CN116413420A - 涉及用于患有晚期癌症的受试者的经活化树突状细胞组合物和免疫治疗处理的方法 - Google Patents

涉及用于患有晚期癌症的受试者的经活化树突状细胞组合物和免疫治疗处理的方法 Download PDF

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CN116413420A
CN116413420A CN202211533672.XA CN202211533672A CN116413420A CN 116413420 A CN116413420 A CN 116413420A CN 202211533672 A CN202211533672 A CN 202211533672A CN 116413420 A CN116413420 A CN 116413420A
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dendritic cell
activated
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M·L·博希
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Northwest Biotherapeutics LLC
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CN202211533672.XA 2015-09-15 2016-09-14 涉及用于患有晚期癌症的受试者的经活化树突状细胞组合物和免疫治疗处理的方法 Pending CN116413420A (zh)

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US201562219058P 2015-09-15 2015-09-15
US62/219,058 2015-09-15
PCT/US2016/051781 WO2017048875A1 (en) 2015-09-15 2016-09-14 Methods relating to activated dendritic cell compositions and immunotherapeutic treatments for subjects with advanced cancers
CN201680066721.XA CN108291204A (zh) 2015-09-15 2016-09-14 涉及用于患有晚期癌症的受试者的经活化树突状细胞组合物和免疫治疗处理的方法

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CN201680066721.XA Pending CN108291204A (zh) 2015-09-15 2016-09-14 涉及用于患有晚期癌症的受试者的经活化树突状细胞组合物和免疫治疗处理的方法

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CN119286782A (zh) * 2024-12-11 2025-01-10 上海赛笠百傲生物医药有限公司 一种高效诱导外周血来源单核细胞至不成熟树突状细胞的方法

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US20190076473A1 (en) * 2017-09-14 2019-03-14 Cellular Approaches, Inc. Autologous and allogenic macrophages and monocytes for use in therapeutic methods
CN110106145B (zh) * 2019-06-12 2021-02-12 蓝莲(杭州)生物科技有限公司 一种未成熟树突状细胞培养液及其未成熟树突状细胞的制备方法
AU2020363707A1 (en) * 2019-10-07 2022-04-28 Northwest Biotherapeutics, Inc. In vitro methods and compositions for enhancing the activation of dendritic cells and t cells, and for inducing a th-1 immune response

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CN102600461A (zh) * 2002-12-06 2012-07-25 西北生物治疗药物公司 给予体外部分成熟的树突细胞治疗肿瘤

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT633929E (pt) 1992-04-01 2004-07-30 Merix Bioscience Inc Metodo para proliferacao (in vitro) de precursores de celulas dentifricas e sua utilizacao para produzir imunogenios
US7659119B2 (en) 1996-02-12 2010-02-09 Argos Therapeutics, Inc. Method and compositions for obtaining mature dendritic cells
US6558951B1 (en) * 1999-02-11 2003-05-06 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds
US20020094545A1 (en) 2000-11-30 2002-07-18 Harris Paul E. Growth of human dendritic cells for cancer immunotherapy in closed system using microcarrier beads
AU2002326463A1 (en) 2001-07-25 2003-02-17 Northwest Biotherapeutics, Inc. Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors
WO2004000444A1 (en) 2002-06-19 2003-12-31 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment
WO2004039968A1 (ja) * 2002-10-30 2004-05-13 Japan Science And Technology Agency 骨髄由来の不死化樹状細胞株
ES2321939T3 (es) * 2003-02-27 2009-06-15 Northwest Biotherapeutics, Inc. Generacion de celulas dendriticas a partir de celulas precursoras dendriticas monociticas con gm-csf en ausencia de citoquinas adicionales.
US20060257359A1 (en) * 2005-02-28 2006-11-16 Cedric Francois Modifying macrophage phenotype for treatment of disease
KR20080109717A (ko) * 2005-12-08 2008-12-17 노쓰웨스트 바이오써라퓨틱스, 인크. 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한조성물 및 방법
JP5382529B2 (ja) * 2007-09-10 2014-01-08 独立行政法人理化学研究所 ヒト樹状細胞の評価方法およびヒト細胞免疫療法剤
EP2072617A1 (en) * 2007-12-12 2009-06-24 Trimed Biotech GmbH Method for producing dendritic cells
MX2011012147A (es) * 2009-05-15 2012-06-19 Irx Therapeutics Inc Inmunoterapia de vacuna.
CN103638517A (zh) * 2013-12-04 2014-03-19 深圳市合一康生物科技有限公司 人树突状细胞疫苗制备的专用试剂盒
WO2016048872A1 (en) * 2014-09-23 2016-03-31 Neostem Oncology, Llc Compositions, methods and kits used to determine potency of dendritic cells in cancer immunitherpay

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102600461A (zh) * 2002-12-06 2012-07-25 西北生物治疗药物公司 给予体外部分成熟的树突细胞治疗肿瘤

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
PETER HELLMAN 等: "Early activation markers of human peripheral dendritic cells", HUMAN IMMUNOLOGY, vol. 68, no. 05, 24 April 2007 (2007-04-24), pages 324, XP022042793, DOI: 10.1016/j.humimm.2007.01.018 *
PING JIN 等: "Molecular signature of maturing dendritic cells:implications for testing the quality of dendritic cell therapies", J TRANSL MED, no. 04, 15 January 2010 (2010-01-15), pages 2 - 3 *
VALERIJUS OSTAPENKO 等: "Therapeutic dentritic cell-based cancer vaccines:the state of the art", CRITICAL REVIEWS IN IMMUNOLOGY, vol. 33, no. 06, 1 January 2013 (2013-01-01), pages 496 *
ZHILIN YIN 等: "Antitumor efficacy of argon-helium cryoablation-generated dendritic cell vaccine in glioma", NEUROIMMUNOLOGY, vol. 25, no. 04, 31 March 2014 (2014-03-31), pages 199 *
付必莽: "半成熟树突状细胞(smDC)激活抗原特异性CD4+CD25+调节T细胞延长小鼠移植皮瓣存活时间", 万方学位导航, 31 March 2010 (2010-03-31) *
董丽英 等: "半成熟树突状细胞和CD4+CD25+Tr在抑制免疫耐受中的关系", 医学综述, vol. 18, no. 14, 20 July 2012 (2012-07-20), pages 2165 *
金莹莹 等: "EB病毒感染可诱导脐带血半成熟树突状细胞生成", 中华医学第十八次全国儿科学术会议, 31 December 2013 (2013-12-31) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119286782A (zh) * 2024-12-11 2025-01-10 上海赛笠百傲生物医药有限公司 一种高效诱导外周血来源单核细胞至不成熟树突状细胞的方法

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