CN116370617A - Day and night compound medicine for treating digestive tract of pet and preparation method thereof - Google Patents
Day and night compound medicine for treating digestive tract of pet and preparation method thereof Download PDFInfo
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- CN116370617A CN116370617A CN202310405527.1A CN202310405527A CN116370617A CN 116370617 A CN116370617 A CN 116370617A CN 202310405527 A CN202310405527 A CN 202310405527A CN 116370617 A CN116370617 A CN 116370617A
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Classifications
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Abstract
The invention discloses a day and night compound medicine for treating digestive tracts of pets, which comprises a day prescription and a night prescription. The compound medicine follows the working characteristics of the digestive system of the pet organism, has more times and more feed intake of animals in the daytime, and ensures that the gastrointestinal tract is in a high-strength working state, and the ingredients such as hawthorn, kudzuvine root, yucca, dried ginger, peppermint, pepsin and the like are added in the daytime, so as to achieve the effects of strengthening spleen, stimulating appetite, resolving food stagnation, promoting digestion and promoting gastric emptying; the feed intake is reduced at night, and the stomach and intestine is in the process of rest and restoration, so that the night formula is added with lactoferrin, L-glutamine, chinese yam, rhizoma polygonati, chinese angelica, yucca and other components, so that the stomach and intestine mucous membrane can be restored, the stomach can be nourished and the immunity of the organism can be improved. Through double care of day and night, the problems of treatment and maintenance of weakness of spleen and stomach, inappetence, anorexia, bad breath and odor, mucous membrane restoration, balance immunity and the like are solved, and a new 24-hour digestion function regulation technology is innovated.
Description
Technical Field
The invention belongs to the technical field of veterinary medicines, in particular to the technical field of treatment of digestive tract diseases of pets, and more particularly relates to a day and night compound medicine for treating digestive tract diseases of pets and a preparation method thereof.
Background
With the improvement of living standard, the number of the pets to be raised is increased, the pet treatment is also attracting social attention, the current treatment method mainly depends on Western medicine, the traditional Chinese veterinary medicine is applied less in the aspect of the pet treatment, and a theoretical system is lacked. The occurrence of a series of problems such as antibiotic abuse and bacterial resistance also suggests that the use of veterinary medicine in our traditional field of pet medicine will tend to be the trend.
At present, probiotics are commonly used for regulating the digestion function in the clinic of pets, but the effect of the probiotics only acts on the intestinal balance beneficial flora, relieves diarrhea, and has no effect on the digestion and absorption functions of the stomach and the intestinal tract. In the clinic of pets, symptoms such as weakness of spleen and stomach, inappetence, anorexia, bad breath and odor of stool often appear, and aiming at the symptoms, the common probiotics, antibacterial and anti-inflammatory or digestion-aiding traditional Chinese medicine composition cannot achieve good treatment effect.
In addition, the traditional pet treatment process ignores the working characteristics of the digestive system of the pet body, the administration of the pet for 24 hours is the same medicine, the food intake of the pet is reduced at night, the stomach and intestine are in the rest and repair process, the organism is subjected to multiple repair of the stomach and intestine mucous membrane, stomach nourishing and stomach protecting and organism immunity improving, but the administration of the antibacterial and anti-inflammatory or digestion assisting medicines at night increases the organism burden such as the stomach and intestine, and the inertia of the digestive system of the normal organism of the pet is destroyed.
Therefore, it is necessary to develop a veterinary pharmaceutical composition suitable for the treatment of the digestive tract of pets, both in drug effect and administration method.
Disclosure of Invention
The invention aims to solve the problem that the existing treatment medicines for treating the symptoms such as weakness of spleen and stomach, inappetence, anorexia, bad breath, bad stool and the like which are common in clinic cannot achieve good treatment effect; simultaneously provides a veterinary medicine composition which is suitable for treating the digestive tract of the pet by both the medicine effect and the medicine application method.
Furthermore, the invention provides a day and night compound medicine for treating the digestive tract of the pet, which follows the working characteristics of the digestive system of the body of the pet, and the day direction is suitable for animals with more ingestion times and ingestion amount in the daytime, so that the effects of strengthening spleen and stimulating appetite, resolving food stagnation and promoting gastric emptying of the animals can be promoted; the night is suitable for the process of reducing the feed intake of animals and resting and repairing the stomach intestine, and can promote the multiple repair of the stomach intestine mucous membrane of the animal body, nourish the stomach and protect the stomach and promote the immunity of the body.
Further, the invention provides a day and night compound medicine for treating digestive tracts of pets, which comprises a day prescription and a night prescription,
the main medicine composition of the diurnal prescription is as follows: yucca, haw, kudzu vine root, dried ginger, peppermint and pepsin;
the main medicine composition of the night prescription is as follows: yucca, rhizoma Polygonati, radix Angelicae sinensis, rhizoma Dioscoreae, lactoferrin, and L-glutamine.
Wherein, the sources and functions of the components are as follows:
yucca is the stem and leaf of Yucca (Yucca multiflora) of Mohuavir. The yucca or yucca powder is yucca extract, and the yucca extract has the functions of deodorizing and reducing ammonia, and reduces the concentration of urea and ammonia in blood; yucca extract contains Yucca polyphenol as natural urease inhibitor, and can inhibit urea from decomposing into ammonia gas, promote microorganism to convert ammonia gas into microorganism protein, and reduce ammonia gas production in feces and urine; the yucca extract contains yucca polysaccharide, which can directly adsorb harmful gases such as ammonia, hydrogen sulfide and the like in intestinal tracts, prevent the nitrification of nitrogen in the feces and urine, lead the nitrogen to exist in an inorganic form and reduce the amount of ammonia volatilized into the air; yucca extract contains Yucca saponin to clean up the waste in intestinal tract, raise the permeability of intestinal wall, raise the absorption of nutrient matters in feed protein and reduce the waste protein discharge in excrement.
Fructus crataegi is dried mature fruit of Crataegus pinnatifida Crataegus pinnatifida Bge. Var. Major N.E.Br. Hawthorn fruit or its extract can treat food stagnation and promote digestion. Has effects in invigorating spleen, stimulating appetite, promoting blood circulation, activating qi-flowing, and dispelling blood stasis, and can be used for treating dyspepsia and food retention. The hawthorn is hawthorn decoction pieces or corresponding extracts thereof, and the quality standard of source medicinal materials of the hawthorn decoction pieces is required to meet the quality requirement of the first hawthorn decoction piece item of Chinese pharmacopoeia 2020.
The radix Puerariae is dried root of Pueraria lobata (Willd.) Ohwi of Leguminosae. It is known as Pueraria lobata. The effect of the radix puerariae in dredging the upper and lower meridians of the human body and transporting water vapor and clear qi upwards is also called as "rising yang", the radix puerariae makes clear yang rise upwards and drives qi of the whole stomach and intestine to rise, so diarrhea can be stopped, and the diarrhea is caused by the fact that the qi of the stomach and intestine drives water to wet and flow downwards. The radix puerariae is a decoction piece of a raw product or a corresponding extract thereof, and the quality standard of the source medicinal materials of the radix puerariae meets the quality requirement of one radix puerariae item in the 2020 edition of Chinese pharmacopoeia.
The rhizoma Zingiberis is dried rhizome of rhizoma Zingiberis recens Zingiber officinale Rosc of Zingiberaceae. Collected in winter, removed fibrous root and silt, dried in the sun or dried at low temperature. The dried slices are dried in the sun or at low temperature. Rhizoma Zingiberis has the effects of warming spleen and stomach, dispelling cold, restoring yang, dredging collaterals, warming lung, and resolving fluid retention. The dried ginger is a dried ginger slice or a corresponding extract thereof, and the quality standard of the source medicinal materials of the dried ginger slice or the corresponding extract thereof all needs to meet the quality requirement of the dried ginger under the first edition of Jiang Xiang of the year 2020 of Chinese pharmacopoeia.
Herba Menthae is dry aerial part of Mentha piperita of Labiatae Mentha haplocalyx Briq. Herba Menthae can relieve abdominal pain, and has antiseptic, antibacterial, diuretic, phlegm eliminating, stomach invigorating, and digestion promoting effects. The mint is a mint decoction piece or a corresponding extract thereof, and the quality standard of source medicinal materials of the mint decoction piece or the corresponding extract thereof is required to meet the quality requirement of a mint item of the 2020 edition of Chinese pharmacopoeia.
Rhizoma Dioscoreae is dried rhizome of Dioscorea opposita Dioscorea opposita thunder. Digging after stem leaves wilt in winter, cutting off root heads, cleaning, removing outer skin and fibrous roots, and drying, which is known as 'Mao Shanyao'; or removing skin, cutting into thick slices, and drying to obtain "Chinese yam slices"; optionally drying rhizoma Dioscoreae, soaking in clear water until there is no dry core, cutting Ji Liangduan, rubbing into cylinder with wood plate, sun drying, polishing, and conventionally known as "rhizoma Dioscoreae". Chinese yam is homologous in medicine and food, and can tonify spleen and stomach deficiency, treat qi deficiency and weakness, dyspepsia and the like by being added with medicine. The Chinese yam is a Chinese yam decoction piece or a corresponding extract thereof, and the quality standard of source medicinal materials of the Chinese yam decoction piece or the corresponding extract thereof all needs to meet the quality requirement of a Chinese pharmacopoeia 2020 edition one Chinese yam item.
Rhizoma Polygonati is dried rhizome of Polygonatum kingianum of Liliaceae Polygonatum kingianum Coll et Hemsl. The rhizoma Polygonati medicinal material or its extract has effects of invigorating spleen, moistening lung, promoting fluid production, invigorating spleen, moistening lung, and invigorating kidney. Can be used for treating qi deficiency of spleen and stomach, tiredness, debilitation, stomach yin deficiency, dry mouth, anorexia, cough due to lung deficiency, cough due to fatigue, hemoptysis, essence and blood deficiency, soreness of waist and knees, premature graying of hair, and internal heat diabetes. The rhizoma polygonati is rhizoma polygonati decoction pieces or corresponding extracts thereof, and the quality standard of source medicinal materials of the rhizoma polygonati decoction pieces or corresponding extracts thereof all need to meet the quality requirement of a rhizoma polygonati item in the 2020 edition of Chinese pharmacopoeia.
Angelica sinensis is the dry root of Angelica sinensis Angelica sinensis (Oliv.) Diels, umbelliferae. The radix Angelicae sinensis or its extract has effects in loosening bowel to relieve constipation, resisting aging, and enhancing immunity. The rhizoma polygonati is Chinese angelica decoction pieces or corresponding extracts thereof, and the quality standard of source medicinal materials of the rhizoma polygonati meets the quality requirement of Chinese pharmacopoeia 2020 edition one Chinese angelica item.
The crude traditional Chinese medicine and the decoction pieces thereof are directly crushed and used for pets with less serious symptoms, the cost is low, and the good treatment effect can be achieved; for the pets with the relatively weak young and the pets with the relatively heavy symptoms, the corresponding extract or decoction is usually adopted for drug administration so as to achieve better treatment effect.
In addition, the day and night compound medicine also contains 3 nutrients of pepsin, lactoferrin and L-glutamine.
Wherein pepsin is extracted from gastric mucosa of pig, sheep or cattle. According to the calculation of a dry product, the activity of pepsin contained in each 1g is not less than 3800 units, and the pepsin is required to meet the quality requirements of the second pepsin item in the 2020 edition of Chinese pharmacopoeia for preparation and quality standard.
L-Glutamine (L-Glutamine), the chemical name of which is L-glutamic acid-5-amide L-aminocarbonyl-butyryl-L-2-aminopentanedioic acid amide. L-glutamine can optimize fat and muscle, increase muscle, decompose redundant fat in human body, promote ulcer healing, and is commonly used as a digestive tract ulcer drug.
Lactoferrin is a safe and reliable natural substance extracted from cow milk, has the functions of regulating immunity and resisting pathogenic microorganisms, and can reduce the number of bad intestinal bacteria after being eaten. Lactoferrin also has the effects of improving gastrointestinal digestion and absorption, preventing gastric ulcer and reducing the probability of pet suffering from iron deficiency anemia.
In the technical scheme, the day and night compound medicine comprises the following traditional Chinese medicine components in parts by weight:
further, the medicine materials used in the daytime prescription are as follows in parts by weight: 10-20 parts of yucca, 2-20 parts of hawthorn, 5-20 parts of kudzuvine root, 1-15 parts of dried ginger, 1-15 parts of peppermint and 1-15 parts of pepsin.
The night prescription comprises the following medicinal materials in parts by weight: 15-35 parts of yucca, 2-20 parts of rhizoma polygonati, 1-15 parts of Chinese angelica, 5-20 parts of Chinese yam, 1-10 parts of lactoferrin and 1-15 parts of L-glutamine.
Furthermore, the medicine materials used in the daytime prescription are as follows in parts by weight: 12-18 parts of yucca, 10-15 parts of hawthorn, 8-16 parts of kudzuvine root, 5-12 parts of dried ginger, 8-12 parts of peppermint and 3-9 parts of pepsin.
The night prescription comprises the following medicinal materials in parts by weight: 18-25 parts of yucca, 8-15 parts of rhizoma polygonati, 8-12 parts of Chinese angelica, 8-18 parts of Chinese yam, 3-8 parts of lactoferrin and 1-8 parts of L-glutamine.
Furthermore, the medicine materials used in the daytime prescription are preferably as follows in parts by weight: 15 parts of yucca, 12 parts of hawthorn, 10 parts of kudzuvine root, 8 parts of dried ginger, 10 parts of peppermint and 6 parts of pepsin;
the medicine materials used by the night are preferably as follows in parts by weight: 20 parts of yucca, 10 parts of rhizoma polygonati, 10 parts of Chinese angelica, 15 parts of Chinese yam, 5 parts of lactoferrin and 2 parts of L-glutamine.
The diurnal medicament and the nocturnal medicament can also be prepared into any one of tablets, pills, decoction, powder, medicinal granules or powder.
Further, the formulation of the day and night compound medicine is a tablet, and the preparation method comprises the preparation of a day tablet and the preparation of a night tablet.
The preparation method of the diurnal tablet comprises the following steps:
1) Pulverizing fructus crataegi, radix Puerariae, rhizoma Zingiberis, and herba Menthae 4 kinds of Chinese medicinal materials respectively, sieving with 100 mesh sieve;
2) Weighing 4 kinds of Chinese medicinal powder of hawthorn, kudzuvine root, dried ginger and peppermint according to diurnal prescription, and yucca extract and pepsin;
3) Adding 5-12% of microcrystalline cellulose, 10-15% of medicinal dextrin and 30-50% of pregelatinized starch in the total formula amount, and stirring and mixing uniformly;
4) Granulating, drying until the water content is lower than 8%, and directly tabletting;
5) Coating, wherein each tablet contains 0.5-2.0 g of medicinal powder.
The preparation method of the night tablet comprises the following steps:
1) Pulverizing 4 Chinese medicinal materials including Yucca, rhizoma Polygonati, radix Angelicae sinensis, and rhizoma Dioscoreae respectively, and sieving with 100 mesh sieve;
2) 4 traditional Chinese medicine powder, yucca extract, lactoferrin and L-glutamine are weighed according to a night prescription;
3) Adding 5-12% of microcrystalline cellulose, 15-20% of medicinal dextrin and 40-60% of pregelatinized starch in the total formula amount, and stirring and mixing uniformly;
4) Granulating, drying until the water content is lower than 8%, and directly tabletting;
5) Coating, wherein each tablet contains 0.5-2.0 g of medicinal powder.
The preparation method of the other tablet of the day and night compound medicine is characterized by comprising the following steps:
diurnal tablets: weighing 5 traditional Chinese medicine extracts of yucca, hawthorn, kudzuvine root, dried ginger and peppermint according to the formula, uniformly mixing, adding 3-8% of microcrystalline cellulose, 5-10% of medicinal dextrin and 20-35% of pregelatinized starch by the total weight of diurnal prescription, uniformly stirring, granulating, drying until the water content is lower than 8%, directly tabletting, wherein each tablet contains 0.1-1.0 g of medicinal powder;
night tablet: the yucca, the rhizoma polygonati, the Chinese angelica and the Chinese yam are weighed according to the formula, 4 traditional Chinese medicine extracts, lactoferrin and L-glutamine are uniformly mixed, 5-10% of microcrystalline cellulose, 5-15% of medicinal dextrin and 10-25% of pregelatinized starch which are all the weight of the night prescription are added, the mixture is uniformly stirred and mixed, and the mixture is granulated and dried until the water content is lower than 8%, and is directly tabletted, wherein each tablet contains 0.1-1.0 g of medicinal powder.
Further, the formulation of the day and night compound medicine is pills, the traditional Chinese medicine materials are crushed, and after passing through a 100-mesh sieve, the traditional Chinese medicine powder of the day and night compound medicines and corresponding nutrients thereof are respectively weighed and uniformly mixed, so that day compound medicine powder and night compound medicine powder can be obtained, and the day compound medicine powder and the night compound medicine powder are respectively added with refined honey to prepare small honeyed pills, and are dried, polished and packaged to obtain the day and night compound medicine.
Further, 100-125g refined honey is added into 100g composite traditional Chinese medicine powder to prepare small honeyed pills, and each pill contains 0.25-1g composite traditional Chinese medicine powder.
Further, the day and night compound medicine is applied to the preparation of veterinary medicines for treating digestive tract diseases of pets.
The day and night compound medicine for treating the digestive tract of the pets has the following advantages:
(1) The invention provides a medicine day and night combined treatment theory for pets for the first time, and a large number of clinical researches and verification prove that the medicine day and night combined treatment theory follows the working characteristics of digestive system of bodies of pets, and the compound medicine for treating the digestive tracts of pets by adopting the medicine day and night combined treatment theory for pets has obvious treatment effect and no toxic or side effect.
(2) The compound medicine for treating the digestive tract of the pets provided by the invention can solve the treatment and maintenance problems of weakness of spleen and stomach, inappetence, anorexia, halitosis, odor, mucous membrane restoration, balance immunity and the like through day and night dual care, innovate a new 24-hour digestive function regulation technology, and can repair gastrointestinal mucous membrane, nourish stomach, protect stomach and promote organism immunity.
(3) The compound medicine for treating the digestive tract of the pets, which is provided by the invention, is suitable for various veterinary medicine dosage forms, has various administration modes, is matched with different digestive tract diseases of the pets, can be used for treating the digestive tract diseases of the pets according to the individual administration requirements of the disease conditions, the growth stage of the pets and the like, has reliable curative effect, is difficult to relapse after treatment, thoroughly solves the problems of poor treatment effect, easy persistence and relapse of the disease conditions of the traditional probiotics for regulating the digestive function, and has great practical significance.
(4) The invention also provides a veterinary medicine composition with the efficacy and the administration method suitable for treating the digestive tract of the pet for the first time, and opens a new treatment idea for treating the diseases of the pet according to the working characteristics of the body system of the pet, thereby having great significance in the field of pet treatment.
(5) The compound medicine for treating the digestive tract of the pets provided by the invention has scientific and reasonable formulation of diurnal prescription and night prescription, accurate medicine selection, and simple matching of several natural traditional Chinese medicinal materials and nutrients, has the effect obviously superior to that of the existing clinical medicines, has simple integral preparation process and low cost, and is suitable for industrial production.
Detailed Description
Specific embodiments of the present invention will be described in detail below with reference to specific examples. It is to be understood that these examples are provided solely for the purpose of illustration and are not intended to limit the scope of the invention, including any obvious variations or modifications, etc. made thereon, as defined by the appended claims.
The experimental methods and the detection methods described in the following examples are all conventional methods unless otherwise specified; the reagents and materials are commercially available unless otherwise specified. The herbal medicines, the traditional Chinese medicine extracts and the related auxiliary materials used in the embodiment and the comparative example are all commercial products, and accord with the quality standard of medicinal materials or related products with qualified quality of related varieties in the 2020 edition of Chinese pharmacopoeia.
Example 1
The embodiment provides a day and night compound medicine formula for treating digestive tracts of pets and a preparation method of tablets of the formula.
The preferred group formulation of this application is case:
the medicine materials used in diurnal prescription are preferably as follows in parts by weight: 15 parts of yucca, 12 parts of hawthorn, 10 parts of kudzuvine root, 8 parts of dried ginger, 10 parts of peppermint and 1 part of pepsin;
the medicine materials used by the night are preferably as follows in parts by weight: 15 parts of yucca, 10 parts of rhizoma polygonati, 10 parts of Chinese angelica, 15 parts of Chinese yam, 5 parts of lactoferrin and 2 parts of L-glutamine.
The preparation method of the diurnal tablet specifically comprises the following steps:
1) Pulverizing fructus crataegi, radix Puerariae, rhizoma Zingiberis, and herba Menthae 4 kinds of Chinese medicinal materials respectively, sieving with 100 mesh sieve;
2) Weighing 15g of yucca powder, 12g of hawthorn powder, 10g of kudzu root powder, 8g of dried Jiang Yaofen, 10g of mint powder and 1g of pepsin;
3) Adding 5.60g microcrystalline cellulose, 6.72g medicinal dextrin and 19.6g pregelatinized starch, and stirring and mixing uniformly;
4) Granulating, drying until the water content is lower than 8%, and directly tabletting;
5) Coating, wherein the dosage of each tablet is 0.5g.
