CN116472292A - 经修饰的蛋白质和蛋白质降解剂 - Google Patents
经修饰的蛋白质和蛋白质降解剂 Download PDFInfo
- Publication number
- CN116472292A CN116472292A CN202180058377.0A CN202180058377A CN116472292A CN 116472292 A CN116472292 A CN 116472292A CN 202180058377 A CN202180058377 A CN 202180058377A CN 116472292 A CN116472292 A CN 116472292A
- Authority
- CN
- China
- Prior art keywords
- ddb1
- protein
- optionally substituted
- alkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020092941 | 2020-05-28 | ||
| CNPCT/CN2020/092941 | 2020-05-28 | ||
| CNPCT/CN2021/081554 | 2021-03-18 | ||
| CN2021081554 | 2021-03-18 | ||
| PCT/CN2021/096782 WO2021239117A1 (en) | 2020-05-28 | 2021-05-28 | Modified proteins and protein degraders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116472292A true CN116472292A (zh) | 2023-07-21 |
Family
ID=78722770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180058377.0A Pending CN116472292A (zh) | 2020-05-28 | 2021-05-28 | 经修饰的蛋白质和蛋白质降解剂 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20230057177A1 (https=) |
| EP (1) | EP4157888A4 (https=) |
| JP (1) | JP2023529099A (https=) |
| CN (1) | CN116472292A (https=) |
| WO (1) | WO2021239117A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| CN115197164B (zh) * | 2021-04-12 | 2025-04-01 | 杜心赟 | 新型噻唑类化合物及其制备方法和用途 |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| IL312013A (en) * | 2021-10-14 | 2024-06-01 | Cullgen Shanghai Inc | Modified proteins and protein degraders |
| JP2026501188A (ja) * | 2022-12-16 | 2026-01-14 | 杭州阿諾生物医薬科技有限公司 | サイクリンｋ分解剤及びその使用 |
| WO2024183798A1 (en) * | 2023-03-07 | 2024-09-12 | Cullgen Inc. | Compounds and methods of treating cancers |
| WO2025054361A1 (en) * | 2023-09-05 | 2025-03-13 | Apellis Pharmaceuticals, Inc. | Complement inhibition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201520583D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| EP3577459A4 (en) * | 2017-02-03 | 2020-12-16 | Celgene Corporation | METHOD OF MEASURING THE AFFINITY OF SMALL MOLECULES FOR CEREBLON |
| KR20200038303A (ko) * | 2017-08-18 | 2020-04-10 | 캠브리지 엔터프라이즈 리미티드 | 모듈형 결합 단백질 |
| US11691984B2 (en) * | 2018-10-12 | 2023-07-04 | The Scripps Research Institute | Compounds and methods for DCAF-mediated protein degradation |
-
2021
- 2021-05-28 WO PCT/CN2021/096782 patent/WO2021239117A1/en not_active Ceased
- 2021-05-28 EP EP21812627.4A patent/EP4157888A4/en active Pending
- 2021-05-28 CN CN202180058377.0A patent/CN116472292A/zh active Pending
- 2021-05-28 JP JP2022573579A patent/JP2023529099A/ja active Pending
- 2021-10-07 US US17/496,628 patent/US20230057177A1/en not_active Abandoned
-
2023
- 2023-07-28 US US18/361,422 patent/US20240066136A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240066136A1 (en) | 2024-02-29 |
| WO2021239117A1 (en) | 2021-12-02 |
| EP4157888A4 (en) | 2024-07-10 |
| EP4157888A1 (en) | 2023-04-05 |
| JP2023529099A (ja) | 2023-07-07 |
| US20230057177A1 (en) | 2023-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |