CN102512531A - Chinese veterinary medicinal composition for preventing and treating pullorum and preparation method of same - Google Patents
Chinese veterinary medicinal composition for preventing and treating pullorum and preparation method of same Download PDFInfo
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Abstract
The invention discloses a Chinese veterinary medicinal composition for preventing and treating pullorum and a preparation method of same. The Chinese veterinary medicinal composition for preventing and treating the pullorum mainly comprises the following components in part by weight: 1-100 parts of Pulsatilla, 1-50 parts of dandelion, 1-50 parts of skullcap, 1-50 parts of honeysuckle, 1-30 parts of Phellodendron amurense, 1-50 parts of flavescens, 1-30 parts of gentian, 1-30 parts of Atractylodes, 1-30 parts of Poria, 1-30 parts of white peony root, 1-50 parts of cortex fraxini, 1-30 parts of smoked plum and 1-30 parts of licorice. The Chinese veterinary medicinal composition for preventing and treating the pullorum can be prepared into any one of commonly-used oral preparations, such as pills, capsules, tablets, powders, granules, oral solution and the like. The Chinese veterinary medicinal composition for preventing and treating the pullorum has a significant effect on treating the pullorum and a very obvious preventive effect, has good prospects of popularization and application, and can promote the healthy development of the pollution-free farming and the residue-free green meat and food processing industry.
Description
Technical field
The present invention relates to a kind of herbal medicine, particularly a kind of is the herbal medicine composition and method of making the same of preventing and treating Pullorum Disease of crude drug with the Chinese herbal medicine.
Background technology
White diarrhea disease is fallen ill for the Pullorum Disease Salmonella infects, and is the common very big a kind of bacterial infectious disease of hazardness.Primary disease shows as acute chickling, newborn young bird is acute sepsis, and 20-45 age in days young bird is subacute, and the chicken that grows up also has generation accidentally.This sick mortality rate of chickling trouble is very high, and grow up laying rate of chicken and incubation rate reduce.
Primary disease is mainly encroached on chickling.Except that chicken, infect naturally and also once be found in turkey, duck, guinea fowl, wild fowl Fang Jianyou takes place.
The infection of primary disease can be by all means, mainly is the infection of egg of carrying disease germs.In the infected chickling body a large amount of pathogen is arranged, most with the feces discharge, pollution feedstuff, drinking-water, repeated transmission dye healthy chick.Ill chickling becomes the chicken that carries disease germs after becoming to live; Because of its ovary is infected, the ovum major part of consequently being produced all contains the Hakuri bacterium, also contains the Hakuri bacterium in the feces of discharge; Just can infect one-tenth chicken to health; The infection of this disease is wide, and mortality rate is high, and the popular of this disease brings heavy losses often for the owner that raises chickens.
This disease all has popular in various places, also be main quarantine object aspect international chicken, the import and export of egg series products.
Primary disease is that being used at present prevent and treating this sick medicine mostly is antibiotic formulations to one of very big infectious disease of poultry husbandry harm, like the tetracycline same clan, and blue or green, streptomycin class.Some family of raising chickens is added medicines such as oxytetracycline, chlortetracycline for a long time and is prevented in order to reduce the generation of Pullorum Disease.Though these medicines have certain prevention effect; But exist weak curative effect; The chickling mortality rate is high, and the life-time service antibiotic can produce drug resistance to chicken, and the chicken drug disposition is residual to exceed standard; Directly influence the outlet of chicken product, cause its residual meat that exceeds standard, egg product can cause direct harm human health.
Utilizing the pure natural Chinese herbal medicine to substitute the antibiotic goods, is the trend of following aquaculture medication.
In order to overcome above-mentioned defective, the present invention is based on differential diagnosis of diseases and the dialectical principle that combines, treating both the principal and secondary aspects of a disease that Chinese veterinarian treats Pullorum Disease; Deficiency and excess is also controlled; Inside and outside logical the accent, emergency is taken in concurrently, filters out the natural plant of invigorating spleen to remove dampness, heat-clearing and toxic substances removing, dampness-eliminating and dysentery-stopping; According to the theoretical prescription of Chinese veterinarian, be prepared from according to certain weight ratio.The minimum prevention of a kind of evident in efficacy, with low cost, noresidue, toxic and side effects and the herbal medicine compositions of treatment Pullorum Disease are provided.
Above-mentioned herbal medicine compositions of the present invention adds the various adjuvants that the preparation different dosage forms can be accepted on galenic pharmacy; For example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the herbal medicine formulation method of routine, for example possibly be pill, capsule, tablet, powder, granule or oral liquid etc.
