U/L, the total bilirubin value is 22.71umol/L, the total cholesterol value is 5.1mmol/L, the triglyceride value is 1.62mmol/L, and the liver function is gradually recovered.
5. Chen Mou Male, age 81
The medicine is taken for a long time to cause medicine liver injury, yellow skin, listlessness, physical weakness and appetite reduction.
The conditioning mode is that under the condition that other medicaments are not used, the appetite of the external application Chinese medicinal ointment prepared by the invention is improved after the external application Chinese medicinal ointment is applied for 3 days; the medicine is applied for 9 days, so that the spirit is obviously improved; after 18 days of application, the physical strength is basically recovered to be normal.
From the clinical test, the invention has obvious curative effect on liver and gall diseases.
Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor it is an exhaustive list of all embodiments but obvious variations or modifications from the list are within the scope of the invention as defined in the claims.
Claims (10)
1. The traditional Chinese medicine composition for soothing liver and promoting bile is characterized by being prepared from the following raw materials in parts by weight: 10-30 parts of platycodon grandiflorum, 10-30 parts of pseudo-ginseng, 10-30 parts of mulberry leaf, 10-30 parts of Huichun grass, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of rhizoma alismatis, 5-10 parts of prepared rehmannia root, 5-10 parts of polygonatum odoratum, 5-10 parts of lucid ganoderma, 10-20 parts of cortex lycii radicis and 10-20 parts of fructus liquidambaris.
2. The traditional Chinese medicine composition for soothing liver and promoting bile of claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 20 parts of platycodon grandiflorum, 20 parts of pseudo-ginseng, 20 parts of mulberry leaf, 20 parts of Huichun grass, 7 parts of bighead atractylodes rhizome, 7 parts of rhizoma alismatis, 7 parts of prepared rehmannia root, 7 parts of radix polygonati officinalis, 7 parts of lucid ganoderma, 15 parts of cortex lycii radicis and 15 parts of fructus liquidambaris.
3. The method for preparing the traditional Chinese medicine composition for soothing liver and promoting bile flow according to any one of claims 1-2, which is characterized by comprising the following steps:
pulverizing radix Platycodi, notoginseng radix, folium Mori, herba Huichi, atractylodis rhizoma, alismatis rhizoma and radix rehmanniae Preparata into Chinese medicinal powder,
extracting rhizoma Polygonati Odorati, ganoderma, cortex Lycii, and fructus Lipuidambaris to obtain plant essential oil;
and fully and uniformly mixing the traditional Chinese medicine powder and the plant essential oil to obtain the traditional Chinese medicine composition for soothing liver and promoting bile.
4. The method for preparing the traditional Chinese medicine composition for soothing liver and promoting bile as claimed in claim 3, wherein the method for preparing the traditional Chinese medicine powder comprises the following steps:
(1) Weighing platycodon grandiflorum, pseudo-ginseng, mulberry leaf, huichun grass, bighead atractylodes rhizome, rhizoma alismatis and prepared rehmannia root according to parts by weight, cleaning and airing;
(2) Freeze-drying the medicinal materials in the step (1) at (-20) - (-40) deg.C for 20-30h;
(3) And (3) carrying out low-temperature ultrafine grinding on the medicinal materials frozen in the step (2), wherein the grinding temperature is 0- (-10) DEG C, the grinding time is 30-60min, and the traditional Chinese medicine powder with the particle size of 0.1-1.0 mu m is selected.
5. The method for preparing a liver soothing and bile benefiting Chinese medicinal composition according to claim 4, wherein in the step (2), the freezing temperature is-30 ℃, and the freezing time is 25 hours.
6. The method for preparing a traditional Chinese medicine composition for soothing liver and promoting bile as claimed in claim 4, wherein in the step (3), the crushing temperature is-5 ℃, and the crushing time is 45min.
7. The method for preparing the traditional Chinese medicine composition for soothing liver and promoting bile flow according to claim 3, wherein the method for preparing the plant essential oil comprises the following steps:
cleaning and airing rhizoma polygonati officinalis, ganoderma lucidum, cortex lycii radicis and fructus liquidambaris according to parts by weight, slicing and crushing, extracting volatile oil by a supercritical carbon dioxide extraction method at 50-100 ℃ under 20-25MPa for 5-6 hours, and obtaining plant essential oil of the rhizoma polygonati officinalis, ganoderma lucidum, cortex lycii radicis and fructus liquidambaris.
8. The method for preparing a traditional Chinese medicine composition for soothing liver and promoting bile flow according to claim 7, wherein the extraction temperature is 75 ℃, the extraction pressure is 22MPa, and the extraction time is 5.5h.
9. Use of a Chinese medicinal composition according to any one of claims 1-2 for the preparation of a plaster for soothing liver and promoting bile flow.
10. The use of claim 9, wherein the patch is applied to an acupoint combination;
the acupoint combination is selected from one or more acupoints of Chaomen, shimen, with pulse, yongquan and Taixi.
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