The preparation method of the night tablet comprises the following steps:
1) Pulverizing 4 Chinese medicinal materials including Yucca, rhizoma Polygonati, radix Angelicae sinensis, and rhizoma Dioscoreae respectively, and sieving with 100 mesh sieve;
2) 15g of silk orchid powder, 10g of rhizoma polygonati powder, 10g of Chinese angelica powder, 15g of Chinese yam powder, 5g of lactoferrin and 2g of L-glutamine are weighed.
3) Adding 5.7g microcrystalline cellulose, 8.55g medicinal dextrin and 28.5g pregelatinized starch according to the total formula amount, and stirring and mixing uniformly;
4) Granulating, drying until the water content is lower than 8%, and directly tabletting;
5) Coating, wherein the dosage of each tablet is 0.5g.
The administration method comprises the following steps: 1 day and 1 night in the morning and 1 night in the evening, and the tablets are mixed in food for direct feeding according to the ratio of the food amount to the medicine amount of the pet of 10:1.
Example 2
The embodiment provides a day and night compound medicine formula for treating digestive tracts of pets and another preparation method of tablets.
The medicine materials used in diurnal prescription are preferably as follows in parts by weight: 15 parts of yucca, 12 parts of hawthorn, 10 parts of kudzuvine root, 8 parts of dried ginger, 10 parts of peppermint and 1 part of pepsin;
the medicine materials used by the night are preferably as follows in parts by weight: 15 parts of yucca, 10 parts of rhizoma polygonati, 10 parts of Chinese angelica, 15 parts of Chinese yam, 5 parts of lactoferrin and 2 parts of L-glutamine.
A method for preparing a day and night compound medicine tablet for treating digestive tract of pets comprises the following steps:
diurnal tablets: weighing 15g of yucca extract, 12g of hawthorn extract, 10g of kudzu root extract, 8g of dried ginger extract, 10g of peppermint extract and 1g of pepsin according to a formula, uniformly mixing, adding 2.55g of microcrystalline cellulose, 5.1g of medicinal dextrin and 12.75g of pregelatinized starch, uniformly stirring, granulating, drying until the water content is lower than 8%, and directly tabletting;
night tablet: weighing 15g of yucca extract, 10g of rhizoma polygonati extract, 10g of angelica extract, 15g of Chinese yam extract, 5g of lactoferrin and 2g L-glutamine according to the formula, uniformly mixing, adding 5.7 microcrystalline cellulose, 2.85g of medicinal dextrin and 6.84g of pregelatinized starch, uniformly stirring and mixing, granulating, drying until the water content is lower than 8%, and directly tabletting.
The administration method is the same as that of example 1, and will not be described here again.
Example 3
The embodiment provides a formula of a day and night compound medicine for treating digestive tract of pets and a preparation method of pills thereof
The medicine materials used in diurnal prescription are preferably as follows in parts by weight: 15 parts of yucca, 12 parts of hawthorn, 10 parts of kudzuvine root, 8 parts of dried ginger, 10 parts of peppermint and 6 parts of pepsin;
the medicine materials used by the night are preferably as follows in parts by weight: 20 parts of yucca, 10 parts of rhizoma polygonati, 10 parts of Chinese angelica, 15 parts of Chinese yam, 5 parts of lactoferrin and 2 parts of L-glutamine.
A method for preparing a day and night compound medicine pill for treating digestive tract of pets comprises the following steps:
1) Pulverizing the Chinese medicinal materials in the formula of the day and night compound medicine respectively, and sieving with 100 mesh sieve;
2) The medicinal powder and corresponding nutrients of the traditional Chinese medicine prescription amounts of the diurnal and nocturnal medicines are respectively weighed according to the prescription amounts and are uniformly mixed;
3) Adding refined honey (100-125 g) into each 100g of composite Chinese medicinal powder, making into small honeyed pill, drying, polishing, and packaging.
Thus, each pill of diurnal Fang Wanji and night formula pill contains 0.25g of compound traditional Chinese medicine powder.
The administration method is the same as that of example 1, and will not be described here again.
Example 4
The embodiment provides a day and night compound medicine tablet for treating digestive tract of pets.
The formula ratio of the minimum dosage of the application is as follows:
the medicine materials used in diurnal prescription are preferably as follows in parts by weight: 10 parts of yucca, 2 parts of hawthorn, 5 parts of kudzuvine root, 1 part of dried ginger, 1 part of peppermint and 1 part of pepsin;
the medicine materials used by the night are preferably as follows in parts by weight: 15 parts of yucca, 2 parts of rhizoma polygonati, 10 parts of Chinese angelica, 15 parts of Chinese yam, 5 parts of lactoferrin and 2 parts of L-glutamine;
the preparation method and the administration method are the same as those of example 2, and are not described in detail here.
Example 5
The embodiment provides a day and night compound medicine tablet for treating digestive tract of pets.