Summary of the invention
Technical problem to be solved by this invention is to overcome the herbal medicine compositions of preventing and treating Pullorum Disease that above-described shortcoming provides a kind of evident in efficacy, with low cost, noresidue, almost non-toxic side effect.
Technical problem to be solved by this invention realizes through following technological approaches.
A kind of herbal medicine compositions of preventing and treating Pullorum Disease of the present invention, the component that is mainly following weight portion is formed:
1～100 part of the Radix Pulsatillae, 1～50 part of Herba Taraxaci, 1～50 part of Radix Scutellariae, 1～50 part of Flos Lonicerae, 1～30 part of Cortex Phellodendri, 1～50 part of Radix Sophorae Flavescentis, 1～30 part of Radix Gentianae, 1～30 part of the Rhizoma Atractylodis Macrocephalae, 1～30 part in Poria, 1～30 part of the Radix Paeoniae Alba, 1～50 part of Cortex Fraxini, 1～30 part of Fructus Mume, 1～30 part in Radix Glycyrrhizae
Be preferably:
30 parts of the Radix Pulsatillaes, 20 parts of Herba Taraxacis, 20 parts of Radix Scutellariaes, 15 parts of Flos Loniceraes, 10 parts of Cortex Phellodendris, 20 parts of Radix Sophorae Flavescentiss, 10 parts of Radix Gentianaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Poria, 15 parts of the Radix Paeoniae Albas, 20 parts of Cortex Fraxinis, 10 parts of Fructus Mumes, 10 parts in Radix Glycyrrhizae.
Above-mentioned herbal medicine compositions of the present invention adds the various adjuvants that on pharmaceutics, can accept required when preparing different dosage form; For example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the herbal medicine formulation method of routine, for example can be pill, capsule, tablet, powder, granule or oral liquid etc.
The principle of herbal medicine compositions utilization Chinese veterinarian principle-method-recipe-medicines of the present invention on the basis of dialectical legislation, selects to accord with the medicine of the state of an illness, its objective is in order to be suitable for the needs of the complicated state of an illness, the synergism of performance medicine.
The present invention is a principal agent with the Radix Pulsatillae, Herba Taraxaci, Radix Scutellariae, Flos Lonicerae, Cortex Phellodendri heat-clearing and toxic substances removing, dampness-eliminating and dysentery-stopping altogether; Radix Sophorae Flavescentis, the detoxifcation of Radix Gentianae dampness, the Rhizoma Atractylodis Macrocephalae, Poria invigorating spleen for diuresis antidiarrheal are accessory drugs; Cortex Fraxini, Fructus Mume dampness astringent therapy antidiarrheal are adjuvant drug; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making.All medicines match treating both the principal and secondary aspects of a disease.
The used herbal raw material of the present invention all can be buied from the Chinese medicine shop, and its specification meets " Chinese veterinary drug allusion quotation " and relevant national veterinary drug standard.
Usage and dosage: dosage of the present invention depends on concrete dosage form; Factors such as the size of chicken (like young bird, growing chickens, big chicken etc.), body weight, prevention or treatment are as guidance: for oral administration: 1) capsule: sick big chicken; Every day 3 times, each 3 of clothes of throwing, every content of dispersion 0.3 gram.2) tablet: sick growing chickens, every day 3 times, each 2 of clothes, 3 of sick big chickens, every content of dispersion 0.3 gram thrown.3) pill: sick poult, every day 3 times, each 3 of clothes of throwing, sick growing chickens is thrown 5 of clothes at every turn, and sick big chicken is thrown 10 of clothes at every turn, per 10 piller content of dispersion, 1 gram.4) powder, granule: be used for prevention or treatment, poult is added 1.5% (prevention)～2% (treatment) in feedstuff; Growing chickens adds 0.75% (prevention)～1.0% (treatment) in feedstuff; Big chicken is added 0.5% (prevention)～1.0% (treatment) in feedstuff; 5) oral liquid: poult is added 0.75% (prevention)～1.0% (treatment) in drinking water; Growing chickens adds 0.5% (prevention)～1.0% (treatment) in drinking water; Big chicken is added 0.25% (prevention)～0.5% (treatment) in drinking water.
The prevention and the treatment that the present invention is directed to Pullorum Disease are very effective, and various crude drug are coordinated each other can play together and at utmost brought into play drug effect, can effectively improve the resistance against diseases of disease chicken body; Heat-clearing and toxic substances removing, heat clearing and damp drying, eliminating pathogenic heat from blood to cure dysentery such as the Radix Pulsatillae among the we, Radix Sophorae Flavescentis, Cortex Fraxini, heat-clearing and toxic substances removing, dysentery relieving such as Herba Taraxaci, Radix Scutellariae, Flos Lonicerae, Cortex Phellodendri, Fructus Mume relieving diarrhea with astringents; The detoxifcation of Radix Gentianae dampness, the Rhizoma Atractylodis Macrocephalae, Poria invigorating spleen for diuresis antidiarrheal, strengthening spleen and nourishing blood in the side, Rhizoma Atractylodis Macrocephalae air making-up and spleen enlivening; The Radix Paeoniae Alba is nourished blood and blood, sees from the modern Chinese medicine pharmacological research, and the Rhizoma Atractylodis Macrocephalae has the effect of enhancing human body immunity function; The Radix Paeoniae Alba has spasmolysis to the intestinal smooth muscle, can suppress multiple enteric pathogenic bacteria simultaneously, the Radix Glycyrrhizae mediation property of medicine; The treatment and the preventive effect that are used for white diarrhea disease are obvious, and also have advantage such as have no side effect, expense is lower.
The specific embodiment
Below further describe the present invention through embodiment, be construed as, these embodiment only are used for the purpose of illustration, never are limited to the present invention.
[embodiment 1] capsular preparation
Take by weighing each raw material by following weight portion: 30 parts of the Radix Pulsatillaes, 20 parts of Herba Taraxacis, 20 parts of Radix Scutellariaes, 15 parts of Flos Loniceraes, 10 parts of Cortex Phellodendris, 20 parts of Radix Sophorae Flavescentiss, 10 parts of Radix Gentianaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Poria, 15 parts of the Radix Paeoniae Albas, 20 parts of Cortex Fraxinis, 10 parts of Fructus Mumes, 10 parts in Radix Glycyrrhizae.
With each raw materials mix of above-mentioned weight portion, grind into fine powder and cross 600～800 mesh sieves and incapsulate and get final product.
The preparation of [embodiment 2] tablet
Take by weighing each raw material by following weight portion: 30 parts of the Radix Pulsatillaes, 20 parts of Herba Taraxacis, 20 parts of Radix Scutellariaes, 15 parts of Flos Loniceraes, 10 parts of Cortex Phellodendris, 20 parts of Radix Sophorae Flavescentiss, 10 parts of Radix Gentianaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Poria, 15 parts of the Radix Paeoniae Albas, 20 parts of Cortex Fraxinis, 10 parts of Fructus Mumes, 10 parts in Radix Glycyrrhizae.With each raw materials mix of above-mentioned weight portion, after grinding into fine powder and crossing 1200～1500 mesh sieves, process tablet and get final product.
The preparation of [embodiment 3] pill
Take by weighing each raw material by following weight portion: 30 parts of the Radix Pulsatillaes, 20 parts of Herba Taraxacis, 20 parts of Radix Scutellariaes, 15 parts of Flos Loniceraes, 10 parts of Cortex Phellodendris, 20 parts of Radix Sophorae Flavescentiss, 10 parts of Radix Gentianaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Poria, 15 parts of the Radix Paeoniae Albas, 20 parts of Cortex Fraxinis, 10 parts of Fructus Mumes, 10 parts in Radix Glycyrrhizae.With each raw materials mix of above-mentioned weight portion, be ground into cross 1200～1500 mesh sieves behind the fine powder after, both processed pill.
The preparation of [embodiment 4] granule
Take by weighing each raw material by following weight portion: 30 parts of the Radix Pulsatillaes, 20 parts of Herba Taraxacis, 20 parts of Radix Scutellariaes, 15 parts of Flos Loniceraes, 10 parts of Cortex Phellodendris, 20 parts of Radix Sophorae Flavescentiss, 10 parts of Radix Gentianaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Poria, 15 parts of the Radix Paeoniae Albas, 20 parts of Cortex Fraxinis, 10 parts of Fructus Mumes, 10 parts in Radix Glycyrrhizae.With each raw materials mix of above-mentioned weight portion, after grinding into fine powder and crossing 1200～1500 mesh sieves, add ethanol and make adhesive, add starch and make filler, in Drygranulatemachine, directly be pressed into granule.
The preparation of [embodiment 5] oral liquid
Take by weighing each raw material by following weight portion: 30 parts of the Radix Pulsatillaes, 20 parts of Herba Taraxacis, 20 parts of Radix Scutellariaes, 15 parts of Flos Loniceraes, 10 parts of Cortex Phellodendris, 20 parts of Radix Sophorae Flavescentiss, 10 parts of Radix Gentianaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Poria, 15 parts of the Radix Paeoniae Albas, 20 parts of Cortex Fraxinis, 10 parts of Fructus Mumes, 10 parts in Radix Glycyrrhizae.With each raw materials mix of above-mentioned weight portion, after decocting for three times, three filtratings are mixed, filter, be concentrated into the concentration of regulation, put cold, the stock solution embedding, irradiation sterilization, after the check, packed products is processed oral liquid and is promptly got.
Experimental example
The observation of curative effect experiment of herbal medicine compositions prevention of the present invention and treatment Pullorum Disease
One, the general data of experiment: adopts herbal medicine compositions of the present invention to treat white diarrhea disease chicken 4945 examples altogether, poult chicken 3355 examples wherein, middle chickling 1070 examples, one-tenth chicken 520 examples; Adopt herbal medicine compositions of the present invention, be used to prevent and treat Pullorum Disease 11862 examples, poult chicken 6886 examples wherein, middle chickling 1676 examples become chicken 80 examples, laying hen 3220 examples.
Two, prevent and treat method:
Usage and dosage: 1) capsule: sick big chicken, throw clothes three every day, and each 3, every content of dispersion 0.3 gram; 2) tablet: sick growing chickens, throw clothes 3 every day, and each 2, sick big chicken, throw clothes 3 every day, and each 3, every content of dispersion 0.3 gram; 3) pill: sick poult, throw clothes 3 every day, and each 3,5 of sick growing chickens, 10 of sick big chickens, per 10 piller content of dispersion, 1 gram; 4) powder, granule: be used for prevention or treatment, in the poult feedstuff, be used to prevent white diarrhea disease, in the poult feedstuff, be used to treat white diarrhea disease by 2% interpolation by 1.5% interpolation; In the growing chickens feedstuff, add 0.75% and be used to prevent white diarrhea disease, in the growing chickens feedstuff, be used to treat white diarrhea disease by 1.0% interpolation.In egg feedstuff, add 0.5% and be used to prevent white diarrhea disease.
Three, application example
2882 of white diarrhea diseases successively take place in Guo Daokoucun totally 3 tame chicken farms in the Zhao Dun town, and wherein the poult chicken is 1812,1070 of big chickling; Adopt herbal medicine compositions of the present invention, by adding the treatment that powder and granule are used for little chickling and big chickling respectively by 2% and 1% of feedstuff weight in the above-mentioned usage and dosage, 2～3 days sick chickens ingest after the general medication, and it is normal that drinking-water recovers; Stop death, gradually fully recover, continuous use 10 days; Consolidate curative effect, the result cures 2774, cure rate 94%.
Zhao Dun town Liu Dukoucun with herbal medicine compositions of the present invention, by above-mentioned therapeutic scheme, treats 1501 of poult white diarrhea diseases altogether, cures 1394, cure rate 92.87%.4774 little chickling of the Huang Jiawan village chicken crowd of neighbouring village are added by 1.5% in feedstuff, connect and feed 10 days, and the Pullorum Disease case does not take place.
Du Jia village, Zhao Dun town raises 2 families, chicken family scattered, and 600 at a family becomes chicken, and wherein 520 white diarrhea disease takes place; By above-mentioned usage and dosage method, every day, three throwing clothes capsule was each 3, and in 1 week of logotype, it is dead that the result does not have 1 example; Other 80, throw 2 in clothes tablet every day, in 1 week of logotype, the new case does not appear in result again; 110 the little chickling in one family, 42 of generation Pullorum Disease, by three throwing clothes pill every day, each 3, dead 3 of result, cure rate 92.8% is pressed secondary throwing every day clothes pill for other 68, and each 2, logotype 10 days, the new case does not appear in the result.
The Xiao Liu village, Zhao Dun town village has the 3 families family of raising chickens, and is respectively 1216 of poult chickens; 1676 of big chickling and 2112 of poult chickens, wherein 1676 and 2112 two families are with herbal medicine composition oral liquid of the present invention, convert 50 kilograms in water and 100 kilograms by per 1000 milliliters; By the administration of routine drinking-water, logotype 12 days, the result does not have white diarrhea disease and takes place; And 1216 groups compare test with the prevention of compound recipe Diverdine, and the generation white diarrhea disease is 106 as a result; The morbidity chicken is thrown clothes 3 times with this herbal medicine compositions pill every day, and each 3, logotype is after three days; Dead 4, continue medication 10 days, other sick young all healing.
Du Jia village, Zhao Dun town, laying hen 3220 laying hens are cultured in 1 tame chicken farm, press the 0.5% interpolation herbal medicine compositions of the present invention of feedstuff weight, logotype 5 days, drug withdrawal 20 days logotype 3 days again, the Pullorum Disease case does not appear in the result.