The maximum dosage formula ratio of the application is as follows:
the medicine materials used in diurnal prescription are preferably as follows in parts by weight: 20 parts of yucca, 20 parts of hawthorn, 20 parts of kudzuvine root, 15 parts of dried ginger, 15 parts of peppermint and 5 parts of pepsin;
the medicine materials used by the night are preferably as follows in parts by weight: 30 parts of yucca, 20 parts of rhizoma polygonati, 15 parts of Chinese angelica, 20 parts of Chinese yam, 10 parts of lactoferrin and 15 parts of L-glutamine;
the preparation method and the administration method are the same as those of example 1, and are not described in detail here.
Example 6
The embodiment provides a test of the efficacy of a day and night compound drug for treating digestive tract of pets
In the western An city of Shaanxi, the drug efficacy test was performed for three years.
Digestive system abnormality cases inclusion criteria: inappetence (less than two-thirds of the food intake level of normal bitdogs of the same age), bad breath, bad stool, vomiting and diarrhea. For those who are not effective for more than 7 days or those who have a repeated condition, the probiotic therapy is often used, and can be incorporated into trial therapy.
The treatment effect detection method comprises the following steps: clinical basic examination, hematology examination, fecal examination, and B-mode ultrasound examination.
During this period, the naturally occurring bitcanines with digestive system abnormalities satisfying the above symptoms were the subjects of verification, and the weight, severity, and symptoms of bitcanines were consistent for a total of 216. The bitcanines suffering from the diseases at the same time are equally divided into 4 groups, and the feeding methods of each group are consistent, so that the drug effect of each group after administration is comparable.
The 4 experimental groups were:
positive drug group: the day tablet and the night tablet prepared in the example 1 are selected, 1 tablet is taken in the morning and 1 tablet is taken in the evening, the tablets are mixed in food for direct feeding, and the ratio of the food amount to the drug amount of the pet is 10:1;
probiotic control group: kang Yuanyi probiotics are selected as clinical common pet probiotics, and are produced by Beijing hundred Lin Kangyuan biotechnology limited liability company, fed with positive medicine groups simultaneously, fed for 1 time in the morning and at night, fed with 0.5g each time, and fed directly by mixing tablets in food according to the ratio of pet food amount to medicine amount of 10:1;
day sheet group for single garment: the diurnal tablets prepared in the example 1 are selected to be fed with a positive medicine group at the same time, 1 diurnal tablet is taken in the morning and evening, and the tablets are mixed in food to be directly fed, and the ratio of the amount of the pet food to the amount of the medicine is 10:1;
night tablet group for single administration: the night tablet prepared in the example 1 is selected to be fed simultaneously with a positive medicine group, 1 night tablet is taken in the morning and evening, and the tablets are mixed in food to be directly fed according to the ratio of the pet food amount to the medicine amount of 10:1;
the treatment effect is as follows:
and (3) healing: the symptoms completely disappeared;
the method is effective: partial symptoms disappear;
invalidation: symptoms were not improved at all, weight was reduced by 10%;
recurrence: after complete disappearance of symptoms, some or all of the symptoms appear within 1 month.
Treatment cycle 1: the therapeutic effect 7 days after administration is shown in table 1:
table 1 treatment cycle treatment effect table
| Experimental group | Healing of the wound | Effective and effective | Invalidation of | Recurrence of |
| Positive medicine set (56) | 15 pieces of | 40 pieces of | 1 part | 0 pieces of |
| Probiotic control group (56) | 3 pieces of | 48 pieces of | 5 pieces of | 0 pieces of |
| Single clothes day piece group (56) | 5 pieces of | 46 only | 3 pieces of | 0 pieces of |
| Night tablet group for single clothes56) | 4 pieces of | 50 pieces of | 2 pieces of | 0 pieces of |
Treatment cycle 2: the therapeutic effect after 14 days of administration is shown in table 2:
table 2 table of therapeutic effects after the 2 nd treatment period
| Experimental group | Healing of the wound | Effective and effective | Invalidation of | Recurrence of |
| Positive medicine set (56) | 49 pieces of | 7 pieces of | 0 pieces of | 0 pieces of |
| Probiotic control group (56) | 37 only | 5 pieces of | 14 pieces of | 0 pieces of |
| Single day piece group (56)) | 41 only | 14 pieces of | 1 part | 0 pieces of |
| Night set (56 pieces) | 35 only | 19 only | 2 pieces of | 0 pieces of |
Treatment cycle 3: the therapeutic effect after 21 days of administration is shown in table 3:
table 3 table of therapeutic effects after the 3 rd treatment period
| Experimental group | Healing of the wound | Effective and effective | Invalidation of | Recurrence of |
| Positive medicine set (56) | 51 only | 5 pieces of | 0 pieces of | 0 pieces of |
| Probiotic control group (56) | 41 only | 13 pieces of | 2 pieces of | 13 pieces of |
| Single clothes day piece group (56) | 42 only | 10 pieces of | 4 pieces of | 5 pieces of |
| Night set (56 pieces) | 45 pieces of | 9 pieces of | 2 pieces of | 1 part |
Treatment cycle 3: the therapeutic effect after 21 days of administration is shown in table 4:
table 4 table of therapeutic effects of each drug after the 3 rd treatment period
| Experimental group | Cure rate | Time of taking effect | Treatment course | Recurrence rate |
| Positive drug group (56)) | 91.07％ | 1.16 | 7.25 | 0 |
| Probiotic control group (56) | 73.21％ | 1.55 | 7.75 | 31.71％ |
| Single clothes day piece group (56) | 75.00％ | 2.35 | 11.35 | 11.90％ |
| Night set (56 pieces) | 80.35％ | 3.15 | 11.05 | 2.22％ |
Note that: the last data is after stopping the medicine by 21 days of medicine application
Cure rate = total number of bitcanines healed/total number of bitcanines per experimental group (56) ×100%
Recurrence rate = total number of bitcanines relapsed/total number of bitcanines healed ×100%
The effective time is the average value of the time used by the healed bitdogs to reach the first cure;
the course of treatment is the average of the time taken from dosing to recovery for the final recovery of bitten dogs.
Analysis of results:
(1) In the 1 st treatment period, the positive medicament group cures the diseased dogs 5 times as much as the probiotics group cures, so that the effect of the day and night compound medicament for treating the digestive tract of the pets is quick; the recovery quantity of the day tablet or the night tablet taken singly is far lower than that of the day and night compound medicine, but also higher than that of the probiotics group.
(2) The positive drug group cured the diseased dogs up to 87.50% and was all effective at treatment cycle 2; the single day tablet is used for curing the sick dogs to 73.21 percent, and is partially effective; the single night tablet is used for curing the sick dogs to 62.50 percent, and is partially effective; while the probiotic group healed the diseased dogs 66.07%, the diseased dogs with ineffective treatment were 25.00%.
(3) After the 3 rd treatment period, the positive drug group heals the sick dogs up to 91.1%, is totally effective and has no recurrence, the treatment course is shortest and the effect is fastest; the cure rate of the probiotics is 73.21 percent, the probiotics take effect but are easier to relapse, and the relapse rate is up to 31.71 percent; the cure rate of the day tablet is lower than that of the night tablet, the day tablet is easier to relapse, and the effect is quicker than that of the night tablet, but the treatment course is longer than that of the night tablet.
Clinical typical cases
Case one: russia Lan Mao, male, 2 years old, 7kg, has been sterilized. The weight of the cat after sterilization is increased by 3kg from 4kg for more than one year before sterilization, the weight of the cat is seriously beyond the normal standard, the excessive weight causes the excessive burden of the cardiovascular system of the cat, the cat shows a very high degree of asthma after a little exercise, and laboratory examination prompts chylomicronemia.
Treatment: the previous free feeding is changed into timing feeding, and the day tablet and the night tablet provided in the embodiment 1 are orally taken to assist conditioning, and the day tablet is fed in the morning and the night tablet is fed in the evening. After 1 month, the mental state of the cat is obviously improved, the exercise quantity is obviously increased, the weight is reduced to 5.6kg after 2 months of continuous use, and the blood report result is normal.
Case two: labrador dogs, male, 4 years old, 30kg, have been sterilized. The bad breath of the dogs is relatively large in body odor, often eliminates soft stool and is bad in malodor. After a plurality of grains are changed, the method has no obvious improvement, laboratory examination body conditions have no obvious abnormality, and B ultrasonic shows that the intestinal peristalsis function is weaker.
Treatment: the medicine provided in example 4 was taken in the morning and evening daily, and the day tablet was fed in the morning and the night tablet was fed in the evening. The problems of defecation and halitosis are obviously improved in 7 days, and the body taste of the case is also obviously improved in three weeks of use.
Case three: about summer dogs, male, 7 years old, 2.1kg, were sterilized. The main complaints feedback that the gastrointestinal function of the dogs is always weaker, the daily feed intake is less, the appetite is poor, no obvious interest is seen in pet snacks, the single feed intake is particularly less, and frequent vomiting can occur when the dogs eat the dogs slightly more. Laboratory examination, the dogs were free of obvious abnormalities.
Treatment: the medicine provided in this example 5 was taken twice daily, and the day tablets were fed in the morning and the night tablets were fed in the evening. After the product is orally taken for one week, the appetite of the dogs is obviously improved, the appetite is increased, the vomiting frequency is obviously reduced-! Weight gain after two weeks of continuous administration was 400g.
In sum, the effect test and clinical typical cases of the day and night compound medicine for treating the digestive tract of the pets have different dosages within the application range, are applicable to pets with different weights, have obvious effect, and can improve the illness state and achieve the treatment effect. The application follows the working characteristics of the digestive system of the pet organism, and the diurnal tablet can promote the effects of strengthening spleen and stimulating appetite, resolving food stagnation and promoting digestion and promoting gastric emptying of animals; the night tablet is in the process of resting and repairing the stomach and intestine, and can promote multiple repair of gastrointestinal mucosa, nourish stomach and promote immunity of the animal body. The double care of day and night solves the treatment and maintenance problems of weakness of spleen and stomach, inappetence, anorexia, bad breath, odor, mucous membrane restoration, balance immunity and the like.
The foregoing is merely a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A day and night compound medicine for treating digestive tract of pets, which is characterized by comprising a day prescription and a night prescription:
the main medicine composition of the diurnal prescription is as follows: yucca, haw, kudzu vine root, dried ginger, peppermint and pepsin;
the main medicine composition of the night prescription is as follows: yucca, rhizoma Polygonati, radix Angelicae sinensis, rhizoma Dioscoreae, lactoferrin, and L-glutamine.
2. The circadian combination according to claim 1, wherein the combination is
The diurnal prescription comprises the following components in parts by weight: 10-30 parts of yucca, 2-20 parts of hawthorn, 5-20 parts of kudzuvine root, 1-15 parts of dried ginger, 1-15 parts of peppermint and 1-15 parts of pepsin.