Can find out from above experiment situation; The herbal medicine compositions that the present invention prevents and treats Pullorum Disease has significant curative effect to the treatment of Pullorum Disease; Its preventive effect is also very obvious, has the good prospect that it is applied, and will promote the sound development of the green meat product processing industry of nuisanceless breed and noresidue.
Claims (5)
1. herbal medicine compositions of preventing and treating Pullorum Disease; It is characterized in that by the component of following weight portion: 1～100 part of the Radix Pulsatillae, 1～50 part of Herba Taraxaci, 1～50 part of Radix Scutellariae, 1～50 part of Flos Lonicerae, 1～30 part of Cortex Phellodendri, 1～50 part of Radix Sophorae Flavescentis, 1～30 part of Radix Gentianae, 1～30 part of the Rhizoma Atractylodis Macrocephalae, 1～30 part in Poria, 1～30 part of the Radix Paeoniae Alba, 1～50 part of Cortex Fraxini, 1～30 part of Fructus Mume, Radix Glycyrrhizae are formed for 1～30 part.
2. a kind of herbal medicine compositions of preventing and treating Pullorum Disease according to claim 1; It is characterized in that said herbal medicine compositions is by following bulk drugs: 30 parts of the Radix Pulsatillaes, 20 parts of Herba Taraxacis, 20 parts of Radix Scutellariaes, 15 parts of Flos Loniceraes, 10 parts of Cortex Phellodendris, 20 parts of Radix Sophorae Flavescentiss, 10 parts of Radix Gentianaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Poria, 15 parts of the Radix Paeoniae Albas, 20 parts of Cortex Fraxinis, 10 parts of Fructus Mumes, Radix Glycyrrhizae are processed for 10 parts.
3. according to the described herbal medicine compositions of claim 2, it is characterized in that: the herbal medicine formulation method according to routine is prepared into any oral formulations commonly used.
4. according to the described herbal medicine compositions of claim 3, it is characterized in that: described oral formulations is pill, capsule, tablet, powder, granule or oral liquid.
5. the application of any one described herbal medicine compositions of claim 1～4 in preparation control white diarrhea disease.
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Cited By (7)
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| CN104258015A (en) * | 2014-09-26 | 2015-01-07 | 河南科技大学 | Traditional Chinese medicine preparation for preventing silky fowl white diarrhea |
| CN104274574A (en) * | 2014-09-28 | 2015-01-14 | 哈尔滨师范大学 | Chinese herb feed additive for preventing chicken diarrhea and preparation method thereof |
| CN104547187A (en) * | 2014-12-29 | 2015-04-29 | 河南天纳图生物科技有限公司 | Compound fermented traditional Chinese medicine for preventing and treating chicken salmonellosis |
| CN104887890A (en) * | 2015-06-11 | 2015-09-09 | 山东新希望六和集团有限公司 | Medicine composition for treating white scour of chicken and preparation method thereof |
| CN105748734A (en) * | 2016-04-07 | 2016-07-13 | 张传津 | Pure traditional Chinese medicine powder for preventing and treating pullorum disease and preparation method thereof |
| CN106421063A (en) * | 2016-08-29 | 2017-02-22 | 旌德县德源农业开发有限公司 | Traditional Chinese medicine composition for treating and treating pullorum disease |
| CN106511564A (en) * | 2015-09-09 | 2017-03-22 | 谭慧敏 | Medicine for treating pullorum disease |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104258015A (en) * | 2014-09-26 | 2015-01-07 | 河南科技大学 | Traditional Chinese medicine preparation for preventing silky fowl white diarrhea |
| CN104258015B (en) * | 2014-09-26 | 2017-07-28 | 河南科技大学 | A kind of Chinese medicine preparation of prevention bamboo silk white diarrhea |
| CN104274574A (en) * | 2014-09-28 | 2015-01-14 | 哈尔滨师范大学 | Chinese herb feed additive for preventing chicken diarrhea and preparation method thereof |
| CN104547187A (en) * | 2014-12-29 | 2015-04-29 | 河南天纳图生物科技有限公司 | Compound fermented traditional Chinese medicine for preventing and treating chicken salmonellosis |
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| CN105748734A (en) * | 2016-04-07 | 2016-07-13 | 张传津 | Pure traditional Chinese medicine powder for preventing and treating pullorum disease and preparation method thereof |
| CN106421063A (en) * | 2016-08-29 | 2017-02-22 | 旌德县德源农业开发有限公司 | Traditional Chinese medicine composition for treating and treating pullorum disease |
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