The night comprises the following components in parts by weight: 15-35 parts of yucca, 2-20 parts of rhizoma polygonati, 1-15 parts of Chinese angelica, 5-20 parts of Chinese yam, 1-10 parts of lactoferrin and 1-15 parts of L-glutamine.
3. The circadian combination according to claim 1, wherein the combination is
The diurnal prescription comprises the following components in parts by weight: 12-18 parts of yucca, 10-15 parts of hawthorn, 8-16 parts of kudzuvine root, 5-12 parts of dried ginger, 8-12 parts of peppermint and 3-9 parts of pepsin.
The night formula comprises the following components in parts by weight: 18-25 parts of yucca, 8-15 parts of rhizoma polygonati, 8-12 parts of Chinese angelica, 8-18 parts of Chinese yam, 3-8 parts of lactoferrin and 1-8 parts of L-glutamine.
4. The circadian combination according to claim 1, wherein the combination is
The diurnal prescription comprises the following components in parts by weight: 15 parts of yucca, 12 parts of hawthorn, 10 parts of kudzuvine root, 8 parts of dried ginger, 10 parts of peppermint and 6 parts of pepsin;
the night comprises the following components in parts by weight: 20 parts of yucca, 10 parts of rhizoma polygonati, 10 parts of Chinese angelica, 15 parts of Chinese yam, 5 parts of lactoferrin and 2 parts of L-glutamine.
5. The day and night compound medicine according to claims 1-4, wherein the day and night medicine can be prepared into any one of tablets, pills, decoction, powder or granules.
6. A method for preparing the day and night compound medicine according to claims 1-4, wherein the preparation method comprises the preparation of day tablets and the preparation of night tablets.
The preparation method of the diurnal tablet comprises the following steps:
1) Pulverizing fructus crataegi, radix Puerariae, rhizoma Zingiberis, and herba Menthae 4 kinds of Chinese medicinal materials respectively, sieving with 100 mesh sieve;
2) Weighing according to diurnal directions: 4 traditional Chinese medicine powder of hawthorn, kudzuvine root, dried ginger and peppermint, yucca extract and pepsin;
3) Adding 5-12% of microcrystalline cellulose, 10-15% of medicinal dextrin and 30-50% of pregelatinized starch in the total formula amount, and stirring and mixing uniformly;
4) Granulating, drying until the water content is lower than 8%, and directly tabletting;
5) Coating, wherein each tablet contains 0.5-2.0 g of medicinal powder.
The preparation method of the night tablet comprises the following steps:
1) Pulverizing 4 Chinese medicinal materials including Yucca, rhizoma Polygonati, radix Angelicae sinensis, and rhizoma Dioscoreae respectively, and sieving with 100 mesh sieve;
2) Weighing according to the formula at night: yucca, polygonatum sibiricum, angelica sinensis, dioscorea opposita 4 traditional Chinese medicine powder, yucca extract, lactoferrin and L-glutamine;
3) Adding 5-12% of microcrystalline cellulose, 15-20% of medicinal dextrin and 40-60% of pregelatinized starch in the total formula amount, and stirring and mixing uniformly;
4) Granulating, drying until the water content is lower than 8%, and directly tabletting;
5) Coating, wherein each tablet contains 0.5-2.0 g of medicinal powder.
7. A further method of preparing a tablet of the circadian combination according to claims 1-4, wherein the preparation method comprises the steps of:
diurnal tablets: weighing 5 traditional Chinese medicine extracts of yucca, hawthorn, kudzuvine root, dried ginger and peppermint according to the formula, uniformly mixing, adding 3-8% of microcrystalline cellulose, 5-10% of medicinal dextrin and 20-35% of pregelatinized starch by the total weight of diurnal prescription, uniformly stirring, granulating, drying until the water content is lower than 8%, and directly tabletting to obtain diurnal tablets, wherein each tablet contains 0.1-1.0 g of medicinal powder;
night tablet: weighing 4 traditional Chinese medicine extracts of yucca, rhizoma polygonati, chinese angelica and Chinese yam according to a formula, uniformly mixing the traditional Chinese medicine extracts, lactoferrin and L-glutamine, adding 5-10% of microcrystalline cellulose, 5-15% of medicinal dextrin and 10-25% of pregelatinized starch in the total weight of the night, uniformly stirring and mixing, granulating, drying until the water content is lower than 8%, and directly tabletting to obtain night tablets, wherein each tablet contains 0.1-1.0 g of medicinal powder.
8. A method for preparing a pill of a day and night compound medicine according to claims 1-4, wherein the formulation of the day and night compound medicine is a pill, the preparation method comprises the steps of crushing the traditional Chinese medicinal materials in the formula, sieving the crushed traditional Chinese medicinal materials with a 100-mesh sieve, respectively weighing the traditional Chinese medicinal powder in the formula amount of day and night and corresponding nutrients, uniformly mixing the traditional Chinese medicinal powder in the formula amount of day and night, obtaining day compound medicine powder and night compound medicine powder, respectively adding refined honey to prepare small honeyed pills, drying, polishing and bagging to obtain the pill.
9. The preparation method of claim 8, wherein 100-125g refined honey is added into 100g composite traditional Chinese medicine powder to prepare small honeyed pills, and the content of the powder in each pill is 0.25-1g.
10. The circadian combination according to any one of claims 1-4, wherein the circadian combination is for use in the preparation of a veterinary drug for the treatment of digestive tract diseases in pets.
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